Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma-bearing mice: protective role of heme oxygenase.

Abstract:

:Changes in the activities of antioxidant enzymes superoxide dismutase, catalase (CAT), glutathione peroxidase and heme oxygenase (HO) and changes in lipid peroxidation and reduced glutathione (GSH) levels were measured in the livers of control and Lewis lung carcinoma (LLC)-bearing mice 24 h after a single injection of cisplatin or CoCl(2). Treatment with cisplatin induced the same degree of lipid peroxidation and GSH depletion as did CoCl(2) but the antioxidant enzymes were differently involved in cisplatin- and cobalt-induced oxidative stress responses. In cobalt-treated mice the activities of these enzymes were either inhibited or not changed significantly and only the HO activity was increased (5-fold) as a main protective enzyme. In cisplatin-treated animals the antioxidant enzymes were activated but the enhancement of HO and CAT was greater in LLC-inoculated mice. It is suggested that these two enzymes represent the protective response against cisplatin toxicity in the livers of tumor-bearing animals.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Christova TY,Gorneva GA,Taxirov SI,Duridanova DB,Setchenska MS

doi

10.1016/s0378-4274(02)00416-2

keywords:

subject

Has Abstract

pub_date

2003-03-03 00:00:00

pages

235-42

issue

3

eissn

0378-4274

issn

1879-3169

pii

S0378427402004162

journal_volume

138

pub_type

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