Abstract:
:The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators that can effect liver damage or repair. This review will summarize our current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride, an industrial chemical, and acetaminophen, a widely used analgesic.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy Bdoi
10.1016/s0378-4274(01)00284-3keywords:
subject
Has Abstractpub_date
2001-03-31 00:00:00pages
317-21issue
1-3eissn
0378-4274issn
1879-3169pii
S0378-4274(01)00284-3journal_volume
120pub_type
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更新日期:2012-10-17 00:00:00
abstract::A single s.c. injection of 60 mg/kg of monocrotaline to rats induced pulmonary alterations characterized by hyaline thrombi of capillaries and arterioles, focal necrosis of alveolar walls, and medial thickening and intimal hyalinosis of arteries. Such pathological alterations became apparent 7 days after injection and...
journal_title:Toxicology letters
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doi:10.1016/0378-4274(84)90225-x
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abstract::Due to the massive reduction of air-change rates in modern, energy-saving houses and dwellings, the contribution of volatile organic compound (VOCs) emissions from wood-based materials to indoor air quality has become increasingly important. To evaluate toxicity of VOC mixtures typically emitted from pine wood and ori...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.03.015
更新日期:2010-06-16 00:00:00
abstract::Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...
journal_title:Toxicology letters
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更新日期:1999-07-30 00:00:00
abstract::Exposure of humans to xenobiotic mixtures is a continuous state during their everyday routine. However, the majority of toxicological studies assess the in vivo effects of individual substances rather than mixtures. Therefore, our main objective was to evaluate the impact of the 12- and 18-month exposure of rats to a ...
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pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.09.015
更新日期:2019-12-15 00:00:00
abstract::A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90153-6
更新日期:1987-07-01 00:00:00
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doi:10.1016/j.toxlet.2017.02.021
更新日期:2017-04-15 00:00:00
abstract::The exposure to cuprizone (CPZ) leads to demyelination in the central nervous system in rodents. To examine the developmental effects of CPZ exposure on hippocampal neurogenesis, pregnant rats were treated with 0, 0.1 or 0.4% CPZ in the diet from gestational day 6 to day 21 after delivery. On postnatal day 21, male of...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.01.022
更新日期:2015-05-05 00:00:00
abstract::Short-term exposure to elevated levels of particulate matter is associated with increased respiratory and cardiovascular mortality and morbidity. However, the mechanisms underlying these effects are still unclear. Recent studies have suggested that inhaled ultrafine particles are able to translocate into the bloodstre...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2007.09.006
更新日期:2008-01-04 00:00:00
abstract::Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.10.024
更新日期:2006-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90199-6
更新日期:1994-03-01 00:00:00
abstract::The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the te...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(96)03741-1
更新日期:1996-11-01 00:00:00
abstract::Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(97)00112-4
更新日期:1998-01-31 00:00:00
abstract::Oral administration of stannous chloride (SnCl2) (1.0 mg Sn2$/kg body weight) to rats, twice daily for 28 days, caused a significant increase in the tin (Sn) content and a corresponding decrease of the calcium (Ca) content in the femoral epiphysis, but was without effect on serum Ca, intestinal Ca absorption, and urin...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(82)90259-4
更新日期:1982-01-01 00:00:00
abstract::Generally recognized as safe (GRAS), a system for review and approval of ingredients for addition to food, was conceived at a time when the need for a less doctrinaire review of food ingredients was critical. The GRAS approval process for a food ingredient relies on the judgment of "...experts qualified by scientific ...
journal_title:Toxicology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.toxlet.2003.07.004
更新日期:2004-04-15 00:00:00
abstract::The toxicity of methylmercury is sufficiently high to justify an evaluation of the risk from the consumption of contaminated food. In the method of risk assessment proposed here, distribution frequencies are assigned to the parameters in question, rather than mean values. Total body burden is estimated by numerical si...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(82)90080-7
更新日期:1982-02-01 00:00:00
abstract::Benzene is a common occupational hazard and a ubiquitous environmental pollutant. Benzene exposure at the levels even below 1ppm still showed hematotoxicity. It is widely accepted that the metabolites of benzene play important roles in the benzene toxicity to the hematopoietic system, but little is known about the eff...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.03.012
更新日期:2011-06-24 00:00:00
abstract::The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(91)90208-n
更新日期:1991-08-01 00:00:00
abstract::The availability of different chemical forms of mercury (Hg) was studied in primary cultures of rat hepatocytes incubated with mercuric acetate (HgAc), mercuric diethyldithiocarbamate (Hg(DTC)2) or methyl mercuric chloride (MeHgCl), labelled with 203Hg. The uptake of Hg was linearly related to the concentration in the...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(89)90105-7
更新日期:1989-10-01 00:00:00
abstract::The neurotoxin 6-hydroxydopamine (6-OHDA) oxidised sulphydryl groups in glyceraldenyde-3-phosphate dehydrogenase (GAPDH) with loss of the dehydrogenase activity of the enzyme. 5-Hydroxydopamine behaved similarly at higher concentrations. This oxidation was accompanied by a transient rise in the acyl phosphatase (non-p...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(02)00013-9
更新日期:2002-03-10 00:00:00
abstract::Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.08.017
更新日期:2019-10-15 00:00:00
abstract::2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism b...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.03.013
更新日期:2017-05-05 00:00:00
abstract::Ursolic acid (UA), a pentacyclic triterpene acid, is reported to have inducing activity of hepatic metallothionein (MT) which responsible for the detoxification of heavy metals; however, the mechanism underlying its effects is poorly understood. To further determine the underlying mechanism of UA, this study investiga...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2004.11.002
更新日期:2005-03-15 00:00:00
abstract:BACKGROUND:Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. METHODS:Two groups of 14 female volunteer...
journal_title:Toxicology letters
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.toxlet.2005.09.029
更新日期:2006-05-05 00:00:00
abstract::Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(90)90185-o
更新日期:1990-12-01 00:00:00
abstract::Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90057-6
更新日期:1981-02-01 00:00:00
abstract::The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that sacchar...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90129-7
更新日期:1983-12-01 00:00:00
abstract::Behavioral endpoints offer special challenges to toxicology. One arises from the sometimes conflicting ways in which adverse effects may be expressed. For example, both increases and decreases in response rates of schedule-controlled performance may be produced by a specific agent, depending on the specific schedule. ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(88)90034-3
更新日期:1988-10-01 00:00:00
abstract::The blood-brain barrier (BBB) is critical to maintain cerebral homeostasis. In this study, we examined the effects of exposure to electromagnetic pulse (EMP) on the functional integrity of BBB and, on the localization and expression of tight junction (TJ) proteins (occludin and ZO-1) in rats. Animals were sham or whol...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.04.011
更新日期:2010-07-15 00:00:00
abstract::Chronic exposure of humans to fluorine compounds in the air, water and food may be atherogenic via the activation of oxidative stress and increased ROS production. The most important factor that promotes the formation of ROS seems to be the oxidoreduction of electron carriers in the critical points of the respiratory ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.03.1167
更新日期:2010-07-01 00:00:00