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DNA reactivity of altertoxin II: Identification of two covalent guanine adducts formed under cell-free conditions.

Abstract：

:Fungi of the genus Alternaria infest many agricultural crops and produce numerous mycotoxins, of which altertoxin II (ATX II) is one of the most mutagenic metabolites. ATX II carries an epoxide group but the formation of DNA adducts has not been demonstrated to date. We report now that ATX II gives rise to two covalent adducts with guanine when incubated with DNA under cell-free conditions. These adducts were demonstrated by LC-high resolution MS after enzymatic degradation of the incubated DNA to deoxynucleosides. The major adduct results from the covalent binding of ATX II, presumably through the epoxide group, to guanine, whereas the minor guanine adduct is derived from the major one by the elimination of two equivalents of water. In addition, a third adduct was detected, formed through covalent binding of ATX II to cytosine followed by the loss of two equivalents of water. The direct DNA reactivity of ATX II may explain its high mutagenicity.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Soukup ST,Fleck SC,Pfeiffer E,Podlech J,Kulling SE,Metzler M

doi

10.1016/j.toxlet.2020.05.018

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

75-81

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(20)30167-3

journal_volume

331

pub_type

杂志文章

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