Abstract:
:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the final treatment) decreased the levels of diacylglycerol and phosphoinositides (phosphatidylinositol, phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate) in a concentration-dependent manner without influencing the levels of phosphatidylcholine in rat cerebrum. These studies indicate impairment of the phosphoinositide messenger system in rat cerebrum following repeated exposure to DBTL.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Subramoniam A,Husain R,Seth PKdoi
10.1016/0378-4274(91)90198-fkeywords:
subject
Has Abstractpub_date
1991-08-01 00:00:00pages
245-50issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(91)90198-Fjournal_volume
57pub_type
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