Preclinical detection of nephrotoxicity: description of the tests and appraisal of their health significance.


:The prevention of renal diseases induced by chemicals requires the use of tests with which adverse renal effects can be detected at a stage when removal from exposure to the offending agent(s) may lead to complete recovery or may at least prevent an accelerated decline in renal function. The screening tests used in clinical medicine for assessing the functional integrity of the kidney are not sufficiently sensitive to attain this objective. In this review, we describe the tests currently available for detecting incipient renal damage and attempt to assess their health significance. A minimal battery of tests is recommended for the detection of groups in industry or in the general population who are at risk. If an increased prevalence of abnormal values for these parameters is found repeatedly in a population, efforts should be made to identify the causal agent(s) and, if possible, to reduce the exposure. Follow-up examinations of subjects identified in this way are also indicated, in order to define the predictive value of the detected changes better.


Toxicol Lett


Toxicology letters


Lauwerys R,Bernard A




Has Abstract


1989-03-01 00:00:00














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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Du LJ,Xiang K,Liu JH,Song ZM,Liu Y,Cao A,Wang H

    更新日期:2018-10-01 00:00:00

  • Transgenic models for detection of mutations in tumors and normal tissues of rodents.

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Mirsalis JC

    更新日期:1995-12-01 00:00:00

  • Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts.

    abstract::In this study, we examined the cytotoxic effects of sanguinarine, a phytoalexin with antimicrobial, anti-oxidant, anti-inflammatory and pro-apoptotic effects, on the blastocyst stage of mouse embryos, subsequent embryonic attachment and outgrowth in vitro and in vivo implantation via embryo transfer. Blastocysts treat...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chan WH

    更新日期:2011-09-10 00:00:00

  • Effect of zinc on cadmium, copper and zinc contents in cadmium exposed rats.

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    journal_title:Toxicology letters

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    authors: Behari JR,Tandon SK

    更新日期:1980-02-01 00:00:00

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    pub_type: 杂志文章


    authors: García MA,Peña D,Alvarez L,Cocca C,Pontillo C,Bergoc R,de Pisarev DK,Randi A

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    pub_type: 杂志文章


    authors: Villa P,Corada M,Bartosek I

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nikolaev V,Naydenova E,Kerimova M,Dimov S,Ivanov E

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lam HR,Ostergaard G,Ladefoged O

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    pub_type: 杂志文章


    authors: Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

    更新日期:2016-02-26 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Abramsson-Zetterberg L,Svensson M,Johnsson L

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Pauluhn J

    更新日期:2018-01-05 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Magos L,Clarkson TW

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  • Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Schulte-Hermann R,Bursch W,Kraupp-Grasl B,Oberhammer F,Wagner A

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    journal_title:Toxicology letters

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Bernard AM,de Russis R,Normand JC,Lauwerys RR

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  • Role of inflammation in chemical-induced hepatotoxicity.

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy B

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  • Thrombocytopenia in rats and dogs administered the antidepressant compound MDL-19,660.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yarrington JT,Kociba GJ,Gibson JP

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  • d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Boadi WY,Urbach J,Brandes JM,Yannai S

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    pub_type: 杂志文章,评审


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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Magnaval R,Batti R,Bouville A,Magnaval JP,Spear RC

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kiyohara C,Hirohata T

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sorensen EM

    更新日期:1988-04-01 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Vral A,Thierens H,Baeyens A,De Ridder L

    更新日期:2004-04-01 00:00:00

  • Increased o- and p-cresol/hippuric acid ratios in the urine of four strains of rat exposed to toluene at thousands-ppm levels.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Inoue O,Seiji K,Ishihara N,Kumai M,Ikeda M

    更新日期:1984-11-01 00:00:00