Simulation of methylmercury toxicity resulting from the consumption of Mediterranean red tuna fish.

Abstract:

:The toxicity of methylmercury is sufficiently high to justify an evaluation of the risk from the consumption of contaminated food. In the method of risk assessment proposed here, distribution frequencies are assigned to the parameters in question, rather than mean values. Total body burden is estimated by numerical simulation on a digital computer. Based on recorded cases of incipient intoxication and allowing a safety factor of 10, the critical body burden has been estimated at between 5, 4 and 6 mg total mercury. From an application of this approach to the assessment of risk from Mediterranean red tuna fish consumption, it appears that there may exist high frequency consumers whose body burdens, while not in the overtly neurotoxic range, approach the computed critical level.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Magnaval R,Batti R,Bouville A,Magnaval JP,Spear RC

doi

10.1016/0378-4274(82)90080-7

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

233-7

issue

2-3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(82)90080-7

journal_volume

10

pub_type

杂志文章
  • Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice.

    abstract::The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00255-1

    authors: Ohhira S,Matsui H,Watanabe K

    更新日期:2000-11-20 00:00:00

  • Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity.

    abstract::A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.08.027

    authors: Kim JA,Han E,Eun CJ,Tak YK,Song JM

    更新日期:2012-10-17 00:00:00

  • Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism.

    abstract::Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.01.006

    authors: Hoffmann M,Fiedor E,Ptak A

    更新日期:2017-03-05 00:00:00

  • Inhibition of mitochondrial respiration by chalepin, a naturally occurring furocoumarin.

    abstract::Polarographic measurements of the rates of oxygen consumption by isolated rat liver mitochondria respiring on pyruvate/malate in metabolic state 4 revealed that additions of micromolar amounts of chalepin, a naturally occurring furocoumarin resulted in significant decreases in respiratory rates. At 16 microM chalepin,...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90151-0

    authors: Olorunsogo OO,Emerole GO,Malomo SO,Thabrew MI

    更新日期:1983-03-01 00:00:00

  • Constitutive expression of the AHR signaling pathway in a bovine mammary epithelial cell line and modulation by dioxin-like PCB and other AHR ligands.

    abstract::Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk. The expression of AHR-target genes, particularly those involved in xenobiotic biotransformation, and their modulation by two DL-PCBs, B[a]P, an...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.09.013

    authors: Girolami F,Spalenza V,Manzini L,Carletti M,Nebbia C

    更新日期:2015-01-05 00:00:00

  • Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma-bearing mice: protective role of heme oxygenase.

    abstract::Changes in the activities of antioxidant enzymes superoxide dismutase, catalase (CAT), glutathione peroxidase and heme oxygenase (HO) and changes in lipid peroxidation and reduced glutathione (GSH) levels were measured in the livers of control and Lewis lung carcinoma (LLC)-bearing mice 24 h after a single injection o...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00416-2

    authors: Christova TY,Gorneva GA,Taxirov SI,Duridanova DB,Setchenska MS

    更新日期:2003-03-03 00:00:00

  • Simultaneous determination of airborne acetaldehyde, acetone, 2-butanone, and cyclohexanone using sampling tubes with 2,4-dinitrophenylhydrazine-coated solid sorbent.

    abstract::The 2,4-dinitrophenylhydrazine (2,4-DNPH) derivatization method mainly used for the determination of airborne formaldehyde was extended for acetaldehyde, acetone, 2-butanone, and cyclohexanone, the next four carbonyl compounds of industrial importance. Sampling devices and sampling conditions were adjusted for the res...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00085-x

    authors: Binding N,Schilder K,Czeschinski PA,Witting U

    更新日期:1998-08-01 00:00:00

  • Validation of alternative methods for developmental toxicity testing.

    abstract::Developmental toxicity testing according to current international guidelines involves exposure of pregnant animals, mostly rats and rabbits, and subsequent assessment of toxic effects in their fetuses. Alternative methods have been developed since the early 1980s. They include cell differentiation assays using either ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2003.12.029

    authors: Piersma AH

    更新日期:2004-04-01 00:00:00

  • The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells.

    abstract::Polyhexamethylene guanidine (PHMG) phosphate is a competitive disinfectant with strong antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths of many people, including infants and pregnant w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.01.005

    authors: Kim HR,Shin DY,Chung KH

    更新日期:2015-03-04 00:00:00

  • Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury.

    abstract::Traditional Chinese medicine (TCM) has become a crucial cause of drug-induced liver injury (DILI). Differ from chemical medicines, TCM feature more complex and mostly indefinite components. This review aimed to clarify the classification, underlying mechanisms and targets of the risk components in TCM-induced liver in...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2020.01.026

    authors: Pan X,Zhou J,Chen Y,Xie X,Rao C,Liang J,Zhang Y,Peng C

    更新日期:2020-05-01 00:00:00

  • Yohimbine attenuates the delayed lethality induced in mice by amitraz, a formamidine pesticide.

    abstract::We have found that a single dose of amitraz, a formamidine pesticide, produces death in mice 2-5 days after dosing. To further examine this phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90016-5

    authors: Moser VC,MacPhail RC

    更新日期:1985-11-01 00:00:00

  • Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development.

    abstract::Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs expose...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.09.010

    authors: Zhang P,Wang G,Lin Z,Wu Y,Zhang J,Liu M,Lee KKH,Chuai M,Yang X

    更新日期:2017-11-05 00:00:00

  • Acute toxicity of latex microspheres.

    abstract::The distribution and acute lethality of i.v. administered 3 micrometers latex spheres were determined in rats. The results extend previous studies demonstrating the similarity between dog and rat in the dynamics of microspheres in these species and the inverse relationship between sphere diameter and hemodynamic toxic...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(81)90035-7

    authors: Yokel RA,Sabo JP,Simmons GH,DeLuca PP

    更新日期:1981-10-01 00:00:00

  • Doxorubicin can penetrate nitrile gloves and induces apoptosis in keratinocytes cell lines.

    abstract::Doxorubicin (DOXO) is an anthracycline antibiotic which is used in the treatment of human malignancies such as leukemia, lymphoma and a number of solid tumors, particularly breast cancer. Anthracyclines have been reported to contaminate chemotherapy workstation surfaces as well as other workplaces surfaces. The occupa...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.04.026

    authors: Boccellino M,Pedata P,Castiglia L,La Porta R,Pieri M,Quagliuolo L,Acampora A,Sannolo N,Miraglia N

    更新日期:2010-08-16 00:00:00

  • Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration.

    abstract::Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondrial protein that is thought to play a role in the pathophysiology of A...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.12.012

    authors: Fišar Z,Musílek K,Benek O,Hroch L,Vinklářová L,Schmidt M,Hroudová J,Raboch J

    更新日期:2021-03-15 00:00:00

  • An overview of values for the threshold of toxicological concern.

    abstract::An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/ex...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2012.03.795

    authors: Hennes EC

    更新日期:2012-06-20 00:00:00

  • Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2.

    abstract::Dimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing at the forefront. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. Therefore, the aim of the presented study was to determine the human NAT and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.11.033

    authors: Meyer MR,Lindauer C,Maurer HH

    更新日期:2014-02-10 00:00:00

  • The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.

    abstract::Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(95)03387-z

    authors: De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

    更新日期:1995-10-01 00:00:00

  • Acute nephrotoxicity induced by N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid in Fischer 344 rats.

    abstract::N-(3,5-Dichlorophenyl)succinimide (NDPS) induces nephrotoxicity via one or more metabolites which arise from oxidation of the succinimide ring. The purpose of this study was to examine the nephrotoxic potential of N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid (3-NDHSA), a potential metabolite of NDPS and a positiona...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(89)90047-7

    authors: Rankin GO,Shih H,Teets VJ,Nicoll DW,Brown PI

    更新日期:1989-09-01 00:00:00

  • Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy.

    abstract::Bothrops (lance-head pit vipers) venoms are rich in weaponised metalloprotease enzymes (SVMP). These toxic enzymes are structurally diverse and functionally versatile. Potent coagulotoxicity is particularly important for prey capture (via stroke-induction) and relevant to human clinical cases (due to consumption of cl...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.08.009

    authors: Sousa LF,Bernardoni JL,Zdenek CN,Dobson J,Coimbra F,Gillett A,Lopes-Ferreira M,Moura-da-Silva AM,Fry BG

    更新日期:2020-10-15 00:00:00

  • DNA reactivity of altertoxin II: Identification of two covalent guanine adducts formed under cell-free conditions.

    abstract::Fungi of the genus Alternaria infest many agricultural crops and produce numerous mycotoxins, of which altertoxin II (ATX II) is one of the most mutagenic metabolites. ATX II carries an epoxide group but the formation of DNA adducts has not been demonstrated to date. We report now that ATX II gives rise to two covalen...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.05.018

    authors: Soukup ST,Fleck SC,Pfeiffer E,Podlech J,Kulling SE,Metzler M

    更新日期:2020-10-01 00:00:00

  • Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects.

    abstract::Particulate air pollution is associated with cardiovascular morbidity and mortality. Fine particles with a diameter <2.5 microm (PM2.5) have an important role in triggering biological responses. These particles, and particularly the ultrafine fraction (<100 nm) penetrate deeply into the respiratory tract. Recently, we...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2003.12.061

    authors: Nemmar A,Hoylaerts MF,Hoet PH,Nemery B

    更新日期:2004-04-01 00:00:00

  • Methylmercury impairs motor function in early development and induces oxidative stress in cerebellar granule cells.

    abstract::Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and youn...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2013.08.002

    authors: Patel E,Reynolds M

    更新日期:2013-10-09 00:00:00

  • Hepatic and muscle injuries in mice treated with heptachlor.

    abstract::Heptachlor is a major component of the insecticide, chlordane. It is a health hazard but is still in use in some countries of Southeast Asia. To elucidate the toxicity of heptachlor its effects on mice after oral and intraperitoneal administration were studied. A 3-day group, 92-day group and 180-day group were given ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(90)90054-p

    authors: Izushi F,Ogata M

    更新日期:1990-11-01 00:00:00

  • The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitro.

    abstract::The upregulated α-synuclein (α-syn) and Tau co-occur in methamphetamine (METH) abusers' brains. Here, we designed experiments mainly to investigate whether α-syn and Tau interact in METH exposure. We detected the expression of α-syn, total Tau, and phosphorylation of Tau at Serine 396 (pSer396 Tau) under in vitro and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.11.028

    authors: Ding J,Lian Y,Meng Y,He Y,Fan H,Li C,Qiu P

    更新日期:2020-02-01 00:00:00

  • Increased neuron specific enolase expression by urothelial cells exposed to or malignantly transformed by exposure to Cd²⁺ or As³⁺.

    abstract::Neuron specific enolase (ENO2, γ-enolase) is a biomarker used to help identify neuroendocrine differentiation in tumors. This laboratory has shown that ENO2 might be a biomarker for exposure to cadmium and arsenite. In this study these observations are extended to the urothelial cell, where environmental exposures are...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.05.003

    authors: Soh M,Dunlevy JR,Garrett SH,Allen C,Sens DA,Zhou XD,Sens MA,Somji S

    更新日期:2012-07-07 00:00:00

  • Exacerbation of carbon tetrachloride-induced liver injury in the rat by methamphetamine.

    abstract::The effect of methamphetamine cotreatment on carbon tetrachloride-induced liver toxicity was examined in male Sprague-Dawley rats. Concurrent administration of methamphetamine was found to greatly increase the extent of liver injury resulting from carbon tetrachloride treatment, as indicated both by measurement of ser...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)03197-5

    authors: Roberts SM,Harbison RD,Westhouse RA,James RC

    更新日期:1995-02-01 00:00:00

  • Effects of blowing sand fine particles on plasma membrane permeability and fluidity, and intracellular calcium levels of rat alveolar macrophages.

    abstract::Ambient fine particulate matter (PM2.5, particulates with an aerodynamic diameter < or = 2.5 microm) can suppress alveolar macrophage (AM) functions, but the data concerning the effects of blowing sand PM2.5 on AMs remain limited. The aim of the present study is to investigate the influences of blowing sand PM2.5 on A...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.01.010

    authors: Geng H,Meng Z,Zhang Q

    更新日期:2005-06-17 00:00:00

  • Reprint of "In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective".

    abstract::Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Reactive metabolites and reactive oxygen species generated during PAH metabolism are detoxified by reactions involving glutathione (GSH). Early life...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.11.017

    authors: Ortiz L,Nakamura B,Li X,Blumberg B,Luderer U

    更新日期:2014-10-15 00:00:00

  • Testicular toxicity following short-term exposure to tri- and hexavalent chromium: an experimental study in the rat.

    abstract::The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(90)90069-x

    authors: Ernst E

    更新日期:1990-05-01 00:00:00