Promutagen activation in partially hepatectomized mice.

Abstract:

:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from either unoperated control, sham-operated control, or Aroclor 1254-induced mice. Increased activity was observed with S-9 preparations made at both 42 h and 148 h following PH.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Vandewaa EA,Barney CC,Gentile JM

doi

10.1016/0378-4274(82)90060-1

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

253-60

issue

3-4

eissn

0378-4274

issn

1879-3169

pii

0378-4274(82)90060-1

journal_volume

14

pub_type

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