The detection of S-glutathionation of hepatic carbonic anhydrase III in rats treated with paraquat or diquat.

Abstract:

:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats were administered i.p. either paraquat at 20 or 40 mg/kg body wt. or diquat at 85 or 170 mg/kg body wt., respectively. The liver was examined at different time points for taking the measurement of the S-glutathionation of carbonic anhydrase III (CA III), thiobarbituric acid-reactive substances (TBARS), vitamin E depletion, glutathione (GSH) and glutathione disulfide (GSSG) contents. The extent of S-glutathionation of CA III was chosen as a marker and was determined by a method combining isoelectric focusing analysis with immunoblotting. Those results indicated that paraquat and diquat significantly increased the generation of TBARS and showed a time-dependent response. The significant effect on vitamin E depletion was only obtained in rats treated with a high dose of diquat for 2 h. Hepatic cellular GSSG contents did not increase but tended to decrease all of the treatments. Although oxidative damage was actually generated in liver, based on the increase of TBARS generation and vitamin E depletion, no increase of CA III S-glutathionation was observed. We propose that the reason for this observation under this circumstance is probably due to the reversible characteristic of CA III S-glutathionation, which has been demonstrated in our previous study (Chai et al., 1991) Arch. Biochem. Biophys. 384, 270-278) and named as dethiolation.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Lii CK,Wang ST,Chen HW

doi

10.1016/0378-4274(95)03621-0

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

97-105

issue

2

eissn

0378-4274

issn

1879-3169

pii

0378-4274(95)03621-0

journal_volume

84

pub_type

杂志文章
  • Estrogen receptor alpha in mouse splenic lymphocytes: possible involvement in immunity.

    abstract::To elucidate relevance of estrogens to immune responses, we investigated whether estrogen receptor alpha (ERalpha) exists in mouse splenic B cells and T cells and the effect of 17beta-estradiol and endocrine disrupting chemicals (EDCs) on lymphocyte mitogenesis. ERalpha was identified in both male and female mouse spl...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00203-5

    authors: Sakazaki H,Ueno H,Nakamuro K

    更新日期:2002-07-21 00:00:00

  • Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat.

    abstract::Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90226-6

    authors: Foster PM,Thomas LV,Cook MW,Walters DG

    更新日期:1983-02-01 00:00:00

  • Validation of alternative methods for developmental toxicity testing.

    abstract::Developmental toxicity testing according to current international guidelines involves exposure of pregnant animals, mostly rats and rabbits, and subsequent assessment of toxic effects in their fetuses. Alternative methods have been developed since the early 1980s. They include cell differentiation assays using either ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2003.12.029

    authors: Piersma AH

    更新日期:2004-04-01 00:00:00

  • Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes.

    abstract::Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, expe...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.03.014

    authors: Lauková M,Pervez S,Rosman R,Velíšková J,Velíšek L,Shakarjian MP

    更新日期:2019-06-15 00:00:00

  • Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype.

    abstract::The carcinogenicity of dichloromethane (DCM) has been demonstrated by mutagenicity studies using bacteria and yeasts and using animal bioassays. Epidemiological studies indicate that exposure to DCM increases the incidences of liver and pancreas cancers. In the present study, we determine whether DCM generates DNA dam...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.09.002

    authors: Olvera-Bello AE,Estrada-Muñiz E,Elizondo G,Vega L

    更新日期:2010-12-15 00:00:00

  • Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.

    abstract::Cytochrome P4501A1 is involved in the metabolism of carcinogenic polycyclic aromatic hydrocarbons; therefore, its inhibition interferes with the carcinogenesis process induced by these compounds in rats. The human and rat CYP1A1 differ by 21% in amino acid sequence, including the active site of the enzyme; this differ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.07.023

    authors: Santes-Palacios R,Romo-Mancillas A,Camacho-Carranza R,Espinosa-Aguirre JJ

    更新日期:2016-09-06 00:00:00

  • Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells.

    abstract::The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.10.002

    authors: Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

    更新日期:2006-03-01 00:00:00

  • Toxicological evaluation by in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves.

    abstract::Toxicity of an aqueous extract prepared from Echinodorus macrophyllus dried leaves, a plant used in folk medicine to treat inflammation and kidney malfunctions, was estimated by different bioassays. Mutagenicity of the aqueous extract was evaluated in the Salmonella/microsome assay (TA97a, TA98, TA100 and TA102 strain...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00220-4

    authors: da Costa Lopes L,Albano F,Augusto Travassos Laranja G,Marques Alves L,Fernando Martins e Silva L,Poubel de Souza G,de Magalhães Araujo I,Firmino Nogueira-Neto J,Felzenszwalb I,Kovary K

    更新日期:2000-08-16 00:00:00

  • Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications.

    abstract::Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nu...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(01)00482-9

    authors: Hartwig A,Schwerdtle T

    更新日期:2002-02-28 00:00:00

  • A repeated dose study of the toxicity of CR applied to the skin of mice.

    abstract::Dibenz (b,f)-1-4 oxazepine (CR) was applied to the skin of C3H and Porton-strain mice, daily for 12 weeks. After a further 80 weeks the animals were sacrificed and examined grossly and histologically. The results were compared with appropriate solvent and untreated controls. No abnormalities were found that could be a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:

    authors: Marrs TC,Gray MI,Colgrave HF,Gall D

    更新日期:1982-10-01 00:00:00

  • Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats.

    abstract::Anti-androgenic chemicals alter sexual differentiation by a variety of mechanisms, and the mechanisms between phthalate esters and p,p'-DDE are considered to be different. We performed an in utero through lactational exposure assay using dicyclohexyl phthalate and p,p'-DDE to investigate the sexual differentiation of ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.04.023

    authors: Yamasaki K,Okuda H,Takeuchi T,Minobe Y

    更新日期:2009-08-25 00:00:00

  • Is the fresh water fish consumption a significant determinant of the internal exposure to perfluoroalkylated substances (PFAS)?

    abstract::PFAS are man-made compounds that are highly spread in the environment. Human dietary exposure to such contaminants is of high concern as they may accumulate in the food chain. Different studies already demonstrated the importance of the fish consumption in the dietary exposure of these molecules and the potential incr...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.07.028

    authors: Denys S,Fraize-Frontier S,Moussa O,Le Bizec B,Veyrand B,Volatier JL

    更新日期:2014-12-01 00:00:00

  • Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.

    abstract::Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90094-9

    authors: Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

    更新日期:1986-02-01 00:00:00

  • Determination of mercury in hair of children.

    abstract::Although high or repeated exposure to different forms of Hg can have serious health consequences, the most important toxicity risk for humans is as methylmercury (MeHg) which exposure is mainly through consumption of fish. Generally, more than the 80% of Hg in hair is as MeHg, which is taken up by hair follicles as Me...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.06.1215

    authors: Pino A,Bocca B,Forte G,Majorani C,Petrucci F,Senofonte O,Alimonti A

    更新日期:2018-12-01 00:00:00

  • N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.

    abstract::The liver carcinogen N-nitrosodimethylamine (NDMA) has to be metabolically activated by specific cytochromes before it can react with cellular macromolecules (e.g. proteins or DNA). Although hepatocytes are believed to be responsible for this activation, the liver tumours originate mainly from non-parenchymal cells (N...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(01)00400-3

    authors: Frei E,Kuchenmeister F,Gliniorz R,Breuer A,Schmezer P

    更新日期:2001-09-15 00:00:00

  • Dioxins, dioxin-like PCBs and non-dioxin-like PCBs in foodstuffs: occurrence and dietary intake in The Netherlands.

    abstract::Data on occurrence of dioxins (polychlorinated dibenzo-p-dioxins [PCDDs] and dibenzofurans [PCDFs]), dioxin-like PCBs (polychlorinated non-ortho and mono-ortho biphenyls) and non-dioxin-like PCBs (as represented by the so-called indicator-PCBs: congeners 28, 52, 101, 118, 138, 153 and 180) in food products consumed in...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.01.028

    authors: Baars AJ,Bakker MI,Baumann RA,Boon PE,Freijer JI,Hoogenboom LA,Hoogerbrugge R,van Klaveren JD,Liem AK,Traag WA,de Vries J

    更新日期:2004-06-15 00:00:00

  • Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol.

    abstract::A physiologically based pharmacokinetic (PBPK) model describing the disposition of 2-butoxyethanol (2-BE) was developed in order to predict the urinary concentration of its major metabolite, butoxyacetic acid (BAA) under a range of exposure scenarios. Based on Corley et al. [Corley, R.A., Bormett, G.A., Ghanayem, B.I....

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.09.012

    authors: Franks SJ,Spendiff MK,Cocker J,Loizou GD

    更新日期:2006-04-10 00:00:00

  • Glutathione is a potential therapeutic target for acrolein toxicity in the cornea.

    abstract::Toxic and volatile chemicals are widely used in household products and previously used as warfare agents, causing a public health threat worldwide. This study aimed to evaluate the extent of injury and mechanisms of acrolein toxicity in the cornea. Primary human corneal stromal fibroblasts cultures (hCSFs) from human ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2021.01.005

    authors: Gupta S,Kamil S,Sinha PR,Rodier JT,Chaurasia SS,Mohan RR

    更新日期:2021-01-06 00:00:00

  • Titanium dioxide nanoparticles cause apoptosis in BEAS-2B cells through the caspase 8/t-Bid-independent mitochondrial pathway.

    abstract::To understand the underlying mechanism for apoptosis induced by titanium dioxide nanoparticles (TNP), human airway epithelial cell line was cultured to investigate the relevant apoptosis pathways. Our results showed that the levels of reactive oxygen species and morphological apoptosis increased in a dose-dependent ma...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.03.014

    authors: Shi Y,Wang F,He J,Yadav S,Wang H

    更新日期:2010-06-16 00:00:00

  • Evaluation of in vitro absorption, decontamination and desorption of organophosphorous compounds from skin and synthetic membranes.

    abstract::Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.03.005

    authors: Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

    更新日期:2013-05-23 00:00:00

  • Using disease-burden method to evaluate the strategies for reduction of aflatoxin exposure in peanuts.

    abstract::Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.07.006

    authors: Wang X,You SH,Lien KW,Ling MP

    更新日期:2019-10-10 00:00:00

  • Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry.

    abstract::This study aims to determine whether quercetin elicits a protective effect against the toxicity of chronic exposure to low-level DDVP using metabonomic technology. Rats were randomly assigned into the control, DDVP-treated, quercetin-treated, and quercetin plus DDVP-treated groups. DDVP and quercetin were given to rat...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.12.017

    authors: Wang H,Li S,Qi L,Xu W,Zeng Y,Hou Y,Zhao X,Sun C

    更新日期:2014-03-03 00:00:00

  • Effects of amaranth on F1 generation mice.

    abstract::The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90290-z

    authors: Tanaka T

    更新日期:1992-05-01 00:00:00

  • Biological monitoring of mercury vapour exposure by scalp hair analysis in comparison to blood and urine.

    abstract::The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the te...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03741-1

    authors: Wilhelm M,Müller F,Idel H

    更新日期:1996-11-01 00:00:00

  • Responses of estrogen sensitive tissues in female Wistar rats to pre- and postnatal isoflavone exposure.

    abstract::Effects of isoflavones on estrogen sensitive tissues are discussed controversially. This study was designed to investigate tissue specific effects of an isoflavone exposure through different periods of life in female Wistar rats and to compare the effects of genistein (GEN) to those of mixed dietary isoflavones, GEN a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.08.019

    authors: Hertrampf T,Ledwig C,Kulling S,Molzberger A,Möller FJ,Zierau O,Vollmer G,Moors S,Degen GH,Diel P

    更新日期:2009-12-15 00:00:00

  • Ten-day repeated-exposure inhalation study of dimethylformamide (DMF) in cynomolgus monkeys.

    abstract::Cynomolgus monkeys showed no measurable adverse effects following inhalation of 500 ppm dimethylformamide (DMF), 6 h/d, 5 d/wk, for 2 weeks either when exposed whole-body or head-only (one monkey per exposure route). Measurement of DMF concentrations into and out of the head-only exposure unit along with measurement o...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90076-i

    authors: Hurtt ME,McCooey KT,Placke ME,Kennedy GL

    更新日期:1991-12-01 00:00:00

  • Comparison of in vivo and in vitro methods for assessing the effects of carbon tetrachloride on the hepatic drug-metabolizing enzyme system.

    abstract::The effect of a single i.p. injection of 0, 20, 200, and 1000 microliter/kg carbon tetrachloride on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane (gamma-hexachlorocyclohexane) and by a battery of in vitro enzyme assays. The data in this...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90116-6

    authors: Chadwick RW,Copeland MF,Carlson GP,Trela BA,Most BM

    更新日期:1988-09-01 00:00:00

  • Antimutagenicity of coriander (Coriandrum sativum) juice on the mutagenesis produced by plant metabolites of aromatic amines.

    abstract::Aromatic amines are metabolically activated into mutagenic compounds by both animal and plant systems. The 4-nitro-o-phenylenediamine (NOP) is a well-known direct-acting mutagen whose mutagenic potential can be enhanced by plant metabolism; m-phenylenediamine (m-PDA) is converted to mutagenic products detected by the ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.05.011

    authors: Cortés-Eslava J,Gómez-Arroyo S,Villalobos-Pietrini R,Espinosa-Aguirre JJ

    更新日期:2004-11-02 00:00:00

  • Multi-walled carbon nanotube inhibits CA1 glutamatergic synaptic transmission in rat's hippocampal slices.

    abstract::The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.06.036

    authors: Chen T,Yang J,Zhang H,Ren G,Yang Z,Zhang T

    更新日期:2014-09-17 00:00:00

  • Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice.

    abstract::Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days sub...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90141-9

    authors: Rattner BA,Michael SD

    更新日期:1985-01-01 00:00:00