In vitro effects of mercury-selenium compounds on enzymes.

abstract：:To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most imp...

journal_title：Toxicology letters

authors： Rappaport SM,Li H,Grigoryan H,Funk WE,Williams ER

更新日期：2012-08-13 00:00:00

abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...

journal_title：Toxicology letters

authors： Kleinman MT,Araujo JA,Nel A,Sioutas C,Campbell A,Cong PQ,Li H,Bondy SC

更新日期：2008-05-05 00:00:00

abstract：:The disposition of methanol and its putative toxic metabolite formate has been studied in humans, non-human primates, and rodents after exposure to high, neurotoxic doses. The rate at which rodents detoxify formate is more rapid than that of primates. Formate, an endogenous biological substrate, is detoxified by metab...

journal_title：Toxicology letters

authors： Medinsky MA,Dorman DC

更新日期：1995-12-01 00:00:00

abstract：:We recently showed in a rat model of dichromate-induced acute renal failure (ARF) that the elimination but not the distribution of pralidoxime was altered resulting in sustained plasma pralidoxime concentrations. The aim of this study was to compare the efficiency of pralidoxime in normal and acute renal failure rats ...

journal_title：Toxicology letters

authors： Kayouka M,Houzé P,Debray M,Baud FJ

更新日期：2009-08-25 00:00:00

abstract：:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...

journal_title：Toxicology letters

authors： Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MA

更新日期：2001-09-15 00:00:00

abstract：:The effect of chlordimeform (CDM) treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment. After acute administration of chlordimeform (100 mg/kg, i.p., 1 hour before killing) differential effects were observed in various parameter...

journal_title：Toxicology letters

authors： Budris DM,Yim GK,Carlson GP,Schnell RC

更新日期：1983-08-01 00:00:00

abstract：:Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present...

journal_title：Toxicology letters

authors： Fernández-Blanco C,Frizzell C,Shannon M,Ruiz MJ,Connolly L

更新日期：2016-08-22 00:00:00

abstract：:Cigarette smoking is the strongest risk factor for lung cancer (LC), but genetically determined variations in pulmonary metabolism of tobacco-derived carcinogens may affect individual risk. Results from a case-control study on LC patients demonstrated the pronounced effect of tobacco smoke on pulmonary xenobiotic meta...

journal_title：Toxicology letters

authors： Bartsch H,Castegnaro M,Rojas M,Camus AM,Alexandrov K,Lang M

更新日期：1992-12-01 00:00:00

abstract：:Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

journal_title：Toxicology letters

authors： Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

更新日期：1987-01-01 00:00:00

abstract：:Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...

journal_title：Toxicology letters

authors： Kamenickova A,Anzenbacherova E,Pavek P,Soshilov AA,Denison MS,Zapletalova M,Anzenbacher P,Dvorak Z

更新日期：2013-07-31 00:00:00

abstract：:Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

journal_title：Toxicology letters

authors： Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

更新日期：2017-10-05 00:00:00

abstract：:The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment of Reproductive Toxicity data indicated the Agency's intention for wide use of the technique. In developmental toxicity experiments, a number of factors need t...

journal_title：Toxicology letters

authors： Foster PM,Auton TR

更新日期：1995-12-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) in 1999 issued draft guidelines on carcinogen risk assessment, which included the use mode of action information in the risk assessment process. We have used the five stages of induction of toxicity as described by Aldridge to illustrate in the case of two drugs, tamoxifen ...

journal_title：Toxicology letters

authors： Lock EA,Smith LL

更新日期：2003-04-11 00:00:00

abstract：:The influence of cold exposure (+ 1 degree C for 24 h) was studied in rats dosed i.p. with 0, 2.5 or 5.0 mumol HgCl2/kg. Cold exposure of controls caused an increased diuresis and solute elimination, except sodium, with almost no variations in urine alkaline phosphatase (ALP) and gammaglutamyl transferase (GGT). Proxi...

journal_title：Toxicology letters

authors： Burgat-Sacaze V,Braun JP,Benard P,Eghbali B,Rico A

更新日期：1982-02-01 00:00:00

abstract：:The distribution of 54Mn in various organs of pregnant rats and of their 19-day-old fetuses and in non-pregnant female rats of various ages has been studied 18 h after an i.v. injection of 54MnCl2. The results indicate that early neonates are more susceptible to manganese (Mn) than the growing rats. The localization o...

journal_title：Toxicology letters

authors： Kaur G,Hasan SK,Srivastava RC

更新日期：1980-05-01 00:00:00

abstract：:Malignant gliomas are the most common and most aggressive primary brain tumor, and for which differentiation therapy has emerged as a promising candidate strategy. In this study, we used in vitro and in vivo assays to examine the differentiation effects of wogonin, a major active constituent of Scutellaria baicalensis...

journal_title：Toxicology letters

authors： Wang Y,Zhang Y,Qian C,Cai M,Li Y,Li Z,You Q,Wang Q,Hu R,Guo Q

更新日期：2013-10-24 00:00:00

abstract：:We have studied the effects of chronic slight to moderate lead exposure on the renin-angiotensin-aldosterone system in normotensive man. Plasma renin activity (PRA), blood angiotensin I (AI) concentration, angiotensin converting enzyme (ACE) activity and aldosterone concentration were measured in 33 normotensive men, ...

journal_title：Toxicology letters

authors： Campbell BC,Meredith PA,Scott JJ

更新日期：1985-04-01 00:00:00

abstract：:Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1...

journal_title：Toxicology letters

authors： Kobayashi S,Sata F,Sasaki S,Ban S,Miyashita C,Okada E,Limpar M,Yoshioka E,Kajiwara J,Todaka T,Saijo Y,Kishi R

更新日期：2013-06-07 00:00:00

abstract：:Chloral (trichloroacetaldehyde), the major metabolite of trichloroethylene (TCE), was investigated for its potential to form DNA-protein cross-links (DPX), a lesion produced by other aldehydes. Chloral did not form DPX in rat liver nuclei at concentrations up to 250 mM for 30 min at 37 degrees C, while chloroacetaldeh...

journal_title：Toxicology letters

authors： Keller DA,Heck HD

更新日期：1988-08-01 00:00:00

abstract：:Exposure to airborne particulate matter (PM) is a major risk factor for allergic airway inflammation such as asthma. Many of the PM components (i.e., polycyclic aromatic hydrocarbons and metals) are redox-active and capable of inducing cellular oxidative stress and injuries including inflammation and cell death. Airwa...

journal_title：Toxicology letters

authors： Li N,Buglak N

更新日期：2015-08-19 00:00:00

abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

journal_title：Toxicology letters

authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

更新日期：2012-10-17 00:00:00

abstract：:Localization of specific mRNA and protein molecules within cells and tissues can provide important information on the effects of a drug within a biological test system and help elucidate mechanisms of drug-induced toxicity and organ dysfunction. The most widely used techniques for measuring the cellular and tissue dis...

journal_title：Toxicology letters

authors： Kind CN

更新日期：2000-03-15 00:00:00

abstract：:EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

journal_title：Toxicology letters

authors： Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

更新日期：1984-07-01 00:00:00

abstract：:The effect of two herbicides (paraquat and 2,4-dichlorophenoxybutyric acid) and two fungicides (mancozeb and captafol) was studied on the growth of Flagellospora penicillioides, Lunulospora curvula and Phalangispora constricta using the poisoned-food technique. The pesticides did not produce any inhibition of growth a...

journal_title：Toxicology letters

authors： Chandrashekar KR,Kaveriappa KM

更新日期：1989-09-01 00:00:00

abstract：:Rates of alkaline hydrolysis of 18 natural or semisynthetic pyrrolizidine alkaloids, all retronecine diesters, have been compared. Steric hindrance around the ester groups was the major factor inhibiting hydrolysis. Relative rates of hydrolysis by esterases in a rat liver homogenate were also dependent on steric hindr...

journal_title：Toxicology letters

authors： Mattocks AR

更新日期：1982-11-01 00:00:00

abstract：:Gaseous butadiene (BUT) was mutagenic towards S. typhimurium strain TA 1530 when the incubation mixture was supplemented with a NADPH-fortified rat liver microsomal preparation; mutagenicity increased with the dose. A significant mutagenic effect was similarly observed when the petri dishes, containing the bacteria bu...

journal_title：Toxicology letters

authors： de Meester C,Poncelet F,Roberfroid M,Mercier M

更新日期：1980-08-01 00:00:00

abstract：:The potential adverse effects of hazardous waste incinerators (HWI) continue to be a subject of worry. The construction of the first and up till now only HWI in Spain finished in 1999. Twenty-six subjects employed at this HWI were divided into three groups: plant, laboratory and administration. Plasma analyses of HCB,...

journal_title：Toxicology letters

authors： Carmen Agramunt M,Domingo A,Domingo JL,Corbella J

更新日期：2003-12-15 00:00:00

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:Due to advances in nanotechnology, exposure to particle compounds in the workplace has become unavoidable. Assessment of their toxicity on health is an important occupational safety issue. This study was conducted in mice to investigate the toxicological effects of submicron and nano-iron oxide particles on pulmonary ...

journal_title：Toxicology letters

authors： Ban M,Langonné I,Huguet N,Goutet M

更新日期：2012-05-05 00:00:00

abstract：:The relative toxicity of three legacy and six emerging brominated flame retardants* was studied in the male Harlan Sprague Dawley rat. The hepatocellular and thyroid toxicity of each flame retardant was evaluated following five-day exposure to each of the nine flame retardants (oral gavage in corn oil) at 0.1-1000 μmo...

journal_title：Toxicology letters

authors： Shockley KR,Cora MC,Malarkey DE,Jackson-Humbles D,Vallant M,Collins BJ,Mutlu E,Robinson VG,Waidyanatha S,Zmarowski A,Machesky N,Richey J,Harbo S,Cheng E,Patton K,Sparrow B,Dunnick JK

更新日期：2020-10-10 00:00:00