Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice.

abstract：:Rat and canine hepatocyte suspensions were exposed to toxic concentrations of ethyl methanesulfonate (EMS) and ionophore A-23187 in the presence and absence of extracellular calcium (Ca2+) and alpha-tocopheryl succinate (alpha-TS). The exogenous administration of alpha-TS (25 microM) completely protected hepatocytes f...

journal_title：Toxicology letters

authors： Fariss MW,Merson MH,O'Hara TM

更新日期：1989-04-01 00:00:00

abstract：:An in vivo intestinal perfusion technique was used to measure the absorption rates of five Cr compounds in black ducks. Cr was absorbed from saline solutions of KCr(SO4)2 and CrO3 at a rate about 1.5 to 2.0 times greater than from solutions of Cr, Cr(NO3)3, and Cr(C5H7O2)3. These results suggest the ionic form of Cr i...

journal_title：Toxicology letters

authors： Eastin WC Jr,Haseltine SD,Murray HC

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:Ethanol intake can increase the sedative effects of gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL), although the real clinical impact is unknown. We studied the clinical impact of the co-ingestion of ethanol in patients presenting to the Emergency Department (ED) with acute toxicity related to GHB/GBL us...

journal_title：Toxicology letters

authors： Galicia M,Dargan PI,Dines AM,Yates C,Heyerdahl F,Hovda KE,Giraudon I,Euro-DEN Plus Research Group.,Wood DM,Miró Ò,Euro-DEN Plus Research Group.

更新日期：2019-10-10 00:00:00

abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...

journal_title：Toxicology letters

authors： Soni M,Nomiyama H,Nomiyama K

更新日期：1990-12-01 00:00:00

abstract：:Fenvalerate, a synthetic pyrethroid insecticide, is an environmental endocrine disruptor and neurodevelopmental toxicant. An early report found that pubertal exposure to high-dose fenvalerate impaired cognitive and behavioral development. Here, we aimed to further investigate the effect of pubertal exposure to low-dos...

journal_title：Toxicology letters

authors： Yang Y,Zhan F,Wang YC,Wang B,Shi MX,Guo C,Xu DX,Meng XH

更新日期：2020-10-10 00:00:00

abstract：:Occupational high-grade lead exposure has been reduced in recent decades as a result of increased regulation. However, environmental lead exposure remains widespread, and is associated with severe toxicity implicated in human diseases. We performed oral intragastric administration of various dose lead acetate to adult...

journal_title：Toxicology letters

authors： Liu J,Jia DY,Cai SZ,Li CP,Zhang MS,Zhang YY,Yan CH,Wang YP

更新日期：2015-05-19 00:00:00

abstract：:Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, we investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult male Lo...

journal_title：Toxicology letters

authors： Ruppert PH,Dyer RS

更新日期：1985-11-01 00:00:00

abstract：:Sertoli cells play a pivotal role in supporting proliferation of germ cells and differentiation during spermatogenesis in mammals. Nanomolar concentrations of Bisphenol A (BPA) can significantly stimulate the proliferation of mouse immature Sertoli (TM4) cells. However, mechanisms by which BPA caused these effects wer...

journal_title：Toxicology letters

authors： Ge LC,Chen ZJ,Liu HY,Zhang KS,Liu H,Huang HB,Zhang G,Wong CK,Giesy JP,Du J,Wang HS

更新日期：2014-04-07 00:00:00

abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1984-10-01 00:00:00

abstract：:Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strate...

journal_title：Toxicology letters

authors： Ferraguti G,Ciolli P,Carito V,Battagliese G,Mancinelli R,Ciafrè S,Tirassa P,Ciccarelli R,Cipriani A,Messina MP,Fiore M,Ceccanti M

更新日期：2017-06-05 00:00:00

abstract：:There is accumulating evidence that both type I and type II DNA-topoisomerases play a key role in cellular differentiation. Human HL-60 leukemia cells can be induced to monocytic or granulocytic differentiation with various compounds; amongst them camptothecin, a topoisomerase I inhibitor and VP-16, VM-26 and mitoxant...

journal_title：Toxicology letters

authors： Gieseler F,Boege F,Clark M,Meyer P

更新日期：1993-04-01 00:00:00

abstract：:Early detection and removal of harmful factors are essential to the proper physical and psychological development of the fetus, presumably showing the effects during the prenatal period and after birth. As one procedure to aid in understanding such factors, we have established a shell-less culture system for video mon...

journal_title：Toxicology letters

authors： Hamamichi S,Nishigori H

更新日期：2001-02-28 00:00:00

abstract：:Due to the specific antimicrobial activity of silver nanoparticles (AgNPs), they are widely used in wound dressings, coatings in medical devices and household products. In spite of the well-documented genotoxicity of AgNPs, the molecular mechanisms of relieving AgNP-induced DNA damage stress remain poorly understood. ...

journal_title：Toxicology letters

authors： Wang D,Yang H,Zhou Z,Zhao M,Chen R,Reed SH

更新日期：2018-05-15 00:00:00

abstract：:Mouse inbred strains with inherited predisposition and resistance to lung cancer provide an essential tool for the dissection of the genetics of this complex disease. We have previously mapped a major locus (Pulmonary adenoma susceptibility 1, Pas1) affecting inherited predisposition to lung cancer in mice on chromoso...

journal_title：Toxicology letters

authors： Manenti G,Nomoto T,De Gregorio L,Gariboldi M,Stefania Falvella F,Nagao M,Dragani TA

更新日期：2000-03-15 00:00:00

abstract：:Clinical epidemiological studies have shown that there is a link between Parkinson's disease (PD) and cancer, but how PD regulates cancer development remains unknown. In our study, the effect of metabotropic glutamate receptor 5 (mGlu5) on hepatoma was explored in a rotenone-induced PD model both in vitro and in vivo....

journal_title：Toxicology letters

authors： Bai XX,Gu L,Yang HM,Xi SS,Xia N,Zhang S,Zhang H

更新日期：2018-05-15 00:00:00

abstract：:Checkpoint kinase 1 (Chk1) is required for both intra-S phase and G2/M checkpoints in cell cycle, and plays critical roles in maintaining genomic stability and transducing DNA damage response. Chk1 deficiency has been shown to inhibit T-cell differentiation and resulted in severe anemia in a Chk1 heterozygous mouse mo...

journal_title：Toxicology letters

authors： Hu W,Zong Q,John-Baptiste A,Jessen B

更新日期：2011-07-28 00:00:00

abstract：:Cigarette smoking is the strongest risk factor for lung cancer (LC), but genetically determined variations in pulmonary metabolism of tobacco-derived carcinogens may affect individual risk. Results from a case-control study on LC patients demonstrated the pronounced effect of tobacco smoke on pulmonary xenobiotic meta...

journal_title：Toxicology letters

authors： Bartsch H,Castegnaro M,Rojas M,Camus AM,Alexandrov K,Lang M

更新日期：1992-12-01 00:00:00

abstract：:Primary cultures of rat hepatocytes were exposed to various concentrations of L-asparaginase derived from Escherichia Coli. Protein synthesis was inhibited by about 33% and cellular glutamine was reduced proportionally to the enzyme concentration. However, protein synthesis was inhibited only by amounts of enzyme able...

journal_title：Toxicology letters

authors： Villa P,Corada M,Bartosek I

更新日期：1986-09-01 00:00:00

abstract：:Human epidermal keratinocytes which have been cultured were treated with the heavy metal ions of cadmium, mercury, copper and zinc. Cytotoxicity was measured either by protein estimation or by using the neutral red assay. Antioxidants were added in order to find out whether heavy metal-induced cytotoxicity is related ...

journal_title：Toxicology letters

authors： Kappus H,Reinhold C

更新日期：1994-04-01 00:00:00

abstract：:Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...

journal_title：Toxicology letters

authors： Winder C

更新日期：2002-03-10 00:00:00

abstract：:Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibit...

journal_title：Toxicology letters

authors： Ge DT,Law PY,Kong SK,Ho YY

更新日期：2009-01-30 00:00:00

abstract：:Results of health survey and biological monitoring in pesticide formulators exposed to a combination of pesticides, an organophosphorus (OP) insecticide (phorate) and a persistent chlorinated insecticide (technical hexachlorocyclohexane; HCH; BHC) are reported. Exposure of 160 workers to a combination of pesticides (m...

journal_title：Toxicology letters

authors： Kashyap SK

更新日期：1986-10-01 00:00:00

abstract：:A direct continuous spectrophotometric assay to measure pyrethroid-cleaving enzymes in human serum was developed using cis- and trans-alpha-naphthyl-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate (cis- and trans-naphthyl-Cl2CA). These substrates show a structure very similar to the pyrethroids most often use...

journal_title：Toxicology letters

authors： Butte W,Kemper K

更新日期：1999-06-30 00:00:00

abstract：:We investigated the cytotoxic effects of formaldehyde (FA) on lymphocytes. FA-exposed mice showed a profound reduction not only in the number of natural killer (NK) cells but also in the expression of NK cell-specific receptors, but these mice did not exhibit decreases in the numbers of T or B lymphocytes. FA exposure...

journal_title：Toxicology letters

authors： Kim EM,Lee HY,Lee EH,Lee KM,Park M,Ji KY,Jang JH,Jeong YH,Lee KH,Yoon IJ,Kim SM,Jeong MJ,Kim KD,Kang HS

更新日期：2013-11-25 00:00:00

abstract：:Isolated, perfused and ventilated guinea-pig lungs were exposed for 10 min to acid (sulphuric + nitric acid) aerosol mimicking acid rain at pH 4.5 or 2.5, as well as to a control distilled water aerosol (pH 6.0-6.5). Lung perfusing solution was recovered and thromboxane (TX) B2 and leukotriene (LT) B4 were measured by...

journal_title：Toxicology letters

authors： Preziosi P,Ciabattoni G

更新日期：1987-11-01 00:00:00

abstract：:This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid fibrils or chrysotil...

journal_title：Toxicology letters

authors： Warheit DB,Hartsky MA,Frame SR

更新日期：1996-11-01 00:00:00

abstract：:Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and...

journal_title：Toxicology letters

authors： Bolden AL,Rochester JR,Kwiatkowski CF

更新日期：2017-10-05 00:00:00

abstract：:There are numerous observations of pharmaceuticals (or their metabolites) as contaminants in wastewater, surface water and groundwater. This implies a potential for indirect human exposure to pharmaceuticals via drinking water supplies. Various effect benchmarks may be employed in an evaluation of the significance of ...

journal_title：Toxicology letters

authors： Webb S,Ternes T,Gibert M,Olejniczak K

更新日期：2003-05-15 00:00:00

abstract：:Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

journal_title：Toxicology letters

authors： Murakami T,Nagamura Y,Hirano K

更新日期：1998-01-31 00:00:00

abstract：:Policosanol is a natural mixture of higher aliphatic primary alcohols. Oral toxicity of policosanol was evaluated in a 12-month study in which doses from 0.5 to 500 mg/kg were given orally to Sprague Dawley (SD) rats (20/sex/group) daily. There was no treatment-related toxicity. Thus, effects on body weight gain, food...

journal_title：Toxicology letters

authors： Alemán CL,Más R,Hernández C,Rodeiro I,Cerejido E,Noa M,Capote A,Menéndez R,Amor A,Fraga V

更新日期：1994-01-01 00:00:00