Protein phosphorylation in alveolar macrophages after stimulation with heavy metal-coated silica particles.

abstract：:Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

journal_title：Toxicology letters

authors： Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

更新日期：2003-07-20 00:00:00

abstract：:Groups of people with no occupational exposure to Br-containing chemicals (29-54 year old, mostly women) in Japan, China and Korea, respectively, offered spot urine samples. Those in China and Korea offered 24 h duplicates of foods of the day. Urine samples were analyzed for Br by ECD-gas chromatography (ECD-GC) after...

journal_title：Toxicology letters

authors： Kawai T,Zhang ZW,Moon CS,Shimbo S,Watanabe T,Matsuda-Inoguchi N,Higashikawa K,Ikeda M

更新日期：2002-08-05 00:00:00

abstract：:There are numerous observations of pharmaceuticals (or their metabolites) as contaminants in wastewater, surface water and groundwater. This implies a potential for indirect human exposure to pharmaceuticals via drinking water supplies. Various effect benchmarks may be employed in an evaluation of the significance of ...

journal_title：Toxicology letters

authors： Webb S,Ternes T,Gibert M,Olejniczak K

更新日期：2003-05-15 00:00:00

abstract：:L-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H₂O₂), were characterized with lower l...

journal_title：Toxicology letters

authors： Lemire J,Mailloux R,Darwich R,Auger C,Appanna VD

更新日期：2011-06-24 00:00:00

abstract：:The 2,4-dinitrophenylhydrazine (2,4-DNPH) derivatization method mainly used for the determination of airborne formaldehyde was extended for acetaldehyde, acetone, 2-butanone, and cyclohexanone, the next four carbonyl compounds of industrial importance. Sampling devices and sampling conditions were adjusted for the res...

journal_title：Toxicology letters

authors： Binding N,Schilder K,Czeschinski PA,Witting U

更新日期：1998-08-01 00:00:00

abstract：:Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

journal_title：Toxicology letters

authors： Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

更新日期：2018-10-15 00:00:00

abstract：:5-Azactydine inhibits cell growth by direct cytotoxic action as well as by inhibition of DNA methyl transferase enzyme. Inhibitors of DNMT have been reported to potentiate the therapeutic activity of cisplatin in vitro. Dose dependent bone marrow toxicity, neurotoxicity and nephrotoxicity are the major side effects of...

journal_title：Toxicology letters

authors： Tikoo K,Ali IY,Gupta J,Gupta C

更新日期：2009-12-15 00:00:00

abstract：:In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental and reproductive toxi...

journal_title：Toxicology letters

authors： Kamrin MA,Carney EW,Chou K,Cummings A,Dostal LA,Harris C,Henck JW,Loch-Caruso R,Miller RK

更新日期：1994-11-01 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. However, in vivo studies in various, soman poisoned animal species showed a therapeutic effect of oximes, with the exac...

journal_title：Toxicology letters

authors： Worek F,Thiermann H,Wille T

更新日期：2018-09-01 00:00:00

abstract：:Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

journal_title：Toxicology letters

authors： De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

更新日期：1995-10-01 00:00:00

abstract：:Computer simulation can be used to integrate existing toxicity information within a biologically realistic framework. Simulation models calculate relevant measures of target tissue dose based on physiological, biochemical and physicochemical properties and readily support the dose, route, species and interchemical ext...

journal_title：Toxicology letters

authors： Clewell HJ 3rd,Andersen ME

更新日期：1989-12-01 00:00:00

abstract：:Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential o...

journal_title：Toxicology letters

authors： Patel R,Rosengren RJ

更新日期：2001-05-31 00:00:00

abstract：:Ambient fine particulate matter (PM2.5, particulates with an aerodynamic diameter < or = 2.5 microm) can suppress alveolar macrophage (AM) functions, but the data concerning the effects of blowing sand PM2.5 on AMs remain limited. The aim of the present study is to investigate the influences of blowing sand PM2.5 on A...

journal_title：Toxicology letters

authors： Geng H,Meng Z,Zhang Q

更新日期：2005-06-17 00:00:00

abstract：:Lindane administration to rats (60 mg/kg b.w.) led to an enhancement in the oxidative stress status of the liver at 4 h after treatment, characterized by increases in hepatic thiobarbituric acid reactants (TBARS) formation and chemiluminescence, reduced glutathione (GSH) depletion, and diminution in the biliary conten...

journal_title：Toxicology letters

authors： Videla LA,Arisi AC,Fuzaro AP,Koch OR,Junqueira VB

更新日期：2000-04-10 00:00:00

abstract：:Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

journal_title：Toxicology letters

authors： Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

更新日期：2016-03-14 00:00:00

abstract：:The molecular basis of the interindividual differences of normal individuals to ionizing radiation is poorly understood. Several studies in telomerase KO mice with short telomeres have uncovered an inverse relationship between telomere length and radiation sensitivity. The present work aims to determine if chromosome ...

journal_title：Toxicology letters

authors： Castella M,Puerto S,Creus A,Marcos R,Surralles J

更新日期：2007-07-30 00:00:00

abstract：:Transcription factor activator protein (AP)-1 can be activated in nitrogen-mustard-injured mouse skin, and is thought to participate in the inflammatory response. AP-1 consists of homo- or heterodimers of Fos [c-Fos, Fos-B, fos-related antigen (Fra)-1 and Fra-2] and Jun (c-Jun, JunB and JunD) family members, and infor...

journal_title：Toxicology letters

authors： Ye F,Zeng Q,Dan G,Dong X,Chen M,Sai Y,Lin H,Zou Z

更新日期：2020-02-01 00:00:00

abstract：:Previous studies have suggested that elevated blood homocysteic acid (HCA) levels increased the risk of Alzheimer's disease (AD), but the underlying mechanisms are unclear. Herein, we studied the neuronal toxicity of HCA and the underlying mechanisms in HT-22 cells. Results showed that HCA induced cell death in concen...

journal_title：Toxicology letters

authors： Tan M,Ouyang Y,Jin M,Chen M,Liu P,Chao X,Chen Z,Chen X,Ramassamy C,Gao Y,Pi R

更新日期：2013-10-23 00:00:00

abstract：:Chloropicrin is an aliphatic volatile nitrate compound that is mainly used as a pesticide. It has several toxic effects in animals and can cause irritating and other health problems in exposed humans. Since the mode of chloropicrin action is poorly understood, the aim of this study was to investigate molecular respons...

journal_title：Toxicology letters

authors： Pesonen M,Pasanen M,Loikkanen J,Naukkarinen A,Hemmilä M,Seulanto H,Kuitunen T,Vähäkangas K

更新日期：2012-06-20 00:00:00

abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

journal_title：Toxicology letters

authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

更新日期：1986-12-01 00:00:00

abstract：:A major issue of inhalation toxicity is that of dose. An inhaled dose is more difficult to determine than the dose from other routes of administration. Via oral or parenteral routes, a discrete amount of test substance is given in a bolus. In inhalation toxicology, the delivered dose depends on the exposure concentrat...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2003-04-11 00:00:00

abstract：:Neomycin (an aminoglycoside antibiotic), ethacrynate (a loop diuretic), cisplatin (an anticancer drug) and mercuric chloride are chemically unrelated drugs which present similar ototoxic and nephrotoxic properties. We have found that all these molecules inhibit inositol phosphate turnover induced by carbachol or gluta...

journal_title：Toxicology letters

authors： Guiramand J,Lenoir M,Pujol R,Récasens M

更新日期：1990-05-01 00:00:00

abstract：:A number of zero tolerance provisions are contained in both food and animal feed law, e.g. for chemical substances whose occurrence is not permitted or is directly prohibited in food or animal feed. In the European Union, bans of this kind were introduced to give consumers and animals the greatest possible protection ...

journal_title：Toxicology letters

authors： Heberer T,Lahrssen-Wiederholt M,Schafft H,Abraham K,Pzyrembel H,Henning KJ,Schauzu M,Braeunig J,Goetz M,Niemann L,Gundert-Remy U,Luch A,Appel B,Banasiak U,Böl GF,Lampen A,Wittkowski R,Hensel A

更新日期：2007-12-10 00:00:00

abstract：:In order to gain basic understanding in the ecotoxicity of endocrine disrupting chemicals or EDCs (including natural chemicals and some pharmaceuticals), many international research groups are currently testing these chemicals using aquatic invertebrates. This paper discusses relevant examples to address key questions...

journal_title：Toxicology letters

authors： Hutchinson TH

更新日期：2002-05-10 00:00:00

abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1984-10-01 00:00:00

abstract：:Benzodiazepines have wide-spread used in pharmacotherapy for their anxiolytic, myorelaxant, hypnotic, amnesic and anticonvulsive properties. Despite benzodiazepines are used in clinics over 50 years, they have not been surprisingly tested for capability to induce major drug-metabolizing cytochromes P450. In the curren...

journal_title：Toxicology letters

authors： Vrzal R,Kubesova K,Pavek P,Dvorak Z

更新日期：2010-03-15 00:00:00

abstract：:The Pseudonaja genus (Brown snakes) is widely distributed across Australia and bites account for significant mortality. Venom-induced consumption coagulopathy (VICC) and, less often, early cardiovascular collapse occur following envenoming by these snakes. We have previously examined possible mechanism(s) behind the e...

journal_title：Toxicology letters

authors： Chaisakul J,Isbister GK,Kuruppu S,Konstantakopoulos N,Hodgson WC

更新日期：2013-08-29 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00

abstract：:Propylene oxide (PO) concentrations >or=300 ppm induced cell proliferation and tumors in rat nasal respiratory epithelium (NRE). Cell proliferation was suggested to result from depletion of glutathione (GSH) in NRE. In order to substantiate this hypothesis, cell proliferation - measured by bromodeoxyuridine incorporat...

journal_title：Toxicology letters

authors： Khan MD,Klein D,Mossbrugger I,Oesterle D,Csanády GA,Quintanilla-Martinez L,Filser JG

更新日期：2009-03-28 00:00:00

abstract：:In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

journal_title：Toxicology letters

authors： Pfister T,Eichinger-Chapelon A

更新日期：2009-11-12 00:00:00