Constitutive expression of the AHR signaling pathway in a bovine mammary epithelial cell line and modulation by dioxin-like PCB and other AHR ligands.

abstract：:Traditional Chinese medicine (TCM) has become a crucial cause of drug-induced liver injury (DILI). Differ from chemical medicines, TCM feature more complex and mostly indefinite components. This review aimed to clarify the classification, underlying mechanisms and targets of the risk components in TCM-induced liver in...

journal_title：Toxicology letters

authors： Pan X,Zhou J,Chen Y,Xie X,Rao C,Liang J,Zhang Y,Peng C

更新日期：2020-05-01 00:00:00

abstract：:Cisplatin, a widely used chemotherapeutic drug, causes ototoxicity in a large percentage of patients. The purpose of this study was to determine the efficacy of epicatechin (EC) as an otoprotective agent to prevent cisplatin toxicity and to investigate the molecular mechanism of EC. The effects of EC on cisplatin-indu...

journal_title：Toxicology letters

authors： Lee JS,Kang SU,Hwang HS,Pyun JH,Choung YH,Kim CH

更新日期：2010-12-15 00:00:00

abstract：:Spontaneous neoplasms in untreated control CD-1 mice (725 males and 725 females) used in carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were alveolar-bronchiolar adenomas (19.3%) followed by hepatocellular adenomas (11.0%), lymphoreticular neoplasms (6.8%), hepatocellular ...

journal_title：Toxicology letters

authors： Chandra M,Frith CH

更新日期：1992-06-01 00:00:00

abstract：:Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

journal_title：Toxicology letters

authors： Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

更新日期：2020-10-01 00:00:00

abstract：:At the present work, different groups of rainbow trouts have been intraperitoneally treated with a polychlorinated biphenyls commercial mixture (Arochlor-1254) at three doses (5, 20 and 70 mg PCBs/ kg body weight) and they have been sampled at 0 (injection moment), 3, 6 and 9 weeks after xenobiotic exposure. Purificat...

journal_title：Toxicology letters

authors： Pérez-López M,Nóvoa-Valiñas MC,Melgar-Riol MJ

更新日期：2002-12-15 00:00:00

abstract：:Short- and medium-term rodent bioassays have been proposed under ICH guidelines for use in testing for the carcinogenic potential of pharmaceuticals. Further evaluation of these models is needed urgently and coordinated efforts are in progress worldwide to expand the available database. Models currently being investig...

journal_title：Toxicology letters

authors： Storer RD

更新日期：2000-03-15 00:00:00

abstract：:Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mea...

journal_title：Toxicology letters

authors： Talaska G,Schamer M,Bailey JR,Ali SF,Scallet AC,Slikker W Jr,Paule MG

更新日期：1992-12-01 00:00:00

abstract：:Synthetic musks are present in fine fragrances, cosmetics, soaps and laundry detergents. One of the most important synthetic musks is 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydro-naphthaline+ ++ (AHTN; annual production: about 1500 metric tons). An increasing number of studies show that AHTN accumulates in surfa...

journal_title：Toxicology letters

authors： Steinberg P,Fischer T,Arand M,Park E,Elmadfa I,Rimkus G,Brunn H,Dienes HP

更新日期：1999-12-20 00:00:00

abstract：:Chloropicrin is an aliphatic volatile nitrate compound that is mainly used as a pesticide. It has several toxic effects in animals and can cause irritating and other health problems in exposed humans. Since the mode of chloropicrin action is poorly understood, the aim of this study was to investigate molecular respons...

journal_title：Toxicology letters

authors： Pesonen M,Pasanen M,Loikkanen J,Naukkarinen A,Hemmilä M,Seulanto H,Kuitunen T,Vähäkangas K

更新日期：2012-06-20 00:00:00

abstract：:Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

journal_title：Toxicology letters

authors： de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

更新日期：2020-05-15 00:00:00

abstract：:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...

journal_title：Toxicology letters

authors： Matsukura M,Koike K,Zon G

更新日期：1995-12-01 00:00:00

abstract：:In this work the in vitro reactions of phosphine with intact red blood cells and membrane-free hemoglobin extracts are reported. We demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreve...

journal_title：Toxicology letters

authors： Potter WT,Rong S,Griffith J,White J,Garry VF

更新日期：1991-06-01 00:00:00

abstract：:Female SWR mice were treated with 1,2-dimethylhydrazine (DMH: 6.8 mg/kg i.p. injection) once weekly for up to 10 weeks, a dosing regime that produced tumours principally within the distal colon (Jackson et al., 1999. Carcinogenesis 20, 509-513). O(6)-Methylguanine (O(6)-MeG) levels, measured using a simple [3H]-based ...

journal_title：Toxicology letters

authors： Jackson PE,Cooper DP,Meyer TA,Wood M,Povey AC,Margison GP

更新日期：2000-06-05 00:00:00

abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

journal_title：Toxicology letters

authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

更新日期：2017-08-05 00:00:00

abstract：:Tetrachloro-p-hydroquinone (TCHQ), the major metabolite of pentachlorophenol (PCP) in mammalian systems, is known to autoxidize to its semiquinone radical under physiological conditions. In this way, PCP could present a potent source of reactive oxygen species (ROS) during metabolization. ROS contribute to numerous mo...

journal_title：Toxicology letters

authors： Dahlhaus M,Almstadt E,Appel KE

更新日期：1994-12-01 00:00:00

abstract：:Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. In China, it has also been employed in herbal remedies for hepatitis and abdominal edema. Since E. milii latex--lyophilized or in natura--proved to be a potent plant molluscicide, its toxicity to non-target organisms has been comp...

journal_title：Toxicology letters

authors： Delgado IF,De-Carvalho RR,De-Oliveira AC,Kuriyama SN,Oliveira-Filho EC,Souza CA,Paumgartten FJ

更新日期：2003-11-30 00:00:00

abstract：:Citrinin (CIT), a fungal metabolite causing nephrotoxicity, has a tolerable daily intake (TDI) value of 0.2μg/kg bw. Contamination of food with CIT is not sufficiently known to allow dietary exposure assessment. Urinary biomonitoring data are available from cohorts of several countries. However, kinetic information is...

journal_title：Toxicology letters

authors： Degen GH,Ali N,Gundert-Remy U

更新日期：2018-01-05 00:00:00

abstract：:E-64d (a calpain and autophagy inhibitor) has previously been shown safe for the treatment of Alzheimer's disease in humans. In the present study, the potential protective mechanism of E-64d on hippocampal aberrant mossy fiber sprouting was examined in a developmental rat model of penicillin-induced recurrent epilepti...

journal_title：Toxicology letters

authors： Ni H,Ren SY,Zhang LL,Sun Q,Tian T,Feng X

更新日期：2013-02-27 00:00:00

abstract：:Although building constructions are a recurring part of urbanization, the health risk of particulate matters (PM) originating from such activities have seldom been subjected to detailed studies. We sought to characterize the relative risk of air borne PM collected from different heights (ground and top floor) of a bui...

journal_title：Toxicology letters

authors： Li H,Fang CH,Shi W,Gurusamy S,Li S,Krishnan MN,George S

更新日期：2015-11-04 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:Aromatic amines are metabolically activated into mutagenic compounds by both animal and plant systems. The 4-nitro-o-phenylenediamine (NOP) is a well-known direct-acting mutagen whose mutagenic potential can be enhanced by plant metabolism; m-phenylenediamine (m-PDA) is converted to mutagenic products detected by the ...

journal_title：Toxicology letters

authors： Cortés-Eslava J,Gómez-Arroyo S,Villalobos-Pietrini R,Espinosa-Aguirre JJ

更新日期：2004-11-02 00:00:00

abstract：:The polychlorinated biphenyls (PCBs) have been demonstrated to be inducers of hepatic microsomal enzymes and some of their effects such as hormonal imbalance, and alteration of lipid and porphyrin metabolism could be ascribed to this mechanism. For this reason, the urinary excretion of D-glucaric acid (DGA), an indire...

journal_title：Toxicology letters

authors： Apostoli P,Mangili A,Carasi S,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Many xenobiotics and carcinogens are oxidized in vitro by prostaglandin-H synthase (PHS) in the presence of arachidonic acid or lipid peroxides. PHS has been suggested to serve as an alternative metabolic activation enzyme to the cytochrome P-450 isoenzymes, particularly in tissues low in monooxygenase activity. This ...

journal_title：Toxicology letters

authors： Degen GH

更新日期：1993-04-01 00:00:00

abstract：:In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

journal_title：Toxicology letters

authors： Pfister T,Eichinger-Chapelon A

更新日期：2009-11-12 00:00:00

abstract：:The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effec...

journal_title：Toxicology letters

authors： Yamamoto H,Tang HW

更新日期：1996-09-01 00:00:00

abstract：:Humans are typically exposed to mixtures of substances, whereby their bioactivity can be significantly altered by co-occurring compounds. Thus, over the last years, research on combinatory effects has gained increasing attention. In particular, several xenoestrogens have been recently reported to interact synergistica...

journal_title：Toxicology letters

authors： Aichinger G,Pantazi F,Marko D

更新日期：2020-02-01 00:00:00

abstract：:The study aimed to investigate the effects of egg white hydrolysate (EWH) on vascular disorders induced by mercury (Hg). For this, male Wistar rats were treated for 60days: Untreated (saline, i.m.); Mercury (HgCl2, i.m., 1st dose 4.6μg/kg, subsequent doses 0.07μg/kg/day); Hydrolysate (EWH, gavage, 1g/kg/day); Hydrolys...

journal_title：Toxicology letters

authors： Rizzetti DA,Martín Á,Corrales P,Fernandez F,Simões MR,Peçanha FM,Vassallo DV,Miguel M,Wiggers GA

更新日期：2017-11-05 00:00:00

abstract：:Cimetidine, a widely prescribed, potent histamine H2-receptor antagonist, is unrelatedly a mild antiandrogen. Since perinatal androgens are essential for normal masculine imprinting, we wanted to determine if maternally administered cimetidine interfered with the development of the male offspring's sex-dependent, hepa...

journal_title：Toxicology letters

authors： Shapiro BH,Bitar MS

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosi...

journal_title：Toxicology letters

authors： Jiang R,Zhou Z,Liao Y,Yang F,Cheng Y,Huang J,Wang J,Chen H,Zhu T,Chao J

更新日期：2019-06-01 00:00:00

abstract：:Arsenic (As), a ubiquitous toxic metal, is an important environmental and industrial pollutant throughout the world. Inorganic As (iAs) is usually more harmful than organic ones and with a high risk of diabetes incidence by exposure. However, the toxicological effects of iAs on growth and function of pancreatic β-cell...

journal_title：Toxicology letters

authors： Lu TH,Su CC,Chen YW,Yang CY,Wu CC,Hung DZ,Chen CH,Cheng PW,Liu SH,Huang CF

更新日期：2011-02-25 00:00:00