The mechanism of methyl mercury toxicity in isolated rat hepatocytes.

abstract：:Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final ma...

journal_title：Toxicology letters

authors： Emmendoerffer A,Hecht M,Boeker T,Mueller M,Heinrich U

更新日期：2000-03-15 00:00:00

abstract：:An occupational health study was conducted on 45 acetone-exposed male workers in combination with 343 non-exposed men to examine the quantitative relationship between the intensity of acetone vapor exposure and the concentration of acetone in urine. The time-weighted average acetone concentrations were measured by mea...

journal_title：Toxicology letters

authors： Kawai T,Yasugi T,Mizunuma K,Horiguchi S,Iguchi H,Ikeda M

更新日期：1992-08-01 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...

journal_title：Toxicology letters

authors： Chapkin RS,Fan Y,Lupton JR

更新日期：2000-03-15 00:00:00

abstract：:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from eithe...

journal_title：Toxicology letters

authors： Vandewaa EA,Barney CC,Gentile JM

更新日期：1982-12-01 00:00:00

abstract：:Chronic exposure to arsenic, a potent carcinogen and toxicant, via drinking water is a worldwide public health problem. Because little is known about early-life effects of arsenic on immunity, we evaluated the impact of in utero exposure on infant immune parameters and morbidity in a pilot study. Pregnant women were e...

journal_title：Toxicology letters

authors： Raqib R,Ahmed S,Sultana R,Wagatsuma Y,Mondal D,Hoque AM,Nermell B,Yunus M,Roy S,Persson LA,Arifeen SE,Moore S,Vahter M

更新日期：2009-03-28 00:00:00

abstract：:There has been a significant evolution in the clinical management of the poisoned patient over the last decade. Interventions that were once the cornerstone of treating the poisoned patient have become passé or have come under intense scrutiny. The advent of evidence-based medicine has forced clinical scientists to re...

journal_title：Toxicology letters

authors： Krenzelok EP

更新日期：2002-02-28 00:00:00

abstract：:Chloroform-induced toxicity in rodents depends on oral dose regimen. We evaluated the absorption and tissue dosimetry of chloroform after gavage administration in various vehicles to male Fischer 344 rats and female B6C3F1 mice. Animals received a single dose of chloroform in corn oil, water, or aqueous 2% emulphor at...

journal_title：Toxicology letters

authors： Dix KJ,Kedderis GL,Borghoff SJ

更新日期：1997-05-16 00:00:00

abstract：:There are numerous observations of pharmaceuticals (or their metabolites) as contaminants in wastewater, surface water and groundwater. This implies a potential for indirect human exposure to pharmaceuticals via drinking water supplies. Various effect benchmarks may be employed in an evaluation of the significance of ...

journal_title：Toxicology letters

authors： Webb S,Ternes T,Gibert M,Olejniczak K

更新日期：2003-05-15 00:00:00

abstract：:Aggregation of α-synuclein (α-syn) in the brain is a defining pathological feature of neurodegenerative disorders classified as synucleinopathies. They include Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Occupational and environmental exposure to manganese (Mn) is asso...

journal_title：Toxicology letters

authors： Verina T,Schneider JS,Guilarte TR

更新日期：2013-03-13 00:00:00

abstract：:Sulfur dioxide (SO2) is one of potential risk factors for induction and/or exacerbation of asthma, but the underlying mechanisms are not well understood. In this study, we investigate the role of SO2 in asthma using a classical asthmatic model with allergic airway inflammation by treating C57BL/6 mice with ovalbumin (...

journal_title：Toxicology letters

authors： Li X,Huang L,Wang N,Yi H,Wang H

更新日期：2018-03-15 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ), a redox cofactor in the mitochondrial respiratory chain, has proven to protect neurons against glutamate-induced damage both in vitro and in vivo. This study was aimed to investigate the possible neuroprotective effects of PQQ in rotenone-induced Parkinson's disease (PD) model. Pre-trea...

journal_title：Toxicology letters

authors： Qin J,Wu M,Yu S,Gao X,Zhang J,Dong X,Ji J,Zhang Y,Zhou L,Zhang Q,Ding F

更新日期：2015-11-04 00:00:00

abstract：:Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...

journal_title：Toxicology letters

authors： Jaiswal PK,Srivastava S,Gupta J,Thakur IS

更新日期：2012-10-17 00:00:00

abstract：:A comparative evaluation of urinary biomarkers was carried out to characterize benzene exposure in a group of 100 traffic policemen of the city of Parma (Italy). All subjects were monitored once, in two consecutive days characterized by similar climatic conditions but preceded by two windy days. Benzene ambient concen...

journal_title：Toxicology letters

authors： Manini P,De Palma G,Andreoli R,Poli D,Petyx M,Corradi M,Mutti A,Apostoli P

更新日期：2008-09-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) was administered to mice, from 5 weeks of age of the F0 generation to the weaning of the F2 generation, in the diet at levels of 0 (control), 0.015, 0.045, 0.135, and 0.405%, and some reproductive and neurobehavioural parameters were measured. There was no consistent significant effect o...

journal_title：Toxicology letters

authors： Tanaka T,Oishi S,Takahashi O

更新日期：1993-03-01 00:00:00

abstract：:Organophosphates are chemical pollutants that are existed widely in the environment, but the reactions of these agents with blood proteins are still not fully clarified. The current story was to analyze the static and dynamic interactions between human serum albumin (HSA) and phenthoate and then uncover the impact of ...

journal_title：Toxicology letters

authors： Ding F,Peng W,Peng YK,Liu BQ

更新日期：2019-10-10 00:00:00

abstract：:The effect of copper (Cu) deficiency on antioxidant status of liver and heart and its effect on adriamycin toxicity was assessed. Weanling rats were fed Cu-adequate (+Cu) and Cu-deficient (-Cu) diets for 3 weeks and then injected intraperitoneally once with saline or adriamycin (8 mg/kg). All -Cu rats had increased he...

journal_title：Toxicology letters

authors： Fischer J,Johnson MA,Tackett RL

更新日期：1991-07-01 00:00:00

abstract：:Cigarette smoke (CS) induced chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in China. However, lack of appropriate animal model slows down the progress in understanding pathogenesis of the disease. The aim of current study is to establish and evaluate a more adequate rat model...

journal_title：Toxicology letters

authors： Zheng H,Liu Y,Huang T,Fang Z,Li G,He S

更新日期：2009-09-28 00:00:00

abstract：:The degradation of cyanogenic glycosides was studied in spontaneously fermenting cassava root pulp and in fresh pulp samples pretreated to prevent either endogenous beta-glycosidase activity, fermentation, or both. The rate of disappearance of the glycosides, as measured by hydrocyanic acid (HCN) production in situ, i...

journal_title：Toxicology letters

authors： Maduagwu EN

更新日期：1983-03-01 00:00:00

abstract：:α-asarone is a natural phenylpropene found in several plants, which are widely used for flavoring foods and treating diseases. Previous studies have demonstrated that α-asarone has many pharmacological functions, while some reports indicated its toxicity. However, little is known about its cardiovascular effects. This...

journal_title：Toxicology letters

authors： Shang X,Ji X,Dang J,Wang L,Sun C,Liu K,Sik A,Jin M

更新日期：2020-05-15 00:00:00

abstract：:Blood lead concentrations (Pb-B, microgram/100 ml) was measured in children and adults, both sexes, living in and around Liège (control group, n = 859) and in the urban center of Verviers (exposed group, n = 568) where houses with lead piping are supplied with corrosive drinking water. In control children, the mean Pb...

journal_title：Toxicology letters

authors： Sartor FA,Rondia D

更新日期：1981-01-01 00:00:00

abstract：:The main objective of this work was to assess the potentiality of in vitro models to study and understand the uranium-induced cytotoxicity on renal cells. Cytotoxicity and morphological studies were performed in a tubular proximal original established cell line (LLC-PK1 cell line). Dose-dependent cytotoxicity response...

journal_title：Toxicology letters

authors： Mirto H,Hengé-Napoli MH,Gibert R,Ansoborlo E,Fournier M,Cambar J

更新日期：1999-02-22 00:00:00

abstract：:The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the te...

journal_title：Toxicology letters

authors： Wilhelm M,Müller F,Idel H

更新日期：1996-11-01 00:00:00

abstract：:Aluminum phosphide (AlP), a widely used fumigant and rodenticide leads to high mortality if ingested. Its toxicity is due to phosphine liberated when it comes in contact with moisture. The exact mechanism of action of phosphine is not known. In this study male Wistar rats were used. The animals received a single dose ...

journal_title：Toxicology letters

authors： Anand R,Kumari P,Kaushal A,Bal A,Wani WY,Sunkaria A,Dua R,Singh S,Bhalla A,Gill KD

更新日期：2012-11-23 00:00:00

abstract：:In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...

journal_title：Toxicology letters

authors： Leng G,Lewalter J

更新日期：2002-08-05 00:00:00

abstract：:Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), ...

journal_title：Toxicology letters

authors： Jordan MC,Waller AR,Chasseaud LF,Barbhaiya RH

更新日期：1994-03-01 00:00:00

abstract：:Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-in...

journal_title：Toxicology letters

authors： Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

更新日期：2004-05-02 00:00:00

abstract：:Cultured human proximal tubule cell monolayers maintained on permeable supports were treated simultaneously with the aminoglycoside antibiotic, gentamicin, and poly-L-aspartic acid (PAA), an inhibitor of aminoglycoside nephrotoxicity. Following 4 days of exposure, cell monolayers were placed into Ussing chambers to al...

journal_title：Toxicology letters

authors： Todd JH,Hottendorf GH

更新日期：1997-02-07 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxin that induces apoptosis of neurons and a pro-inflammatory response in microglial cells. First, we found that TCDD induced proliferation of HAPI microglial cells in a dose- and time-dependent manner. Flow cytometry analysis showed that this proliferati...

journal_title：Toxicology letters

authors： Xu G,Li Y,Yoshimoto K,Wu Q,Chen G,Iwata T,Mizusawa N,Wan C,Nie X

更新日期：2014-01-30 00:00:00

abstract：:Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...

journal_title：Toxicology letters

authors： Winder C

更新日期：2002-03-10 00:00:00