Intracellular behaviour of uranium(VI) on renal epithelial cell in culture (LLC-PK1): influence of uranium speciation.

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civ...

journal_title：Toxicology letters

authors： Holmes WW,Keyser BM,Paradiso DC,Ray R,Andres DK,Benton BJ,Rothwell CC,Hoard-Fruchey HM,Dillman JF,Sciuto AM,Anderson DR

更新日期：2016-02-26 00:00:00

abstract：:Monocytes, separated from human peripheral blood, were preincubated with different polycyclic aromatic hydrocarbons (PAHs) for 24 h and the production of superoxide ions (O*2-) was then measured using as a stimulating agent phorbol 12-myristate 13-acetate. A significantly enhanced O*2- production is only observed when...

journal_title：Toxicology letters

authors： Fabiani R,De Bartolomeo A,Rosignoli P,Sebastiani B,Morozzi G

更新日期：1999-10-29 00:00:00

abstract：:Oral administration of stannous chloride (SnCl2) (1.0 mg Sn2$/kg body weight) to rats, twice daily for 28 days, caused a significant increase in the tin (Sn) content and a corresponding decrease of the calcium (Ca) content in the femoral epiphysis, but was without effect on serum Ca, intestinal Ca absorption, and urin...

journal_title：Toxicology letters

authors： Yamaguchi M,Sugii K,Okada S

更新日期：1982-01-01 00:00:00

abstract：:Chronic wound healing disorders that occur as a result of a sulfur mustard (SM) exposure present a particular challenge. These chronic wounds are similar to other chronic wounds. In the past, it has been shown that mesenchymal stem cells (MSC) play an important role in the healing of chronic wounds. An important prope...

journal_title：Toxicology letters

authors： Schmidt A,Steinritz D,Rothmiller S,Thiermann H,Scherer AM

更新日期：2018-09-01 00:00:00

abstract：:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from eithe...

journal_title：Toxicology letters

authors： Vandewaa EA,Barney CC,Gentile JM

更新日期：1982-12-01 00:00:00

abstract：:Pyrethroids, a group of insecticides with high efficiency, low toxicity and wide spectrum, are used for pest control in agriculture. Here, we administered two representative pyrethroids (cypermethrin and deltamethrin) and an equal volume of vehicle (corn oil) to the pregnant ICR mice. This study investigated the effec...

journal_title：Toxicology letters

authors： Guo J,Xu J,Zhang J,An L

更新日期：2018-05-01 00:00:00

abstract：:The role of intra- and extracellular calcium in the activation of human polymorphonuclear leukocytes (PMNL) to produce reactive oxygen metabolites (ROM) were studied by using soluble, formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA), or particulate stimuli, quartz or chrysotile. A calciu...

journal_title：Toxicology letters

authors： Ruotsalainen M,Naarala J,Savolainen KM

更新日期：1995-08-01 00:00:00

abstract：:The repeated dose toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male and female newborn rats given TBBPA orally at 0, 40, 200, or 600 mg/kg per day for 18 days from 4 days of age until weaning at 21 days of age. Half the rats in each dose group were sacrificed for a full gross necropsy ...

journal_title：Toxicology letters

authors： Fukuda N,Ito Y,Yamaguchi M,Mitumori K,Koizumi M,Hasegawa R,Kamata E,Ema M

更新日期：2004-04-21 00:00:00

abstract：:The present study was undertaken in an attempt to reconcile the seemingly conflicting observations that glutathione-dependent biotransformation of methyl parathion (O,O-dimethyl-O-(4-nitrophenyl)phosphorothionate) by hepatic supernatant or partially purified glutathione S-transferases occurs in vitro, but not to any s...

journal_title：Toxicology letters

authors： Huang YS,Sultatos LG

更新日期：1993-06-01 00:00:00

abstract：:Strong epidemiological evidence supports the association between increased air pollution and the risk of developing atherosclerotic cardiovascular diseases (CVDs). However, the mechanism remains unclear. As an environmental air pollutant and benzo-a-pyrene (BP) metabolite, BP-1,6-quinone (BP-1,6-Q) is present in the p...

journal_title：Toxicology letters

authors： Shukla H,Chitrakar R,Bibi HA,Gaje G,Koucheki A,Trush MA,Zhu H,Li YR,Jia Z

更新日期：2020-04-01 00:00:00

abstract：:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechani...

journal_title：Toxicology letters

authors： Feyereisen R

更新日期：1995-12-01 00:00:00

abstract：:Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

journal_title：Toxicology letters

authors： Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

更新日期：2013-05-23 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00

abstract：:We previously reported that NR2E3, an orphan nuclear receptor, plays an important role in maintaining the basal expression of estrogen receptor α (ER) and that the NR2E3 level is highly correlated with the relapse-free survival of breast cancer patients. Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-...

journal_title：Toxicology letters

authors： Khanal T,Kim D,Johnson A,Choubey D,Kim K

更新日期：2015-09-17 00:00:00

abstract：:The common food preparation processes, frying, broiling and baking, can give rise to air pollutants that are known to be mutagenic and carcinogenic in animal tests. A large number of persons can be exposed to such fumes as cooking is performed in most households and in many commercial enterprises. Additional studies o...

journal_title：Toxicology letters

authors： Löfroth G

更新日期：1994-06-01 00:00:00

abstract：:Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

journal_title：Toxicology letters

authors： Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

更新日期：2014-04-07 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

journal_title：Toxicology letters

authors： Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

更新日期：2014-08-04 00:00:00

abstract：:A comparison of the effects produced by size-fractionated tire particles (TP10 and TP2.5) and similar-sized urban particulate matter (PM10 and PM2.5), collected in Milan in 2007, on the lungs of mice has been performed. The focus is on early acute lung responses following intratracheal instillation of aerosolized part...

journal_title：Toxicology letters

authors： Mantecca P,Farina F,Moschini E,Gallinotti D,Gualtieri M,Rohr A,Sancini G,Palestini P,Camatini M

更新日期：2010-10-05 00:00:00

abstract：:Cigarette smoke (CS) is known to cause mitochondrial dysfunction leading to cellular senescence in lung cells. We determined the mechanism of mitochondrial dysfunction by CS in lung epithelial cells. CS extract (CSE) treatment differentially affected mitochondrial function, such as membrane potential, mitochondrial re...

journal_title：Toxicology letters

authors： Sundar IK,Maremanda KP,Rahman I

更新日期：2019-12-15 00:00:00

abstract：:A multi-unit, dynamic flow, inhalation exposure system which is capable of accommodating 12 mice per unit has been described. Components of the system include a mixing board, one or more glass distributing tubes, and detachable glass chamber tubes. The flow of a specified concentration of test gas exits from the mixin...

journal_title：Toxicology letters

authors： Kapeghian JC,Waters IW,Jones AB

更新日期：1985-02-01 00:00:00

abstract：:Malignant gliomas are the most common and most aggressive primary brain tumor, and for which differentiation therapy has emerged as a promising candidate strategy. In this study, we used in vitro and in vivo assays to examine the differentiation effects of wogonin, a major active constituent of Scutellaria baicalensis...

journal_title：Toxicology letters

authors： Wang Y,Zhang Y,Qian C,Cai M,Li Y,Li Z,You Q,Wang Q,Hu R,Guo Q

更新日期：2013-10-24 00:00:00

abstract：:A 13-week subchronic toxicity study of thiamphenicol (TAP) was performed in F344 rats. The minimum lethal dose was estimated to be greater than 10 g/kg body weight, when a single dose of 4-10 g/kg of TAP was given orally. In the subchronic toxicity study, groups of 12 F344 rats of each sex were given solutions contain...

journal_title：Toxicology letters

authors： Ando J,Ishihara R,Imai S,Takano S,Kitamura T,Takahashi M,Yoshida M,Maekawa A

更新日期：1997-04-28 00:00:00

abstract：:The dose-response curve obtained in toxicity testing is a mirror image of the susceptibility distribution in the treated population, i.e. it follows increasing tolerance of the individuals to the adverse effects of the chemical under investigation. Defining a dose as a maximum tolerated exposure level, therefore, spli...

journal_title：Toxicology letters

authors： Lutz WK

更新日期：2002-02-07 00:00:00

abstract：:Bilitranslocase (BTL) is a plasma membrane carrier that transports organic anions of physiological and pharmacological interest. It is expressed in basolateral plasma membrane of kidney and liver. BTL has been recently described as a marker of transition from normal tissue to its neoplastic transformation in human kid...

journal_title：Toxicology letters

authors： Trebucobich MS,Hazelhoff MH,Chevalier AA,Passamonti S,Brandoni A,Torres AM

更新日期：2014-03-03 00:00:00

abstract：:New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection...

journal_title：Toxicology letters

authors： Richter LHJ,Herrmann J,Andreas A,Park YM,Wagmann L,Flockerzi V,Müller R,Meyer MR

更新日期：2019-05-01 00:00:00

abstract：:In Europe and the USA the prevalence of certain forms of allergic disease is rising; an increase that can not be reconciled simply on the basis of changes in diagnostic fashion. The changes observed have been too rapid to be explained by alterations in the gene pool and, as a consequence, there has been a growing inte...

journal_title：Toxicology letters

authors： Kimber I

更新日期：1998-12-28 00:00:00

abstract：:As information regarding microarray data sets and toxicogenomic biomarkers grows rapidly, the process of analyzing data and interpreting the results is increasingly complicated. To facilitate data analysis, a simple expression ratio-based scoring method called the TGP1 score was previously proposed [Kiyosawa, N., Shiw...

journal_title：Toxicology letters

authors： Kiyosawa N,Ando Y,Watanabe K,Niino N,Manabe S,Yamoto T

更新日期：2009-07-24 00:00:00

abstract：:Lead (Pb) exposure impairs the nervous system, of which the injury of cognitive development is obvious. But the mechanism of Pb induced disorders of neuro-transmission remain elusive. In this study, primary hippocampal neurons were exposed to Pb at the dosage of 5 μM from days in vitro (DIV) 3 to DIV14 and the electro...

journal_title：Toxicology letters

authors： Ding JJ,Zou RX,He HM,Lou ZY,Xu Y,Wang HL

更新日期：2018-10-15 00:00:00

abstract：:Zinc chloride (0.01 mM kept for 3h) is not toxic to cultured cerebellar granule neurons (CGNs) while kainate (0.1mM kept for 3h) demonstrates some but very low toxicity towards these cells. Measurements of the relative intraneuronal zinc ion concentration showed that increase in [Zn(2+)](i) under the simultaneous acti...

journal_title：Toxicology letters

authors： Lozier ER,Stelmashook EV,Uzbekov RE,Novikova SV,Zorov SD,Alieva IB,Arbeille B,Zorov DB,Isaev NK

更新日期：2012-01-05 00:00:00