Abstract：
:Early life exposure to certain kinds of chemicals is of concern because of a possible increase in cancer risk, but relevant data are limited. In the present experiment, modifying effects of prepubertal administration of potassium perchlorate (KClO(4)) and tetrabromobisphenol A (TBBPA) on susceptibility to multi-organ carcinogenesis were evaluated. F344 dam rats were administered 0% (control), 0.01%, 0.1% or 1% TBBPA in diet or 0.01% KClO(4) in drinking water after parturition. Their weaned offspring in each group were treated for 2 weeks in the same manner. From 6 weeks of age, all offspring were treated with N-bis(2-hydroxypropyl)nitrosamine in drinking water for 4 weeks. In addition the females at 7 weeks of age were gavaged once with 7,12-dimethylbenz(a)anthracene. At weeks 39 and 47 of age, the males and females, respectively, were euthanized and the liver, kidney, lung, esophagus, thyroid, urinary bladder, testis, epididymis, ovary and mammary gland were histopathologically examined. The incidences of thyroid follicular adenomas in 1% TBBPA females (p<0.05) and of transitional cell papillomas in the urinary bladder of 0.01%, 0.1% and 1% TBBPA females were increased (p<0.05) as compared to the controls. These results indicate that prepubertal exposure to TBBPA raises susceptibility to thyroid and urinary bladder tumorigenesis in rats. Although causes of the effect on thyroid carcinogenesis might be direct and/or indirect hormonal actions, further studies are needed for confirmation.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Imai T,Takami S,Cho YM,Hirose M,Nishikawa Adoi
10.1016/j.toxlet.2008.12.013subject
Has Abstractpub_date
2009-03-28 00:00:00pages
160-7issue
3eissn
0378-4274issn
1879-3169pii
S0378-4274(08)01388-Xjournal_volume
185pub_type
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journal_title：Toxicology letters
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更新日期：1982-08-01 00:00:00
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更新日期：1982-03-01 00:00:00
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更新日期：2016-07-25 00:00:00
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更新日期：1995-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-03-16 00:00:00
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pub_type： 杂志文章
doi：10.1016/0378-4274(90)90017-g
更新日期：1990-02-01 00:00:00
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doi：10.1016/0378-4274(91)90066-f
更新日期：1991-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.07.009
更新日期：2011-10-10 00:00:00
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更新日期：2020-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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更新日期：2017-11-05 00:00:00
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更新日期：2013-02-13 00:00:00
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doi：10.1016/j.toxlet.2011.04.032
更新日期：2011-07-28 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.10.008
更新日期：2016-01-05 00:00:00
abstract：:Administration of carcinogenic doses of urethane to male rats (for 30 days) and to females (for 45 days) caused degranulation of microsomes of livers and lungs to approx. 15 and 35%, respectively. The cholesterol levels also declined more than 50% in urethane-treated rats when compared with controls. Studies on struct...
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(95)03621-0
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.07.021
更新日期：2016-09-30 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.01.027
更新日期：2014-04-07 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：1995-05-01 00:00:00
abstract：:Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.11.007
更新日期：2012-02-05 00:00:00
abstract：:Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER). Many lines of evidence reveal that BPA has an impact as an endocrine disruptor even at low doses. However, its binding to ER and hormonal activity is extremely weak, making the intrinsic significance ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.08.012
更新日期：2006-12-01 00:00:00
abstract：:In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible tools for predicting the toxicity of chemicals when little or no empirical data are available. A fundamental understanding of toxicological principles has been considered an important com...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(95)03374-t
更新日期：1995-09-01 00:00:00
