Cytokine regulation of chemical sensitization.

abstract：:Genomic DNA is under continuous assault by various chemical species produced by normal cellular metabolism. In addition, exposure to exogenous agents adds further insult. Modification of DNA by chemical carcinogens has long been recognized as an early event in carcinogenesis and many DNA adducts have been characterize...

journal_title：Toxicology letters

authors： Shuker DE

更新日期：2002-08-05 00:00:00

abstract：:Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...

journal_title：Toxicology letters

authors： Persoons R,Arnoux D,Monssu T,Culié O,Roche G,Duffaud B,Chalaye D,Maitre A

更新日期：2014-12-01 00:00:00

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...

journal_title：Toxicology letters

authors： Nagaya T,Ishikawa N,Hata H

更新日期：1990-12-01 00:00:00

abstract：:Cadmium is a carcinogenic metal known to increase the expression of several protooncogenes in a variety of cells. although the underlying mechanisms are unknown. Renal mesangial cells are smooth muscle cells in which Ca2+ signaling pathways regulate the induction of c-fos through both cAMP-dependent and mitogen-activa...

journal_title：Toxicology letters

authors： Templeton DM,Wang Z,Miralem T

更新日期：1998-03-16 00:00:00

abstract：:Several incidences of reduction in the fertility (sperm count) have been reported in India and worldwide as well. Adulteration of food and consumption of adulterated mustard oil with argemone oil (AO) are presumed to be the factors for reduction in sperm count. In the present study we have studied the exfoliation of g...

journal_title：Toxicology letters

authors： Mishra V,Saxena DK,Das M

更新日期：2009-04-25 00:00:00

abstract：:Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final ma...

journal_title：Toxicology letters

authors： Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

更新日期：2000-03-15 00:00:00

abstract：:Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

journal_title：Toxicology letters

authors： Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

更新日期：2013-05-23 00:00:00

abstract：:Effect of chrysotile dust alone or together with Candida albicans administered intratracheally in guinea pigs was studied in the genesis of pleural plaques over a period of 12 months. A significant increase of mucopolysaccharides, phosphorus, calcium and -SH content was detected in pleural fluid of animals treated wit...

journal_title：Toxicology letters

authors： Saxena KC,Srivastava L,Ali S,Dogra RK

更新日期：1982-10-01 00:00:00

abstract：:Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...

journal_title：Toxicology letters

authors： Miyakawa Y,Takahashi M,Furukawa F,Toyoda K,Sato H,Hayashi Y

更新日期：1986-11-01 00:00:00

abstract：:The binding of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to mouse peroxisome proliferator-activated receptor α ligand binding domain (mPPARα-LBD) was examined by a combination of in vitro investigation and in silico simulation. Fluorescence polarization (FP) assay showed that halogenated BPA...

journal_title：Toxicology letters

authors： Zhang J,Li T,Wang T,Guan T,Yu H,Li Z,Wang Y,Wang Y,Zhang T

更新日期：2018-02-01 00:00:00

abstract：:The effect of zinc (Zn) administration on the uptake and retention of cadmium (Cd), copper (Cu) and Zn in liver, kidneys and testes of cadmium exposed rats was investigated. Exposure to Cd caused a significant increase in the uptake of these metals in the 3 organs. The administration of Zn after the Cd exposure had li...

journal_title：Toxicology letters

authors： Behari JR,Tandon SK

更新日期：1980-02-01 00:00:00

abstract：:Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet. Chronic Cd exposure is a public health concern because Cd is a known carcinogen; it accumulates in the body and causes kidney damage. The National Health and Nutritional Examination Survey (NHANE...

journal_title：Toxicology letters

authors： Ruiz P,Mumtaz M,Osterloh J,Fisher J,Fowler BA

更新日期：2010-09-15 00:00:00

abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

journal_title：Toxicology letters

authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chrom...

journal_title：Toxicology letters

authors： Hulo S,Chérot-Kornobis N,Howsam M,Crucq S,de Broucker V,Sobaszek A,Edme JL

更新日期：2014-04-07 00:00:00

abstract：:Due to the specific antimicrobial activity of silver nanoparticles (AgNPs), they are widely used in wound dressings, coatings in medical devices and household products. In spite of the well-documented genotoxicity of AgNPs, the molecular mechanisms of relieving AgNP-induced DNA damage stress remain poorly understood. ...

journal_title：Toxicology letters

authors： Wang D,Yang H,Zhou Z,Zhao M,Chen R,Reed SH

更新日期：2018-05-15 00:00:00

abstract：:Lead (Pb) exposure during development impairs a variety of cognitive, behavioral and neurochemical processes resulting in deficits in learning, memory, attention, impulsivity and executive function. Numerous studies have attempted to model this effect of Pb in rodents, with the majority of studies focusing on hippocam...

journal_title：Toxicology letters

authors： Anderson DW,Mettil W,Schneider JS

更新日期：2016-03-30 00:00:00

abstract：:Sulfur dioxide (SO2) is one of potential risk factors for induction and/or exacerbation of asthma, but the underlying mechanisms are not well understood. In this study, we investigate the role of SO2 in asthma using a classical asthmatic model with allergic airway inflammation by treating C57BL/6 mice with ovalbumin (...

journal_title：Toxicology letters

authors： Li X,Huang L,Wang N,Yi H,Wang H

更新日期：2018-03-15 00:00:00

abstract：:New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify...

journal_title：Toxicology letters

authors： Richter LHJ,Beck A,Flockerzi V,Maurer HH,Meyer MR

更新日期：2019-02-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism b...

journal_title：Toxicology letters

authors： Han M,Liu X,Liu S,Su G,Fan X,Chen J,Yuan Q,Xu G

更新日期：2017-05-05 00:00:00

abstract：:To test the hypothesis that 3-7 ring polycyclic aromatic hydrocarbons (PAHs) are responsible for the prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS), the present study evaluates the PDT potency of DMSO-extracts of 7 heavy fuel oils (HFO), varying in their PAH content, and 1 highly...

journal_title：Toxicology letters

authors： Kamelia L,de Haan L,Ketelslegers HB,Rietjens IMCM,Boogaard PJ

更新日期：2019-10-15 00:00:00

abstract：:New psychoactive substances (NPS) are an increasing problem in clinical and forensic toxicology. The knowledge of their metabolism is important for toxicological risk assessment and for developing toxicological urine screenings. Considering the huge numbers of NPS annually appearing on the market, metabolism studies s...

journal_title：Toxicology letters

authors： Richter LHJ,Maurer HH,Meyer MR

更新日期：2017-10-05 00:00:00

abstract：:Sister-chromatid exchanges (SCEs) were analyzed from peripheral lymphocyte cultures of 8 men and 16 women who had been exposed to environmental cadmium (Cd), and 6 controls. Average Cd concentrations in blood of the Cd-polluted group were 8.9 micrograms/l for men and 10.0 micrograms/l for women. These were no signific...

journal_title：Toxicology letters

authors： Nogawa K,Tsuritani I,Yamada Y,Kido T,Honda R,Ishizaki M,Kurihara T

更新日期：1986-09-01 00:00:00

abstract：:Rat and canine hepatocyte suspensions were exposed to toxic concentrations of ethyl methanesulfonate (EMS) and ionophore A-23187 in the presence and absence of extracellular calcium (Ca2+) and alpha-tocopheryl succinate (alpha-TS). The exogenous administration of alpha-TS (25 microM) completely protected hepatocytes f...

journal_title：Toxicology letters

authors： Fariss MW,Merson MH,O'Hara TM

更新日期：1989-04-01 00:00:00

abstract：:Autophagy, which works to remove stress and maintain cellular homeostasis, is usually considered a "pro-survival" signal. Contrarily, apoptosis is programmed "pro-death" machinery. Polychlorinated biphenyls (PCBs) are a group of ubiquitous industrial pollutants. Our previous studies illustrated that a PCB quinone meta...

journal_title：Toxicology letters

authors： Shi Q,Wang Y,Dong W,Song E,Song Y

更新日期：2019-05-15 00:00:00

abstract：:A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with...

journal_title：Toxicology letters

authors： Hayashi Y,Katayama H

更新日期：1981-12-01 00:00:00

abstract：:Cisplatin, a widely used chemotherapeutic drug, causes ototoxicity in a large percentage of patients. The purpose of this study was to determine the efficacy of epicatechin (EC) as an otoprotective agent to prevent cisplatin toxicity and to investigate the molecular mechanism of EC. The effects of EC on cisplatin-indu...

journal_title：Toxicology letters

authors： Lee JS,Kang SU,Hwang HS,Pyun JH,Choung YH,Kim CH

更新日期：2010-12-15 00:00:00

abstract：:Nickel (Ni) can disorder testosterone synthesis in rat Leydig cells, whereas the mechanisms remain unclear. The aim of this study was to investigate the role of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) in Ni-induced disturbance of testosterone synthesis in rat Leydig cells. The testo...

journal_title：Toxicology letters

authors： Han A,Zou L,Gan X,Li Y,Liu F,Chang X,Zhang X,Tian M,Li S,Su L,Sun Y

更新日期：2018-06-15 00:00:00

abstract：:A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with...

journal_title：Toxicology letters

authors： Naganuma A,Satoh M,Koyama Y,Imura N

更新日期：1985-02-01 00:00:00

abstract：:While numerous surveys highlighted the natural co-occurrence of mycotoxins in food, data about their toxicological combined effects is still limited. This is especially the case for chronic exposure conditions, although the latter are more representative of the mycotoxin risk associated with food consumption than acut...

journal_title：Toxicology letters

authors： Smith MC,Madec S,Pawtowski A,Coton E,Hymery N

更新日期：2017-10-05 00:00:00