Abstract：
:The availability of different chemical forms of mercury (Hg) was studied in primary cultures of rat hepatocytes incubated with mercuric acetate (HgAc), mercuric diethyldithiocarbamate (Hg(DTC)2) or methyl mercuric chloride (MeHgCl), labelled with 203Hg. The uptake of Hg was linearly related to the concentration in the medium and increased in the order Hg(DTC)2 greater than MeHgCl greater than HgAc when similar concentrations of Hg were used. A maximum concentration of Hg was reached after 4 h incubation with Hg(DTC)2 while incubation with HgAc and MeHgCl resulted in a slow continuous accumulation of Hg for up to 24 h. Hg added as HgAc was bound to proteins in the incubation medium to a greater extent than Hg added as Hg(DTC)2 or MeHgCl. Differences in affinity to the medium, as well as in lipophilicity, may partly explain the observed differential uptake of these Hg compounds. The enzyme alcohol dehydrogenase was inhibited by HgAc and Hg(DTC)2 to a similar extent at comparable cellular concentrations of Hg. On the other hand, glutathione reductase was inhibited to a higher degree by HgAc than by Hg(DTC)2, indicating that Hg(DTC)2 remains at least temporarily in the complexed form and that the enzyme is less susceptible to Hg in this form. Both enzymes were much less susceptible to MeHgCl than to HgAc or Hg(DTC)2. The results from the present study indicate that diethyldithiocarbamate can increase the transport of Hg across the cellular membrane by complex formation with Hg and thereby increase the toxicity of Hg.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Hellström-Lindahl E,Oskarsson Adoi
10.1016/0378-4274(89)90105-7subject
Has Abstractpub_date
1989-10-01 00:00:00pages
87-98issue
1eissn
0378-4274issn
1879-3169pii
0378-4274(89)90105-7journal_volume
49pub_type
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更新日期：1986-01-01 00:00:00
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更新日期：1997-01-15 00:00:00
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journal_title：Toxicology letters
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更新日期：1998-12-28 00:00:00
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pub_type： 杂志文章
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journal_title：Toxicology letters
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更新日期：2018-06-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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更新日期：2001-09-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2012-05-05 00:00:00
abstract：:Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(87)90083-x
更新日期：1987-01-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.03.002
更新日期：2012-06-01 00:00:00
abstract：:Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2005-12-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：1995-12-01 00:00:00
abstract：:When cells from the human cell line NHIK3025 were cultured for 4 days, with hexavalent chromium (K2Cr2O7) at a concentration of 8 . 10(-7)M, the relative cell number was reduced to 38%. This effect of hexavalent chromium was abolished if ascorbic acid and chromate were added simultaneously to the incubation medium, bu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90146-1
更新日期：1982-09-01 00:00:00
abstract：:The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respective...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90058-6
更新日期：1988-06-01 00:00:00
abstract：:Triptolide (TP) is the main ingredient of Chinese herb Tripterygium wilfordii Hook f. (TWHF). Despite of its multifunction in pharmaceutics, accumulating evidences showed that TP caused obvious hepatotoxicity in clinic. The current study investigated the role of Notch1 signaling in TP-induced hepatotoxicity. Our data ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.10.024
更新日期：2019-01-01 00:00:00
