Macroscopic sites of anesthetic action: brain versus spinal cord.

abstract：:Polybrominated diphenyl ethers (PBDEs) are widespread environmental pollutants, and the levels of certain congeners have been increasing in biota and abiota in recent decades. Some PBDEs are lipophilic and persistent, resulting in bioaccumulation in the environment. Their structural similarity to other polyhalogenated...

journal_title：Toxicology letters

authors： Peters AK,Sanderson JT,Bergman A,van den Berg M

更新日期：2006-07-01 00:00:00

abstract：:BH3 mimetics, such as BH3I-1, act as Bcl-2 antagonists, promote apoptosis and are used in basic research studies on apoptotic signaling and are currently tested as experimental anti-tumor agents. The present study addresses time- and dose-dependent responses of BH3I-1 on apoptosis, cellular stress defense mediated by ...

journal_title：Toxicology letters

authors： Stucki D,Brenneisen P,Reichert AS,Stahl W

更新日期：2018-10-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD to substrate proteins. In the human genome, 16 different genes encoding for members of this emerging family of enzymes have been identified. Know...

journal_title：Toxicology letters

authors： Meli E,Pangallo M,Baronti R,Chiarugi A,Cozzi A,Pellegrini-Giampietro DE,Moroni F

更新日期：2003-04-04 00:00:00

abstract：:Dysregulated cell proliferation and tumorigenesis is frequently encountered in several cancers including hepatocellular carcinogenesis (HCC). Thus, agents that inhibit cell proliferation and restrain hepatic tumorigenesis through cell cycle regulation have a beneficial effect in the treatment of hepatocellular carcino...

journal_title：Toxicology letters

authors： Raghunandhakumar S,Paramasivam A,Senthilraja S,Naveenkumar C,Asokkumar S,Binuclara J,Jagan S,Anandakumar P,Devaki T

更新日期：2013-10-23 00:00:00

abstract：:Due to advances in nanotechnology, exposure to particle compounds in the workplace has become unavoidable. Assessment of their toxicity on health is an important occupational safety issue. This study was conducted in mice to investigate the toxicological effects of submicron and nano-iron oxide particles on pulmonary ...

journal_title：Toxicology letters

authors： Ban M,Langonné I,Huguet N,Goutet M

更新日期：2012-05-05 00:00:00

abstract：:Checkpoint kinase 1 (Chk1) is required for both intra-S phase and G2/M checkpoints in cell cycle, and plays critical roles in maintaining genomic stability and transducing DNA damage response. Chk1 deficiency has been shown to inhibit T-cell differentiation and resulted in severe anemia in a Chk1 heterozygous mouse mo...

journal_title：Toxicology letters

authors： Hu W,Zong Q,John-Baptiste A,Jessen B

更新日期：2011-07-28 00:00:00

abstract：:The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-...

journal_title：Toxicology letters

authors： Tomida T,Okamura H,Satsukawa M,Yokoi T,Konno Y

更新日期：2015-07-02 00:00:00

abstract：:Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

journal_title：Toxicology letters

authors： Hoffmann M,Fiedor E,Ptak A

更新日期：2017-03-05 00:00:00

abstract：:Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

journal_title：Toxicology letters

authors： Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

更新日期：2014-04-07 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) has a salutary effect on hemorrhagic, traumatic and endotoxic shock. The role of FDP on compound 48/80-induced shock was therefore investigated. Sprague Dawley aged male rats (448+/-7.4 gm body weight) were randomly assigned into three groups and treated intraperitoneally with diphenhydr...

journal_title：Toxicology letters

authors： Figueroa AH,Stone RH,Cohly HH,Lehan PH,Markov AK

更新日期：2001-06-20 00:00:00

abstract：:Polarographic measurements of the rates of oxygen consumption by isolated rat liver mitochondria respiring on pyruvate/malate in metabolic state 4 revealed that additions of micromolar amounts of chalepin, a naturally occurring furocoumarin resulted in significant decreases in respiratory rates. At 16 microM chalepin,...

journal_title：Toxicology letters

authors： Olorunsogo OO,Emerole GO,Malomo SO,Thabrew MI

更新日期：1983-03-01 00:00:00

abstract：:A single s.c. injection of 60 mg/kg of monocrotaline to rats induced pulmonary alterations characterized by hyaline thrombi of capillaries and arterioles, focal necrosis of alveolar walls, and medial thickening and intimal hyalinosis of arteries. Such pathological alterations became apparent 7 days after injection and...

journal_title：Toxicology letters

authors： Hayashi Y,Kokubo T,Takahashi M,Furukawa F,Otsuka H,Hashimoto K

更新日期：1984-04-01 00:00:00

abstract：:Oltipraz (OPZ) is a known inducer of glutathione S-transferases and a mechanism-based inhibitor of cytochrome P450 1A2. Given the detoxification characteristics of this compound, the transcriptional effects of OPZ, along with the related naturally occurring compounds 3H-1,2-dithiole-3-thione (D3T) and sulforaphane (SF...

journal_title：Toxicology letters

authors： Konwinski RR,Haddad R,Chun JA,Klenow S,Larson SC,Haab BB,Furge LL

更新日期：2004-11-28 00:00:00

abstract：:Numerous chemicals released into the environment by man are able to disrupt the functioning of the endocrine system by binding to estrogen receptors in estrogen-responsive cells. The ability of o,p'-dichlorodiphenyl trichloroethane (DDT) and methoxychlor to compete with estradiol for binding to estrogen receptors in M...

journal_title：Toxicology letters

authors： vom Saal FS,Nagel SC,Palanza P,Boechler M,Parmigiani S,Welshons WV

更新日期：1995-05-01 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ), a redox cofactor in the mitochondrial respiratory chain, has proven to protect neurons against glutamate-induced damage both in vitro and in vivo. This study was aimed to investigate the possible neuroprotective effects of PQQ in rotenone-induced Parkinson's disease (PD) model. Pre-trea...

journal_title：Toxicology letters

authors： Qin J,Wu M,Yu S,Gao X,Zhang J,Dong X,Ji J,Zhang Y,Zhou L,Zhang Q,Ding F

更新日期：2015-11-04 00:00:00

abstract：:Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-Dawley (SD) rats were used to establish animal models...

journal_title：Toxicology letters

authors： Cao XN,Shen LJ,Wu SD,Yan C,Zhou Y,Xiong G,Wang YC,Liu Y,Liu B,Tang XL,Guo M,Liu DY,Long CL,Sun M,He DW,Lin T,Wei GH

更新日期：2017-01-15 00:00:00

abstract：:Lithocholic acid (LCA) supplementation in the diet results in intrahepatic cholestasis and bile infarcts. Previously we showed that an innate immune response is critical for cholestatic liver injury in the bile duct ligated mice. Thus, the purpose of this study was to investigate the role of neutrophils in the mechani...

journal_title：Toxicology letters

authors： Woolbright BL,Li F,Xie Y,Farhood A,Fickert P,Trauner M,Jaeschke H

更新日期：2014-07-03 00:00:00

abstract：:1. General anaesthetics induce reversible structural and functional modifications of the proton pump bacteriorhodopsin contained in the purple membrane of halobacteria. 2. This short paper describes the phenomenological similarity between the effects of anaesthetics and heating on this system. 3. pH dependence and the...

journal_title：Toxicology letters

authors： Gao MM,Boucher F

更新日期：1998-11-23 00:00:00

abstract：:A multi-unit, dynamic flow, inhalation exposure system which is capable of accommodating 12 mice per unit has been described. Components of the system include a mixing board, one or more glass distributing tubes, and detachable glass chamber tubes. The flow of a specified concentration of test gas exits from the mixin...

journal_title：Toxicology letters

authors： Kapeghian JC,Waters IW,Jones AB

更新日期：1985-02-01 00:00:00

abstract：:The effect of dietary vomitoxin on the serum IgA and IgG responses to two model intestinal antigens, casein and cholera toxin (CT), were assessed in 4 experimental groups: (1) mice fed casein-based diet, (2) mice fed casein-based diet containing 25 ppm vomitoxin, (3) mice fed casein-based diet and immunized with CT, a...

journal_title：Toxicology letters

authors： Pestka JJ,Moorman MA,Warner RL

更新日期：1990-01-01 00:00:00

abstract：:Cultured Chinese hamster ovary (CHO) cells were incubated with dilutions of natural or synthetic crude oils and subsequently exposed to near ultraviolet light (NUV). Although the magnitude of photo-induced cytotoxicity in CHO was essentially independent of the source of the oil (within a factor of two), two shale oils...

journal_title：Toxicology letters

authors： Strniste GF,Bingham JM,Okinaka RT,Chen DJ

更新日期：1982-10-01 00:00:00

abstract：:Cimetidine, a widely prescribed, potent histamine H2-receptor antagonist, is unrelatedly a mild antiandrogen. Since perinatal androgens are essential for normal masculine imprinting, we wanted to determine if maternally administered cimetidine interfered with the development of the male offspring's sex-dependent, hepa...

journal_title：Toxicology letters

authors： Shapiro BH,Bitar MS

更新日期：1991-01-01 00:00:00

abstract：:Dermal toxicity of the new multi-insect repellent N,N-diethylphenylacetamide (DEPA) was studied in female rabbits. LD50 of DEPA was estimated to be 3505 mg/kg b.w. On daily topical application for 21 d at a dose of 50 mg/kg b.w., dermal irritancy score and blood chemistry changes indicated that the compound is non-irr...

journal_title：Toxicology letters

authors： Rao SS,Agarwal MK,Rao KM,Swamy RV

更新日期：1989-01-01 00:00:00

abstract：:Several perfluoroalkyl compounds (PFCs) are ubiquitous environmental contaminants that can biomagnify in species at high trophic levels including wild birds. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have been detected in wild birds and are known to reduce hatching success of laboratory-expose...

journal_title：Toxicology letters

authors： O'Brien JM,Crump D,Mundy LJ,Chu S,McLaren KK,Vongphachan V,Letcher RJ,Kennedy SW

更新日期：2009-10-28 00:00:00

abstract：:Fenvalerate, a synthetic pyrethroid insecticide, is an environmental endocrine disruptor and neurodevelopmental toxicant. An early report found that pubertal exposure to high-dose fenvalerate impaired cognitive and behavioral development. Here, we aimed to further investigate the effect of pubertal exposure to low-dos...

journal_title：Toxicology letters

authors： Yang Y,Zhan F,Wang YC,Wang B,Shi MX,Guo C,Xu DX,Meng XH

更新日期：2020-10-10 00:00:00

abstract：:The tobacco smoking habit interferes with the innate host defence system against infections. Recurrent infections accelerated the functional respiratory decline. The present study assessed the effects of ceftaroline on TLR2 and TLR4 and on pro-inflammatory responses in airway epithelial cells (16HBE cell line and prim...

journal_title：Toxicology letters

authors： Pace E,Ferraro M,Di Vincenzo S,Siena L,Gjomarkaj M

更新日期：2016-09-06 00:00:00

abstract：:The aim of this study is to predict dermal permeability of four phenolic biocides in four different formulations using a linear solvation energy relationship (LSER) approach, with a calibrated flow through diffusion cell system. Mathematical descriptors were determined in the laboratory, by mathematical computations, ...

journal_title：Toxicology letters

authors： Vijay V,Yeatts JL Jr,Riviere JE,Baynes RE

更新日期：2007-12-10 00:00:00

abstract：:Doxorubicin (DOX) is a chemotherapeutic agent of which the medical use is limited due to cardiotoxicity. While acute cardiotoxicity is reversible, chronic cardiotoxicity is persistent or progressive, dose-dependent and irreversible. While DOX mechanisms of action are not fully understood yet, 3 toxicity processes are ...

journal_title：Toxicology letters

authors： Verheijen M,Schrooders Y,Gmuender H,Nudischer R,Clayton O,Hynes J,Niederer S,Cordes H,Kuepfer L,Kleinjans J,Caiment F

更新日期：2018-09-15 00:00:00

abstract：:Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

journal_title：Toxicology letters

authors： Silva LR,Girard D

更新日期：2016-09-30 00:00:00

abstract：:Guidelines concerning the preclinical safety assessment of therapeutic proteins are available, e.g. in the European Community (EC Notes for Guidance). Unlike rather rigidly prescribing test systems such as those known for chemical substances, it is agreed that for biotechnologically-produced products, testing may be q...

journal_title：Toxicology letters

authors： Bass R,Kleeberg U,Schröder H,Scheibner E

更新日期：1992-12-01 00:00:00