Induction of renin release from isolated glomeruli by inorganic mercury(II).

abstract：:The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-...

journal_title：Toxicology letters

authors： Tomida T,Okamura H,Satsukawa M,Yokoi T,Konno Y

更新日期：2015-07-02 00:00:00

abstract：:Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer ...

journal_title：Toxicology letters

authors： Jones JM,Yeralan O,Hines G,Maher M,Roberts DW,Benson RW

更新日期：1990-07-01 00:00:00

abstract：:The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...

journal_title：Toxicology letters

authors： Yamaguchi M,Takahashi K

更新日期：1983-10-01 00:00:00

abstract：:As a main clinical feature of obstructive sleep apnea (OSA), intermittent hypoxia (IH) induces oxidative stress, leading to damage to a variety of organs, including kidney. Metallothionein (MT) is a potent antioxidant that protects kidney against oxidative damage. Our previous studies demonstrated that MT prevented IH...

journal_title：Toxicology letters

authors： Wu H,Zhou S,Kong L,Chen J,Feng W,Cai J,Miao L,Tan Y

更新日期：2015-01-22 00:00:00

abstract：:Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

journal_title：Toxicology letters

authors： Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

更新日期：2012-02-05 00:00:00

abstract：:Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing...

journal_title：Toxicology letters

authors： Chung WG,Yu IJ,Park CS,Lee KH,Roh HK,Cha YN

更新日期：1999-01-11 00:00:00

abstract：:The involvement of neurotrophins after radiation injury during brain development were studied in pregnant mice (C 57/B1) exposed on gestation day 15 to X-ray doses of 0.02-2 Gy. Nerve growth factor protein (NGF) and different cholinergic markers were investigated on postnatal day 1 (P1) and day 21 (P21); in situ hybri...

journal_title：Toxicology letters

authors： Dimberg Y,Vazquez M,Söderström S,Ebendal T

更新日期：1997-01-15 00:00:00

abstract：:Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

journal_title：Toxicology letters

authors： Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

更新日期：2017-10-05 00:00:00

abstract：:Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

journal_title：Toxicology letters

authors： Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

更新日期：2016-03-14 00:00:00

abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

journal_title：Toxicology letters

authors： Okey AB,Riddick DS,Harper PA

更新日期：1994-01-01 00:00:00

abstract：:Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

journal_title：Toxicology letters

authors： Silva LR,Girard D

更新日期：2016-09-30 00:00:00

abstract：:The necessity to protect humans from the adverse effects of chemicals on structure and function of the developing and/or mature nervous system is increasingly recognized among regulatory bodies throughout the world. Whereas structural changes dominated much of neurotoxicological research in the past, functional marker...

journal_title：Toxicology letters

authors： Winneke G,Lilienthal H

更新日期：1992-12-01 00:00:00

abstract：:Saikosaponin-d (SSd), one of the main constituents of the total saikosaponins extracted from Bupleurum falcatum L, possesses anti-inflammatory and anti-apoptosis effect. Recently, SSd was proved to improve depressive symptoms although exhibit hepatotoxicity in animals, but the central nervous system (CNS) toxicity of ...

journal_title：Toxicology letters

authors： Lixing X,Zhouye J,Liting G,Ruyi Z,Rong Q,Shiping M

更新日期：2018-03-01 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. However, in vivo studies in various, soman poisoned animal species showed a therapeutic effect of oximes, with the exac...

journal_title：Toxicology letters

authors： Worek F,Thiermann H,Wille T

更新日期：2018-09-01 00:00:00

abstract：:Mycotoxins and heavy metals are ubiquitous in the environment and contaminate many foods. The widespread use of pesticides in crop production to control disease contributes further to the chemical contamination of foods. Thus multiple chemical contaminants threaten the safety of many food commodities; hence the presen...

journal_title：Toxicology letters

authors： Clarke R,Connolly L,Frizzell C,Elliott CT

更新日期：2015-10-01 00:00:00

abstract：:Lead (Pb) exposure impairs the nervous system, of which the injury of cognitive development is obvious. But the mechanism of Pb induced disorders of neuro-transmission remain elusive. In this study, primary hippocampal neurons were exposed to Pb at the dosage of 5 μM from days in vitro (DIV) 3 to DIV14 and the electro...

journal_title：Toxicology letters

authors： Ding JJ,Zou RX,He HM,Lou ZY,Xu Y,Wang HL

更新日期：2018-10-15 00:00:00

abstract：:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

journal_title：Toxicology letters

authors： Baños G,Lopez-Zetina P,Franco M

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...

journal_title：Toxicology letters

authors： Im DS,Shin HJ,Yang KJ,Jung SY,Song HY,Hwang HS,Gil HW

更新日期：2017-08-05 00:00:00

abstract：:The dose-response curve obtained in toxicity testing is a mirror image of the susceptibility distribution in the treated population, i.e. it follows increasing tolerance of the individuals to the adverse effects of the chemical under investigation. Defining a dose as a maximum tolerated exposure level, therefore, spli...

journal_title：Toxicology letters

authors： Lutz WK

更新日期：2002-02-07 00:00:00

abstract：UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....

journal_title：Toxicology letters

authors： Kim YJ,Kim TW,Park SR,Kim HT,Jung DY,Ryu SY,Jung JY

更新日期：2016-01-22 00:00:00

abstract：:There is a trend towards increasing doses of pralidoxime to treat human organophosphate poisonings that may have relevance in subpopulations. Indeed, pralidoxime is eliminated unchanged by the renal route. This study assesses the effect of renal failure on the kinetics of pralidoxime in a rat model of acute renal fail...

journal_title：Toxicology letters

authors： Kayouka M,Houzé P,Risède P,Debray M,Baud FJ

更新日期：2009-01-10 00:00:00

abstract：:After toxicological studies with nitrate/nitrite in rats it was observed with nuclear magnetic resonance that N-methylnicotinamide (NMN), a metabolite of tryptophan was increased. The use of NMN as a biomarker for nitrate/nitrite exposure was investigated further in additional experiments with rats and in a human stud...

journal_title：Toxicology letters

authors： Jansen EH,van den Berg RH,Boink AB,Hegger C,Meulenbelt J

更新日期：1995-05-01 00:00:00

abstract：:E-64d (a calpain and autophagy inhibitor) has previously been shown safe for the treatment of Alzheimer's disease in humans. In the present study, the potential protective mechanism of E-64d on hippocampal aberrant mossy fiber sprouting was examined in a developmental rat model of penicillin-induced recurrent epilepti...

journal_title：Toxicology letters

authors： Ni H,Ren SY,Zhang LL,Sun Q,Tian T,Feng X

更新日期：2013-02-27 00:00:00

abstract：:The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the te...

journal_title：Toxicology letters

authors： Wilhelm M,Müller F,Idel H

更新日期：1996-11-01 00:00:00

abstract：:Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...

journal_title：Toxicology letters

authors： Mou Z,Yuan YH,Zhang Z,Song LK,Chen NH

更新日期：2020-05-15 00:00:00

abstract：:Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...

journal_title：Toxicology letters

authors： Scheri RC,Lee J,Barofsky DF,Curtis LR

更新日期：2009-12-01 00:00:00

abstract：:Sertoli cells play a pivotal role in supporting proliferation of germ cells and differentiation during spermatogenesis in mammals. Nanomolar concentrations of Bisphenol A (BPA) can significantly stimulate the proliferation of mouse immature Sertoli (TM4) cells. However, mechanisms by which BPA caused these effects wer...

journal_title：Toxicology letters

authors： Ge LC,Chen ZJ,Liu HY,Zhang KS,Liu H,Huang HB,Zhang G,Wong CK,Giesy JP,Du J,Wang HS

更新日期：2014-04-07 00:00:00

abstract：:Conversion of hepatic stellate cells (HSCs) into hepatic myofibroblasts is a necessary event during the development of liver fibrosis. DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of profibrotic genes, is selectively induced in myofibroblasts...

journal_title：Toxicology letters

authors： Bian EB,Huang C,Wang H,Chen XX,Zhang L,Lv XW,Li J

更新日期：2014-01-13 00:00:00

abstract：:Pregnant rats were exposed to 0, 100, 200, 400 or 800 ppm of carbon disulfide (CS2), 100 ppm of hydrogen sulfide (H2S) alone or in combination with 400 and 800 ppm CS2, 6 h/d during days 6-20 of gestation. Maternal reproduction and fetal parameters were evaluated on gestational day 21. Treatment with 100 or 200 ppm CS...

journal_title：Toxicology letters

authors： Saillenfait AM,Bonnet P,de Ceaurriz J

更新日期：1989-07-01 00:00:00

abstract：:Work with sub-natural levels of deuterium (D) in animals has demonstrated an anti-cancer effect of low D-concentration in water. Our objective was to investigate whether deuterium-depleted water (DDW) can overturn reverse manganese (Mn)-induced reduction in life span, using the Caenorhabditis elegans (C. elegans) as a...

journal_title：Toxicology letters

authors： Avila DS,Somlyai G,Somlyai I,Aschner M

更新日期：2012-06-20 00:00:00