Abstract:
:Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute and long term pathological consequences are observed in the lung following a single exposure to these vesicants. Evidence from our laboratories and others suggest that macrophages and the inflammatory mediators they release play an important role in mustard-induced lung injury. In this paper, the pathogenic effects of SM and NM on the lung are reviewed, along with the potential role of inflammatory macrophages and mediators they release in mustard-induced pulmonary toxicity.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Malaviya R,Sunil VR,Venosa A,Vayas KN,Heck DE,Laskin JD,Laskin DLdoi
10.1016/j.toxlet.2015.10.011subject
Has Abstractpub_date
2016-02-26 00:00:00pages
2-7eissn
0378-4274issn
1879-3169pii
S0378-4274(15)30074-6journal_volume
244pub_type
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