Induction of renin release from isolated glomeruli by inorganic mercury(II).


:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli was used to measure the mercury(II)-induced renin release in vitro. The glomeruli were isolated from female BALBc mice. HgCl2 was found to be capable of inducing renin release directly from JGC. The effect is concentration-dependent (P < 0.05, r = 0.914 and P < 0.01, r = 0.982, with and without Neutral Red vital staining) and becomes apparent already at a mercury(II) ion concentration as low as 1 microM. The renin-releasing effect of the mercury ion is to be inhibited by dithiothreitol (DTT) (renin activity 20.37 vs. 2.60 ng/ml.h in supernatant) as well as the elevated osmotic concentration of the incubating bath medium (20.37 vs. 6.84 ng/ml.h). This suggests that certain membrane sulfhydryl groups are implicated in the process on the one hand, and it is also in accordance with the known sensitivity of the renin granules to osmotic pressure on the other hand. Light and electron micrographs also demonstrate the direct, effective role of Hg(II) in the renin release process. Therefore, it is assumed that apart from its influence on tubulo-glomerular feedback a direct way of action of mercury(II) on renin release must also be taken into account.


Toxicol Lett


Toxicology letters


Kozma L,Lenkey A,Varga E,Gomba S




Has Abstract


1996-04-01 00:00:00














  • Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.

    abstract::The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tomida T,Okamura H,Satsukawa M,Yokoi T,Konno Y

    更新日期:2015-07-02 00:00:00

  • Effects of lithium and rubidium on immune responses of rats.

    abstract::Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jones JM,Yeralan O,Hines G,Maher M,Roberts DW,Benson RW

    更新日期:1990-07-01 00:00:00

  • Calcitonin inhibits the increase in bone acid phosphatase activity by high dose of zinc in rats.

    abstract::The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yamaguchi M,Takahashi K

    更新日期:1983-10-01 00:00:00

  • Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice.

    abstract::As a main clinical feature of obstructive sleep apnea (OSA), intermittent hypoxia (IH) induces oxidative stress, leading to damage to a variety of organs, including kidney. Metallothionein (MT) is a potent antioxidant that protects kidney against oxidative damage. Our previous studies demonstrated that MT prevented IH...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wu H,Zhou S,Kong L,Chen J,Feng W,Cai J,Miao L,Tan Y

    更新日期:2015-01-22 00:00:00

  • Inhibition of store-operated Ca(2+) channels prevent ethanol-induced intracellular Ca(2+) increase and cell injury in a human hepatoma cell line.

    abstract::Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

    更新日期:2012-02-05 00:00:00

  • Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene.

    abstract::Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chung WG,Yu IJ,Park CS,Lee KH,Roh HK,Cha YN

    更新日期:1999-01-11 00:00:00

  • Effects of X-irradiation on nerve growth factor in the developing mouse brain.

    abstract::The involvement of neurotrophins after radiation injury during brain development were studied in pregnant mice (C 57/B1) exposed on gestation day 15 to X-ray doses of 0.02-2 Gy. Nerve growth factor protein (NGF) and different cholinergic markers were investigated on postnatal day 1 (P1) and day 21 (P21); in situ hybri...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Dimberg Y,Vazquez M,Söderström S,Ebendal T

    更新日期:1997-01-15 00:00:00

  • The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation.

    abstract::Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

    更新日期:2017-10-05 00:00:00

  • DBP-induced endoplasmic reticulum stress in male germ cells causes autophagy, which has a cytoprotective role against apoptosis in vitro and in vivo.

    abstract::Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

    更新日期:2016-03-14 00:00:00

  • The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds.

    abstract::A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Okey AB,Riddick DS,Harper PA

    更新日期:1994-01-01 00:00:00

  • Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1β and IL-8.

    abstract::Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Silva LR,Girard D

    更新日期:2016-09-30 00:00:00

  • Extrapolation from animals to humans: scientific and regulatory aspects.

    abstract::The necessity to protect humans from the adverse effects of chemicals on structure and function of the developing and/or mature nervous system is increasingly recognized among regulatory bodies throughout the world. Whereas structural changes dominated much of neurotoxicological research in the past, functional marker...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Winneke G,Lilienthal H

    更新日期:1992-12-01 00:00:00

  • Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice.

    abstract::Saikosaponin-d (SSd), one of the main constituents of the total saikosaponins extracted from Bupleurum falcatum L, possesses anti-inflammatory and anti-apoptosis effect. Recently, SSd was proved to improve depressive symptoms although exhibit hepatotoxicity in animals, but the central nervous system (CNS) toxicity of ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lixing X,Zhouye J,Liting G,Ruyi Z,Rong Q,Shiping M

    更新日期:2018-03-01 00:00:00

  • The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study.

    abstract::Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. However, in vivo studies in various, soman poisoned animal species showed a therapeutic effect of oximes, with the exac...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Worek F,Thiermann H,Wille T

    更新日期:2018-09-01 00:00:00

  • Challenging conventional risk assessment with respect to human exposure to multiple food contaminants in food: A case study using maize.

    abstract::Mycotoxins and heavy metals are ubiquitous in the environment and contaminate many foods. The widespread use of pesticides in crop production to control disease contributes further to the chemical contamination of foods. Thus multiple chemical contaminants threaten the safety of many food commodities; hence the presen...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Clarke R,Connolly L,Frizzell C,Elliott CT

    更新日期:2015-10-01 00:00:00

  • Pb inhibits hippocampal synaptic transmission via cyclin-dependent kinase-5 dependent Synapsin 1 phosphorylation.

    abstract::Lead (Pb) exposure impairs the nervous system, of which the injury of cognitive development is obvious. But the mechanism of Pb induced disorders of neuro-transmission remain elusive. In this study, primary hippocampal neurons were exposed to Pb at the dosage of 5 μM from days in vitro (DIV) 3 to DIV14 and the electro...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ding JJ,Zou RX,He HM,Lou ZY,Xu Y,Wang HL

    更新日期:2018-10-15 00:00:00

  • A vasoactive serum component and reactivity of isolated rat aorta after chronic alcohol administration.

    abstract::Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Baños G,Lopez-Zetina P,Franco M

    更新日期:1995-02-01 00:00:00

  • Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein.

    abstract:BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Im DS,Shin HJ,Yang KJ,Jung SY,Song HY,Hwang HS,Gil HW

    更新日期:2017-08-05 00:00:00

  • Differences in individual susceptibility to toxic effects of chemicals determine the dose-response relationship and consequences of setting exposure standards.

    abstract::The dose-response curve obtained in toxicity testing is a mirror image of the susceptibility distribution in the treated population, i.e. it follows increasing tolerance of the individuals to the adverse effects of the chemical under investigation. Defining a dose as a maximum tolerated exposure level, therefore, spli...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Lutz WK

    更新日期:2002-02-07 00:00:00

  • Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity.

    abstract:UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kim YJ,Kim TW,Park SR,Kim HT,Jung DY,Ryu SY,Jung JY

    更新日期:2016-01-22 00:00:00

  • Acute renal failure alters the kinetics of pralidoxime in rats.

    abstract::There is a trend towards increasing doses of pralidoxime to treat human organophosphate poisonings that may have relevance in subpopulations. Indeed, pralidoxime is eliminated unchanged by the renal route. This study assesses the effect of renal failure on the kinetics of pralidoxime in a rat model of acute renal fail...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kayouka M,Houzé P,Risède P,Debray M,Baud FJ

    更新日期:2009-01-10 00:00:00

  • A new physiological biomarker for nitrate exposure in humans.

    abstract::After toxicological studies with nitrate/nitrite in rats it was observed with nuclear magnetic resonance that N-methylnicotinamide (NMN), a metabolite of tryptophan was increased. The use of NMN as a biomarker for nitrate/nitrite exposure was investigated further in additional experiments with rats and in a human stud...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jansen EH,van den Berg RH,Boink AB,Hegger C,Meulenbelt J

    更新日期:1995-05-01 00:00:00

  • Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.

    abstract::E-64d (a calpain and autophagy inhibitor) has previously been shown safe for the treatment of Alzheimer's disease in humans. In the present study, the potential protective mechanism of E-64d on hippocampal aberrant mossy fiber sprouting was examined in a developmental rat model of penicillin-induced recurrent epilepti...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ni H,Ren SY,Zhang LL,Sun Q,Tian T,Feng X

    更新日期:2013-02-27 00:00:00

  • Biological monitoring of mercury vapour exposure by scalp hair analysis in comparison to blood and urine.

    abstract::The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the te...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wilhelm M,Müller F,Idel H

    更新日期:1996-11-01 00:00:00

  • Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease.

    abstract::Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Mou Z,Yuan YH,Zhang Z,Song LK,Chen NH

    更新日期:2020-05-15 00:00:00

  • Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins.

    abstract::Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Scheri RC,Lee J,Barofsky DF,Curtis LR

    更新日期:2009-12-01 00:00:00

  • Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells.

    abstract::Sertoli cells play a pivotal role in supporting proliferation of germ cells and differentiation during spermatogenesis in mammals. Nanomolar concentrations of Bisphenol A (BPA) can significantly stimulate the proliferation of mouse immature Sertoli (TM4) cells. However, mechanisms by which BPA caused these effects wer...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ge LC,Chen ZJ,Liu HY,Zhang KS,Liu H,Huang HB,Zhang G,Wong CK,Giesy JP,Du J,Wang HS

    更新日期:2014-04-07 00:00:00

  • Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats.

    abstract::Conversion of hepatic stellate cells (HSCs) into hepatic myofibroblasts is a necessary event during the development of liver fibrosis. DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of profibrotic genes, is selectively induced in myofibroblasts...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Bian EB,Huang C,Wang H,Chen XX,Zhang L,Lv XW,Li J

    更新日期:2014-01-13 00:00:00

  • Effects of inhalation exposure to carbon disulfide and its combination with hydrogen sulfide on embryonal and fetal development in rats.

    abstract::Pregnant rats were exposed to 0, 100, 200, 400 or 800 ppm of carbon disulfide (CS2), 100 ppm of hydrogen sulfide (H2S) alone or in combination with 400 and 800 ppm CS2, 6 h/d during days 6-20 of gestation. Maternal reproduction and fetal parameters were evaluated on gestational day 21. Treatment with 100 or 200 ppm CS...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Saillenfait AM,Bonnet P,de Ceaurriz J

    更新日期:1989-07-01 00:00:00

  • Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model.

    abstract::Work with sub-natural levels of deuterium (D) in animals has demonstrated an anti-cancer effect of low D-concentration in water. Our objective was to investigate whether deuterium-depleted water (DDW) can overturn reverse manganese (Mn)-induced reduction in life span, using the Caenorhabditis elegans (C. elegans) as a...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Avila DS,Somlyai G,Somlyai I,Aschner M

    更新日期:2012-06-20 00:00:00