Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration.

abstract：:1,3,5-Trinitro-2-acetyl pyrrole (TNAP) is a product derived from the reaction of 2-acetyl pyrrole with nitrite in the model of Maillard browning systems. This compound is moderately mutagenic to the Salmonella strains TA98 and TA100 and is markedly cytotoxic to mouse C3H10T1/2 cells. Experiments are performed to inves...

journal_title：Toxicology letters

authors： Lin YL,Tseng TH,Hsu JD,Chu CY,Wang CJ

更新日期：1996-12-16 00:00:00

abstract：:Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet. Chronic Cd exposure is a public health concern because Cd is a known carcinogen; it accumulates in the body and causes kidney damage. The National Health and Nutritional Examination Survey (NHANE...

journal_title：Toxicology letters

authors： Ruiz P,Mumtaz M,Osterloh J,Fisher J,Fowler BA

更新日期：2010-09-15 00:00:00

abstract：:The effects of flavoglaucin from Aspergillus chevalieri (Mangin) Thom et Church on mitochondrial reactions have been investigated to obtain insight into the mode of actions on biomembranes by means of isolated rat liver mitochondria. It was found that flavoglaucin exhibited a strong uncoupling effect on oxidative phos...

journal_title：Toxicology letters

authors： Kawai K,Mori H,Kitamura J

更新日期：1983-12-01 00:00:00

abstract：:α-asarone is a natural phenylpropene found in several plants, which are widely used for flavoring foods and treating diseases. Previous studies have demonstrated that α-asarone has many pharmacological functions, while some reports indicated its toxicity. However, little is known about its cardiovascular effects. This...

journal_title：Toxicology letters

authors： Shang X,Ji X,Dang J,Wang L,Sun C,Liu K,Sik A,Jin M

更新日期：2020-05-15 00:00:00

abstract：:Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer ...

journal_title：Toxicology letters

authors： Jones JM,Yeralan O,Hines G,Maher M,Roberts DW,Benson RW

更新日期：1990-07-01 00:00:00

abstract：:The interaction of zinc(II) on the toxicokinetics of 2,5-hexanedione (2,5-HD), the ultimate toxic metabolite of n-hexane, was performed by quantifying the changes of two urinary biomarkers, free 2,5-HD and pyrrole derivatives, in rats exposed to 2,5-HD and to 2,5-HD plus zinc acetate. Eight groups of Wistar rats were ...

journal_title：Toxicology letters

authors： Mateus ML,dos Santos AP,Batoréu MC

更新日期：2001-02-03 00:00:00

abstract：:Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...

journal_title：Toxicology letters

authors： Imai T,Onose J,Hasumura M,Takizawa T,Hirose M

更新日期：2006-06-20 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major problem in drug development. Although some in vitro methods assessing DILI risk that utilize hepatic cell death or cellular stress as markers have been developed, the predictive ability of these tests is low. In this study, we sought to develop a novel cell-based assay for t...

journal_title：Toxicology letters

authors： Oda S,Matsuo K,Nakajima A,Yokoi T

更新日期：2016-01-22 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) has a salutary effect on hemorrhagic, traumatic and endotoxic shock. The role of FDP on compound 48/80-induced shock was therefore investigated. Sprague Dawley aged male rats (448+/-7.4 gm body weight) were randomly assigned into three groups and treated intraperitoneally with diphenhydr...

journal_title：Toxicology letters

authors： Figueroa AH,Stone RH,Cohly HH,Lehan PH,Markov AK

更新日期：2001-06-20 00:00:00

abstract：:Safety assessment procedures still rely heavily if not exclusively on the results of tests carried out in laboratory animals, then extrapolated to man. There are few examples of environmental compounds examined extensively enough in both man and animals to permit a critical comparison of the accuracy of such risk asse...

journal_title：Toxicology letters

authors： Guzelian PS

更新日期：1992-12-01 00:00:00

abstract：:Male mice (Q strain) received a single i.p. injection of 14 organophosphorus compounds, including 11 insecticides, administered on separate occasions. After a recovery period of 10 to 15 days, the cytogenic effects were analyzed in primary spermatocytes at diakinesis-metaphase I corresponding to the treatment of A4-B ...

journal_title：Toxicology letters

authors： Degraeve N,Chollet MC,Moutschen J

更新日期：1984-06-01 00:00:00

abstract：:Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...

journal_title：Toxicology letters

authors： Persoons R,Arnoux D,Monssu T,Culié O,Roche G,Duffaud B,Chalaye D,Maitre A

更新日期：2014-12-01 00:00:00

abstract：:Cocaine remains a widely abused substance. While most addicts take cocaine intranasally, a considerable number abuse cocaine by mouth. It has been assumed that after oral exposure cocaine is hydrolyzed in the stomach rendering it ineffective. This study investigated the effect of orally administered cocaine on liver f...

journal_title：Toxicology letters

authors： Labib R,Turkall R,Abdel-Rahman MS

更新日期：2001-12-15 00:00:00

abstract：:The co-ordinated glucuronidation and export of compounds from cells is an important determinant in the detoxification of many compounds in vivo. Many UDP-glucuronosyltransferases (UGTs) and several multidrug resistance proteins (MRPs) have been cloned and individually expressed to assess specificity of glucuronidation...

journal_title：Toxicology letters

authors： Cuff RL,Wade LT,Rychlik B,Jedlitschky GA,Burchell B

更新日期：2001-03-31 00:00:00

abstract：:Dermal toxicity of the new multi-insect repellent N,N-diethylphenylacetamide (DEPA) was studied in female rabbits. LD50 of DEPA was estimated to be 3505 mg/kg b.w. On daily topical application for 21 d at a dose of 50 mg/kg b.w., dermal irritancy score and blood chemistry changes indicated that the compound is non-irr...

journal_title：Toxicology letters

authors： Rao SS,Agarwal MK,Rao KM,Swamy RV

更新日期：1989-01-01 00:00:00

abstract：:Evaluating myelotoxicity is essential for ensuring the safety of novel drugs before they are approved for clinical applications. Although in vivo prediction of the maximum tolerated doses (MTDs) of anticancer drugs is usually performed in rodents, the results are not always applicable to clinical treatment because dru...

journal_title：Toxicology letters

authors： Ito R,Nagai D,Igo N,Okuda Y,Sekine K,Ichimura E,Katano I,Mizushima T,Goto M,Ohnishi Y,Ito M,Okamoto K

更新日期：2017-11-05 00:00:00

abstract：:The effects of selenium on cellular toxicity and histochemical distribution of mercury were examined in a cell culture system of mouse peritoneal macrophages. Selenium protected against the toxicity of mercury in cultures exposed to 4 microM of mercuric chloride. Selenomethionine caused a significant increase in cell ...

journal_title：Toxicology letters

authors： Christensen M,Rungby J,Mogensen SC

更新日期：1989-06-01 00:00:00

abstract：:The neurotoxin 6-hydroxydopamine (6-OHDA) oxidised sulphydryl groups in glyceraldenyde-3-phosphate dehydrogenase (GAPDH) with loss of the dehydrogenase activity of the enzyme. 5-Hydroxydopamine behaved similarly at higher concentrations. This oxidation was accompanied by a transient rise in the acyl phosphatase (non-p...

journal_title：Toxicology letters

authors： Hayes JP,Tipton KF

更新日期：2002-03-10 00:00:00

abstract：:Using equimolar quantities of 2 chemical allergens, toluene diisocyanate (TDI), noted for its ability to cause respiratory hypersensitivity, and dinitrochlorobenzene (DNCB), noted for its dermal sensitizing activity, the mouse was evaluated as a possible model to indicate respiratory hypersensitivity. A previously pub...

journal_title：Toxicology letters

authors： Satoh T,Kramarik JA,Tollerud DJ,Karol MH

更新日期：1995-06-01 00:00:00

abstract：:Samples of PM(2.5) were gravimetrically collected during the winter 2005/2006 in the urban area of Milan (North Italy). Samples were chemically characterized and the particles were detached from filters to determine their cytotoxic effects on the A549 cell line. Based on the potential toxicological relevance of its co...

journal_title：Toxicology letters

authors： Gualtieri M,Mantecca P,Corvaja V,Longhin E,Perrone MG,Bolzacchini E,Camatini M

更新日期：2009-07-10 00:00:00

abstract：:The in vitro N-methylating capability of rabbit tissue cytosolic preparations, utilizing S-adenosyl-L-[methyl-3H]methionine as methyl donor, is described. Dialysed preparations from the lung, liver and kidney are capable of N-methylating 3- and 4-phenylpyridines and 3,3'- and 4,4'-bispyridyls; the corresponding 2-subs...

journal_title：Toxicology letters

authors： Godin CS,Crooks PA,Damani LA

更新日期：1986-12-01 00:00:00

abstract：:Due to advances in nanotechnology, exposure to particle compounds in the workplace has become unavoidable. Assessment of their toxicity on health is an important occupational safety issue. This study was conducted in mice to investigate the toxicological effects of submicron and nano-iron oxide particles on pulmonary ...

journal_title：Toxicology letters

authors： Ban M,Langonné I,Huguet N,Goutet M

更新日期：2012-05-05 00:00:00

abstract：:P-glycoprotein (Pgp) participates in the export of numerous toxins, drugs, and physiological compounds. To examine the involvement of Pgp in smoke-induced oral cell insult, the effects of extracts of the mainstream tobacco smoke (TS) on Pgp were studied in an oral epidermal carcinoma cell line, OECM-1. TS was first ex...

journal_title：Toxicology letters

authors： Pan WC,Chen RM,Shen YC,Chen CC,Ueng YF

更新日期：2009-03-10 00:00:00

abstract：:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

journal_title：Toxicology letters

authors： Baños G,Lopez-Zetina P,Franco M

更新日期：1995-02-01 00:00:00

abstract：:Acute effects of CHBrCl2 on microsomal lipid metabolism were studied in the liver of male Wistar rats administered a single oral dose (215 mg/kg). 3 h after administration, the modulation of phospholipid metabolism and the accumulation of triacylglycerol (TG) were noted in the microsomal membranes. A marked decrease i...

journal_title：Toxicology letters

authors： Koyama Y,Nakazawa Y

更新日期：1985-12-01 00:00:00

abstract：:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...

journal_title：Toxicology letters

authors： Subramoniam A,Husain R,Seth PK

更新日期：1991-08-01 00:00:00

abstract：:Toxicological data used for risk assessments must undergo an evaluation of reliability. Nevertheless, a reliability evaluation scheme for such data has yet to be established in China. A method termed TRAM (Toxicological data Reliability Assessment Method) was developed to evaluate toxicological data reliability. A que...

journal_title：Toxicology letters

authors： Bian Q,Ping Y,Jun W,Lyu Z,Song Y,Zhang L,Liu Z

更新日期：2019-09-01 00:00:00

abstract：:Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...

journal_title：Toxicology letters

authors： Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

更新日期：1986-02-01 00:00:00

abstract：:Considering of novel biochemical modulation by some foods and beverages, we have performed screening for green tea components that have enhancing effects on doxorubicin (DOX) induced antitumor activity. Components, such as caffeine, theanine, (-)-epigallocatechin gallate (EGCG) and flavonoids have inhibitory effects o...

journal_title：Toxicology letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-04-03 00:00:00