Interaction of carbaryl and N-nitrosocarbaryl with microsomal monooxygenase activities.

abstract：:The efflux transporter breast cancer resistance protein (BCRP/ABCG2) decrease intestinal absorption of many food toxicants. Oleic acid increases absorption of the specific BCRP substrate mitoxantrone (MXR), and also BCRP gene expression in human intestinal Caco-2 cells, suggesting that oleic acid affect the BCRP funct...

journal_title：Toxicology letters

authors： Aspenström-Fagerlund B,Tallkvist J,Ilbäck NG,Glynn AW

更新日期：2015-09-02 00:00:00

abstract：:Morphological malformations induced by tributyltin (TBT) exposure during embryonic development have already been characterized in various taxonomic groups, but, nonetheless, the molecular processes underlying these changes remain obscure. The present study provides the first genome-wide screening for differentially ex...

journal_title：Toxicology letters

authors： Scheider J,Afonso-Grunz F,Jessl L,Hoffmeier K,Winter P,Oehlmann J

更新日期：2018-03-01 00:00:00

abstract：:Nonylphenol (NP) is a representative endocrine disruptor that has an adverse effect on male reproduction and posses direct hazard to Sertoli cells, but the mechanism remains incompletely elucidated. In the present study, based on the structural comparability and high affinity between NP and membrane phospholipid molec...

journal_title：Toxicology letters

authors： Gong Y,Pan X,Huang Y,Gao Z,Yu H,Han X

更新日期：2008-12-15 00:00:00

abstract：:This study attempted the liposomalization of coproporphyrin I (CPI) with hydrophobic properties. Liposomalization of CPI was not successful at any pH when using lactate buffer. In contrast, when using 9% sucrose/10mM phosphate buffer (pH 7.8), CPI liposomes (Lipo-CPI) and polyethyleneglycol (PEG) modified liposomes (P...

journal_title：Toxicology letters

authors： Sadzuka Y,Iwasaki F,Sugiyama I,Horiuchi K,Hirano T,Ozawa H,Kanayama N,Oku N

更新日期：2008-11-10 00:00:00

abstract：:Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk. The expression of AHR-target genes, particularly those involved in xenobiotic biotransformation, and their modulation by two DL-PCBs, B[a]P, an...

journal_title：Toxicology letters

authors： Girolami F,Spalenza V,Manzini L,Carletti M,Nebbia C

更新日期：2015-01-05 00:00:00

abstract：:Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, an...

journal_title：Toxicology letters

authors： Dean CE,Hargis BM,Hargis PS

更新日期：1991-08-01 00:00:00

abstract：:Benzo(a)pyrene (B(a)P), a potent environmental procarcinogen, has been shown to cause cell cycle alternation. However, the mechanisms involved in this effect are not well understood yet. Our current results demonstrated that B(a)P exposure led to cell proliferation and a 33.5% increase in S phase cells as well as a 26...

journal_title：Toxicology letters

authors： Gao A,Liu B,Shi X,Jia X,Ye M,Jiao S,You B,Huang C

更新日期：2007-04-05 00:00:00

abstract：:A multi-unit, dynamic flow, inhalation exposure system which is capable of accommodating 12 mice per unit has been described. Components of the system include a mixing board, one or more glass distributing tubes, and detachable glass chamber tubes. The flow of a specified concentration of test gas exits from the mixin...

journal_title：Toxicology letters

authors： Kapeghian JC,Waters IW,Jones AB

更新日期：1985-02-01 00:00:00

abstract：:We have designed a low-cost, compact, head-only exposure system which is easy to use and allows exposure of up to 8 or 16 small rodents depending on the chamber used with the system. Animals are exposed without anesthesia or extreme restraint. Deflection tubes at the chamber inlet and outlet serve to provide turbulent...

journal_title：Toxicology letters

authors： Francovitch RJ,Deal DL,Tayyeb MI,Wolpert RL,Boger JR 3rd,Valentini JE,Menzel DB

更新日期：1987-09-01 00:00:00

abstract：:The subacute nephrotoxicity of more than 20 industrial solvents has been compared in female Sprague-Dawley rats. The animals were given 5 i.p. injections of the solvents per week for 2 weeks at doses ranging from 1/20 to 1/5 of the i.p. or oral LD50 and the urinary excretion of N-acetyl-beta-D-glucosaminidase, beta 2-...

journal_title：Toxicology letters

authors： Bernard AM,de Russis R,Normand JC,Lauwerys RR

更新日期：1989-02-01 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify...

journal_title：Toxicology letters

authors： Richter LHJ,Beck A,Flockerzi V,Maurer HH,Meyer MR

更新日期：2019-02-01 00:00:00

abstract：:Chloral (trichloroacetaldehyde), the major metabolite of trichloroethylene (TCE), was investigated for its potential to form DNA-protein cross-links (DPX), a lesion produced by other aldehydes. Chloral did not form DPX in rat liver nuclei at concentrations up to 250 mM for 30 min at 37 degrees C, while chloroacetaldeh...

journal_title：Toxicology letters

authors： Keller DA,Heck HD

更新日期：1988-08-01 00:00:00

abstract：:Victims of nerve agents basically require antidotal treatment. There is need for novel antidotes and for therapeutic procedures that are specifically adapted to these patients. To cope with this challenge, in vitro test systems which are easy to handle and allow for conducting long-term studies would be of great benef...

journal_title：Toxicology letters

authors： Drexler B,Seeger T,Grasshoff C,Thiermann H,Antkowiak B

更新日期：2011-09-25 00:00:00

abstract：:The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effect of the OP Crotylsarin (CRS) on respir...

journal_title：Toxicology letters

authors： Klein-Rodewald T,Seeger T,Dutschmann M,Worek F,Mörschel M

更新日期：2011-09-25 00:00:00

abstract：:A number of studies have demonstrated that co-exposure to low levels of melamine and cyanuric acid elicits renal toxicity due to the formation of melamine cyanurate crystals in the kidney nephrons. In this work, we investigated if co-exposure of rats to these compounds leads to alterations in the expression of the gen...

journal_title：Toxicology letters

authors： Camacho L,Kelly KP,Beland FA,Gamboa da Costa G

更新日期：2011-10-10 00:00:00

abstract：:The objective of the present study was to identify the polychlorinated biphenyl congeners of Aroclor 1254 that are responsible for the induction of the cytosolic bioactivation of aromatic amines. Various chlorobiphenyls, ranging from di- to hexa-substituted, were administered to rats and the ability of the hepatic cyt...

journal_title：Toxicology letters

authors： Marczylo T,Ioannides C

更新日期：1997-07-21 00:00:00

abstract：:Primary cultures of rat hepatocytes were exposed to various concentrations of L-asparaginase derived from Escherichia Coli. Protein synthesis was inhibited by about 33% and cellular glutamine was reduced proportionally to the enzyme concentration. However, protein synthesis was inhibited only by amounts of enzyme able...

journal_title：Toxicology letters

authors： Villa P,Corada M,Bartosek I

更新日期：1986-09-01 00:00:00

abstract：:Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development of lung cancers have suggested a synergism between arsenit...

journal_title：Toxicology letters

authors： Pang Y,Xu Y,Li H,Li Y,Zhao Y,Jiang R,Shen L,Zhou J,Wang X,Liu Q

更新日期：2013-04-12 00:00:00

abstract：:Monitoring of human exposure to persistent organic pollutants POPs and heavy metals have taken place since 1994 in a circumpolar study conducted under the Arctic monitoring and assessment programme (AMAP). The study has confirmed that Arctic populations relying on marine food (Inuit) have an exposure level of POPs and...

journal_title：Toxicology letters

authors： Hansen JC

更新日期：2000-03-15 00:00:00

abstract：:To clarify a possible mechanism of zinc (Zn)-induced tolerance to cadmium (Cd) toxicity on bone formation, femurs from 9-day-old chick embryos were cultured for 6 days by the roller-tube method in the presence of Cd (2, 4 or 9 microM) and/or Zn (60 microM). Zn prevented a decrease in bone growth caused by Cd at 4 and ...

journal_title：Toxicology letters

authors： Kaji T,Takata M,Hoshino T,Miyahara T,Kozuka H,Kurashige Y,Koizumi F

更新日期：1988-11-01 00:00:00

abstract：:Paraquat poisoning results in damages of multiple organs including liver, kidney and lung, and antioxidants have been proven to have protective effects. As a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), was introduced to clinical use recently, its protective effect was studied on acute ...

journal_title：Toxicology letters

authors： Saibara T,Toda K,Wakatsuki A,Ogawa Y,Ono M,Onishi S

更新日期：2003-06-05 00:00:00

abstract：:Manganese (Mn) is an essential trace element required for normal function and development. However, exposure to this metal at elevated levels may cause manganism, a progressive neurodegenerative disorder with neurological symptoms similar to idiopathic Parkinson's disease (IPD). Elevated body burdens of Mn from exposu...

journal_title：Toxicology letters

authors： Stephenson AP,Schneider JA,Nelson BC,Atha DH,Jain A,Soliman KF,Aschner M,Mazzio E,Renee Reams R

更新日期：2013-04-26 00:00:00

abstract：:Since cell death by apoptosis is achieved through complex interactions between numerous molecular components, cells may fail to die when stimulated because of molecular abnormalities in the apoptosis pathway or in its control mechanisms. Such inappropriate cell survival is well established when apoptosis is suppressed...

journal_title：Toxicology letters

authors： Williams GT,Critchlow MR,Hedge VL,O'Hare KB

更新日期：1998-12-28 00:00:00

abstract：:The peripheral-type benzodiazepine receptor (PBR), a putative receptor in Leydig cells, modulates steroidogenesis. Since benzodiazepines are commonly used in regional anesthesia, their peripheral effects need to be defined. Therefore, this study set out to investigate in vitro effects of the benzodiazepine midazolam (...

journal_title：Toxicology letters

authors： So EC,Chang YT,Hsing CH,Poon PW,Leu SF,Huang BM

更新日期：2010-02-01 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent mal...

journal_title：Toxicology letters

authors： Miyake M,Ito Y,Suzuki H,Tomizawa M,Sato H,Liu M,Okamura A,Nakajima T,Ohtani K,Takino H,Inagaki H,Kamijima M

更新日期：2018-03-15 00:00:00

abstract：:Intraperitoneal injection (50 mg/kg) of 2-nitropropane (2-NP) induced lipid accumulation, centrilobular necrosis, degranulation of rough endoplasmic reticulum, proliferation of smooth endoplasmic reticulum and mitochondrial abnormalities in rat liver 24 h after exposure. These pathological changes were accompanied by ...

journal_title：Toxicology letters

authors： Zitting A,Savolainen H,Nickels J

更新日期：1981-11-01 00:00:00

abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...

journal_title：Toxicology letters

authors： Jaurand MC,Magne L,Bignon J

更新日期：1983-02-01 00:00:00

abstract：:Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. In order to evaluate the complex relationship between the genotoxicity and the AhR-mediated activity of...

journal_title：Toxicology letters

authors： Hrubá E,Vondráček J,Líbalová H,Topinka J,Bryja V,Souček K,Machala M

更新日期：2011-10-10 00:00:00