Effects of zinc toxicity on thyroid function and histology in broiler chicks.

Abstract:

:Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, and multiple endocrinopathies were observed following short-term (1-2 weeks) exposure to the high Zn diet. Reduced levels of serum cholesterol, high-density lipoprotein cholesterol, and growth hormone were associated with HZ feeding. Depressed levels of circulating thyroid hormones and histological evidence that follicle area of thyroids from HZ birds was 63% less than CON indicated that impaired growth of HZ birds may be caused, in part, by reduced thyroidal function.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Dean CE,Hargis BM,Hargis PS

doi

10.1016/0378-4274(91)90205-k

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

309-18

issue

3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(91)90205-K

journal_volume

57

pub_type

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