Preclinical detection of nephrotoxicity: description of the tests and appraisal of their health significance.


:The prevention of renal diseases induced by chemicals requires the use of tests with which adverse renal effects can be detected at a stage when removal from exposure to the offending agent(s) may lead to complete recovery or may at least prevent an accelerated decline in renal function. The screening tests used in clinical medicine for assessing the functional integrity of the kidney are not sufficiently sensitive to attain this objective. In this review, we describe the tests currently available for detecting incipient renal damage and attempt to assess their health significance. A minimal battery of tests is recommended for the detection of groups in industry or in the general population who are at risk. If an increased prevalence of abnormal values for these parameters is found repeatedly in a population, efforts should be made to identify the causal agent(s) and, if possible, to reduce the exposure. Follow-up examinations of subjects identified in this way are also indicated, in order to define the predictive value of the detected changes better.


Toxicol Lett


Toxicology letters


Lauwerys R,Bernard A




Has Abstract


1989-03-01 00:00:00














  • Inhalation of enflurane and halothane at subanesthetic concentrations and effects on circulating serum testosterone, luteinizing hormone and follicle-stimulating hormone in the male rat.

    abstract::The present study was carried out in order to investigate the effects of inhaled volatile anesthetic gases in subanesthetic concentrations on circulating hormones essential for normal male reproduction. Male mature rats were exposed daily, up to 11 days, to halothane or enflurane in concentrations up to 500 and 1000 p...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Cameron AM,Dale O,Haug E,Nilsen OG

    更新日期:1983-12-01 00:00:00

  • Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice.

    abstract::Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-in...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

    更新日期:2004-05-02 00:00:00

  • The application of toxicological parameters in emergency response and planning.

    abstract::Effective emergency preparedness and response planning are needed to assist responders in making sound decisions under the stressful and confusing conditions accompanying a major accidental release of hazardous materials. One of the most important decisions to be made is the extent and duration of the evacuation of pe...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Wiener RK,Shaver DK

    更新日期:1989-12-01 00:00:00

  • Isolation and partial purification of Lantana (Lantana camara L.) toxins.

    abstract::A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sharma OP,Dawra RK,Makkar HP

    更新日期:1987-07-01 00:00:00

  • Induction of the rat hepatic cytosolic arylamine oxidase by a series of polychlorinated biphenyls: association with the Ah locus.

    abstract::The objective of the present study was to identify the polychlorinated biphenyl congeners of Aroclor 1254 that are responsible for the induction of the cytosolic bioactivation of aromatic amines. Various chlorobiphenyls, ranging from di- to hexa-substituted, were administered to rats and the ability of the hepatic cyt...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Marczylo T,Ioannides C

    更新日期:1997-07-21 00:00:00

  • Mutagenic effects of fluphenazine hydrochloride in Drosophila melanogaster.

    abstract::The mutagenic potential of fluphenazine hydrochloride was tested on male germ cells of Drosophila melanogaster. The criterion used was sex-linked recessive lethal mutations. Oregon-K males of D. melanogaster, reared on a medium containing 0.01, 0.02 and 0.03 mg/ml of the drug, were screened for sex-linked recessive le...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rao KP,Rao MS

    更新日期:1980-12-01 00:00:00

  • Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

    abstract::Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

    更新日期:2018-10-15 00:00:00

  • Protective effect of methionine against vinyl chloride-mediated depression of non-protein sulphydryls and cytochrome p-450.

    abstract::Potentiality of a protective effect of methionine against hepatotoxic action of vinyl chloride (VC) was assessed on rats, induced with phenobarbital and thereafter exposed to 50 000 ppm VC for 5 h. This extremely high dosage of VC warranted the appearance of drastic symptoms of liver injury in the course of 20 h poste...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wisniewska-Knypl JM,Sokal JA,Klimczak J,Dajniak A,Bogdanikowa B

    更新日期:1981-05-01 00:00:00

  • Challenging conventional risk assessment with respect to human exposure to multiple food contaminants in food: A case study using maize.

    abstract::Mycotoxins and heavy metals are ubiquitous in the environment and contaminate many foods. The widespread use of pesticides in crop production to control disease contributes further to the chemical contamination of foods. Thus multiple chemical contaminants threaten the safety of many food commodities; hence the presen...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Clarke R,Connolly L,Frizzell C,Elliott CT

    更新日期:2015-10-01 00:00:00

  • Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells.

    abstract::Autophagy, which works to remove stress and maintain cellular homeostasis, is usually considered a "pro-survival" signal. Contrarily, apoptosis is programmed "pro-death" machinery. Polychlorinated biphenyls (PCBs) are a group of ubiquitous industrial pollutants. Our previous studies illustrated that a PCB quinone meta...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Shi Q,Wang Y,Dong W,Song E,Song Y

    更新日期:2019-05-15 00:00:00

  • Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication.

    abstract:OBJECTIVE:Ethanol intake can increase the sedative effects of gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL), although the real clinical impact is unknown. We studied the clinical impact of the co-ingestion of ethanol in patients presenting to the Emergency Department (ED) with acute toxicity related to GHB/GBL us...

    journal_title:Toxicology letters

    pub_type: 杂志文章,多中心研究


    authors: Galicia M,Dargan PI,Dines AM,Yates C,Heyerdahl F,Hovda KE,Giraudon I,Euro-DEN Plus Research Group.,Wood DM,Miró Ò,Euro-DEN Plus Research Group.

    更新日期:2019-10-10 00:00:00

  • Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes.

    abstract::Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, expe...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lauková M,Pervez S,Rosman R,Velíšková J,Velíšek L,Shakarjian MP

    更新日期:2019-06-15 00:00:00

  • T(H1)-directed modulation of in vitro cytokine production in human peripheral blood mononuclear cells by styrene-7.8-oxide.

    abstract::Styrene and its chiral main metabolite styrene-7.8-oxide are well characterized regarding their cytotoxic, genotoxic and neurotoxic properties. To our knowledge, no data exist on the influence of styrene and styrene-7.8-oxide on immune reactions. Epidemiological studies suggest that exposure to environmental pollutant...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Merker GH,Metzner G,Raabe F

    更新日期:2006-01-05 00:00:00

  • Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice.

    abstract::Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sutjarit S,Nakayama SM,Ikenaka Y,Ishizuka M,Banlunara W,Rerkamnuaychoke W,Kumagai S,Poapolathep A

    更新日期:2014-08-17 00:00:00

  • A new method to evaluate toxicological data reliability in risk assessments.

    abstract::Toxicological data used for risk assessments must undergo an evaluation of reliability. Nevertheless, a reliability evaluation scheme for such data has yet to be established in China. A method termed TRAM (Toxicological data Reliability Assessment Method) was developed to evaluate toxicological data reliability. A que...

    journal_title:Toxicology letters

    pub_type: 共识发展会议,杂志文章


    authors: Bian Q,Ping Y,Jun W,Lyu Z,Song Y,Zhang L,Liu Z

    更新日期:2019-09-01 00:00:00

  • Circulating microRNA profiles altered in mice after 28 d exposure to perfluorooctanoic acid.

    abstract::Perfluorooctanoic acid (PFOA) is a stable man-made compound with many industrial and commercial uses. Recently, however, concern has been raised that it may induce various toxicological effects such as hepatotoxicity, immunotoxicity, and developmental toxicity. Because levels of circulating microRNAs (miRNAs) can be a...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yan S,Wang J,Zhang W,Dai J

    更新日期:2014-01-03 00:00:00

  • Acute iron overload leads to hypothalamic-pituitary-gonadal axis abnormalities in female rats.

    abstract::Iron plays a critical role in a mammal's physiological processes. However, iron tissue deposits have been shown to act as endocrine disrupters. Studies that evaluate the effect of acute iron overload on hypothalamic-pituitary-gonadal (HPG) axis health are particularly sparse. This study demonstrates that acute iron ov...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rossi EM,Marques VB,Nunes Dde O,Carneiro MT,Podratz PL,Merlo E,dos Santos L,Graceli JB

    更新日期:2016-01-05 00:00:00

  • Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness.

    abstract::Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

    更新日期:2020-03-01 00:00:00

  • LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol.

    abstract::Antioxidants of the vitamin E family have protective effects against metal toxicity. We examined the protective effect of racemic LLU-alpha [2,7,8-trimethyl-2-(carboxyethyl)-6-hydroxychroman] a metabolite of gamma-tocopherol, in comparison to the effect of alpha- and gamma-tocopherol in rats treated with sodium dichro...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Appenroth D,Karge E,Kiessling G,Wechter WJ,Winnefeld K,Fleck C

    更新日期:2001-07-06 00:00:00

  • Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.

    abstract::New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Richter LHJ,Herrmann J,Andreas A,Park YM,Wagmann L,Flockerzi V,Müller R,Meyer MR

    更新日期:2019-05-01 00:00:00

  • Renal damage caused by gentamicin: a study of the effect in vitro using isolated rat proximal tubular fragments.

    abstract::The clinical use of gentamicin (G) is limited because of its nephrotoxic potential. The administration of G (50 mg/kg) to rats in a 10-day daily treatment gave a biphasic pattern of lactate dehydrogenase (LDH) and N-acetyl-beta-D-glucosaminidase (NAG) excretion. Alkaline phosphatase (ALP) was highly elevated during th...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Obatomi DK,Plummer DT

    更新日期:1995-01-01 00:00:00

  • Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice.

    abstract::A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Naganuma A,Satoh M,Koyama Y,Imura N

    更新日期:1985-02-01 00:00:00

  • Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep.

    abstract::The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model per...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lautz LS,Hoeks S,Oldenkamp R,Hendriks AJ,Dorne JLCM,Ragas AMJ

    更新日期:2020-01-01 00:00:00

  • Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles.

    abstract::The study was designed to conduct human in vivo and in vitro studies on the gastrointestinal absorption of nanoparticles, using titanium dioxide as a model compound, and to compare nanoparticle behaviour with that of larger particles. A supplier's characterisation data may not fully describe a particle formulation. Mo...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jones K,Morton J,Smith I,Jurkschat K,Harding AH,Evans G

    更新日期:2015-03-04 00:00:00

  • Human urinary biomarkers of dioxin exposure: analysis by metabolomics and biologically driven data dimensionality reduction.

    abstract::Untargeted metabolomic approaches offer new opportunities for a deeper understanding of the molecular events related to toxic exposure. This study proposes a metabolomic investigation of biochemical alterations occurring in urine as a result of dioxin toxicity. Urine samples were collected from Czech chemical workers ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jeanneret F,Boccard J,Badoud F,Sorg O,Tonoli D,Pelclova D,Vlckova S,Rutledge DN,Samer CF,Hochstrasser D,Saurat JH,Rudaz S

    更新日期:2014-10-15 00:00:00

  • Chilli extract treatment and induction of eye lesions in hamsters.

    abstract::On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

    更新日期:1985-10-01 00:00:00

  • Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice.

    abstract::Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days sub...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rattner BA,Michael SD

    更新日期:1985-01-01 00:00:00

  • Chromium(VI) promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer.

    abstract::Chromium (Cr) is widely used in industry, making its toxicity a matter of concern. Although hexavalent Cr [Cr(VI)] can promote cancer cell proliferation in several cancers, there is little evidence implicating Cr(VI) in cancer cell migration, especially in prostate cancer. We show that the Cr concentration is higher i...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zhang C,Cai K,Feng Q,Xu Y,Zhang Z

    更新日期:2019-01-01 00:00:00

  • DBP-induced endoplasmic reticulum stress in male germ cells causes autophagy, which has a cytoprotective role against apoptosis in vitro and in vivo.

    abstract::Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

    更新日期:2016-03-14 00:00:00

  • Effect of trimethyltin on ornithine decarboxylase in various regions of the mouse brain.

    abstract::Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ali SF,Newport GD,Slikker W Jr,Bondy SC

    更新日期:1987-03-01 00:00:00