Abstract:
:To clarify a possible mechanism of zinc (Zn)-induced tolerance to cadmium (Cd) toxicity on bone formation, femurs from 9-day-old chick embryos were cultured for 6 days by the roller-tube method in the presence of Cd (2, 4 or 9 microM) and/or Zn (60 microM). Zn prevented a decrease in bone growth caused by Cd at 4 and 9 microM. An increase in calcium (Ca) content of diaphysis was inhibited by Zn in both the presence and absence of Cd. Histologically, Zn protected a Cd-induced degenerative change of mesenchymal cells in the periosteum and that of osteoblasts around the trabecula at each Cd level. At 60 microM Zn, Cd accumulated less in the bone at 2 microM but more at 9 microM. From these results, it was concluded that Zn prevented Cd-induced toxicity in the process of ossification except calcification in a culture system by two different mechanisms, i.e. a decreasing Cd accumulation at a low level of Cd and probably an induction of metallothionein (MT)-like protein at a high level of Cd.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kaji T,Takata M,Hoshino T,Miyahara T,Kozuka H,Kurashige Y,Koizumi Fdoi
10.1016/0378-4274(88)90149-xsubject
Has Abstractpub_date
1988-11-01 00:00:00pages
219-27issue
1-2eissn
0378-4274issn
1879-3169pii
0378-4274(88)90149-Xjournal_volume
44pub_type
杂志文章abstract::Ursolic acid (UA), a pentacyclic triterpene acid, is reported to have inducing activity of hepatic metallothionein (MT) which responsible for the detoxification of heavy metals; however, the mechanism underlying its effects is poorly understood. To further determine the underlying mechanism of UA, this study investiga...
journal_title:Toxicology letters
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更新日期:2005-03-15 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:1987-09-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2004-11-28 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.12.018
更新日期:2012-03-25 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90217-5
更新日期:1983-02-01 00:00:00
abstract::Testicular Leydig cells express estrogen receptors and are the predominant source of the male sex steroid hormone testosterone (T). Previous studies demonstrated that genistein acts through estrogen receptors in Leydig cells. In the present study, pre-treatment of Leydig cells isolated from 35 day-old male Long Evans ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.11.005
更新日期:2009-02-10 00:00:00
abstract::Spontaneous and mitomycin C-induced sister chromatid exchanges (SCEs) in lymphocytes were analyzed in 24 non-smokers and 24 sex- and age-matched smokers. Mean spontaneous SCE frequency for non-smokers was 9.8 SCEs/cell, and that for smokers was 11.5 SCEs/cell. The difference was statistically significant (P less than ...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1985-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1998-11-23 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1983-05-01 00:00:00
abstract::Although formaldehyde (FA) has been classified as a human leukemogen, the mechanisms of leukemogenesis remain elusive. Previously, using colony-forming assays in semi-solid media, we showed that FA exposure in vivo and in vitro was toxic to human hematopoietic stem/progenitor cells. In the present study, we have appli...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2014-01-13 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2006-04-10 00:00:00
abstract::The neurotoxin 6-hydroxydopamine (6-OHDA) oxidised sulphydryl groups in glyceraldenyde-3-phosphate dehydrogenase (GAPDH) with loss of the dehydrogenase activity of the enzyme. 5-Hydroxydopamine behaved similarly at higher concentrations. This oxidation was accompanied by a transient rise in the acyl phosphatase (non-p...
journal_title:Toxicology letters
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更新日期:2002-03-10 00:00:00
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更新日期:2001-02-03 00:00:00
abstract::Sulfur dioxide (SO2) is a ubiquitous air pollutant, presents in low concentrations in the urban air, and in higher concentrations in the working environment. In the present study, male Wistar rats were housed in exposure chambers and treated with 14.00+/-1.53, 28.00+/-2.12 and 56.00+/-4.28 mg/m3 SO2 for 6 h/day for 7 ...
journal_title:Toxicology letters
pub_type: 杂志文章,随机对照试验
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更新日期:2005-12-30 00:00:00
abstract::Uncertainty in risk assessment can be reduced by increasing the use of relevant data specific to the particular xenobiotic and exposed organism. We describe the development of a preliminary, mechanism-based exposure response model for chloroform hepatotoxicity consistig of toxicokinetic (TK) and toxicodynamic (TD) sub...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
abstract::Regions with heavy industry are in many ways regions of crisis. The health of the population is primarily affected by the different air pollutants. Dust, with all its organic (dioxins and furans) and inorganic (heavy metals) contents, makes up the greatest part of the air-borne pollutants. The influence on health of e...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(96)03731-9
更新日期:1996-11-01 00:00:00
abstract::Toxicogenomics describes the measurement of global gene expression changes in biological samples exposed to toxicants. This new technology promises to greatly facilitate research into toxicant mechanisms, with the possibility of assisting in the detection of compounds with the potential to cause adverse health effects...
journal_title:Toxicology letters
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更新日期:2003-04-11 00:00:00
abstract::Benzene is a human leukemogen, and a bone marrow toxin and carcinogen in experimental animals. The reactive intermediates involved in benzene toxicity and their mechanism(s) of action have not been clearly delineated. We have investigated the clastogenic and cytotoxic effects of trans,trans-muconaldehyde (MUC), a reac...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00340-x
更新日期:2001-05-19 00:00:00
abstract::Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2013-07-31 00:00:00
abstract::In the olfactory epithelium the primary olfactory neurons are in contact with the environment in the nasal cavity and they are also connected to the olfactory bulbs of the brain. These neurons may therefore provide a pathway by which foreign materials may reach the brain. Inhalation of cobalt-containing dust or fumes ...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00