Abstract：
:The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effect of melatonin against potassium cyanide-induced seizures was dose dependent. The LD50 value of potassium cyanide, based on 24-h mortality, was also significantly increased by 1.3-fold by preinjection of melatonin. Potassium cyanide (8 mg/kg, s.c.) increased lipid peroxidation in whole brain of mice, and the increased lipid peroxidation was completely abolished when cyanide-induced seizures were stopped by preadministration of melatonin. These results suggest that melatonin, a pineal hormone, may protect against cyanide-induced neurotoxicity with its free radical scavenging effects in mice.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Yamamoto H,Tang HWdoi
10.1016/0378-4274(96)03671-5subject
Has Abstractpub_date
1996-09-01 00:00:00pages
19-24issue
1eissn
0378-4274issn
1879-3169pii
0378427496036715journal_volume
87pub_type
杂志文章abstract：:A diversity of chemicals cause discrete lesions in the kidney by a number of different mechanisms, and similar types of chemicals may give rise to more than one target cell injury. Screening for these lesions in vivo may be unreliable if a single noninvasive or invasive criterion is used. Instead, evidence of nephroto...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(89)90132-x
更新日期：1989-03-01 00:00:00
abstract：:Considering of novel biochemical modulation by some foods and beverages, we have performed screening for green tea components that have enhancing effects on doxorubicin (DOX) induced antitumor activity. Components, such as caffeine, theanine, (-)-epigallocatechin gallate (EGCG) and flavonoids have inhibitory effects o...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(99)00290-8
更新日期：2000-04-03 00:00:00
abstract：:In recent years, the detrimental effects of high iodine on intelligence are gaining tons of attention, but the relationship between high iodine and neurotoxicity is controversial. This study aimed to explore whether high iodine intake may impair intelligence and the roles of apoptosis and autophagy in high iodine-indu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.08.020
更新日期：2018-11-01 00:00:00
abstract：:Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and treatment of exposed individuals from the general population or of emergency responders. Such exposu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.03.002
更新日期：2014-12-15 00:00:00
abstract：:Intraperitoneal (i.p.) administration of a cadmium (Cd) salt at concentrations of 1.0, 2.5 and 4.0 mg CdCl2/kg body wt. caused severe liver injury in rats 24 h after administration. The toxic effects were most evident in the intermediate dose of 2.5 mg. Thymidine kinase (TK), the key enzyme of the salvage pathway of D...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90010-h
更新日期：1992-11-01 00:00:00
abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.09.012
更新日期：2018-12-15 00:00:00
abstract：:Lithocholic acid (LCA) supplementation in the diet results in intrahepatic cholestasis and bile infarcts. Previously we showed that an innate immune response is critical for cholestatic liver injury in the bile duct ligated mice. Thus, the purpose of this study was to investigate the role of neutrophils in the mechani...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.04.001
更新日期：2014-07-03 00:00:00
abstract：:Rat and canine hepatocyte suspensions were exposed to toxic concentrations of ethyl methanesulfonate (EMS) and ionophore A-23187 in the presence and absence of extracellular calcium (Ca2+) and alpha-tocopheryl succinate (alpha-TS). The exogenous administration of alpha-TS (25 microM) completely protected hepatocytes f...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(89)90086-6
更新日期：1989-04-01 00:00:00
abstract：:Oral administration of stannous chloride (SnCl2) (1.0 mg Sn2$/kg body weight) to rats, twice daily for 28 days, caused a significant increase in the tin (Sn) content and a corresponding decrease of the calcium (Ca) content in the femoral epiphysis, but was without effect on serum Ca, intestinal Ca absorption, and urin...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90259-4
更新日期：1982-01-01 00:00:00
abstract：:The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90137-5
更新日期：1981-04-01 00:00:00
abstract：:Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.05.021
更新日期：2016-08-22 00:00:00
abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a proven animal carcinogen. Occupational cohorts with the highest exposures imply that there is a small risk of all cancers combined, but it is difficult to pinpoint the confounding effect of the main chemicals. Studies after major accidents do not unequivocally confirm th...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2012.02.007
更新日期：2012-05-05 00:00:00
abstract：:The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination behaviour in simple solutions and assess the effects of complex formation upon skin permeatio...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.01.017
更新日期：2011-05-10 00:00:00
abstract：:N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90193-5
更新日期：1983-05-01 00:00:00
abstract：:Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(90)90150-k
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.05.023
更新日期：2017-08-05 00:00:00
abstract：:The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)03202-i
更新日期：1995-03-01 00:00:00
abstract：:The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respective...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90058-6
更新日期：1988-06-01 00:00:00
abstract：:A number of zero tolerance provisions are contained in both food and animal feed law, e.g. for chemical substances whose occurrence is not permitted or is directly prohibited in food or animal feed. In the European Union, bans of this kind were introduced to give consumers and animals the greatest possible protection ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.10.002
更新日期：2007-12-10 00:00:00
abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(94)90139-2
更新日期：1994-01-01 00:00:00
abstract：:Mice given single i.v. doses of some radiopharmaceuticals containing stannous chloride as a reducing agent, showed significant inhibition of hepatic azo-reductase and aromatic hydroxylase activity at dose levels which contained as little as 0.2 mg/kg of stannous chloride. Cytochrome P-450 content was also reduced sign...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90105-4
更新日期：1983-09-01 00:00:00
abstract：:Fatty acid composition was studied in milk at day 14 and in liver at day 24 after parturition of lactating rats exposed to 0 ppm, 5 ppm or 25 ppm cadmium (Cd) via drinking water for 17 days during lactation, and in the brain of their offspring at day 19 after birth. In the liver phospholipid fraction, 22:5(n-3) was si...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.12.012
更新日期：2004-03-14 00:00:00
abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.03.001
更新日期：2008-05-05 00:00:00
abstract：:Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative biochemical, pathologic and...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(95)03409-9
更新日期：1995-11-01 00:00:00
abstract：:Two-week oral administration of MDL-19,660, a triazole antidepressant compound, resulted in a dose-related thrombocytopenia in rats given 40-360 mg/kg/d and dogs treated with 5-50 mg/kg/d. Consumptive loss of platelets was not apparent since splenomegaly, hemorrhage, microscopic thrombi or prolonged coagulation times ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(91)90098-q
更新日期：1991-04-01 00:00:00
abstract：:One of the major dose-limiting toxicities induced by antimicrotubule antitumor agents such as vinca alkaloids and taxanes is peripheral neuropathy. The neurotoxicity of TZT-1027 (a dolastatin 10 derivative antimicrotubule agent) was thus assessed using the animal models for antimicrotubule agent-induced neurotoxicity....
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00327-7
更新日期：2001-04-30 00:00:00
abstract：:The mammalian xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a gene superfamily (SULT). Ten distinct human SULT forms are known. Two SULT forms represent splice variants, the other forms are encoded by separate genes. Common functional polymorphisms of the transcribed region are known for ...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(99)00214-3
更新日期：2000-03-15 00:00:00
abstract：:Tetrachloro-p-hydroquinone (TCHQ), the major metabolite of pentachlorophenol (PCP) in mammalian systems, is known to autoxidize to its semiquinone radical under physiological conditions. In this way, PCP could present a potent source of reactive oxygen species (ROS) during metabolization. ROS contribute to numerous mo...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)90085-x
更新日期：1994-12-01 00:00:00
abstract：:Sex difference was observed in the aryl hydrocarbon hydroxylase (AHH) activity of liver in the C3H/He strain of mice. Treatment with estradiol showed an increase in AHH activity in gonadectomized female mice, but not in males. Testosterone, however, lowered AHH activity in both the gonadectomized male and female. Foll...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90148-4
更新日期：1980-01-01 00:00:00
abstract：:To characterize the accumulated hazards associated with the inhalation of gases typical of combustion products, a time-integrated value known as the fractional effective dose (FED) is used. This FED is maintained by the International Organization for Standardization (ISO) and made publicly available as the Standard IS...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.09.012
更新日期：2016-11-16 00:00:00
