Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh.

abstract：:The effect of sodium selenite administered acutely or repeatedly on the biochemical components of the hepatic microsomal monooxygenase enzyme system was examined in male rats. 72 h following acute administration of selenium (2.4 mg Se/kg, i.p.), there was a significant decrease in ethylmorphine-N-demethylase activity ...

journal_title：Toxicology letters

authors： Schnell RC,Early JL,Deimling MJ,Merrick BA,Davies MH

更新日期：1983-06-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) in 1999 issued draft guidelines on carcinogen risk assessment, which included the use mode of action information in the risk assessment process. We have used the five stages of induction of toxicity as described by Aldridge to illustrate in the case of two drugs, tamoxifen ...

journal_title：Toxicology letters

authors： Lock EA,Smith LL

更新日期：2003-04-11 00:00:00

abstract：:Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

journal_title：Toxicology letters

authors： Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

更新日期：1987-01-01 00:00:00

abstract：:Phosgene Oxime (CX, Cl2CNOH), a halogenated oxime, is a potent chemical weapon that causes immediate acute injury and systemic effects. CX, grouped together with vesicating agents, is an urticant or nettle agent with highly volatile, reactive, corrosive, and irritating vapor, and has considerably different chemical pr...

journal_title：Toxicology letters

authors： Goswami DG,Agarwal R,Tewari-Singh N

更新日期：2018-09-01 00:00:00

abstract：:Pregnant rats were given di-n-butyltin dichloride (DBT) by gastric intubation at a dose of 0, 2.5, 5.0, 7.5 or 10.0 mg/kg on days 7-15 of pregnancy. Maternal toxicity occurred in the 7.5 and 10.0 mg/kg groups as evidenced by a significant increase in maternal death and decrease in food consumption and body weight gain...

journal_title：Toxicology letters

authors： Ema M,Itami T,Kawasaki H

更新日期：1991-11-01 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs. Developmental abnormalities were observed in surviving embryos of each of the 3 sp...

journal_title：Toxicology letters

authors： Fulton MH,Chambers JE

更新日期：1985-08-01 00:00:00

abstract：:There is a trend towards increasing doses of pralidoxime to treat human organophosphate poisonings that may have relevance in subpopulations. Indeed, pralidoxime is eliminated unchanged by the renal route. This study assesses the effect of renal failure on the kinetics of pralidoxime in a rat model of acute renal fail...

journal_title：Toxicology letters

authors： Kayouka M,Houzé P,Risède P,Debray M,Baud FJ

更新日期：2009-01-10 00:00:00

abstract：:Monitoring of human exposure to persistent organic pollutants POPs and heavy metals have taken place since 1994 in a circumpolar study conducted under the Arctic monitoring and assessment programme (AMAP). The study has confirmed that Arctic populations relying on marine food (Inuit) have an exposure level of POPs and...

journal_title：Toxicology letters

authors： Hansen JC

更新日期：2000-03-15 00:00:00

abstract：:Polarographic measurements of the rates of oxygen consumption by isolated rat liver mitochondria respiring on pyruvate/malate in metabolic state 4 revealed that additions of micromolar amounts of chalepin, a naturally occurring furocoumarin resulted in significant decreases in respiratory rates. At 16 microM chalepin,...

journal_title：Toxicology letters

authors： Olorunsogo OO,Emerole GO,Malomo SO,Thabrew MI

更新日期：1983-03-01 00:00:00

abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...

journal_title：Toxicology letters

authors： Jaurand MC,Magne L,Bignon J

更新日期：1983-02-01 00:00:00

abstract：:The effect of aflatoxin B1 on the uptake and incorporation of [3H]leucine and [3H]uridine and on phagocytosis of latex particles was studied using cultures of rat liver macrophages (Kuffer cells). Aflatoxin B1 inhibited the incorporation of both isotopes, but inhibition of uridine incorporation was greater than that o...

journal_title：Toxicology letters

authors： Mohapatra NK,Roberts JF

更新日期：1985-12-01 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p. Hepatoxicity was assessed b...

journal_title：Toxicology letters

authors： Carlson GP

更新日期：1996-06-01 00:00:00

abstract：:Lead (Pb) alters the susceptibility to different pathogens suggesting that macrophage-mediated defense mechanisms, through activation of toll-like receptors (TLRs), may be affected by Pb. The aim of this study was to test whether activation of TLR4 is a targeted molecule to the effect of environmentally relevant Pb co...

journal_title：Toxicology letters

authors： Luna AL,Acosta-Saavedra LC,Martínez M,Torres-Avilés N,Gómez R,Calderón-Aranda ES

更新日期：2012-11-15 00:00:00

abstract：:Early life exposure to certain kinds of chemicals is of concern because of a possible increase in cancer risk, but relevant data are limited. In the present experiment, modifying effects of prepubertal administration of potassium perchlorate (KClO(4)) and tetrabromobisphenol A (TBBPA) on susceptibility to multi-organ ...

journal_title：Toxicology letters

authors： Imai T,Takami S,Cho YM,Hirose M,Nishikawa A

更新日期：2009-03-28 00:00:00

abstract：:A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...

journal_title：Toxicology letters

authors： Monteith DK,Connor TH,Benvenuto JA,Fairchild EJ,Theiss JC

更新日期：1988-03-01 00:00:00

abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

journal_title：Toxicology letters

authors： Okey AB,Riddick DS,Harper PA

更新日期：1994-01-01 00:00:00

abstract：:Blood lead concentrations (Pb-B, microgram/100 ml) was measured in children and adults, both sexes, living in and around Liège (control group, n = 859) and in the urban center of Verviers (exposed group, n = 568) where houses with lead piping are supplied with corrosive drinking water. In control children, the mean Pb...

journal_title：Toxicology letters

authors： Sartor FA,Rondia D

更新日期：1981-01-01 00:00:00

abstract：:Zinc chloride (0.01 mM kept for 3h) is not toxic to cultured cerebellar granule neurons (CGNs) while kainate (0.1mM kept for 3h) demonstrates some but very low toxicity towards these cells. Measurements of the relative intraneuronal zinc ion concentration showed that increase in [Zn(2+)](i) under the simultaneous acti...

journal_title：Toxicology letters

authors： Lozier ER,Stelmashook EV,Uzbekov RE,Novikova SV,Zorov SD,Alieva IB,Arbeille B,Zorov DB,Isaev NK

更新日期：2012-01-05 00:00:00

abstract：:Epidemiological investigations indicate that effects related to prenatal adverse environments on the organs of the offspring could continue to adulthood. This study intends to confirm that prenatal nicotine exposure (PNE) increases the susceptibility of osteoarthritis (OA) in the male offspring, and to explore the pot...

journal_title：Toxicology letters

authors： Chen B,Lu KH,Ni QB,Li QX,Gao H,Wang H,Chen LB

更新日期：2019-10-10 00:00:00

abstract：:In this study, we examined the cytotoxic effects of sanguinarine, a phytoalexin with antimicrobial, anti-oxidant, anti-inflammatory and pro-apoptotic effects, on the blastocyst stage of mouse embryos, subsequent embryonic attachment and outgrowth in vitro and in vivo implantation via embryo transfer. Blastocysts treat...

journal_title：Toxicology letters

authors： Chan WH

更新日期：2011-09-10 00:00:00

abstract：:alpha-Zearalanol (alpha-ZAL), a phytochemical with both antioxidant and estrogen-like properties, has been shown to retard progression of atherosclerosis and regulate cardiovascular function in part through suppression of endothelin-1 (ET-1) secretion. However, the precise nature behind alpha-ZAL-elicited inhibition o...

journal_title：Toxicology letters

authors： Xu H,Duan J,Dai S,Wu Y,Sun R,Ren J

更新日期：2008-07-10 00:00:00

abstract：:The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...

journal_title：Toxicology letters

authors： Scotti TM,Chernoff N,Linder R,McElroy WK

更新日期：1981-11-01 00:00:00

abstract：:BH3 mimetics, such as BH3I-1, act as Bcl-2 antagonists, promote apoptosis and are used in basic research studies on apoptotic signaling and are currently tested as experimental anti-tumor agents. The present study addresses time- and dose-dependent responses of BH3I-1 on apoptosis, cellular stress defense mediated by ...

journal_title：Toxicology letters

authors： Stucki D,Brenneisen P,Reichert AS,Stahl W

更新日期：2018-10-01 00:00:00

abstract：:The role of intra- and extracellular calcium in the activation of human polymorphonuclear leukocytes (PMNL) to produce reactive oxygen metabolites (ROM) were studied by using soluble, formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA), or particulate stimuli, quartz or chrysotile. A calciu...

journal_title：Toxicology letters

authors： Ruotsalainen M,Naarala J,Savolainen KM

更新日期：1995-08-01 00:00:00

abstract：:Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...

journal_title：Toxicology letters

authors： Lu TH,Chen CH,Lee MJ,Ho TJ,Leung YM,Hung DZ,Yen CC,He TY,Chen YW

更新日期：2010-05-04 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00

abstract：:Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...

journal_title：Toxicology letters

authors： Jaiswal PK,Srivastava S,Gupta J,Thakur IS

更新日期：2012-10-17 00:00:00

abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

journal_title：Toxicology letters

authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

更新日期：1980-12-01 00:00:00