Methylmercury impairs motor function in early development and induces oxidative stress in cerebellar granule cells.

Abstract:

:Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and young children are the most vulnerable. A common symptom of perinatal exposure to methylmercury is increased sensory (visual) deficits, motor impairment, and an overall cognitive decline. Research has indicated that the developing cerebellum, specifically the cerebellar granular layer, is particularly vulnerable to methylmercury neurotoxicity. This review examines the effects of low-level methylmercury exposure on motor coordination. We specifically focus on the role of cerebellar granule cells in methylmercury neurotoxicity. We suggest that methylmercury induces oxidative stress in cerebellar granule cells, which subsequently results in apoptotic cell death. Understanding the mechanism by which methylmercury induces toxicity within the developing brain will allow for enhanced treatments and potential reversal of the detrimental effects.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Patel E,Reynolds M

doi

10.1016/j.toxlet.2013.08.002

subject

Has Abstract

pub_date

2013-10-09 00:00:00

pages

265-72

issue

3

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(13)01273-3

journal_volume

222

pub_type

杂志文章,评审
  • Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.

    abstract::Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. These findings provoked the present in vitro study which was designed to determine the inhibition, aging, spontaneou...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.10.009

    authors: Worek F,Aurbek N,Wille T,Eyer P,Thiermann H

    更新日期:2011-01-15 00:00:00

  • Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery.

    abstract::Coumarin and its derivatives are widely employed as a fragrance in cosmetics and skin care products. The skin absorption level and possible disruption to the skin by topical application of coumarins were evaluated in this study. Percutaneous absorption of osthole, daphnoretin, coumarin, byakangelicin, and 7-hydroxycou...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.02.009

    authors: Pan TL,Wang PW,Aljuffali IA,Leu YL,Hung YY,Fang JY

    更新日期:2014-04-21 00:00:00

  • Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.

    abstract::Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90094-9

    authors: Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

    更新日期:1986-02-01 00:00:00

  • In vitro effect of aflatoxin B1 on rat liver macrophages (Kuffer cells).

    abstract::The effect of aflatoxin B1 on the uptake and incorporation of [3H]leucine and [3H]uridine and on phagocytosis of latex particles was studied using cultures of rat liver macrophages (Kuffer cells). Aflatoxin B1 inhibited the incorporation of both isotopes, but inhibition of uridine incorporation was greater than that o...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90039-6

    authors: Mohapatra NK,Roberts JF

    更新日期:1985-12-01 00:00:00

  • Genotoxicity--threshold or not? Introduction of cases of industrial chemicals.

    abstract::Many industrially and environmentally important industrial carcinogens display effects that lead them to be viewed and regulated as 'genotoxic compounds'. Some of these chemicals cause experimental tumours only at high or toxic doses. The current view is that non-threshold principles should be applied for risk assessm...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(02)00495-2

    authors: Bolt HM

    更新日期:2003-04-11 00:00:00

  • Lipoxygenase-mediated biotransformation of p-aminophenol in the presence of glutathione: possible conjugate formation.

    abstract::This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP). Horseradish peroxidase was employed as a positive control. GSH depletion or an increase in the absorption at 327 nm with time due to GS-PAP formation w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(99)00188-5

    authors: Yang X,Kulkarni AP

    更新日期:2000-01-05 00:00:00

  • Modulatory effect of calcium on the influx and binding of cadmium in primary cultures of neonatal rat hepatocytes.

    abstract::Primary cultures of rat hepatocytes were exposed to 3 or 30 microM stable cadmium (Cd) in the presence or absence of 1.8 or 3.6 mM calcium (Ca). The presence of Ca significantly reduced the efflux of lactate dehydrogenase (LDH) from cells regardless of Cd concentration or exposure time. During a 3-h time interval, the...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90006-9

    authors: Sorensen EM

    更新日期:1988-04-01 00:00:00

  • Stimulation of protein kinase A activity and induced terminal differentiation of human skin fibroblasts in culture by low-frequency electromagnetic fields.

    abstract::In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00095-2

    authors: Löschinger M,Thumm S,Hämmerle H,Rodemann HP

    更新日期:1998-08-01 00:00:00

  • A spectrophotometric assay for pyrethroid-cleaving enzymes in human serum.

    abstract::A direct continuous spectrophotometric assay to measure pyrethroid-cleaving enzymes in human serum was developed using cis- and trans-alpha-naphthyl-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate (cis- and trans-naphthyl-Cl2CA). These substrates show a structure very similar to the pyrethroids most often use...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(99)00030-2

    authors: Butte W,Kemper K

    更新日期:1999-06-30 00:00:00

  • The multidrug resistance-associated protein 1 transports methoxychlor and protects the seminiferous epithelium from injury.

    abstract::We examined the ability of the multidrug resistance-associated protein 1 (MRP1/ABCC1) to transport pesticides, as this transporter mediates the cellular efflux of a variety of xenobiotics, typically as glucuronide, sulfate, or glutathione conjugates. NIH3T3 cells stably expressing MRP1 were 3.37-fold more resistant to...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00485-x

    authors: Tribull TE,Bruner RH,Bain LJ

    更新日期:2003-04-30 00:00:00

  • Effect of cadmium on some enzyme activities in first-trimester human placentae.

    abstract::Explants from first-trimester placentae obtained from non-smoking women were incubated with doses of 0, 0.75, 1.5, 3, 6 and 12 micrograms of cadmium (Cd) as CdCl2 for 6 or 24 h. At the end of the incubation period, the activities of placental aryl hydrocarbon hydroxylase (AHH) (a phase I enzyme), quinone reductase (QR...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90270-t

    authors: Boadi WY,Urbach J,Brandes JM,Yannai S

    更新日期:1992-04-01 00:00:00

  • Stem Leydig cell regeneration in the adult rat testis is inhibited after a short-term triphenyltin exposure.

    abstract::Triphenyltin (TPT) is an organotin compound and may be an endocrine disruptor, impairing the male reproductive system. However, the effect of short-term TPT exposure on stem Leydig cell regeneration later on remains unknown. Here, we show that TPT affects stem Leydig cell regeneration in the adult rat testis. Adult ma...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.02.010

    authors: Ni C,Fang Y,Chen X,Wu K,Li H,Wang Y,Zhenkun L,Lian Q,Ge RS

    更新日期:2019-05-15 00:00:00

  • Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep.

    abstract::The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model per...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.10.008

    authors: Lautz LS,Hoeks S,Oldenkamp R,Hendriks AJ,Dorne JLCM,Ragas AMJ

    更新日期:2020-01-01 00:00:00

  • Ethanolamine stimulates repair processes in acute CCl4 damage of mouse liver.

    abstract::Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(97)00112-4

    authors: Murakami T,Nagamura Y,Hirano K

    更新日期:1998-01-31 00:00:00

  • Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.

    abstract::Triptolide (TP) is the main ingredient of Chinese herb Tripterygium wilfordii Hook f. (TWHF). Despite of its multifunction in pharmaceutics, accumulating evidences showed that TP caused obvious hepatotoxicity in clinic. The current study investigated the role of Notch1 signaling in TP-induced hepatotoxicity. Our data ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.10.024

    authors: Shen F,Xiong Z,Kong J,Wang L,Cheng Y,Jin J,Huang Z

    更新日期:2019-01-01 00:00:00

  • Induction of renin release from isolated glomeruli by inorganic mercury(II).

    abstract::Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03637-5

    authors: Kozma L,Lenkey A,Varga E,Gomba S

    更新日期:1996-04-01 00:00:00

  • The pentachlorophenol metabolite tetrachloro-p-hydroquinone induces the formation of 8-hydroxy-2-deoxyguanosine in liver DNA of male B6C3F1 mice.

    abstract::Tetrachloro-p-hydroquinone (TCHQ), the major metabolite of pentachlorophenol (PCP) in mammalian systems, is known to autoxidize to its semiquinone radical under physiological conditions. In this way, PCP could present a potent source of reactive oxygen species (ROS) during metabolization. ROS contribute to numerous mo...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90085-x

    authors: Dahlhaus M,Almstadt E,Appel KE

    更新日期:1994-12-01 00:00:00

  • Formaldehyde exposure impairs the function and differentiation of NK cells.

    abstract::We investigated the cytotoxic effects of formaldehyde (FA) on lymphocytes. FA-exposed mice showed a profound reduction not only in the number of natural killer (NK) cells but also in the expression of NK cell-specific receptors, but these mice did not exhibit decreases in the numbers of T or B lymphocytes. FA exposure...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.09.008

    authors: Kim EM,Lee HY,Lee EH,Lee KM,Park M,Ji KY,Jang JH,Jeong YH,Lee KH,Yoon IJ,Kim SM,Jeong MJ,Kim KD,Kang HS

    更新日期:2013-11-25 00:00:00

  • Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.

    abstract::A computer program (Q-test) was used to evaluate the combined toxic effects of nerve agent GF and its combined form with sarin (GB/GF) in mice. Efficacy of Jielin Injection, the 2-PAM-containing antidote used successfully in China for the treatment of organophosphate pesticide poisoning, was also evaluated and compare...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(97)00057-x

    authors: Luo C,Liang J

    更新日期:1997-08-22 00:00:00

  • Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.

    abstract::Stable and specific biomacromolecular adducts can be used to measure in vivo doses of reactive compounds. An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (±)-anti-BP-7,8-diol-9,10-epoxide ((±)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.09.019

    authors: Westberg EA,Singh R,Hedebrant U,Koukouves G,Souliotis VL,Farmer PB,Segerbäck D,Kyrtopoulos S,Törnqvist MÅ

    更新日期:2015-01-05 00:00:00

  • Defining critical periods for itraconazole-induced cleft palate, limb defects and axial skeletal malformations in the mouse.

    abstract::The main aim of the study was to identify the critical periods of susceptibility for itraconazole-mediated teratogenesis in the mouse. Pregnant ICR (CD-1) mice received a single oral administration of itraconazole at 50 mg/kg b.w., 150 mg/kg b.w. or 250 mg/kg b.w. on gestation day 8, 9, 10, 11 or 12. Control animals w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2006.08.004

    authors: Tiboni GM,Marotta F,Del Corso A,Giampietro F

    更新日期:2006-11-01 00:00:00

  • Chilli extract treatment and induction of eye lesions in hamsters.

    abstract::On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90002-5

    authors: Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

    更新日期:1985-10-01 00:00:00

  • The BH3 mimetic compound BH3I-1 impairs mitochondrial dynamics and promotes stress response in addition to its pro-apoptotic key function.

    abstract::BH3 mimetics, such as BH3I-1, act as Bcl-2 antagonists, promote apoptosis and are used in basic research studies on apoptotic signaling and are currently tested as experimental anti-tumor agents. The present study addresses time- and dose-dependent responses of BH3I-1 on apoptosis, cellular stress defense mediated by ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.07.017

    authors: Stucki D,Brenneisen P,Reichert AS,Stahl W

    更新日期:2018-10-01 00:00:00

  • The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells.

    abstract::Polyhexamethylene guanidine (PHMG) phosphate is a competitive disinfectant with strong antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths of many people, including infants and pregnant w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.01.005

    authors: Kim HR,Shin DY,Chung KH

    更新日期:2015-03-04 00:00:00

  • General 4-week toxicity study with EMS in the rat.

    abstract::In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.04.031

    authors: Pfister T,Eichinger-Chapelon A

    更新日期:2009-11-12 00:00:00

  • Urinary N-acetyl-beta-D-glucosaminidase and beta 2-microglobulin in 'itai-itai' disease.

    abstract::N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90193-5

    authors: Nogawa K,Yamada Y,Honda R,Tsuritani I,Ishizaki M,Sakamoto M

    更新日期:1983-05-01 00:00:00

  • The relationship between itai-itai disease among inhabitants of the Jinzu River basin and cadmium in rice.

    abstract::Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90236-9

    authors: Nogawa K,Yamada Y,Honda R,Ishizaki M,Tsuritani I,Kawano S,Kato T

    更新日期:1983-07-01 00:00:00

  • Skin absorption of aniline from aqueous solutions in man.

    abstract::The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous soluti...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90231-4

    authors: Baranowska-Dutkeiwicz B

    更新日期:1982-03-01 00:00:00

  • Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.

    abstract::Low concentrations of arachidonic acid monoepoxides protect against ischemia/reperfusion injury. This study examined whether low concentrations of the linoleic acid monoepoxide, cis-12,13-epoxy-9-octadecenoic acid (12,13-EOA), protect renal cells against decreases in mitochondrial and transport functions induced by hy...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2003.11.002

    authors: Nowak G,Grant DF,Moran JH

    更新日期:2004-03-01 00:00:00

  • A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromatase.

    abstract::In this study we evaluated the rat Leydig cell carcinoma cell line R2C and the human adrenocorticocarcinoma cell line H295R for their suitability as in vitro screening tools for potential interference of xenobiotics with aromatase activity. A 24h exposure to prochloraz (PRO), fadrozole (FAD) and epoxyconazole (EPO) re...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2003.10.002

    authors: Heneweer M,van den Berg M,Sanderson JT

    更新日期:2004-01-15 00:00:00