当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers.

Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers.

Abstract：

:Citrinin (CIT), a fungal metabolite causing nephrotoxicity, has a tolerable daily intake (TDI) value of 0.2μg/kg bw. Contamination of food with CIT is not sufficiently known to allow dietary exposure assessment. Urinary biomonitoring data are available from cohorts of several countries. However, kinetic information is lacking for CIT, hampering the use of urinary biomonitoring data to estimate the daily intake. We have investigated the kinetics of CIT after oral intake in two human volunteers on two occasions. Urinary excretion showed that ingested CIT undergoes conversion to dihydro-citrinone (DH-CIT) which is then excreted in the urine along with parent compound. The cumulative urinary excretion within 24h was between 32.9% and 70.8% (median 40.2%) of the sum of CIT and DH-CIT ('total CIT'). The median half-life in urine was 6.7h for CIT and 8.9h for DH-CIT. The median half-life in plasma accounted to 9.4h. The daily urinary excretion for 'total CIT' served to estimate a provisional daily CIT intake using published urine biomarker data in several cohorts. European cohorts had an exposure well below the TDI whereas in Bangladesh the exposure in one cohort exceeded the TDI.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Degen GH,Ali N,Gundert-Remy U

doi

10.1016/j.toxlet.2017.10.006

subject

Has Abstract

pub_date

2018-01-05 00:00:00

pages

43-48

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(17)31418-2

journal_volume

282

pub_type

杂志文章

相关文献

TOXICOLOGY LETTERS文献大全
  • Winter fine particulate matter from Milan induces morphological and functional alterations in human pulmonary epithelial cells (A549).

    abstract：:Samples of PM(2.5) were gravimetrically collected during the winter 2005/2006 in the urban area of Milan (North Italy). Samples were chemically characterized and the particles were detached from filters to determine their cytotoxic effects on the A549 cell line. Based on the potential toxicological relevance of its co...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2009.03.003

    authors： Gualtieri M,Mantecca P,Corvaja V,Longhin E,Perrone MG,Bolzacchini E,Camatini M

    更新日期：2009-07-10 00:00:00

  • Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.

    abstract：:Oltipraz (OPZ) is a known inducer of glutathione S-transferases and a mechanism-based inhibitor of cytochrome P450 1A2. Given the detoxification characteristics of this compound, the transcriptional effects of OPZ, along with the related naturally occurring compounds 3H-1,2-dithiole-3-thione (D3T) and sulforaphane (SF...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2004.06.006

    authors： Konwinski RR,Haddad R,Chun JA,Klenow S,Larson SC,Haab BB,Furge LL

    更新日期：2004-11-28 00:00:00

  • Effect of diet on colonic-programmed cell death: molecular mechanism of action.

    abstract：:Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-4274(99)00263-5

    authors： Chapkin RS,Fan Y,Lupton JR

    更新日期：2000-03-15 00:00:00

  • DNA adducts in hamster and rat tracheas exposed to benzo(a)pyrene in vitro.

    abstract：:Syrian golden hamsters are much more susceptible than Wistar rats to the induction of tracheal tumors by benzo(a)pyrene (BP). In order to investigate whether this difference is reflected in the pattern of DNA-adduct induction and removal, tracheas from either species were isolated and exposed to BP (5 micrograms/ml) i...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(94)90016-7

    authors： Roggeband R,Wolterbeek AP,van den Berg PT,Baan RA

    更新日期：1994-06-01 00:00:00

  • In vitro reconstituted tissue as an alternative to human respiratory tract.

    abstract：:The data obtained from in vitro systems utilizing human cells and tissues should form a basic part of the information necessary for risk assessment. The most important thing for such systems is, therefore, to simulate the structures and functions of cells and tissues in the native organ as closely as possible. In desi...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(96)03721-6

    authors： Emura M,Ochiai A,Hirohashi S

    更新日期：1996-11-01 00:00:00

  • Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol).

    abstract：:The effect of dietary vomitoxin on the serum IgA and IgG responses to two model intestinal antigens, casein and cholera toxin (CT), were assessed in 4 experimental groups: (1) mice fed casein-based diet, (2) mice fed casein-based diet containing 25 ppm vomitoxin, (3) mice fed casein-based diet and immunized with CT, a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(90)90254-j

    authors： Pestka JJ,Moorman MA,Warner RL

    更新日期：1990-01-01 00:00:00

  • Attenuation of eNOS expression in cadmium-induced hypertensive rats.

    abstract：:Cadmium (Cd) has been reported to induce hypertension in both humans and animals; however, its mechanism has not been clearly elucidated. Vascular tone is one of the factors contributing to hypertension. This study was conducted to investigate the effects of Cd exposure on vascular muscarinic receptor responses to ace...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2007.11.002

    authors： Yoopan N,Watcharasit P,Wongsawatkul O,Piyachaturawat P,Satayavivad J

    更新日期：2008-01-30 00:00:00

  • Cytokine regulation of chemical sensitization.

    abstract：:The skin is an immunologically active tissue. Epidermal cells, both keratinocytes and Langerhans cells (LC), produce constitutively or can be stimulated to produce a variety of cytokines, many of which play important roles in the induction and regulation of allergic responses to sensitizing chemicals. Tumor necrosis f...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(95)03497-8

    authors： Kimber I,Holliday MR,Dearman RJ

    更新日期：1995-12-01 00:00:00

  • Biological monitoring of bidi industry workers occupationally exposed to tobacco.

    abstract：:Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(99)00097-1

    authors： Bhisey RA,Bagwe AN,Mahimkar MB,Buch SC

    更新日期：1999-09-05 00:00:00

  • An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models.

    abstract：:One of the major dose-limiting toxicities induced by antimicrotubule antitumor agents such as vinca alkaloids and taxanes is peripheral neuropathy. The neurotoxicity of TZT-1027 (a dolastatin 10 derivative antimicrotubule agent) was thus assessed using the animal models for antimicrotubule agent-induced neurotoxicity....

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(01)00327-7

    authors： Ogawa T,Mimura Y,Isowa K,Kato H,Mitsuishi M,Toyoshi T,Kuwayama N,Morimoto H,Murakoshi M,Nakayama T

    更新日期：2001-04-30 00:00:00

  • Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism.

    abstract：:Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2017.01.006

    authors： Hoffmann M,Fiedor E,Ptak A

    更新日期：2017-03-05 00:00:00

  • Activation of styrene to styrene oxide in hepatocytes and subcellular fractions of rat liver.

    abstract：:The oxidation of styrene to styrene oxide and the hydration of this metabolite to styrene glycol was investigated in hepatocytes, 9000 x g supernatant (S9) and the microsomal fraction from rat liver. Similar amounts of free styrene oxide were found in microsomes, hepatocytes and S9. However, on the basis of the format...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(84)90120-6

    authors： Belvedere G,Elovaara E,Vainio H

    更新日期：1984-11-01 00:00:00

  • Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration.

    abstract：:Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondrial protein that is thought to play a role in the pathophysiology of A...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2020.12.012

    authors： Fišar Z,Musílek K,Benek O,Hroch L,Vinklářová L,Schmidt M,Hroudová J,Raboch J

    更新日期：2021-03-15 00:00:00

  • Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype.

    abstract：:The carcinogenicity of dichloromethane (DCM) has been demonstrated by mutagenicity studies using bacteria and yeasts and using animal bioassays. Epidemiological studies indicate that exposure to DCM increases the incidences of liver and pancreas cancers. In the present study, we determine whether DCM generates DNA dam...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2010.09.002

    authors： Olvera-Bello AE,Estrada-Muñiz E,Elizondo G,Vega L

    更新日期：2010-12-15 00:00:00

  • Importance of species differences in experimental pulmonary carcinogenicity of inhaled cadmium for extrapolation to humans.

    abstract：:There is sufficient evidence for pulmonary carcinogenicity of inhaled cadmium (Cd) compounds in rats whereas no such evidence was found in mice and hamsters, indicating significant species differences in the pulmonary response to inhaled Cd. We hypothesized that expression of metallothionein (MT) protein in the lung a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(94)90046-9

    authors： Oberdörster G,Cherian MG,Baggs RB

    更新日期：1994-06-01 00:00:00

  • d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.

    abstract：:Cataract is the leading cause of blindness with an estimated 16 million people affected worldwide. d-galactose (d-gal) is a reducing sugar that widely distributed in foodstuffs, and studies show that d-gal could promote cataract formation by damaging nature lens epithelial cells (LECs). However, the underlying mechani...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2018.02.001

    authors： Xu Y,Li Y,Ma L,Xin G,Wei Z,Zeng Z,Xing Z,Li S,Niu H,Huang W

    更新日期：2018-06-01 00:00:00

  • Classification of chemicals as sensitisers based on new test methods.

    abstract：:For the last decade, classification schemes worldwide have recognised that certain chemicals may need to be categorised as skin or respiratory sensitisers. Although differing in detail, the schemes use similar criteria for designating materials as sensitisers, based on either direct evidence from exposed humans or the...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(92)90186-n

    authors： Botham PA

    更新日期：1992-12-01 00:00:00

  • Immediate and delayed effects of subchronic Paraquat exposure during an early differentiation stage in 3D-rat brain cell cultures.

    abstract：:Xenobiotic exposure is a risk factor in the etiology of neurodegenerative disease. It was recently hypothesized that restricted exposure during brain development could predispose for a neurodegenerative disease later in life. As neuroinflammation contributes to progressive neurodegeneration, it is suspected that neuro...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.02.001

    authors： Sandström von Tobel J,Zoia D,Althaus J,Antinori P,Mermoud J,Pak HS,Scherl A,Monnet-Tschudi F

    更新日期：2014-10-15 00:00:00

  • No evidence of genotoxic effect in vivo of the phytosterol oxidation products triols and epoxides.

    abstract：:Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2007.07.006

    authors： Abramsson-Zetterberg L,Svensson M,Johnsson L

    更新日期：2007-09-10 00:00:00

  • In vivo effect of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mouse liver microsomes.

    abstract：:In vivo administration of 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produced much higher hepatic microsomal aryl hydrocarbon hydroxylase (AHH) induction than 7,8-benzoflavone (7,8-BF) in both aromatic hydrocarbon (Ah)-responsive and nonresponsive strains of mice. Simultaneous treatment o...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(93)90095-f

    authors： Kiyohara C,Hirohata T

    更新日期：1993-02-01 00:00:00

  • Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.

    abstract：:Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2013.05.007

    authors： Kamenickova A,Anzenbacherova E,Pavek P,Soshilov AA,Denison MS,Zapletalova M,Anzenbacher P,Dvorak Z

    更新日期：2013-07-31 00:00:00

  • Optimization issues in physiological toxicokinetic modeling: a case study with benzene.

    abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(93)90103-5

    authors： Woodruff TJ,Bois FY

    更新日期：1993-08-01 00:00:00

  • Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages.

    abstract：:The NLRP3 inflammasome, composed of caspase-1, NLRP3 and ASC, plays a critical role in the clearance of microbial pathogens. Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungicide in agriculture, caused a decrease in pro-caspase-1 and NLRP3 levels...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2015.04.012

    authors： Muroi M,Tanamoto K

    更新日期：2015-06-15 00:00:00

  • Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein.

    abstract：BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2017.05.023

    authors： Im DS,Shin HJ,Yang KJ,Jung SY,Song HY,Hwang HS,Gil HW

    更新日期：2017-08-05 00:00:00

  • Loss of mitochondrial membrane potential is not essential to hepatocyte killing by allyl alcohol.

    abstract：:Allyl alcohol-induced LDH leakage from isolated rat hepatocytes was preceded by a decrease in rhodmine 123 retention, signifying a loss of mitochondrial membrane potential. Addition of dithiothreitol (DTT) prevented the drop in membrane potential and completely prevented cell killing by allyl alcohol. In contrast, cyc...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(95)03426-9

    authors： Rikans LE,Cai DY,Hornbook KR

    更新日期：1995-11-15 00:00:00

  • Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis.

    abstract：:General anaesthesia is an important measure in the treatment of patients suffering from organophosphorus intoxication. The intravenous anaesthetic etomidate seems to be well suited for this purpose because of its stable haemodynamics. Here we raise the question whether the anaesthetic properties of etomidate are alter...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2010.07.016

    authors： Drexler B,Antkowiak B,Thiermann H,Seeger T,Grasshoff C

    更新日期：2010-10-20 00:00:00

  • Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

    abstract：:Cisplatin is prescribed for the treatment of solid tumors and elicits toxicity to kidney tubules, which limits its clinical use. Nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2) is a critical transcription factor that has been shown to protect against kidney injury through activation of antioxidant mechanism...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2016.07.021

    authors： Atilano-Roque A,Aleksunes LM,Joy MS

    更新日期：2016-09-30 00:00:00

  • Indirect human exposure to pharmaceuticals via drinking water.

    abstract：:There are numerous observations of pharmaceuticals (or their metabolites) as contaminants in wastewater, surface water and groundwater. This implies a potential for indirect human exposure to pharmaceuticals via drinking water supplies. Various effect benchmarks may be employed in an evaluation of the significance of ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(03)00071-7

    authors： Webb S,Ternes T,Gibert M,Olejniczak K

    更新日期：2003-05-15 00:00:00

  • Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behaviour in male mice.

    abstract：:Numerous chemicals released into the environment by man are able to disrupt the functioning of the endocrine system by binding to estrogen receptors in estrogen-responsive cells. The ability of o,p'-dichlorodiphenyl trichloroethane (DDT) and methoxychlor to compete with estradiol for binding to estrogen receptors in M...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(95)03316-5

    authors： vom Saal FS,Nagel SC,Palanza P,Boechler M,Parmigiani S,Welshons WV

    更新日期：1995-05-01 00:00:00

  • Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery.

    abstract：:Coumarin and its derivatives are widely employed as a fragrance in cosmetics and skin care products. The skin absorption level and possible disruption to the skin by topical application of coumarins were evaluated in this study. Percutaneous absorption of osthole, daphnoretin, coumarin, byakangelicin, and 7-hydroxycou...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.02.009

    authors： Pan TL,Wang PW,Aljuffali IA,Leu YL,Hung YY,Fang JY

    更新日期：2014-04-21 00:00:00