Abstract：
:The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) is not an amino acid that is normally found in proteins. Our previous autoradiographic study of (3)H-labeled BMAA in adult mice unexpectedly revealed a tissue distribution similar to that of protein amino acids. The aim of this study was to characterize the distribution of free and protein-bound BMAA in neonatal rat tissues following a short exposure using autoradiographic imaging and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The autoradiographic imaging of (14)C-L-BMAA demonstrated a distinct uptake of radioactivity that was retained following acid extraction in tissues with a high rate of cell turnover and/or protein synthesis. The UHPLC-MS/MS analysis conclusively demonstrated a dose-dependent increase of protein-associated BMAA in neonatal rat tissues. The level of protein-associated BMAA in the liver was more than 10 times higher than that in brain regions not fully protected by the blood-brain barrier which may be due to the higher rate of protein synthesis in the liver. In conclusion, this study demonstrated that BMAA was associated with rat proteins suggesting that BMAA may be misincorporated into proteins. However, protein-associated BMAA seemed to be cleared over time, as none of the samples from adult rats had any detectable free or protein-associated BMAA.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Karlsson O,Jiang L,Andersson M,Ilag LL,Brittebo EBdoi
10.1016/j.toxlet.2014.01.027subject
Has Abstractpub_date
2014-04-07 00:00:00pages
1-5issue
1eissn
0378-4274issn
1879-3169pii
S0378-4274(14)00038-1journal_volume
226pub_type
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pub_type： 杂志文章
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journal_title：Toxicology letters
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doi：10.1016/0378-4274(95)03365-r
更新日期：1995-09-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.09.008
更新日期：2013-11-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.11.017
更新日期：2014-10-15 00:00:00
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.02.012
更新日期：2007-04-25 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00334-8
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(94)90026-4
更新日期：1994-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.12.022
更新日期：2020-05-15 00:00:00
abstract：:Stable and specific biomacromolecular adducts can be used to measure in vivo doses of reactive compounds. An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (±)-anti-BP-7,8-diol-9,10-epoxide ((±)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, ...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2015-01-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2008.06.003
更新日期：2008-08-15 00:00:00
abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90002-5
更新日期：1985-10-01 00:00:00
