Embryonic toxicity of sanguinarine through apoptotic processes in mouse blastocysts.

Abstract:

:In this study, we examined the cytotoxic effects of sanguinarine, a phytoalexin with antimicrobial, anti-oxidant, anti-inflammatory and pro-apoptotic effects, on the blastocyst stage of mouse embryos, subsequent embryonic attachment and outgrowth in vitro and in vivo implantation via embryo transfer. Blastocysts treated with 0.5-2 μM sanguinarine exhibited significantly increased apoptosis and a corresponding decrease in total cell number. Notably, the implantation success rates of blastocysts pretreated with sanguinarine were lower than that of their control counterparts. Moreover, in vitro treatment with 0.5-2 μM sanguinarine was associated with increased resorption of post-implantation embryos and decreased fetal weight. Our results collectively indicate that sanguinarine induces apoptosis and retards early post-implantation development in vitro and in vivo. In addition, sanguinarine induces apoptotic injury effects on mouse blastocysts through intrinsic and extrinsic apoptotic signaling processes to impair sequent embryonic development. However, the extent to which sanguinarine exerts teratogenic effects on early human development is not known at present, and further studies are required to establish effective protection strategies against its cytotoxic effects.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Chan WH

doi

10.1016/j.toxlet.2011.06.018

subject

Has Abstract

pub_date

2011-09-10 00:00:00

pages

285-92

issue

3

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(11)01285-9

journal_volume

205

pub_type

杂志文章
  • Anesthetic-induced structural changes in the nicotinic acetylcholine receptor.

    abstract::The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. This spectral map is affected by th...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00183-0

    authors: Ryan SE,Nguyen HP,Baenziger JE

    更新日期:1998-11-23 00:00:00

  • Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity.

    abstract::Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-Dawley (SD) rats were used to establish animal models...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.12.004

    authors: Cao XN,Shen LJ,Wu SD,Yan C,Zhou Y,Xiong G,Wang YC,Liu Y,Liu B,Tang XL,Guo M,Liu DY,Long CL,Sun M,He DW,Lin T,Wei GH

    更新日期:2017-01-15 00:00:00

  • Allergy, asthma and the environment: an introduction.

    abstract::In Europe and the USA the prevalence of certain forms of allergic disease is rising; an increase that can not be reconciled simply on the basis of changes in diagnostic fashion. The changes observed have been too rapid to be explained by alterations in the gene pool and, as a consequence, there has been a growing inte...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00320-8

    authors: Kimber I

    更新日期:1998-12-28 00:00:00

  • Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure.

    abstract::Accumulation of N2-(trans-isoestragol-3'-yl)-2'-deoxyguanosine (E-3'-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficient. To this end human HepaRG cells were exposed to repeating cycles of 2 h e...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.11.009

    authors: Yang S,Wesseling S,Rietjens IMCM

    更新日期:2021-02-01 00:00:00

  • Extremely low dose of acrylamide decreases lifespan in Caenorhabditis elegans.

    abstract::The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.04.037

    authors: Hasegawa K,Miwa S,Tsutsumiuchi K,Taniguchi H,Miwa J

    更新日期:2004-09-10 00:00:00

  • DNA damage by filtered, tar- and aerosol-free cigarette smoke in rodent cells: a novel evaluation.

    abstract::Nuclear accumulation of the tumorsuppressor protein p53 indicates the occurrence of chromatin injury (J. Cancer Res. Clin. Oncol. 1991, 117, 30; Oncogene 1993, 8, 307) and may be used as an analytical tool to detect genotoxic agents. This mechanism was used to evaluate the DNA-damaging potency (clastogenicity) of the ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03711-3

    authors: Hess RD,Brandner G

    更新日期:1996-11-01 00:00:00

  • Effects of toxic doses of urethane on rat liver and lung microsomes.

    abstract::Administration of carcinogenic doses of urethane to male rats (for 30 days) and to females (for 45 days) caused degranulation of microsomes of livers and lungs to approx. 15 and 35%, respectively. The cholesterol levels also declined more than 50% in urethane-treated rats when compared with controls. Studies on struct...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90170-4

    authors: Renuka,Dani HM

    更新日期:1983-01-01 00:00:00

  • The effect of cyclosporin A on pulmonary fibrosis induced by butylated hydroxytoluene, bleomycin and beryllium sulfate.

    abstract::Interstitial pulmonary fibrosis is characterized by an abnormal accumulation of fibroblasts with a resultant increase in lung collagen content. Previous research has implied a possible involvement of the T-lymphocyte in this process. We used cyclosporin A (Cy A), a known immunosuppressant, to deplete T-lymphocyte-depe...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90162-6

    authors: Sendelbach LE,Lindenschmidt RC,Witschi HP

    更新日期:1985-08-01 00:00:00

  • In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: structural and functional impairment.

    abstract::Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds....

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.12.020

    authors: Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon P

    更新日期:2014-03-03 00:00:00

  • Vascular wall damage in rats induced by organophosphorus insecticide methidathion.

    abstract::We have examined the effect of subchronic methidathion (MD) administration on vascular wall damage. The experimental groups were: control group and rats treated with 5 mg/kg MD. The MD group was given MD by gavage for 5 days a week for 4 weeks at a dose level of 5 mg/kg per day by using corn oil as the vehicle. The le...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.08.012

    authors: Yavuz T,Delibas N,Yildirim B,Altuntas I,Candir O,Cora A,Karahan N,Ibrisim E,Kutsal A

    更新日期:2005-01-15 00:00:00

  • Quinolone antibacterial-agent-induced cutaneous phototoxicity: ear swelling reactions in Balb/c mice.

    abstract::The phototoxic potentials of quinolone derivatives and the possibility of free radical contribution to their phototoxicity were investigated by measuring increments in ear thickness. Balb/c mice, fasted overnight, were orally administered ofloxacin (OFLX), lomefloxacin (LMFX), enoxacin (ENX), ciprofloxacin (CPFX) and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90176-7

    authors: Wagai N,Tawara K

    更新日期:1991-10-01 00:00:00

  • Thymic atrophy in mice induced by cadmium administration.

    abstract::The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(81)90137-5

    authors: Yamada YK,Shimizu F,Kawamura R,Kubota K

    更新日期:1981-04-01 00:00:00

  • A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon.

    abstract::In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90256-j

    authors: Navarra P,Martire M,del Carmine R,Pozzoli G,Preziosi P

    更新日期:1992-12-01 00:00:00

  • Polycyclic aromatic hydrocarbon coated onto Fe(2)O(3) particles: assessment of cellular membrane damage and antioxidant system disruption in human epithelial lung cells (L132) in culture.

    abstract::The aim of this study was to investigate the oxidative effects of Fe(2)O(3), benzo(a)pyrene (B(a)P) and pyrene, alone or in association (B(a)P or pyrene coated onto Fe(2)O(3) particles), in normal human embryonic lung epithelial cells (L132) in culture. We evaluated: (i) membrane integrity, through fatty acid release ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00231-9

    authors: Garçon G,Shirali P,Garry S,Fontaine M,Zerimech F,Martin A,Hannothiaux MH

    更新日期:2000-09-30 00:00:00

  • Therapeutic response to single intravenous bolus administration of formate dehydrogenase in methanol-intoxicated rats.

    abstract::Methanol remains to be a major public and environmental health hazard. Formic acid is the toxic metabolite responsible for the metabolic acidosis observed in methanol poisoning in humans, in non-human primates and in folate-depleted rodents. Cytochrome oxidase inhibition by formate leads to lactic acid accumulation, w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.07.017

    authors: Muthuvel A,Rajamani R,Sheeladevi R

    更新日期:2006-02-20 00:00:00

  • Relationship between oxidative metabolites of hydrazine and hydrazine-induced mutagenicity.

    abstract::Hydrazine (Hz) mutagenicity was observed in a test using Escherichia coli B/r strain, WP2 uvrA and was enhanced by the addition of rat liver microsomal fraction containing a generating system, while the enhanced mutagenicity was diminished by the addition of metyrapone to the microsome-free levels. On the other hand, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90006-8

    authors: Noda A,Ishizawa M,Ohno K,Sendo T,Noda H

    更新日期:1986-05-01 00:00:00

  • Classification of chemicals as sensitisers based on new test methods.

    abstract::For the last decade, classification schemes worldwide have recognised that certain chemicals may need to be categorised as skin or respiratory sensitisers. Although differing in detail, the schemes use similar criteria for designating materials as sensitisers, based on either direct evidence from exposed humans or the...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(92)90186-n

    authors: Botham PA

    更新日期:1992-12-01 00:00:00

  • Evaluation of in vitro absorption, decontamination and desorption of organophosphorous compounds from skin and synthetic membranes.

    abstract::Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.03.005

    authors: Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

    更新日期:2013-05-23 00:00:00

  • An in vivo comparison of the efficacy of CSL box jellyfish antivenom with antibodies raised against nematocyst-derived Chironex fleckeri venom.

    abstract::Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.02.008

    authors: Winter KL,Isbister GK,Jacoby T,Seymour JE,Hodgson WC

    更新日期:2009-06-01 00:00:00

  • Induction of renin release from isolated glomeruli by inorganic mercury(II).

    abstract::Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03637-5

    authors: Kozma L,Lenkey A,Varga E,Gomba S

    更新日期:1996-04-01 00:00:00

  • Importance of species selection in drug toxicity testing.

    abstract::The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00263-x

    authors: Morton DM

    更新日期:1998-12-28 00:00:00

  • Effects of sodium pentachlorophenate on enzymes of energy metabolism in tissues of Notopterus notopterus.

    abstract::Effect of sublethal concentrations (0.0083, 0.0055, 0.0041, 0.0033 and 0.0028 mg/l) of sodium penta-chlorophenate (Na-PCP) on the enzymes SDH, PDH and LDH in brain, liver and gills of Notopterus notopterus after 15 ad 30 days exposure were studied. SDH and PDH were inhibited, and LDH were stimulated significantly at m...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90091-1

    authors: Verma SR,Rani S,Dalela RC

    更新日期:1982-02-01 00:00:00

  • Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.

    abstract::Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes. We investigated SM toxicity in a human keratinocyte cell line (HaCaT) and used GSH and NAC to cou...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.09.002

    authors: Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

    更新日期:2016-02-26 00:00:00

  • Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein.

    abstract::Oleanolic acid is a triterpenoid compound that has been shown to protect against liver injury produced by some hepatotoxicants. This study was designed to characterize the protective effects of oleanolic acid on carbon tetrachloride-induced hepatotoxicity, and the role of metallothionein in the protection. Oleanolic a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00009-5

    authors: Liu Y,Hartley DP,Liu J

    更新日期:1998-03-31 00:00:00

  • Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells.

    abstract::The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.10.002

    authors: Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

    更新日期:2006-03-01 00:00:00

  • Predisposition to lung tumorigenesis.

    abstract::Mouse inbred strains with inherited predisposition and resistance to lung cancer provide an essential tool for the dissection of the genetics of this complex disease. We have previously mapped a major locus (Pulmonary adenoma susceptibility 1, Pas1) affecting inherited predisposition to lung cancer in mice on chromoso...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(99)00232-5

    authors: Manenti G,Nomoto T,De Gregorio L,Gariboldi M,Stefania Falvella F,Nagao M,Dragani TA

    更新日期:2000-03-15 00:00:00

  • Dimethylacetamide pharmacokinetics following inhalation exposures to rats and mice.

    abstract::Whole-body inhalation exposures to N,N-dimethylacetamide (DMAC) were conducted with male rats (Crl:CD BR) and mice (Crl:CD-1 (ICR)BR). Exposure concentrations were 50, 150, 300 and 500 ppm. The exposure routines consisted of single 1-, 3-, or 6-h exposures and ten 6-h exposures (10 exposure days in 2 weeks). Area unde...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90061-2

    authors: Hundley SG,Lieder PH,Valentine R,McCooey KT,Kennedy GL Jr

    更新日期:1994-09-01 00:00:00

  • Methylglyoxal has injurious effects on maturation of mouse oocytes, fertilization, and fetal development, via apoptosis.

    abstract::Methylglyoxal (MG) is a metabolite of glucose. The serum MG level is increased in diabetic patients, and MG is implicated in diabetic complications related to embryonic development injury. We previously reported cytotoxic effects of MG on mouse embryonic stem cells and blastocysts, and a further association with defec...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.01.007

    authors: Chang YJ,Chan WH

    更新日期:2010-04-01 00:00:00

  • Oxidative stress and inflammatory response to printer toner particles in human epithelial A549 lung cells.

    abstract::Reports on adverse health effects related to occupational exposure to toner powder are still inconclusive. Therefore, we have previously conducted an in vitro-study to characterize the genotoxic potential of three commercially available black printer toner powders in A549 lung cells. In these cell-based assays it was ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.11.018

    authors: Könczöl M,Weiß A,Gminski R,Merfort I,Mersch-Sundermann V

    更新日期:2013-02-04 00:00:00

  • Critical genes as early warning signs: example of vinyl chloride.

    abstract::We have analysed liver angiosarcomas from individuals having been occupationally exposed to vinyl chloride (VC) to identify, in cancer-related genes, lesions which could be VC-specific. Two genetic alterations have been identified: the first one is a GGC --> GAT (Gly --> Asp, Asp13p21) mutation at codon 13 in the Ki-r...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00255-0

    authors: Marion MJ

    更新日期:1998-12-28 00:00:00