Urinary excretion of heptanones, heptanoles and 2,5-heptanedione after controlled acute exposure of volunteers to n-heptane.

Abstract:

:A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, we collected information on urinary n-heptane metabolite concentrations and the time course of metabolite excretion. Relationships between external and internal exposure were analysed to investigate the suitability of selected metabolites to reflect n-heptane uptake. Twenty healthy, non-smoking males (aged 19-38 years, median 25.5) were exposed for 3 h to 167, 333 and 500 ppm n-heptane, each. Spot urine samples of the volunteers, collected before exposure and during the following 24 h, were analysed for heptane-2-one, 3-one, 4-one, 2,5-dione, 1-ol, 2-ol, 3-ol, and 4-ol using headspace solid phase dynamic extraction gas chromatography/mass spectrometry (HS-SPDE-GC/MS). Starting from median pre-exposure concentrations between <0.5 (3-one) and 82.9 μg/L (4-one), exposure increased the concentrations for all parameters except for 4-one. Median post-exposure concentrations ranged up to 840.4 μg/L (2-ol) and decreased with half-lifes <3 h after exposure. Non-parametric correlation analyses (n = 47, p < 0.05) revealed weak to moderate associations of volume related metabolite excretion with external exposure for 2-one, 3-one and 2,5-dione (R = 0.332-0.753). Heptanol excretion was moderately associated with exposure (R ≥ 0.509) only after creatinine adjustment. Lacking association with external exposure impedes the use of 4-one as heptane biomarker, whereas 2-ol and 3-ol turned out to be sensitive indicators of exposure if creatinine correction is applied. By providing fundamental data on a panel of eight potential heptane metabolites, our study can help to promote biological monitoring of n-heptane exposure.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Rossbach B,Kegel P,Letzel S

doi

10.1016/j.toxlet.2018.03.031

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

81-90

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(18)30124-3

journal_volume

298

pub_type

杂志文章
  • Aviation gasoline: comparative subchronic nephrotoxicity study in the male rat.

    abstract::Biochemical and histopathologic parameters of nephrotoxicity were measured in groups of male Fischer-344 rats after a 2-week, 5-days-a-week schedule of oral administration (0.5 ml/kg) of the following substances: aviation gasoline (grade 100) (AVG), automobile regular unleaded gasoline (ULG) and 2,2,4-trimethylpentane...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90124-5

    authors: Gérin M,Viau C,Talbot D,Greselin E

    更新日期:1988-11-01 00:00:00

  • Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of human airway epithelial cells.

    abstract::Little information is available upon the effects of carbon nanotubes (CNT) on the airway barrier. Here we study the barrier function of Calu-3 human airway epithelial cells, grown on permeable filters, after the exposure to commercial single-walled or multi-walled CNT, produced through chemical vapour deposition. To a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2008.02.007

    authors: Rotoli BM,Bussolati O,Bianchi MG,Barilli A,Balasubramanian C,Bellucci S,Bergamaschi E

    更新日期:2008-05-05 00:00:00

  • The effects of mono-2-ethylhexyl phathalate, adriamycin and N-ethyl-N-nitrosourea on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis.

    abstract::Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(03)00170-x

    authors: Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

    更新日期:2003-07-20 00:00:00

  • Peroxisome proliferator-activated receptor α mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice.

    abstract::Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.04.019

    authors: Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

    更新日期:2014-08-04 00:00:00

  • Effects of triphenyltin acetate on pregnancy in rats by oral administration.

    abstract::A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregn...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90108-i

    authors: Noda T,Morita S,Yamano T,Shimizu M,Yamada A

    更新日期:1991-04-01 00:00:00

  • Calcitonin inhibits the increase in bone acid phosphatase activity by high dose of zinc in rats.

    abstract::The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90276-x

    authors: Yamaguchi M,Takahashi K

    更新日期:1983-10-01 00:00:00

  • Comparative proteomic analysis of fluoride treated rat bone provides new insights into the molecular mechanisms of fluoride toxicity.

    abstract::Long-term excessive intake of fluoride (F) could lead to chronic fluorosis. To explore the underlying molecular mechanisms, present study is designed to elucidate the effect of fluoride on proteome expression of bone in sodium fluoride (NaF)-treated SD rats. Hematoxylin and eosin (H&E) staining was used to determine t...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.04.006

    authors: Wei Y,Zeng B,Zhang H,Chen C,Wu Y,Wang N,Wu Y,Zhao D,Zhao Y,Iqbal J,Shen L

    更新日期:2018-07-01 00:00:00

  • In vivo and in vitro effect of chelating agents on drug metabolizing enzymes of the rat.

    abstract::Rats given calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA), diethylenetriaminepentaacetic acid (DTPA), dimercaprol, p-aminosalicylic acid (PAS), or d-penicillamine (penicillamine) i.p. for 7 successive days showed a significant decrease in the activity of hepatic microsomal benzphetamine N-demethylase. Th...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90097-1

    authors: Dalvi RR,McGowan C,Ademoyero A

    更新日期:1980-06-01 00:00:00

  • Influence of maternal restraint stress on the long-lasting effects induced by prenatal exposure to perfluorooctane sulfonate (PFOS) in mice.

    abstract::The behavioral effects of concurrent maternal exposure to restraint stress and perfluorooctane sulfonate (PFOS) were assessed in the offspring of mice at 3 months of age. Plug positive females were divided into two groups. Animals were given by gavage 0 and 6mg PFOS/kg/day on gestation days 12-18. One-half of the anim...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2007.05.006

    authors: Fuentes S,Colomina MT,Vicens P,Domingo JL

    更新日期:2007-07-10 00:00:00

  • Effects of chlordimeform on heart rate and body temperature of unanesthetized, unrestrained rats.

    abstract::Heart rate (HR) and body core temperature (Tco) were monitored in unanesthetized, unrestrained adult Sprague-Dawley rats following intraperitoneal administration of 0, 10, 30, or 60 mg/kg of the pesticide chlordimeform (CDM). Significant non-dose-related decreases were observed in both HR and Tco in all treated groups...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90208-6

    authors: Watkinson WP,Gordon CJ

    更新日期:1987-02-01 00:00:00

  • Differences in elimination rates of methylmercury between two genetic variant strains of mice.

    abstract::This study demonstrates an intraspecies difference in elimination of methylmercury between two genetic variant strains of mice. Following a single non-toxic dose of 203Hg labeled methylmercury (0.5 mg Hg/kg i.p.), the half-time of 203Hg elimination in the CBA/J inbred strain was 7.4 days compared to 3.0 days in the CF...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90114-9

    authors: Kostyniak PJ

    更新日期:1980-10-01 00:00:00

  • Genotoxicity studies of benzofuran dioxetanes and epoxides with isolated DNA, bacteria and mammalian cells.

    abstract::1,2-Dioxetanes, very reactive and high energy molecules, are involved as labile intermediates in dioxygenase-activated aerobic metabolism and in physiological processes. Various toxicological tests reveal that dioxetanes are indeed genotoxic. In supercoiled DNA of bacteriophage PM2 they induce endonuclease-sensitive s...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(93)90045-y

    authors: Adam W,Ahrweiler M,Saha-Möller CR,Sauter M,Schönberger A,Epe B,Müller E,Schiffmann D,Stopper H,Wild D

    更新日期:1993-04-01 00:00:00

  • Modulatory effect of calcium on the influx and binding of cadmium in primary cultures of neonatal rat hepatocytes.

    abstract::Primary cultures of rat hepatocytes were exposed to 3 or 30 microM stable cadmium (Cd) in the presence or absence of 1.8 or 3.6 mM calcium (Ca). The presence of Ca significantly reduced the efflux of lactate dehydrogenase (LDH) from cells regardless of Cd concentration or exposure time. During a 3-h time interval, the...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90006-9

    authors: Sorensen EM

    更新日期:1988-04-01 00:00:00

  • Effects of DMSA-coated Fe3O4 magnetic nanoparticles on global gene expression of mouse macrophage RAW264.7 cells.

    abstract::Fe(3)O(4) magnetic nanoparticles (MNPs) coated with 2,3-dimercaptosuccinnic acid (DMSA) are considered to be a promising nanomaterial with biocompatibility. In the present study, the effects of DMSA-coated Fe(3)O(4) MNPs on the expression of all identified mouse genes, which regulate various cellular biological proces...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.05.1031

    authors: Liu Y,Chen Z,Gu N,Wang J

    更新日期:2011-08-28 00:00:00

  • Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders.

    abstract::Human saliva offers a unique noninvasive approach for populational study. Purposes of this study were to investigate the feasibility of using saliva manganese (Mn) concentration as a biomarker of Mn exposure among career welders and to study the variations of Mn, copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) in ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.toxlet.2007.10.003

    authors: Wang D,Du X,Zheng W

    更新日期:2008-01-04 00:00:00

  • Influence of paracetamol (acetaminophen) on cadmium-induced lipid peroxidation in hepatocytes from starved rats.

    abstract::Isolated hepatocytes form thiobarbituric acid (TBA)-reactants, a parameter of lipid peroxidation (LPO), when exposed to cadmium (Cd). Paracetamol (Para) inhibits this response, dependent on time and concentration. Cd-induced SH-group decline, however, and enhanced plasma membrane permeability to Trypan Blue (TB) were ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90210-2

    authors: Müller L

    更新日期:1983-02-01 00:00:00

  • Glutathione conjugation in the isolated perfused rabbit lung: the effects of carbon monoxide, buthionine sulfoximine and cibacron blue.

    abstract::The effect of carbon monoxide (CO) on pulmonary glutathione-S-transferase (GST) activity was investigated using the isolated perfused rabbit lung (IPRL) preparation. CO at a concentration of 7.5% did not alter the conjugation of glutathione (GSH) with 1,2-epoxy-(p-nitrophenoxy)propane (ENP) in the IPRL. The rate of GS...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(90)90164-h

    authors: Yang CM,Carlson GP

    更新日期:1990-06-01 00:00:00

  • Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

    abstract::Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.07.019

    authors: Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

    更新日期:2018-10-15 00:00:00

  • L-asparaginase effects on inhibition of protein synthesis and lowering of the glutamine content in cultured rat hepatocytes.

    abstract::Primary cultures of rat hepatocytes were exposed to various concentrations of L-asparaginase derived from Escherichia Coli. Protein synthesis was inhibited by about 33% and cellular glutamine was reduced proportionally to the enzyme concentration. However, protein synthesis was inhibited only by amounts of enzyme able...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90113-x

    authors: Villa P,Corada M,Bartosek I

    更新日期:1986-09-01 00:00:00

  • Human biological monitoring for exposure assessment in response to an incident involving hazardous materials.

    abstract::Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and treatment of exposed individuals from the general population or of emergency responders. Such exposu...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.03.002

    authors: Scheepers PT,van Brederode NE,Bos PM,Nijhuis NJ,van de Weerdt RH,van der Woude I,Eggens ML

    更新日期:2014-12-15 00:00:00

  • Mechanism of neurobehavioral alteration.

    abstract::Behavioral toxicology is an emerging field which is becoming increasingly important in risk assessment of exposure to neurotoxic substances, due to the high sensitivity of behavior towards neurotoxic action and the integration in behavioral functions of several underlying processes and neurofunctions, such as motor, s...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(99)00251-9

    authors: Lucchini R,Albini E,Placidi D,Alessio L

    更新日期:2000-03-15 00:00:00

  • The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.

    abstract::Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(95)03387-z

    authors: De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

    更新日期:1995-10-01 00:00:00

  • XPF plays an indispensable role in relieving silver nanoparticle induced DNA damage stress in human cells.

    abstract::Due to the specific antimicrobial activity of silver nanoparticles (AgNPs), they are widely used in wound dressings, coatings in medical devices and household products. In spite of the well-documented genotoxicity of AgNPs, the molecular mechanisms of relieving AgNP-induced DNA damage stress remain poorly understood. ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.02.022

    authors: Wang D,Yang H,Zhou Z,Zhao M,Chen R,Reed SH

    更新日期:2018-05-15 00:00:00

  • A vasoactive serum component and reactivity of isolated rat aorta after chronic alcohol administration.

    abstract::Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)03180-0

    authors: Baños G,Lopez-Zetina P,Franco M

    更新日期:1995-02-01 00:00:00

  • Magnetic nanogels as dual triggered anticancer drug delivery: Toxicity evaluation on isolated rat liver mitochondria.

    abstract::This study aimed to evaluate bio-safety of magnetic chitosan nanogels as dual triggered drug carrier for doxorubicin through analysis of mitochondrial function. In the present study, chitosan/TPP nanogels containing magnetite nanoparticles (NPs) were prepared according to the ionotropic gelation method as novel pH-sen...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.06.004

    authors: Sadighian S,Rostamizadeh K,Hosseini MJ,Hamidi M,Hosseini-Monfared H

    更新日期:2017-08-15 00:00:00

  • Skin absorption of aniline from aqueous solutions in man.

    abstract::The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous soluti...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90231-4

    authors: Baranowska-Dutkeiwicz B

    更新日期:1982-03-01 00:00:00

  • Genetic differences between C57BL/6 and DBA/2 mice in the inductions of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol, and bilirubin by 3-methylcholanthrene.

    abstract::In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later. In DBA/2 mice, neither AHH nor transferase activit...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90146-0

    authors: Nemoto N,Takayama S

    更新日期:1980-01-01 00:00:00

  • Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.

    abstract::We previously reported that NR2E3, an orphan nuclear receptor, plays an important role in maintaining the basal expression of estrogen receptor α (ER) and that the NR2E3 level is highly correlated with the relapse-free survival of breast cancer patients. Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.06.1708

    authors: Khanal T,Kim D,Johnson A,Choubey D,Kim K

    更新日期:2015-09-17 00:00:00

  • Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease.

    abstract::Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2020.01.019

    authors: Mou Z,Yuan YH,Zhang Z,Song LK,Chen NH

    更新日期:2020-05-15 00:00:00

  • Pharmacokinetics and metabolism of ethylenediamine in the swiss webster mouse following oral or intravenous dosing.

    abstract::Male Swiss Webster mice were given an intravenous dose of 50 mg/kg, or an oral gavage dose of 5, 50 or 500 mg/kg [1, 2-(14)C]-ethylenediamine dihydrochloride, and its fate was followed for 48 h. Ethylenediamine (EDA) was readily absorbed from the gut (bioavailability, 87% measured at 50 mg/kg). Absorption was rapid as...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00252-6

    authors: Leung HW

    更新日期:2000-09-30 00:00:00