Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.

Abstract:

:Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutaneous (s.c.) injection of Soman, the intensities of toxic signs were significantly correlated with the degree of striatal AChE inhibition. In the case of Sarin, the corresponding r-values were not significant except for tremors. For Tabun-induced chewing, tremor and hind-limb abduction, the r-values were significant. The neurotoxicity was most intense between 15 min to 2 h after treatment, but at 2 or 6 h, the r-values were well below 0.5. The inhibition of brain AChE was maximal by 30 min and was still high at 24 h.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

doi

10.1016/0378-4274(86)90094-9

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

121-9

issue

2

eissn

0378-4274

issn

1879-3169

pii

0378-4274(86)90094-9

journal_volume

30

pub_type

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