Abstract:
:Polarographic measurements of the rates of oxygen consumption by isolated rat liver mitochondria respiring on pyruvate/malate in metabolic state 4 revealed that additions of micromolar amounts of chalepin, a naturally occurring furocoumarin resulted in significant decreases in respiratory rates. At 16 microM chalepin, respiration was inhibited by at least 40%. A maximum inhibition of 60% was obtained at 80 microM chalepin. Whereas 16 microM chalepin gave 76% reduction of respiratory control ratio, at most 80% reduction was obtained at greater than or equal to 80 microM chalepin. There was no significant effect on either metabolic state 4 respiration or respiratory control ratio when succinate was used as electron donor. A comparison with the effects of rotenone indicates that chalepin is probably only one-tenth as potent as this classical inhibitor of respiration. These results show that chalepin-like rotenone is an inhibitor of energy coupling site 1.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Olorunsogo OO,Emerole GO,Malomo SO,Thabrew MIdoi
10.1016/0378-4274(83)90151-0subject
Has Abstractpub_date
1983-03-01 00:00:00pages
323-7issue
4eissn
0378-4274issn
1879-3169pii
0378-4274(83)90151-0journal_volume
15pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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abstract::Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...
journal_title:Toxicology letters
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