Abstract：
:Increased glutamate release is associated with serious neurological disorders such as epilepsy, stroke, Alzheimer's disease and other brain injuries. Excessive glutamate release and subsequent glutamatergic neuronal stimulation increase the production of reactive oxygen species (ROS), which in turn induce oxidative stress, excitotoxicity and neuronal damage. A number of studies have shown that co-exposure of neuronal cells to glutamate, and an environmental toxin, lead, can greatly amplify glutamate excitotoxicity and cell death through apoptosis or necrosis. Even though the mechanisms of excitotoxicity or those of glutamate-lead interactions have not been exhaustively delineated, there is ample evidence to suggest that increased production of ROS may play an important role in both events. Subsequently, increased DNA binding of redox-regulated transcription factors, NF-kappaB and AP-1, seems to be associated with these events. Induction of an immediate early gene, c-fos, is seen in neuronal cells exposed to glutamate or lead. Immediate early genes are important in regulating the expression of other neuronal genes; Elevated expressions of the genes encoding Hsp70 or cyclo-oxygenase-2 seem to be involved in the apoptosis or necrosis induced by glutamate, and may be associated with induction of several of the genes in cells exposed to lead, or to the glutamate-lead combination. Further studies are required to clarify the mechanisms of glutamate-lead neurotoxicity.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Savolainen KM,Loikkanen J,Eerikäinen S,Naarala Jdoi
10.1016/s0378-4274(98)00233-1keywords:
subject
Has Abstractpub_date
1998-12-28 00:00:00pages
363-7eissn
0378-4274issn
1879-3169pii
S0378-4274(98)00233-1journal_volume
102-103pub_type
杂志文章,评审abstract：:The binding of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to mouse peroxisome proliferator-activated receptor α ligand binding domain (mPPARα-LBD) was examined by a combination of in vitro investigation and in silico simulation. Fluorescence polarization (FP) assay showed that halogenated BPA...
journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(94)90089-2
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2009-07-24 00:00:00
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更新日期：1997-02-07 00:00:00
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更新日期：1996-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1998-01-16 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00183-0
更新日期：1998-11-23 00:00:00
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pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90149-x
更新日期：1988-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90205-3
更新日期：1982-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00023-4
更新日期：1997-05-16 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2002-02-28 00:00:00
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.12.007
更新日期：2017-01-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1984-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.02.010
更新日期：2019-05-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(01)00284-3
更新日期：2001-03-31 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(95)03482-x
更新日期：1995-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90052-2
更新日期：1982-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90082-3
更新日期：1988-05-01 00:00:00
