Urinary trehalase activity and renal brush-border damage in inhabitants of a cadmium-polluted area (Jinzu River basin).

Abstract:

:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the reference area. Renal trehalase is specifically localized in tubular brush borders [M. Nakano, J. Histochem. Cytochem., 30 (1982) 1243-1248]. From these results it is inferred that tubular brush-border damage occurs in inhabitants of the Jinzu River basin.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

doi

10.1016/0378-4274(86)90206-7

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

159-66

issue

2-3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(86)90206-7

journal_volume

34

pub_type

杂志文章
  • Changes in correlation coefficients of exposure markers as a function of intensity of occupational exposure to toluene.

    abstract::This study was initiated to identify a marker of choice to monitor occupational exposure to toluene through quantitative evaluation of changes in correlation coefficients (CCs), taking advantage of a large database. Six known or proposed exposure markers in end-of-shift blood (B) and urine (U) were studied, i.e., tolu...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2008.05.003

    authors: Ikeda M,Ukai H,Kawai T,Inoue O,Maejima Y,Fukui Y,Ohashi F,Okamoto S,Takada S,Sakurai H

    更新日期:2008-07-10 00:00:00

  • Spontaneous tumors in control F344 and charles river-CD rats and Charles River CD-1 and B6C3HF1 mice.

    abstract::The incidence of spontaneous neoplasms in outbred, inbred and F1 hybrid strains was compared using the Charles River-CD rat and mouse, the F344 rat, and B6C3HF1 mouse. These strains are commonly used in carcinogenic studies. Each strain has a consistent pattern of tumor occurrence; testicular, pituitary and lymphoreti...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90113-8

    authors: Sher SP,Jensen RD,Bokelman DL

    更新日期:1982-04-01 00:00:00

  • Comparative proteomic analysis of fluoride treated rat bone provides new insights into the molecular mechanisms of fluoride toxicity.

    abstract::Long-term excessive intake of fluoride (F) could lead to chronic fluorosis. To explore the underlying molecular mechanisms, present study is designed to elucidate the effect of fluoride on proteome expression of bone in sodium fluoride (NaF)-treated SD rats. Hematoxylin and eosin (H&E) staining was used to determine t...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.04.006

    authors: Wei Y,Zeng B,Zhang H,Chen C,Wu Y,Wang N,Wu Y,Zhao D,Zhao Y,Iqbal J,Shen L

    更新日期:2018-07-01 00:00:00

  • Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II.

    abstract::Human steroid sulfatase (STS) plays an important role in regulating the formation of biologically active estrogens and may be a promising target for treating estrogen-mediated carcinogenesis. The molecular mechanism of STS gene expression, however, is still not clear. Growth factors are known to increase STS activity ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.09.006

    authors: Sung CH,Im HJ,Park N,Kwon Y,Shin S,Ye DJ,Cho NH,Park YS,Choi HK,Kim D,Chun YJ

    更新日期:2013-11-25 00:00:00

  • Acute effect of bromodichloromethane on lipid metabolism in rat liver microsomes.

    abstract::Acute effects of CHBrCl2 on microsomal lipid metabolism were studied in the liver of male Wistar rats administered a single oral dose (215 mg/kg). 3 h after administration, the modulation of phospholipid metabolism and the accumulation of triacylglycerol (TG) were noted in the microsomal membranes. A marked decrease i...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90032-3

    authors: Koyama Y,Nakazawa Y

    更新日期:1985-12-01 00:00:00

  • Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity.

    abstract:UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.12.004

    authors: Kim YJ,Kim TW,Park SR,Kim HT,Jung DY,Ryu SY,Jung JY

    更新日期:2016-01-22 00:00:00

  • Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes.

    abstract::The development of novel alternative testing methods is required to identify the sensitizing capacity of chemicals as a replacement for animal experimentation. We aimed to evaluate in vitro assays as screening tools for detecting skin sensitizers. The murine epidermal keratinocyte cell line HEL-30 was exposed to 16 re...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.10.017

    authors: Son D,Na Y,Cho WS,Lee BH,Heo Y,Park JH,Seok SH

    更新日期:2013-01-10 00:00:00

  • An investigation of activities and paraoxon sensitivities of hepatic aliesterases in beta-naphthoflavone-treated rats.

    abstract::Aliesterases (carboxylesterases, EC 3.1.1.1) are serine esterases which may protect acetylcholinesterase during organophosphorus insecticide intoxication by providing alternative phosphorylation sites. Levels of hepatic aliesterase activity were investigated after the intraperitoneal administration of beta-naphthoflav...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90108-2

    authors: Watson AM,Chambers H,Chambers JE

    更新日期:1994-05-01 00:00:00

  • Enzymological and biochemical changes produced by chronic chromium exposure in a teleost fish, Channa punctatus.

    abstract::The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90003-6

    authors: Sastry KV,Sunita K

    更新日期:1983-04-01 00:00:00

  • Consideration of individual susceptibility in adverse pesticide effects.

    abstract::The modern environmental awareness leads to the realisation that the human metabolism is stressed by a huge number of chemical substances. Generally, these background exposures, consisting predominantly from natural and partly from industrial as well as life style sources, are tolerated without any adverse effects. Pe...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(99)00040-5

    authors: Lewalter J,Leng G

    更新日期:1999-06-30 00:00:00

  • Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.

    abstract::Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes. We investigated SM toxicity in a human keratinocyte cell line (HaCaT) and used GSH and NAC to cou...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.09.002

    authors: Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

    更新日期:2016-02-26 00:00:00

  • Cadmium, copper and zinc-binding protein (metallothionein) in the liver of the water lizard Triturus pyrrhogaster.

    abstract::A low-Mr copper (Cu) and zinc (Zn)-binding protein was present in the liver of a control water lizard Triturus pyrrhogaster. Cadmium (Cd) accumulated in the liver of the animals after intramuscular injections of Cd salt and was bound to Cu- and Zn-binding protein of a single isoform that had properties characteristic ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(84)90203-0

    authors: Suzuki KT,Akitomi H,Kawamura R

    更新日期:1984-05-01 00:00:00

  • Identification of aldo-keto reductases as NRF2-target marker genes in human cells.

    abstract::Transcription factor NF-E2-related factor 2 (NRF2) plays a crucial role in the cellular defense against oxidative/electrophilic stress by up-regulating multiple antioxidant genes. Numerous studies with genetically modified animals have demonstrated that Nrf2 is a sensitivity determining factor upon the exposure to env...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.12.026

    authors: Jung KA,Choi BH,Nam CW,Song M,Kim ST,Lee JY,Kwak MK

    更新日期:2013-03-27 00:00:00

  • No change in serum dopamine-beta-hydroxylase activity in workers exposed to trichloroethylene.

    abstract::To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(90)90187-q

    authors: Nagaya T,Ishikawa N,Hata H

    更新日期:1990-12-01 00:00:00

  • The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice.

    abstract::Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2021.01.008

    authors: Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

    更新日期:2021-01-08 00:00:00

  • The multidrug resistance-associated protein 1 transports methoxychlor and protects the seminiferous epithelium from injury.

    abstract::We examined the ability of the multidrug resistance-associated protein 1 (MRP1/ABCC1) to transport pesticides, as this transporter mediates the cellular efflux of a variety of xenobiotics, typically as glucuronide, sulfate, or glutathione conjugates. NIH3T3 cells stably expressing MRP1 were 3.37-fold more resistant to...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00485-x

    authors: Tribull TE,Bruner RH,Bain LJ

    更新日期:2003-04-30 00:00:00

  • Preclinical detection of nephrotoxicity: description of the tests and appraisal of their health significance.

    abstract::The prevention of renal diseases induced by chemicals requires the use of tests with which adverse renal effects can be detected at a stage when removal from exposure to the offending agent(s) may lead to complete recovery or may at least prevent an accelerated decline in renal function. The screening tests used in cl...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(89)90113-6

    authors: Lauwerys R,Bernard A

    更新日期:1989-03-01 00:00:00

  • Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats.

    abstract::Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990s. In this study, we examined the effect of organoph...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.02.016

    authors: Hirosawa N,Ueyama J,Kondo T,Kamijima M,Takagi K,Fujinaka S,Hirate A,Hasegawa T,Wakusawa S

    更新日期:2011-05-30 00:00:00

  • Toxic effects of a high dose of non-ionic iodinated contrast media on renal glomerular and aortic endothelial cells in aged rats in vivo.

    abstract::Iodinated contrast media (CM) can induce apoptosis and necrosis of renal tubular cells. The injuries of endothelial cells induced by CM on the systemic condition have not been fully understood. To assess the toxic effects of non-ionic CM on the glomerular and aortic endothelial cells, iopromide and iodixanol, two kind...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.02.011

    authors: Zhao Y,Tao Z,Xu Z,Tao Z,Chen B,Wang L,Li C,Chen L,Jia Q,Jia E,Zhu T,Yang Z

    更新日期:2011-05-10 00:00:00

  • Ozone-induced human respiratory dysfunction and disease.

    abstract::Exercising volunteers exposed in chambers to as little as 80 ppb O3 for several hours exhibit impaired lung function and irritative lower airway symptoms. Comparable changes occur among children and young adults exposed to summer smog containing O3. Intensity of the response is reproducible but varies widely among ind...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(95)03565-6

    authors: Bromberg PA,Koren HS

    更新日期:1995-12-01 00:00:00

  • The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.

    abstract::Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development of lung cancers have suggested a synergism between arsenit...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.01.004

    authors: Pang Y,Xu Y,Li H,Li Y,Zhao Y,Jiang R,Shen L,Zhou J,Wang X,Liu Q

    更新日期:2013-04-12 00:00:00

  • Protein association of the neurotoxin and non-protein amino acid BMAA (β-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats.

    abstract::The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) is not an amino acid that is normally found in proteins. Our previous autoradiographic study of (3)H-labeled BMAA in adult mice unexpectedly revealed a tissue distribution similar to that of protein amino acids. The aim of this study was to characterize the...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.01.027

    authors: Karlsson O,Jiang L,Andersson M,Ilag LL,Brittebo EB

    更新日期:2014-04-07 00:00:00

  • Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice.

    abstract::Furocoumarins are a group of natural products with many biological activities. Clinical evidences have demonstrated the important contribution of furocoumarins to the toxicity of some foods and herbs. In order to assess liver and kidney toxicity of furocoumarins, male mice were orally administrated with psoralen, isop...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.11.030

    authors: Wang X,Lou YJ,Wang MX,Shi YW,Xu HX,Kong LD

    更新日期:2012-02-25 00:00:00

  • Human biological monitoring for exposure assessment in response to an incident involving hazardous materials.

    abstract::Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and treatment of exposed individuals from the general population or of emergency responders. Such exposu...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.03.002

    authors: Scheepers PT,van Brederode NE,Bos PM,Nijhuis NJ,van de Weerdt RH,van der Woude I,Eggens ML

    更新日期:2014-12-15 00:00:00

  • Environmental exposure to pesticides and risk of thyroid diseases.

    abstract::Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.08.017

    authors: Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

    更新日期:2019-10-15 00:00:00

  • Role of inflammation in chemical-induced lung cancer.

    abstract::Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final ma...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(99)00285-4

    authors: Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

    更新日期:2000-03-15 00:00:00

  • Differential effects on the cyanogenic glycoside content of fermenting cassava root pulp by beta-glucosidase and microbial activities.

    abstract::The degradation of cyanogenic glycosides was studied in spontaneously fermenting cassava root pulp and in fresh pulp samples pretreated to prevent either endogenous beta-glycosidase activity, fermentation, or both. The rate of disappearance of the glycosides, as measured by hydrocyanic acid (HCN) production in situ, i...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90153-4

    authors: Maduagwu EN

    更新日期:1983-03-01 00:00:00

  • Is the acceptable daily intake as presently used an axiom or a dogma?

    abstract::International scientific committees, regional scientific committees such as those of the European Union, and national regulatory agencies generally use the uncertainly factor approach for establishing acceptable or tolerable intakes of substances that exhibit thresholds of toxicity. No observed adverse effect levels (...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2008.06.003

    authors: Galli CL,Marinovich M,Lotti M

    更新日期:2008-08-15 00:00:00

  • Chronic cadmium exposure induces transcriptional activation of the Wnt pathway and upregulation of epithelial-to-mesenchymal transition markers in mouse kidney.

    abstract::The transition metal cadmium (Cd) is an environmental pollutant which damages the kidneys. Chronic Cd exposure may induce renal fibrosis and/or cancer, but the signaling pathways involved are not understood. The Wnt pathway is a key signaling cascade responsible for renal development, fibrosis and cancer. Hence the ef...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.05.007

    authors: Chakraborty PK,Scharner B,Jurasovic J,Messner B,Bernhard D,Thévenod F

    更新日期:2010-09-15 00:00:00

  • Induction of chromosome aberrations by phenobarbitone in the germ cells of Swiss male mice.

    abstract::The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. H...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90002-9

    authors: Nandan SD,Rao MS

    更新日期:1982-11-01 00:00:00