Abstract:
:Changes in the activities of antioxidant enzymes superoxide dismutase, catalase (CAT), glutathione peroxidase and heme oxygenase (HO) and changes in lipid peroxidation and reduced glutathione (GSH) levels were measured in the livers of control and Lewis lung carcinoma (LLC)-bearing mice 24 h after a single injection of cisplatin or CoCl(2). Treatment with cisplatin induced the same degree of lipid peroxidation and GSH depletion as did CoCl(2) but the antioxidant enzymes were differently involved in cisplatin- and cobalt-induced oxidative stress responses. In cobalt-treated mice the activities of these enzymes were either inhibited or not changed significantly and only the HO activity was increased (5-fold) as a main protective enzyme. In cisplatin-treated animals the antioxidant enzymes were activated but the enhancement of HO and CAT was greater in LLC-inoculated mice. It is suggested that these two enzymes represent the protective response against cisplatin toxicity in the livers of tumor-bearing animals.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Christova TY,Gorneva GA,Taxirov SI,Duridanova DB,Setchenska MSdoi
10.1016/s0378-4274(02)00416-2keywords:
subject
Has Abstractpub_date
2003-03-03 00:00:00pages
235-42issue
3eissn
0378-4274issn
1879-3169pii
S0378427402004162journal_volume
138pub_type
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