Glutathione S-transferase cytosolic isoforms as biomarkers of polychlorinated biphenyl (Arochlor-1254) experimental contamination in rainbow trout.

abstract：:A wholesomeness feeding study was carried out in mice fed equal amounts of cod or redfish, comprising 45% of the diet. Three groups of animals received either irradiated [1.75 kGy (175 krad)] fish, non-irradiated fish or stock ration. A 90-day subchronic study, a multigeneration reproduction, a dominant lethality and ...

journal_title：Toxicology letters

authors： van Petten LE,Calkins JE,McConnell RF,Gottschalk HM,Elias PS

更新日期：1980-12-01 00:00:00

abstract：:The toxic mechanism of endosulfan, a widely used organochlorine pesticide, was investigated in Saccharomyces cerevisiae and human cell lines. A concentration-dependent inhibition of cell growth was observed when S. cerevisiae was exposed to endosulfan, and its cytotoxicity (IC(50)) was found to be 49 microM and 86 mic...

journal_title：Toxicology letters

authors： Sohn HY,Kwon CS,Kwon GS,Lee JB,Kim E

更新日期：2004-07-15 00:00:00

abstract：:Overexposure to manganese (Mn) has been known to induce neuronal death and neurodegenerative symptoms. However, the precise mechanisms underlying Mn neurotoxicity remain incompletely understood. In the present study, we established a Mn-exposed rat model and found that downregulation of wild type p53-induced phosphata...

journal_title：Toxicology letters

authors： Ma X,Han J,Wu Q,Liu H,Shi S,Wang C,Wang Y,Xiao J,Zhao J,Jiang J,Wan C

更新日期：2015-05-19 00:00:00

abstract：:Generally recognized as safe (GRAS), a system for review and approval of ingredients for addition to food, was conceived at a time when the need for a less doctrinaire review of food ingredients was critical. The GRAS approval process for a food ingredient relies on the judgment of "...experts qualified by scientific ...

journal_title：Toxicology letters

authors： Burdock GA,Carabin IG

更新日期：2004-04-15 00:00:00

abstract：:In order to assess the applicability of the micronucleus (MN) and G2 assays as biomarkers of in vitro radiosensitivity and cancer susceptibility, we investigated the inter- and intra-individual variation of these endpoints. For the MN assay unstimulated blood cultures from 57 healthy donors were exposed in vitro to 3....

journal_title：Toxicology letters

authors： Vral A,Thierens H,Baeyens A,De Ridder L

更新日期：2004-04-01 00:00:00

abstract：:Cocaine remains a widely abused substance. While most addicts take cocaine intranasally, a considerable number abuse cocaine by mouth. It has been assumed that after oral exposure cocaine is hydrolyzed in the stomach rendering it ineffective. This study investigated the effect of orally administered cocaine on liver f...

journal_title：Toxicology letters

authors： Labib R,Turkall R,Abdel-Rahman MS

更新日期：2001-12-15 00:00:00

abstract：:Oleanolic acid is a triterpenoid compound that has been shown to protect against liver injury produced by some hepatotoxicants. This study was designed to characterize the protective effects of oleanolic acid on carbon tetrachloride-induced hepatotoxicity, and the role of metallothionein in the protection. Oleanolic a...

journal_title：Toxicology letters

authors： Liu Y,Hartley DP,Liu J

更新日期：1998-03-31 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00

abstract：:Apoptosis is a type of programmed cell death involved in growth control of tissues. It is considered as a cellular suicide functionally opposite to mitosis. It may serve to remove "unwanted" damaged or dangerous, e.g. precancerous, cells. Chemical compounds can interfere with the regulatory network which controls apop...

journal_title：Toxicology letters

authors： Schulte-Hermann R,Bursch W,Kraupp-Grasl B,Oberhammer F,Wagner A

更新日期：1992-12-01 00:00:00

abstract：:Induction of endotoxin tolerance in rats led to reductions in bile flow and BSP excretion. BSP serum retention or storage of BSP in the liver was not affected. Although serum alanine aminotransferase (ALT) activity was slightly elevated in endotoxin-tolerant rats, the levels of serum aspartate amino-transferase (AST) ...

journal_title：Toxicology letters

authors： Boelsterli UA,Abernathy CO,Balazs T,Zimmerman HJ

更新日期：1982-05-01 00:00:00

abstract：:Cyanobacteria ("blue-green algae"), such as Oscillatoria sp., are a ubiquitous group of bacteria found in freshwater systems worldwide that are linked to illness and in some cases, death among humans and animals. Exposure to cyanobacteria occurs via ingestion of contaminated water or food-products. Exposure of the gut...

journal_title：Toxicology letters

authors： Swanson-Mungerson M,Incrocci R,Subramaniam V,Williams P,Hall ML,Mayer AMS

更新日期：2017-06-05 00:00:00

abstract：:Accumulation of N2-(trans-isoestragol-3'-yl)-2'-deoxyguanosine (E-3'-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficient. To this end human HepaRG cells were exposed to repeating cycles of 2 h e...

journal_title：Toxicology letters

authors： Yang S,Wesseling S,Rietjens IMCM

更新日期：2021-02-01 00:00:00

abstract：:Melamine can cause urinary stones related to nephropathy of the kidney and hyperplasia or carcinoma of the bladder, but the mechanism of stone formation is not well understood. In this study, male rats were administered melamine for thirteen weeks to establish melamine bladder stone models and the stones were analysed...

journal_title：Toxicology letters

authors： Liu JD,Liu JJ,Yuan JH,Tao GH,Wu DS,Yang XF,Yang LQ,Huang HY,Zhou L,Xu XY,Hu JJ,Zhuang ZX

更新日期：2012-08-03 00:00:00

abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

journal_title：Toxicology letters

authors： Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

更新日期：2006-03-01 00:00:00

abstract：:Spontaneous and mitomycin C-induced sister chromatid exchanges (SCEs) in lymphocytes were analyzed in 24 non-smokers and 24 sex- and age-matched smokers. Mean spontaneous SCE frequency for non-smokers was 9.8 SCEs/cell, and that for smokers was 11.5 SCEs/cell. The difference was statistically significant (P less than ...

journal_title：Toxicology letters

authors： Nagaya T,Toriumi H

更新日期：1985-06-01 00:00:00

abstract：:Triphenyltin (TPT) is an organotin compound and may be an endocrine disruptor, impairing the male reproductive system. However, the effect of short-term TPT exposure on stem Leydig cell regeneration later on remains unknown. Here, we show that TPT affects stem Leydig cell regeneration in the adult rat testis. Adult ma...

journal_title：Toxicology letters

authors： Ni C,Fang Y,Chen X,Wu K,Li H,Wang Y,Zhenkun L,Lian Q,Ge RS

更新日期：2019-05-15 00:00:00

abstract：:Combined effects of mycotoxin mixtures are of major concern due to the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon the fu...

journal_title：Toxicology letters

authors： Tammer B,Lehmann I,Nieber K,Altenburger R

更新日期：2007-04-25 00:00:00

abstract：OBJECTIVES:Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as reactivation can be anticipated. An obidoxime plasma level i...

journal_title：Toxicology letters

authors： Thiermann H,Eyer F,Felgenhauer N,Pfab R,Zilker T,Eyer P,Worek F

更新日期：2010-09-01 00:00:00

abstract：:Furocoumarins are a group of natural products with many biological activities. Clinical evidences have demonstrated the important contribution of furocoumarins to the toxicity of some foods and herbs. In order to assess liver and kidney toxicity of furocoumarins, male mice were orally administrated with psoralen, isop...

journal_title：Toxicology letters

authors： Wang X,Lou YJ,Wang MX,Shi YW,Xu HX,Kong LD

更新日期：2012-02-25 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors have recently emerged as a new class of anti-cancer agents. Trichostatin A (TSA), a classical HDAC inhibitor, has been demonstrated to induce cell cycle arrest, promote cell apoptosis, and inhibit metastasis. However, the molecular mechanism underlying TSA function has not been fu...

journal_title：Toxicology letters

authors： Liu Y,He G,Wang Y,Guan X,Pang X,Zhang B

更新日期：2013-07-31 00:00:00

abstract：:Epidemiological investigations indicate that effects related to prenatal adverse environments on the organs of the offspring could continue to adulthood. This study intends to confirm that prenatal nicotine exposure (PNE) increases the susceptibility of osteoarthritis (OA) in the male offspring, and to explore the pot...

journal_title：Toxicology letters

authors： Chen B,Lu KH,Ni QB,Li QX,Gao H,Wang H,Chen LB

更新日期：2019-10-10 00:00:00

abstract：:The acute toxicity of organothiophosphate insecticides like parathion results from their metabolic activation by cytochromes P450. The present study is directed towards the characterization of cytochrome-P450-dependent metabolism of parathion by various mouse brain regions. Intraperitoneal administration of [35S]parat...

journal_title：Toxicology letters

authors： Soranno TM,Sultatos LG

更新日期：1992-01-01 00:00:00

abstract：:A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with...

journal_title：Toxicology letters

authors： Naganuma A,Satoh M,Koyama Y,Imura N

更新日期：1985-02-01 00:00:00

abstract：:The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...

journal_title：Toxicology letters

authors： Yamada YK,Shimizu F,Kawamura R,Kubota K

更新日期：1981-04-01 00:00:00

abstract：:Methylglyoxal (MG) is a metabolite of glucose. The serum MG level is increased in diabetic patients, and MG is implicated in diabetic complications related to embryonic development injury. We previously reported cytotoxic effects of MG on mouse embryonic stem cells and blastocysts, and a further association with defec...

journal_title：Toxicology letters

authors： Chang YJ,Chan WH

更新日期：2010-04-01 00:00:00

abstract：:Shikonin, a natural red colorant, is widely used for food garnishment and cosmetic ingredient in the world. Shikonin also possesses a variety of pharmacological actions, including anti-inflammation and anti-cancer activities. However, little is known about its effects on the UDP-glucuronosyltransferases (UGT) activity...

journal_title：Toxicology letters

authors： Cheng Y,Tang S,Chen A,Zhang Y,Liu M,Wang X

更新日期：2019-09-15 00:00:00

abstract：:Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds....

journal_title：Toxicology letters

authors： Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon P

更新日期：2014-03-03 00:00:00

abstract：:The alpha(2)-adrenoceptor antagonist yohimbine is known to interact with the effects of opioid receptor agonists in vivo, and thus could modulate the action of morphine-like analgesics. The focus of the present work was to further study these interactions in a cell culture endowed with opioid and alpha(2)-adrenoceptor...

journal_title：Toxicology letters

authors： Polanco MJ,Alguacil LF,Albella B,Segovia JC,González-Martín C

更新日期：2009-09-10 00:00:00

abstract：:Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-...

journal_title：Toxicology letters

authors： Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

更新日期：2021-01-08 00:00:00

abstract：:In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible tools for predicting the toxicity of chemicals when little or no empirical data are available. A fundamental understanding of toxicological principles has been considered an important com...

journal_title：Toxicology letters

authors： Bradbury SP

更新日期：1995-09-01 00:00:00