Preclinical detection of nephrotoxicity: description of the tests and appraisal of their health significance.


:The prevention of renal diseases induced by chemicals requires the use of tests with which adverse renal effects can be detected at a stage when removal from exposure to the offending agent(s) may lead to complete recovery or may at least prevent an accelerated decline in renal function. The screening tests used in clinical medicine for assessing the functional integrity of the kidney are not sufficiently sensitive to attain this objective. In this review, we describe the tests currently available for detecting incipient renal damage and attempt to assess their health significance. A minimal battery of tests is recommended for the detection of groups in industry or in the general population who are at risk. If an increased prevalence of abnormal values for these parameters is found repeatedly in a population, efforts should be made to identify the causal agent(s) and, if possible, to reduce the exposure. Follow-up examinations of subjects identified in this way are also indicated, in order to define the predictive value of the detected changes better.


Toxicol Lett


Toxicology letters


Lauwerys R,Bernard A




Has Abstract


1989-03-01 00:00:00














  • Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats.

    abstract::Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

    更新日期:1998-05-01 00:00:00

  • Risk assessment in combustion toxicology: Should carbon dioxide be recognized as a modifier of toxicity or separate toxicological entity?

    abstract::To characterize the accumulated hazards associated with the inhalation of gases typical of combustion products, a time-integrated value known as the fractional effective dose (FED) is used. This FED is maintained by the International Organization for Standardization (ISO) and made publicly available as the Standard IS...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Pauluhn J

    更新日期:2016-11-16 00:00:00

  • Determinants of occupational exposure to metals by gas metal arc welding and risk management measures: a biomonitoring study.

    abstract::Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Persoons R,Arnoux D,Monssu T,Culié O,Roche G,Duffaud B,Chalaye D,Maitre A

    更新日期:2014-12-01 00:00:00

  • Methylglyoxal has injurious effects on maturation of mouse oocytes, fertilization, and fetal development, via apoptosis.

    abstract::Methylglyoxal (MG) is a metabolite of glucose. The serum MG level is increased in diabetic patients, and MG is implicated in diabetic complications related to embryonic development injury. We previously reported cytotoxic effects of MG on mouse embryonic stem cells and blastocysts, and a further association with defec...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chang YJ,Chan WH

    更新日期:2010-04-01 00:00:00

  • Toxic effects of mosquito coil (a mosquito repellent) smoke on rats. II. Morphological changes of the respiratory system.

    abstract::A group of 20 female albino rats was exposed to mosquito coil smoke, 8 h a day, 6 days per week, for 60 days. An additional group receiving air exposure served as control. The smoke-exposed animals had a lower body weight than the controls. Smoke-induced histopathological lesions, including an inflammation of the trac...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Liu WK,Wong MH

    更新日期:1987-12-01 00:00:00

  • Teratogenicity of (TCDF) in mice.

    abstract::Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is tera...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Weber H,Lamb JC,Harris MW,Moore JA

    更新日期:1984-02-01 00:00:00

  • Methylmercury chloride induces alveolar type II epithelial cell damage through an oxidative stress-related mitochondrial cell death pathway.

    abstract::Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lu TH,Chen CH,Lee MJ,Ho TJ,Leung YM,Hung DZ,Yen CC,He TY,Chen YW

    更新日期:2010-05-04 00:00:00

  • The role of gamma-aminobutyric acid/glycinergic synaptic transmission in mediating bilirubin-induced hyperexcitation in developing auditory neurons.

    abstract::Hyperbilirubinemia is a common clinical phenomenon observed in human newborns. A high level of bilirubin can result in severe jaundice and bilirubin encephalopathy. However, the cellular mechanisms underlying bilirubin excitotoxicity are unclear. Our previous studies showed the action of gamma-aminobutyric acid (GABA)...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yin XL,Liang M,Shi HB,Wang LY,Li CY,Yin SK

    更新日期:2016-01-05 00:00:00

  • Adductomics: characterizing exposures to reactive electrophiles.

    abstract::To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most imp...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rappaport SM,Li H,Grigoryan H,Funk WE,Williams ER

    更新日期:2012-08-13 00:00:00

  • Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

    abstract::Cisplatin is prescribed for the treatment of solid tumors and elicits toxicity to kidney tubules, which limits its clinical use. Nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2) is a critical transcription factor that has been shown to protect against kidney injury through activation of antioxidant mechanism...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Atilano-Roque A,Aleksunes LM,Joy MS

    更新日期:2016-09-30 00:00:00

  • Influence of polyaminocarboxylic acids on the removal of manganese-54 from the body organs of sham-operated and partially hepatectomized rats.

    abstract::EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

    更新日期:1984-07-01 00:00:00

  • The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO₂ in human alveolar epithelial cells.

    abstract::Metal oxide NPs are abundantly produced in nanotech industries and are emitted in several combustion processes, suggesting the need to characterize their toxic impact on the human respiratory system. The acute toxicity and the morphological changes induced by copper oxide and titanium dioxide NPs (nCuO and nTiO₂) on t...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Moschini E,Gualtieri M,Colombo M,Fascio U,Camatini M,Mantecca P

    更新日期:2013-10-24 00:00:00

  • Thymic atrophy in mice induced by cadmium administration.

    abstract::The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yamada YK,Shimizu F,Kawamura R,Kubota K

    更新日期:1981-04-01 00:00:00

  • In vitro prenatal developmental toxicity induced by some petroleum substances is mediated by their 3- to 7-ring PAH constituent with a potential role for the aryl hydrocarbon receptor (AhR).

    abstract::To test the hypothesis that 3-7 ring polycyclic aromatic hydrocarbons (PAHs) are responsible for the prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS), the present study evaluates the PDT potency of DMSO-extracts of 7 heavy fuel oils (HFO), varying in their PAH content, and 1 highly...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kamelia L,de Haan L,Ketelslegers HB,Rietjens IMCM,Boogaard PJ

    更新日期:2019-10-15 00:00:00

  • Role of NADPH oxidase in cooperative reactive oxygen species generation in dopaminergic neurons induced by combined treatment with dieldrin and lindane.

    abstract::Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative tox...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sharma H,Hirko AC,King MA,Liu B

    更新日期:2018-12-15 00:00:00

  • Study on dermal toxicity and urinary metabolites of the new insect repellent N,N-diethylphenylacetamide in rabbits.

    abstract::Dermal toxicity of the new multi-insect repellent N,N-diethylphenylacetamide (DEPA) was studied in female rabbits. LD50 of DEPA was estimated to be 3505 mg/kg b.w. On daily topical application for 21 d at a dose of 50 mg/kg b.w., dermal irritancy score and blood chemistry changes indicated that the compound is non-irr...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rao SS,Agarwal MK,Rao KM,Swamy RV

    更新日期:1989-01-01 00:00:00

  • Glutathione S-transferase cytosolic isoforms as biomarkers of polychlorinated biphenyl (Arochlor-1254) experimental contamination in rainbow trout.

    abstract::At the present work, different groups of rainbow trouts have been intraperitoneally treated with a polychlorinated biphenyls commercial mixture (Arochlor-1254) at three doses (5, 20 and 70 mg PCBs/ kg body weight) and they have been sampled at 0 (injection moment), 3, 6 and 9 weeks after xenobiotic exposure. Purificat...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Pérez-López M,Nóvoa-Valiñas MC,Melgar-Riol MJ

    更新日期:2002-12-15 00:00:00

  • A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon.

    abstract::In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Navarra P,Martire M,del Carmine R,Pozzoli G,Preziosi P

    更新日期:1992-12-01 00:00:00

  • Bisphenol A exposure via thermal paper receipts.

    abstract::Bisphenol A (BPA) has one of the highest production volumes of all chemicals worldwide. It has been widely studied because of its endocrine modulating activity. In addition to dietary intake, absorption of BPA via the skin from handling thermal papers is believed to be a relevant route of exposure. We studied BPA expo...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Porras SP,Heinälä M,Santonen T

    更新日期:2014-11-04 00:00:00

  • Furan is not genotoxic in the micronucleus assay in vivo or in vitro.

    abstract::Furan, a potential human carcinogen, is formed during heat-treatment of food. Previous studies of the genotoxicity of furan have given disparate results. Hence, there is a need for complementary data to clarify the mechanism behind the carcinogenicity of furan. In this study, we have used the flow cytometer-based micr...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Durling LJ,Svensson K,Abramsson-Zetterberg L

    更新日期:2007-02-28 00:00:00

  • Genotoxicity induced in cultured Chinese hamster cells exposed to natural or synthetic crude oils and near ultraviolet light.

    abstract::Cultured Chinese hamster ovary (CHO) cells were incubated with dilutions of natural or synthetic crude oils and subsequently exposed to near ultraviolet light (NUV). Although the magnitude of photo-induced cytotoxicity in CHO was essentially independent of the source of the oil (within a factor of two), two shale oils...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Strniste GF,Bingham JM,Okinaka RT,Chen DJ

    更新日期:1982-10-01 00:00:00

  • Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway.

    abstract::Chronic exposure to arsenic increases the risk of developing a variety of human cancers including lung carcinomas. However, the exact molecular mechanism underlying arsenic carcinogenicity remains largely unknown. Autophagy is a conserved catabolic process for maintaining cellular protein homeostasis whose defects mig...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wu L,Wang Z,Li X,He X,Han Y,Chen Y,Liu L,Fu L,Zhang T

    更新日期:2020-10-10 00:00:00

  • Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test.

    abstract::Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

    更新日期:2016-02-03 00:00:00

  • MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells.

    abstract::Histone deacetylase (HDAC) inhibitors have recently emerged as a new class of anti-cancer agents. Trichostatin A (TSA), a classical HDAC inhibitor, has been demonstrated to induce cell cycle arrest, promote cell apoptosis, and inhibit metastasis. However, the molecular mechanism underlying TSA function has not been fu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Liu Y,He G,Wang Y,Guan X,Pang X,Zhang B

    更新日期:2013-07-31 00:00:00

  • Potential mechanisms of tumorigenic action of diethanolamine in mice.

    abstract::Diethanolamine (DEA), a secondary amine found in a number of consumer products, reportedly induces liver tumors in mice. In an attempt to define the tumorigenic mechanism of DEA, N-nitrosodiethanolamine (NDELA) formation in vivo and development of choline deficiency were examined in mice. DEA was administered with or ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Stott WT,Bartels MJ,Brzak KA,Mar M,Markham DA,Thornton CM,Zeisel SH

    更新日期:2000-04-03 00:00:00

  • Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1.

    abstract::Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibit...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ge DT,Law PY,Kong SK,Ho YY

    更新日期:2009-01-30 00:00:00

  • Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats.

    abstract::Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990s. In this study, we examined the effect of organoph...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hirosawa N,Ueyama J,Kondo T,Kamijima M,Takagi K,Fujinaka S,Hirate A,Hasegawa T,Wakusawa S

    更新日期:2011-05-30 00:00:00

  • Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles.

    abstract::The study was designed to conduct human in vivo and in vitro studies on the gastrointestinal absorption of nanoparticles, using titanium dioxide as a model compound, and to compare nanoparticle behaviour with that of larger particles. A supplier's characterisation data may not fully describe a particle formulation. Mo...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jones K,Morton J,Smith I,Jurkschat K,Harding AH,Evans G

    更新日期:2015-03-04 00:00:00

  • Evaluation of the subacute nephrotoxicity of cyclohexane and other industrial solvents in the female Sprague-Dawley rat.

    abstract::The subacute nephrotoxicity of more than 20 industrial solvents has been compared in female Sprague-Dawley rats. The animals were given 5 i.p. injections of the solvents per week for 2 weeks at doses ranging from 1/20 to 1/5 of the i.p. or oral LD50 and the urinary excretion of N-acetyl-beta-D-glucosaminidase, beta 2-...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Bernard AM,de Russis R,Normand JC,Lauwerys RR

    更新日期:1989-02-01 00:00:00

  • Methoxetamine--a novel recreational drug with potent hallucinogenic properties.

    abstract::Methoxetamine is one of the constantly growing group of novel psychoactive substances that has emerged in recent years. The compound belongs to the arylcyclohexylamine class, which is used for its recreational and psychedelic effects. Methoxetamine is a structural analogue of ketamine, with a much longer duration of a...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Zawilska JB

    更新日期:2014-11-04 00:00:00