当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > Determinants of occupational exposure to metals by gas metal arc welding and risk management measures: a biomonitoring study.

Determinants of occupational exposure to metals by gas metal arc welding and risk management measures: a biomonitoring study.

Abstract：

:Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium sized enterprises of a biomonitoring strategy based on urine spot-samples, to characterize the factors influencing the internal doses of metals in gas metal arc welders and to recommend effective risk management measures. 137 welders were recruited and urinary levels of metals were measured by ICP-MS on post-shift samples collected at the end of the working week. Cr, Ni and Mn mean concentrations (respectively 0.43, 1.69 and 0.27 μg/g creatinine) were well below occupational health guidance values, but still higher than background levels observed in the general population, confirming the absorption of metals generated in welding fumes. Both welding parameters (nature of base metal, welding technique) and working conditions (confinement, welding and grinding durations, mechanical ventilation and welding experience) were predictive of occupational exposure. Our results confirm the interest of biomonitoring for assessing health risks and recommending risk management measures for welders.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Persoons R,Arnoux D,Monssu T,Culié O,Roche G,Duffaud B,Chalaye D,Maitre A

doi

10.1016/j.toxlet.2014.09.008

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

135-41

issue

2

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(14)01342-3

journal_volume

231

pub_type

杂志文章

相关文献

TOXICOLOGY LETTERS文献大全
  • Molecular biology of insecticide resistance.

    abstract：:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechani...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(95)03470-6

    authors： Feyereisen R

    更新日期：1995-12-01 00:00:00

  • Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring.

    abstract：:The exposure to cuprizone (CPZ) leads to demyelination in the central nervous system in rodents. To examine the developmental effects of CPZ exposure on hippocampal neurogenesis, pregnant rats were treated with 0, 0.1 or 0.4% CPZ in the diet from gestational day 6 to day 21 after delivery. On postnatal day 21, male of...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2015.01.022

    authors： Abe H,Tanaka T,Kimura M,Mizukami S,Imatanaka N,Akahori Y,Yoshida T,Shibutani M

    更新日期：2015-05-05 00:00:00

  • Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.

    abstract：:Aluminum phosphide (AlP), a widely used fumigant and rodenticide leads to high mortality if ingested. Its toxicity is due to phosphine liberated when it comes in contact with moisture. The exact mechanism of action of phosphine is not known. In this study male Wistar rats were used. The animals received a single dose ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2012.09.020

    authors： Anand R,Kumari P,Kaushal A,Bal A,Wani WY,Sunkaria A,Dua R,Singh S,Bhalla A,Gill KD

    更新日期：2012-11-23 00:00:00

  • Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects.

    abstract：:Particulate air pollution is associated with cardiovascular morbidity and mortality. Fine particles with a diameter <2.5 microm (PM2.5) have an important role in triggering biological responses. These particles, and particularly the ultrafine fraction (<100 nm) penetrate deeply into the respiratory tract. Recently, we...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2003.12.061

    authors： Nemmar A,Hoylaerts MF,Hoet PH,Nemery B

    更新日期：2004-04-01 00:00:00

  • Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins.

    abstract：:Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2009.07.029

    authors： Scheri RC,Lee J,Barofsky DF,Curtis LR

    更新日期：2009-12-01 00:00:00

  • Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice.

    abstract：:Lithocholic acid (LCA) supplementation in the diet results in intrahepatic cholestasis and bile infarcts. Previously we showed that an innate immune response is critical for cholestatic liver injury in the bile duct ligated mice. Thus, the purpose of this study was to investigate the role of neutrophils in the mechani...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.04.001

    authors： Woolbright BL,Li F,Xie Y,Farhood A,Fickert P,Trauner M,Jaeschke H

    更新日期：2014-07-03 00:00:00

  • Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles.

    abstract：:A comparison of the effects produced by size-fractionated tire particles (TP10 and TP2.5) and similar-sized urban particulate matter (PM10 and PM2.5), collected in Milan in 2007, on the lungs of mice has been performed. The focus is on early acute lung responses following intratracheal instillation of aerosolized part...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2010.07.002

    authors： Mantecca P,Farina F,Moschini E,Gallinotti D,Gualtieri M,Rohr A,Sancini G,Palestini P,Camatini M

    更新日期：2010-10-05 00:00:00

  • The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary.

    abstract：:Toxicity of a compound for an organism is dependent on the route of exposure, the amount (or concentration), the way in which the compound is taken up, distributes and is eliminated from the organism (ADME, kinetics) and the intrinsic properties (reactivity; mode of action, dynamics) of the compound towards the organi...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-4274(02)00367-3

    authors： Blaauboer BJ

    更新日期：2003-02-18 00:00:00

  • Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release.

    abstract：:High mobility group box 1 (HMGB1) is a DNA-binding protein that is abundantly expressed in most tissues. Recently, HMGB1 has gained much attention for its regulation of immunity and inflammation. Yet its role in toluene diisocyanate (TDI)-induced asthma still remains poorly characterized. In this study, mice were sens...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2015.08.1108

    authors： Yao L,Zhao H,Tang H,Song J,Dong H,Zou F,Cai S

    更新日期：2015-11-19 00:00:00

  • DBP-induced endoplasmic reticulum stress in male germ cells causes autophagy, which has a cytoprotective role against apoptosis in vitro and in vivo.

    abstract：:Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2016.01.016

    authors： Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

    更新日期：2016-03-14 00:00:00

  • Effects of selenium on toxicity and ultrastructural localization of mercury in cultured murine macrophages.

    abstract：:The effects of selenium on cellular toxicity and histochemical distribution of mercury were examined in a cell culture system of mouse peritoneal macrophages. Selenium protected against the toxicity of mercury in cultures exposed to 4 microM of mercuric chloride. Selenomethionine caused a significant increase in cell ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(89)90144-6

    authors： Christensen M,Rungby J,Mogensen SC

    更新日期：1989-06-01 00:00:00

  • Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells.

    abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2005.10.002

    authors： Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

    更新日期：2006-03-01 00:00:00

  • Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid.

    abstract：:Previous studies indicated that the enantiomers of thalidomide and its analogue EM12 exhibit differing teratogenic potencies. Unfortunately, these substances proved to be unstable and racemised considerably, so that the intrinsic teratogenic potencies of the pure enantiomers were difficult to elucidate. We have theref...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(89)90099-4

    authors： Hauck RS,Nau H

    更新日期：1989-10-01 00:00:00

  • A comparative study of leukaemia inhibitory factor and interleukin-1alpha intracellular content in a human keratinocyte cell line after exposure to cosmetic fragrances and sodium dodecyl sulphate.

    abstract：:According to European laws animal testing in cosmetic industry will be prohibited in a few years and it will be replaced by alternative methods based on cell and tissue culture. Many ingredients of cosmetic formulations are potentially causes of skin inflammation and sensibilization. Since cytotoxicity is known, among...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2009.10.013

    authors： Parodi A,Sanguineti R,Catalano M,Penco S,Pronzato MA,Scanarotti C,Bassi AM

    更新日期：2010-02-01 00:00:00

  • Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein.

    abstract：:Oleanolic acid is a triterpenoid compound that has been shown to protect against liver injury produced by some hepatotoxicants. This study was designed to characterize the protective effects of oleanolic acid on carbon tetrachloride-induced hepatotoxicity, and the role of metallothionein in the protection. Oleanolic a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(98)00009-5

    authors： Liu Y,Hartley DP,Liu J

    更新日期：1998-03-31 00:00:00

  • Acute iron overload leads to hypothalamic-pituitary-gonadal axis abnormalities in female rats.

    abstract：:Iron plays a critical role in a mammal's physiological processes. However, iron tissue deposits have been shown to act as endocrine disrupters. Studies that evaluate the effect of acute iron overload on hypothalamic-pituitary-gonadal (HPG) axis health are particularly sparse. This study demonstrates that acute iron ov...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2015.10.027

    authors： Rossi EM,Marques VB,Nunes Dde O,Carneiro MT,Podratz PL,Merlo E,dos Santos L,Graceli JB

    更新日期：2016-01-05 00:00:00

  • Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice.

    abstract：:The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effec...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(96)03671-5

    authors： Yamamoto H,Tang HW

    更新日期：1996-09-01 00:00:00

  • LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol.

    abstract：:Antioxidants of the vitamin E family have protective effects against metal toxicity. We examined the protective effect of racemic LLU-alpha [2,7,8-trimethyl-2-(carboxyethyl)-6-hydroxychroman] a metabolite of gamma-tocopherol, in comparison to the effect of alpha- and gamma-tocopherol in rats treated with sodium dichro...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(01)00368-x

    authors： Appenroth D,Karge E,Kiessling G,Wechter WJ,Winnefeld K,Fleck C

    更新日期：2001-07-06 00:00:00

  • Monitoring of pesticide applicators for potential dermal exposure to malathion and biomarkers in urine.

    abstract：:Malathion was applied to roses in three Finnish greenhouses by hand held lance sprayers. The potential dermal exposure of applicators to this insecticide was measured. Total urine production of each applicator was also collected up to 24 h post application. In the urine samples the specific metabolite of malathion, ma...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(02)00181-9

    authors： Tuomainen A,Kangas JA,Meuling WJ,Glass RC

    更新日期：2002-08-05 00:00:00

  • HIV-1 antiretrovirals induce oxidant injury and increase intima-media thickness in an atherogenic mouse model.

    abstract：:A growing body of evidence suggests HIV patients are at a greater risk for developing atherosclerosis. However, clinical investigations have generated conflicting results with regard to whether antiretrovirals are independently involved in the development of HIV-associated atherosclerosis. By administering antiretrovi...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2009.02.017

    authors： Jiang B,Hebert VY,Khandelwal AR,Stokes KY,Dugas TR

    更新日期：2009-06-22 00:00:00

  • T(H1)-directed modulation of in vitro cytokine production in human peripheral blood mononuclear cells by styrene-7.8-oxide.

    abstract：:Styrene and its chiral main metabolite styrene-7.8-oxide are well characterized regarding their cytotoxic, genotoxic and neurotoxic properties. To our knowledge, no data exist on the influence of styrene and styrene-7.8-oxide on immune reactions. Epidemiological studies suggest that exposure to environmental pollutant...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2005.06.014

    authors： Merker GH,Metzner G,Raabe F

    更新日期：2006-01-05 00:00:00

  • The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective.

    abstract：:The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of "omics" technologies into toxicological research, the question arises as to how sensitive these technologies are relative to classical regulatory toxicity parameters. BASF SE a...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.03.004

    authors： van Ravenzwaay B,Montoya GA,Fabian E,Herold M,Krennrich G,Looser R,Mellert W,Peter E,Strauss V,Walk T,Kamp H

    更新日期：2014-05-16 00:00:00

  • Determination of arsenic in urine by atomic absorption spectrophotometry for biological monitoring of occupational exposure to arsenic.

    abstract：:An atomic absorption spectrophotometric (AAS) method was successfully applied to analysis of urine for arsenic (As) as a measure of biological monitoring of occupational exposure to As in Vietnam. The application of the method to urine samples from 75 non-exposed control urbanites (after 2-day abstinence from sea food...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(99)00087-9

    authors： Dang TM,Tran QT,Vu KV

    更新日期：1999-09-05 00:00:00

  • Biologically based dose response model for hepatic toxicity: a mechanistically based replacement for traditional estimates of noncancer risk.

    abstract：:Uncertainty in risk assessment can be reduced by increasing the use of relevant data specific to the particular xenobiotic and exposed organism. We describe the development of a preliminary, mechanism-based exposure response model for chloroform hepatotoxicity consistig of toxicokinetic (TK) and toxicodynamic (TD) sub...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(95)03528-1

    authors： Conolly RB,Butterworth BE

    更新日期：1995-12-01 00:00:00

  • Prenatal administration of indomethacin modulates Th2 cytokines in juvenile rats.

    abstract：:Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investigate the mechanism behind the suppression of antibody production. IND ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2008.11.013

    authors： Kushima K,Sakuma S,Furusawa S,Fujiwara M

    更新日期：2009-02-25 00:00:00

  • Urinary mutagenicity after controlled exposure to environmental tobacco smoke (ETS).

    abstract：:20 non-smokers on a defined diet low in polycyclic aromatic hydrocarbons (PAH) were exposed to environmental tobacco smoke (ETS) in an unventilated room for 8 h. The urinary mutagenicity in the 24-h urine samples as tested with the Salmonella (TA98) microsome assay did not significantly increase after exposure to eith...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(87)90098-1

    authors： Scherer G,Westphal K,Biber A,Hoepfner I,Adlkofer F

    更新日期：1987-01-01 00:00:00

  • Currently available in vitro methods used in the regulatory toxicology.

    abstract：:About two decades ago in vitro mutagenicity tests were adopted as the first in vitro methods in regulatory toxicology. For reasons of animal welfare and better science, many validation studies of various in vitro methods were performed between 1985 and 1995 for their potential to replace the Draize eye irritation test...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-4274(01)00492-1

    authors： Liebsch M,Spielmann H

    更新日期：2002-02-28 00:00:00

  • The effects of n-alcohols on evoked synaptic potentials in rat hippocampal slices: Hill coefficients account for the cut-off phenomenon.

    abstract：:The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on th...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(00)00186-7

    authors： Takehana K,Hirota K,Roth SH,Masuda A,Ito Y

    更新日期：2000-05-19 00:00:00

  • Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.

    abstract：:The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2008.07.020

    authors： Yang ST,Wang X,Jia G,Gu Y,Wang T,Nie H,Ge C,Wang H,Liu Y

    更新日期：2008-10-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin up-regulates stathmin 1 in the eye: suggestive evidence for the involvement of stathmin 1 in accelerated eye opening in mice induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract：:When pregnant mice were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the average time to eye opening in the offspring was shortened by about a day. How acceleration of eye opening by TCDD occurs remains unknown. To reveal the underlying mechanisms of the accelerated eye opening, pregnant mice were intraperit...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2010.04.001

    authors： Gin DW,Kim HR,Lee DM,Lee SH,Seong AR,Hwang JA,Park JH

    更新日期：2010-07-01 00:00:00