A spectrophotometric assay for pyrethroid-cleaving enzymes in human serum.

abstract：:Reactivity of phenoxyl radicals towards biomolecules (proteins, nucleic acids and lipids) is essential for antioxidant (protective) versus prooxidant (cytotoxic) effects of phenolic compounds (antioxidants, phytochemicals, environmental pollutants and toxic chemicals). The present study demonstrates for the first time...

journal_title：Toxicology letters

authors： Ritov VB,Menshikova EV,Goldman R,Kagan VE

更新日期：1996-10-01 00:00:00

abstract：:Xenobiotic exposure is a risk factor in the etiology of neurodegenerative disease. It was recently hypothesized that restricted exposure during brain development could predispose for a neurodegenerative disease later in life. As neuroinflammation contributes to progressive neurodegeneration, it is suspected that neuro...

journal_title：Toxicology letters

authors： Sandström von Tobel J,Zoia D,Althaus J,Antinori P,Mermoud J,Pak HS,Scherl A,Monnet-Tschudi F

更新日期：2014-10-15 00:00:00

abstract：:Fe(3)O(4) magnetic nanoparticles (MNPs) coated with 2,3-dimercaptosuccinnic acid (DMSA) are considered to be a promising nanomaterial with biocompatibility. In the present study, the effects of DMSA-coated Fe(3)O(4) MNPs on the expression of all identified mouse genes, which regulate various cellular biological proces...

journal_title：Toxicology letters

authors： Liu Y,Chen Z,Gu N,Wang J

更新日期：2011-08-28 00:00:00

abstract：:Lead is a toxic heavy metal with many recognized adverse health side effects. The central nervous system is the main target of lead toxicity. Although many studies on lead toxicity were conducted, the mechanism of lead toxicity remains uncertain. One possible attribution is the immature blood-brain barrier that causes...

journal_title：Toxicology letters

authors： Yang Y,Zhang X,Fu Y,Yang H

更新日期：2014-06-16 00:00:00

abstract：:The effects of flavoglaucin from Aspergillus chevalieri (Mangin) Thom et Church on mitochondrial reactions have been investigated to obtain insight into the mode of actions on biomembranes by means of isolated rat liver mitochondria. It was found that flavoglaucin exhibited a strong uncoupling effect on oxidative phos...

journal_title：Toxicology letters

authors： Kawai K,Mori H,Kitamura J

更新日期：1983-12-01 00:00:00

abstract：:The blood-cerebrospinal fluid barrier (BCB) plays a key role in maintaining copper (Cu) homeostasis in the brain. Cumulative evidences indicate that lead (Pb) exposure alters cerebral Cu homeostasis, which may underlie the development of neurodegenerative diseases. This study investigated the roles of Cu transporter 1...

journal_title：Toxicology letters

authors： Zheng G,Zhang J,Xu Y,Shen X,Song H,Jing J,Luo W,Zheng W,Chen J

更新日期：2014-02-10 00:00:00

abstract：:After toxicological studies with nitrate/nitrite in rats it was observed with nuclear magnetic resonance that N-methylnicotinamide (NMN), a metabolite of tryptophan was increased. The use of NMN as a biomarker for nitrate/nitrite exposure was investigated further in additional experiments with rats and in a human stud...

journal_title：Toxicology letters

authors： Jansen EH,van den Berg RH,Boink AB,Hegger C,Meulenbelt J

更新日期：1995-05-01 00:00:00

abstract：:Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...

journal_title：Toxicology letters

authors： Kulshrestha SK,Arora N

更新日期：1984-01-01 00:00:00

abstract：:A comparison of the effects produced by size-fractionated tire particles (TP10 and TP2.5) and similar-sized urban particulate matter (PM10 and PM2.5), collected in Milan in 2007, on the lungs of mice has been performed. The focus is on early acute lung responses following intratracheal instillation of aerosolized part...

journal_title：Toxicology letters

authors： Mantecca P,Farina F,Moschini E,Gallinotti D,Gualtieri M,Rohr A,Sancini G,Palestini P,Camatini M

更新日期：2010-10-05 00:00:00

abstract：:The aim of this study was to investigate the oxidative effects of Fe(2)O(3), benzo(a)pyrene (B(a)P) and pyrene, alone or in association (B(a)P or pyrene coated onto Fe(2)O(3) particles), in normal human embryonic lung epithelial cells (L132) in culture. We evaluated: (i) membrane integrity, through fatty acid release ...

journal_title：Toxicology letters

authors： Garçon G,Shirali P,Garry S,Fontaine M,Zerimech F,Martin A,Hannothiaux MH

更新日期：2000-09-30 00:00:00

abstract：:Troglitazone (Tro) is a thiazolidinedione antidiabetic drug that was withdrawn from the market due to its association with idiosyncratic severe liver injury. Tro has never induced liver injury in experimental animals in vivo. It was assumed that the species differences between human and experimental animals in the pha...

journal_title：Toxicology letters

authors： Kakuni M,Morita M,Matsuo K,Katoh Y,Nakajima M,Tateno C,Yokoi T

更新日期：2012-10-02 00:00:00

abstract：:Apoptosis has been described as programmed active cell death. Overexpression of the c-Myc gene has been shown to induce apoptosis in Rat1A/Myc-ER cells when combined with a growth blocking agent. In the present study, we tested whether 4-Hydroxynonenal (HNE) or N-acetyl-L-cysteine (LNAC) affect apoptotic death in seru...

journal_title：Toxicology letters

authors： Yildiz D,Erçal N,Frank RL,Matthews RH

更新日期：1996-12-31 00:00:00

abstract：:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...

journal_title：Toxicology letters

authors： Tanaka T

更新日期：1992-05-01 00:00:00

abstract：:An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/ex...

journal_title：Toxicology letters

authors： Hennes EC

更新日期：2012-06-20 00:00:00

abstract：:Aminoglycoside antibiotics play an integral role in antimicrobial chemotherapy. Unfortunately, these drugs are known to cause nephrotoxicity in man and experimental animals. In fact, the incidence of renal dysfunction during the course of clinical treatment with aminoglycoside antibiotics is approximately 10%. Over th...

journal_title：Toxicology letters

authors： Kacew S,Bergeron MG

更新日期：1990-05-01 00:00:00

abstract：:Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was a...

journal_title：Toxicology letters

authors： Bhisey RA,Bagwe AN,Mahimkar MB,Buch SC

更新日期：1999-09-05 00:00:00

abstract：:Oxidative damage plays a key role in septic shock induced by lipopolysaccharide (LPS) which is known to enhance the formation of reactive oxygen species (ROS). In this study, biochemical parameters indicative of oxidative stress were tested in the rat heart following LPS challenge, with and without pretreatment with t...

journal_title：Toxicology letters

authors： Ben-Shaul V,Lomnitski L,Nyska A,Zurovsky Y,Bergman M,Grossman S

更新日期：2001-08-06 00:00:00

abstract：:The elution profile of urine from rats given 63Ni i.p. using a Sephadex G-25 column was studied to investigate the chemical form and pattern of nickel (Ni) excretion. Ni was excreted probably as a mixture of complexes with chemical constituents of urine (molecular weight 200-250) within 24 h after 63Ni injection. 63Ni...

journal_title：Toxicology letters

authors： Verma HS,Behari JR,Tandon SK

更新日期：1980-03-01 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

journal_title：Toxicology letters

authors： Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

更新日期：2014-04-07 00:00:00

abstract：:One of the major side effects of aminoglycoside antibiotics (AG) is ototoxicity. The authors review the literature revealing many controversies on every aspect of this side-effect. Although epidemiological studies have to face the problem of reliable evaluation techniques, the incidence of cochleo- and vestibulotoxic ...

journal_title：Toxicology letters

authors： Govaerts PJ,Claes J,van de Heyning PH,Jorens PG,Marquet J,De Broe ME

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Although thousands of different chemicals have been identified in cigarette smoke, the characterization of their urinary metabolites still requires significant research. The aim of this work was to perform an untargeted metabolomic approach to a pilot cross-sectional study conducted on subjects with differen...

journal_title：Toxicology letters

authors： Frigerio G,Mercadante R,Campo L,Polledri E,Boniardi L,Olgiati L,Missineo P,Nash WJ,Dunn WB,Fustinoni S

更新日期：2020-09-01 00:00:00

abstract：:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

journal_title：Toxicology letters

authors： Kozma L,Lenkey A,Varga E,Gomba S

更新日期：1996-04-01 00:00:00

abstract：:The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individu...

journal_title：Toxicology letters

authors： Smolders R,Koch HM,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R,Hays SM,Aylward LL

更新日期：2014-12-01 00:00:00

abstract：:The effects of selenium on cellular toxicity and histochemical distribution of mercury were examined in a cell culture system of mouse peritoneal macrophages. Selenium protected against the toxicity of mercury in cultures exposed to 4 microM of mercuric chloride. Selenomethionine caused a significant increase in cell ...

journal_title：Toxicology letters

authors： Christensen M,Rungby J,Mogensen SC

更新日期：1989-06-01 00:00:00

abstract：:Due to the massive reduction of air-change rates in modern, energy-saving houses and dwellings, the contribution of volatile organic compound (VOCs) emissions from wood-based materials to indoor air quality has become increasingly important. To evaluate toxicity of VOC mixtures typically emitted from pine wood and ori...

journal_title：Toxicology letters

authors： Gminski R,Tang T,Mersch-Sundermann V

更新日期：2010-06-16 00:00:00

abstract：:The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. H...

journal_title：Toxicology letters

authors： Nandan SD,Rao MS

更新日期：1982-11-01 00:00:00

abstract：:In this study, the action of 3-nitropropionic acid (3-NP) on the parameters of the cortical and peripheral evoked potentials was investigated in rats in different administration schemes (20 mg/kg i.p. during recording or 24 h before, and 5x 15 mg/kg daily 28 days before recording) to elucidate some neurophysiological ...

journal_title：Toxicology letters

authors： Szabó A,Papp A,Nagymajtényi L,Vezér T

更新日期：2006-01-25 00:00:00

abstract：:Skin esterases serve an important pharmacological function as they can be utilised for activation of topically applied ester prodrugs. Understanding the nature of these enzymes, with respect to their role and local activity, is essential to defining the efficacy of ester prodrugs. Minipigs are used as models to study ...

journal_title：Toxicology letters

authors： Jewell C,Prusakiewicz JJ,Ackermann C,Payne NA,Fate G,Williams FM

更新日期：2007-09-10 00:00:00

abstract：:The in vitro interactions of carbaryl and carcinogenic N-nitrosocarbaryl with rat liver microsomal monooxygenase activities are compared. The inhibitory effect of the nitroso-compound is demonstrated to be non-competitive on aminopyrine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase. The nature of...

journal_title：Toxicology letters

authors： Beraud M,Forgue MF,Pipy B,Derache P

更新日期：1989-02-01 00:00:00