Abstract:
:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from either unoperated control, sham-operated control, or Aroclor 1254-induced mice. Increased activity was observed with S-9 preparations made at both 42 h and 148 h following PH.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Vandewaa EA,Barney CC,Gentile JMdoi
10.1016/0378-4274(82)90060-1subject
Has Abstractpub_date
1982-12-01 00:00:00pages
253-60issue
3-4eissn
0378-4274issn
1879-3169pii
0378-4274(82)90060-1journal_volume
14pub_type
杂志文章abstract::Effective emergency preparedness and response planning are needed to assist responders in making sound decisions under the stressful and confusing conditions accompanying a major accidental release of hazardous materials. One of the most important decisions to be made is the extent and duration of the evacuation of pe...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/0378-4274(89)90043-x
更新日期:1989-12-01 00:00:00
abstract::Dermal toxicity of the new multi-insect repellent N,N-diethylphenylacetamide (DEPA) was studied in female rabbits. LD50 of DEPA was estimated to be 3505 mg/kg b.w. On daily topical application for 21 d at a dose of 50 mg/kg b.w., dermal irritancy score and blood chemistry changes indicated that the compound is non-irr...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(89)90160-4
更新日期:1989-01-01 00:00:00
abstract::In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(92)90256-j
更新日期:1992-12-01 00:00:00
abstract::Sulphur mustard (SM) is a blistering agent that causes debilitating damage to the skin, eyes and respiratory system. In cases of severe exposure, immunodepletion can occur as well as death, due to secondary infections. The toxicity of SM is thought to be mediated in part by the alkylation of nucleic acids and proteins...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.11.009
更新日期:2012-02-25 00:00:00
abstract::Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent mal...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.12.023
更新日期:2018-03-15 00:00:00
abstract::To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(90)90187-q
更新日期:1990-12-01 00:00:00
abstract::Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Because inhibition of N-methyl-d-aspartate (NMDA) receptors is one of the possible mechanisms underlying developmental neurotoxicity of toluene, the purpose of the present study was to examine the effects of toluene exposure during two ma...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.06.026
更新日期:2011-09-10 00:00:00
abstract::Several studies have demonstrated that bisphenol A (BPA) exhibited weak estrogenic activity in the 3-day uterotrophic assay using ovariectomized (OVX) and immature rats (Toxicol. Lett. 115 (2000) 231; Regul. Toxicol. Pharmacol. 32 (2000) 118; J. Toxicol. Sci. 26 (2001) 111) and BPA also possessed anti-androgenic activ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(02)00130-3
更新日期:2002-09-05 00:00:00
abstract::The present study was carried out in order to investigate the effects of inhaled volatile anesthetic gases in subanesthetic concentrations on circulating hormones essential for normal male reproduction. Male mature rats were exposed daily, up to 11 days, to halothane or enflurane in concentrations up to 500 and 1000 p...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90139-x
更新日期:1983-12-01 00:00:00
abstract::Early detection and removal of harmful factors are essential to the proper physical and psychological development of the fetus, presumably showing the effects during the prenatal period and after birth. As one procedure to aid in understanding such factors, we have established a shell-less culture system for video mon...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(00)00300-3
更新日期:2001-02-28 00:00:00
abstract::In order to assess the applicability of the micronucleus (MN) and G2 assays as biomarkers of in vitro radiosensitivity and cancer susceptibility, we investigated the inter- and intra-individual variation of these endpoints. For the MN assay unstimulated blood cultures from 57 healthy donors were exposed in vitro to 3....
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2003.12.044
更新日期:2004-04-01 00:00:00
abstract::Dietary ethoxyquin (EQ) and methionine hydroxy analog (MHA) protected 6-8-month-old wethers from toxic doses of bitterweed (Hymenoxys odorata DC.). The EQ-MHA group received sweet feed (corn, oats, dehydrated alfalfa pellets, cane molasses and minerals), 500 g/day/sheep, supplemented with EQ and MHA (0.5% and 1.0% of ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90005-x
更新日期:1983-04-01 00:00:00
abstract::The plastic chemical bisphenol A (BPA) has recently been suspected to be a base structure of endocrine disrupting chemicals, which achieve their adverse effects by interfering with human nuclear receptors. For instance, BPA, bisphenol AF, and tetrabromo- or tetrachloro-BPA (X₄-BPA) have been characterized as binders f...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.05.020
更新日期:2012-07-20 00:00:00
abstract::Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant cont...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.06.015
更新日期:2010-10-05 00:00:00
abstract::Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.07.006
更新日期:2019-10-10 00:00:00
abstract::Mice given single i.v. doses of some radiopharmaceuticals containing stannous chloride as a reducing agent, showed significant inhibition of hepatic azo-reductase and aromatic hydroxylase activity at dose levels which contained as little as 0.2 mg/kg of stannous chloride. Cytochrome P-450 content was also reduced sign...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90105-4
更新日期:1983-09-01 00:00:00
abstract::Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/j.toxlet.2020.01.019
更新日期:2020-05-15 00:00:00
abstract::Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.02.008
更新日期:2009-06-01 00:00:00
abstract::Allyl alcohol-induced LDH leakage from isolated rat hepatocytes was preceded by a decrease in rhodmine 123 retention, signifying a loss of mitochondrial membrane potential. Addition of dithiothreitol (DTT) prevented the drop in membrane potential and completely prevented cell killing by allyl alcohol. In contrast, cyc...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03426-9
更新日期:1995-11-15 00:00:00
abstract::Lead (Pb) exposure during development impairs a variety of cognitive, behavioral and neurochemical processes resulting in deficits in learning, memory, attention, impulsivity and executive function. Numerous studies have attempted to model this effect of Pb in rodents, with the majority of studies focusing on hippocam...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.01.011
更新日期:2016-03-30 00:00:00
abstract::Drug-induced liver injury (DILI) is a major problem in drug development. Although some in vitro methods assessing DILI risk that utilize hepatic cell death or cellular stress as markers have been developed, the predictive ability of these tests is low. In this study, we sought to develop a novel cell-based assay for t...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.10.029
更新日期:2016-01-22 00:00:00
abstract:OBJECTIVE:The aim of this investigation was to identify pathways involved in pneumoconiosis susceptibility, clarify their potential mechanisms, and generate SNP-to-gene to pathway hypotheses using an analytical pathway-based approach. METHODS:The identify candidate causal SNPs and pathways (ICSNPathway) was used to pe...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.10.028
更新日期:2015-01-05 00:00:00
abstract::Inorganic arsenic (As), the most toxic form of As found in water and food, is considered a human carcinogen. Numerous studies show its systemic toxicity, describing pathologies associated with chronic exposure. The main pathway of exposure to inorganic As is oral, but many of the events that occur during its passage t...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.01.011
更新日期:2018-04-01 00:00:00
abstract::Lithocholic acid (LCA) is both a secondary bile acid and a vitamin D receptor (VDR) ligand. The VDR is activated by 1,25-dihydroxy vitamin D3 and plays an important role in maintaining integrity of the intestinal mucosal barrier. LCA can also substitute for vitamin D to carry out the in vivo functions of vitamin D. Ho...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.08.024
更新日期:2019-11-01 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors have recently emerged as a new class of anti-cancer agents. Trichostatin A (TSA), a classical HDAC inhibitor, has been demonstrated to induce cell cycle arrest, promote cell apoptosis, and inhibit metastasis. However, the molecular mechanism underlying TSA function has not been fu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.05.643
更新日期:2013-07-31 00:00:00
abstract::By the gas plant at Schwaan (a small city near Rostock), tar and other by-products were released into the river Warnow which supplies Rostock with drinking water 20 km downstream. The tar-contaminated river sediment contained phenols and polycyclic aromatic hydrocarbons (PAH), indicating a mutagenic potential. Investi...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(96)03761-7
更新日期:1996-11-01 00:00:00
abstract::The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approx...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2004.10.001
更新日期:2005-02-15 00:00:00
abstract::The separation and determination of 3-nitropropionic acid (NPA) in bovine urine by reverse-phase HPLC is described. The method utilizes a rapid ethyl acetate extraction and this clean-up step also improves the chromatographic resolution of NPA in bovine plasma. A simple colorimetric method is also developed for the ra...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(90)90013-c
更新日期:1990-02-01 00:00:00
abstract::Recent hypothesis suggesting a role for environmental toxins in the pathogenesis of neurodegenerative disorders has stimulated interest in research on xenobiotic metabolizing capability of the brain. In addition to possible irreversible loss of neurons through bioactivation in situ in the nervous tissue, the metabolis...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/0378-4274(95)03508-7
更新日期:1995-12-01 00:00:00
abstract::Betel quid chewing, which contributes high concentration of safrole in saliva, is a popular oral habit in Taiwan. Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known. Here, we used LC/ESI-ITMS(n) and LC/QTOF-MS confirmed safrole-dGMP as reference standard to dete...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.09.013
更新日期:2008-12-15 00:00:00