Abstract:
:The distribution and acute lethality of i.v. administered 3 micrometers latex spheres were determined in rats. The results extend previous studies demonstrating the similarity between dog and rat in the dynamics of microspheres in these species and the inverse relationship between sphere diameter and hemodynamic toxicity. The results suggest that 3 micrometers spheres may be safe imaging agents or drug delivery systems for spleen and liver when administered slowly. Acute hemodynamic toxicity appears to be a function of the total volume of the spheres injected.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Yokel RA,Sabo JP,Simmons GH,DeLuca PPdoi
10.1016/0378-4274(81)90035-7subject
Has Abstractpub_date
1981-10-01 00:00:00pages
165-70issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(81)90035-7journal_volume
9pub_type
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journal_title:Toxicology letters
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abstract::Chlorpyrifos (CHP), an OP-based pesticide, induces hypothermia in the rat followed by a fever that persists for several days. The cytokine, tumor necrosis factor-alpha (TNF), is induced by lipopolysaccharide (LPS) and released during fever and has both pyrogenic and cryogenic (i.e. antipyretic) properties. Administeri...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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abstract::Gaseous butadiene (BUT) was mutagenic towards S. typhimurium strain TA 1530 when the incubation mixture was supplemented with a NADPH-fortified rat liver microsomal preparation; mutagenicity increased with the dose. A significant mutagenic effect was similarly observed when the petri dishes, containing the bacteria bu...
journal_title:Toxicology letters
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更新日期:1980-08-01 00:00:00
abstract:UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....
journal_title:Toxicology letters
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journal_title:Toxicology letters
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abstract::Molecular epidemiologic research involves the identification of relations between previous exposure to some putative causative agent and subsequent biological effects in a cluster of individuals in populations. There is intensive current research in the field of molecular epidemiology, and this research has a direct i...
journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2013-05-23 00:00:00
abstract::Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
abstract::Intraperitoneal (i.p.) and intravenous (i.v.) injection of 44Ti in a chloride solution into mice produced no detectable translocation in body fluids. There was no obvious interorgan exchange up to 16 days after injection. The whole body biological retention half-lives had a mean of 642 days for both routes, another in...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1980-07-01 00:00:00
abstract::The transition metal cadmium (Cd) is an environmental pollutant which damages the kidneys. Chronic Cd exposure may induce renal fibrosis and/or cancer, but the signaling pathways involved are not understood. The Wnt pathway is a key signaling cascade responsible for renal development, fibrosis and cancer. Hence the ef...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.05.007
更新日期:2010-09-15 00:00:00
abstract::Iron is a unique poison because it is not a xenobiotic. It is an essential element and highly reactive. Because of the critical dependence upon iron and its potential to damage tissues, elaborate mechanisms have evolved for its efficient absorption, transport, cellular uptake, storage and conservation. These are incom...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1998-12-28 00:00:00
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journal_title:Toxicology letters
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更新日期:2002-07-21 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(99)00107-1
更新日期:1999-09-05 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2020-05-15 00:00:00
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journal_title:Toxicology letters
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更新日期:1995-11-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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更新日期:2002-12-15 00:00:00
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journal_title:Toxicology letters
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更新日期:2010-08-16 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.07.896
更新日期:2018-04-01 00:00:00
abstract::Glutathione (GSH) levels, glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) as antioxidant defense system were evaluated in CHO-K1 cells after beauvericin (BEA) exposure. The effect of N-acetyl-cysteine (NAC) pre-treatment was assessed. GSH levels significantly decrease 18% a...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.02.023
更新日期:2014-05-02 00:00:00
abstract::Perfluorooctanoic acid (PFOA) is a stable man-made compound with many industrial and commercial uses. Recently, however, concern has been raised that it may induce various toxicological effects such as hepatotoxicity, immunotoxicity, and developmental toxicity. Because levels of circulating microRNAs (miRNAs) can be a...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.10.017
更新日期:2014-01-03 00:00:00
abstract::CYP2E1 metabolizes 1,3-butadiene (BD) into genotoxic and possibly carcinogenic 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol (EB-diol). The dose response of DNA and protein adducts derived from BD metabolites increases linearly at low BD exposures and then saturates at higher expos...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.08.025
更新日期:2013-11-25 00:00:00
abstract::Modulation of the cytochrome P450 (CYP) monooxygenase system by cadmium was investigated in male, adult DBA/2J mice treated with a single dose (16 micromol/kg body weight, i.p.) of cadmium chloride (CdCl2). Total CYP content of liver and kidney microsomes decreased maximally (56% and 85%, respectively) 24 and 18 h, re...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2003.10.029
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abstract::Benzophenone-3 (2-hydroxy-4-methoxybenzophenone, BZ-3) is a UV absorber that is used extensively in medicine, cosmetics and industry as a sunscreen and color fastener. Exposure to the chemical is through the dermal and oral route. Bioavailability of the chemical absorbed through the skin is different from that seen th...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90101-5
更新日期:1994-08-01 00:00:00
abstract::Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute and long term pathological consequences are observed in the lung following a single exposure to these vesicants. Evidence from our laboratorie...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/j.toxlet.2015.10.011
更新日期:2016-02-26 00:00:00
abstract::1,2-Dioxetanes, very reactive and high energy molecules, are involved as labile intermediates in dioxygenase-activated aerobic metabolism and in physiological processes. Various toxicological tests reveal that dioxetanes are indeed genotoxic. In supercoiled DNA of bacteriophage PM2 they induce endonuclease-sensitive s...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(93)90045-y
更新日期:1993-04-01 00:00:00
abstract::Benzene is a human leukemogen, and a bone marrow toxin and carcinogen in experimental animals. The reactive intermediates involved in benzene toxicity and their mechanism(s) of action have not been clearly delineated. We have investigated the clastogenic and cytotoxic effects of trans,trans-muconaldehyde (MUC), a reac...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00340-x
更新日期:2001-05-19 00:00:00