Chlordecone potentiates auto-immune hepatitis and promotes brain entry of MHV3 during viral hepatitis in mouse models.

abstract：:The phototoxic potentials of quinolone derivatives and the possibility of free radical contribution to their phototoxicity were investigated by measuring increments in ear thickness. Balb/c mice, fasted overnight, were orally administered ofloxacin (OFLX), lomefloxacin (LMFX), enoxacin (ENX), ciprofloxacin (CPFX) and ...

journal_title：Toxicology letters

authors： Wagai N,Tawara K

更新日期：1991-10-01 00:00:00

abstract：:Gaseous butadiene (BUT) was mutagenic towards S. typhimurium strain TA 1530 when the incubation mixture was supplemented with a NADPH-fortified rat liver microsomal preparation; mutagenicity increased with the dose. A significant mutagenic effect was similarly observed when the petri dishes, containing the bacteria bu...

journal_title：Toxicology letters

authors： de Meester C,Poncelet F,Roberfroid M,Mercier M

更新日期：1980-08-01 00:00:00

abstract：:Nerve agent toxicity is primarily due to the synaptic build up of toxic levels of acetylcholine. The acute lethal effects of the nerve agents are generally attributed to respiratory failure caused by a combination of effects at both central and peripheral levels and are further complicated by copious secretions, muscl...

journal_title：Toxicology letters

authors： RamaRao G,Bhattacharya BK

更新日期：2012-01-05 00:00:00

abstract：:In this work the in vitro reactions of phosphine with intact red blood cells and membrane-free hemoglobin extracts are reported. We demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreve...

journal_title：Toxicology letters

authors： Potter WT,Rong S,Griffith J,White J,Garry VF

更新日期：1991-06-01 00:00:00

abstract：:To help minimize errors and confusion in the scientific literature, a few principles can be followed. The original intent and hypothesis of each study should be made clear, and deviations from the initial purpose should be stated. The hypothesis-testing portions of the research need to be clearly differentiated from t...

journal_title：Toxicology letters

authors： Maurissen JP

更新日期：1995-12-01 00:00:00

abstract：:Generally recognized as safe (GRAS), a system for review and approval of ingredients for addition to food, was conceived at a time when the need for a less doctrinaire review of food ingredients was critical. The GRAS approval process for a food ingredient relies on the judgment of "...experts qualified by scientific ...

journal_title：Toxicology letters

authors： Burdock GA,Carabin IG

更新日期：2004-04-15 00:00:00

abstract：:It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...

journal_title：Toxicology letters

authors： Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

更新日期：2012-09-03 00:00:00

abstract：:The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this...

journal_title：Toxicology letters

authors： González Cid M,Mudry M,Larripa I

更新日期：1995-03-01 00:00:00

abstract：:Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-in...

journal_title：Toxicology letters

authors： Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

更新日期：2004-05-02 00:00:00

abstract：:Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been ...

journal_title：Toxicology letters

authors： Park EJ,Park K

更新日期：2009-01-30 00:00:00

abstract：:The effect of sorbic acid alone and in combination with sodium nitrite has been studied on bone marrow chromosomes of mice following 30 days oral treatment. Bone marrow of mice exposed to sorbic acid (15 mg/kg) and sorbic acid nitrite (7.5-1 mg/kg) showed an increase in mitotic index indicating that the drugs had an e...

journal_title：Toxicology letters

authors： Banerjee TS,Giri AK

更新日期：1986-05-01 00:00:00

abstract：:The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods ...

journal_title：Toxicology letters

authors： Hasegawa K,Miwa S,Tsutsumiuchi K,Taniguchi H,Miwa J

更新日期：2004-09-10 00:00:00

abstract：:BH3 mimetics, such as BH3I-1, act as Bcl-2 antagonists, promote apoptosis and are used in basic research studies on apoptotic signaling and are currently tested as experimental anti-tumor agents. The present study addresses time- and dose-dependent responses of BH3I-1 on apoptosis, cellular stress defense mediated by ...

journal_title：Toxicology letters

authors： Stucki D,Brenneisen P,Reichert AS,Stahl W

更新日期：2018-10-01 00:00:00

abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

journal_title：Toxicology letters

authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

更新日期：2017-08-05 00:00:00

abstract：:Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

journal_title：Toxicology letters

authors： Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

更新日期：1987-01-01 00:00:00

abstract：:Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits...

journal_title：Toxicology letters

authors： Nagl V,Woechtl B,Schwartz-Zimmermann HE,Hennig-Pauka I,Moll WD,Adam G,Berthiller F

更新日期：2014-08-17 00:00:00

abstract：:Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet. Chronic Cd exposure is a public health concern because Cd is a known carcinogen; it accumulates in the body and causes kidney damage. The National Health and Nutritional Examination Survey (NHANE...

journal_title：Toxicology letters

authors： Ruiz P,Mumtaz M,Osterloh J,Fisher J,Fowler BA

更新日期：2010-09-15 00:00:00

abstract：:Styrene oxide, a metabolite of styrene, reacts with many centres in nucleosides but in DNA N-7-, N2- and O6-guanine are the main sites. A 32P-postlabelling method was developed for the detection of O6-styrene oxide DNA adducts from white blood cells. The method involved use of nuclease P1 and magnet transfer. The O6 a...

journal_title：Toxicology letters

authors： Hemminki K,Vodicka P

更新日期：1995-05-01 00:00:00

abstract：:The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

journal_title：Toxicology letters

authors： Ohhira S,Matsui H,Watanabe K

更新日期：2000-11-20 00:00:00

abstract：:Neurological complications as well as movement disorders are relevant symptoms in animals and humans chronically exposed to dithiocarbamates. Using rat pheochromocytoma cells differentiated by NGF (PC12), we investigated whether propineb affects acetylcholine (Ach) release and the molecular mechanisms involved. Propin...

journal_title：Toxicology letters

authors： Viviani B,Bartesaghi S,Binaglia M,Corsini E,Boraso M,Grazi E,Galli CL,Marinovich M

更新日期：2008-11-10 00:00:00

abstract：:It has been reported that lead could induce apoptosis in a variety of cell types. Although mitochondrion is regarded as the most pertinent pathway in mediating apoptosis, the exact mechanisms of lead-induced apoptosis are still largely unknown. Furthermore, there is little information about expressions and regulations...

journal_title：Toxicology letters

authors： Xu J,Ji LD,Xu LH

更新日期：2006-10-10 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) and aryl hydrocarbon receptor (AhR) both require dimerization with AhR nuclear translocator (ARNT) to initiate transcription of their respective target genes. It has been proposed that competition for ARNT results in decreased targeting of AhR to cytochrome P450 1A1 (CYP1A1...

journal_title：Toxicology letters

authors： Allen JW,Johnson RS,Bhatia SN

更新日期：2005-01-15 00:00:00

abstract：:Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential o...

journal_title：Toxicology letters

authors： Patel R,Rosengren RJ

更新日期：2001-05-31 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman. Here, we investigate the binding mechanism f...

journal_title：Toxicology letters

authors： Fu F,Liu H,Gao R,Zhao P,Lu X,Zhang R,Wang L,Wang H,Pei C

更新日期：2020-03-15 00:00:00

abstract：:Over the last twenty years research has provided an important insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of immunostimulating drugs and adjuvants. In this article we provide an update of the present knowledge relating to the various par...

journal_title：Toxicology letters

authors： Batista-Duharte A,Lindblad EB,Oviedo-Orta E

更新日期：2011-06-10 00:00:00

abstract：:An intensive study was conducted to provide data on intra- and inter-individual variation in urinary excretion of a series of ingredients in personal care products (parabens, triclosan, benzophenones) and bisphenol A (BPA, not expected to be an ingredient) in 8 volunteers over 6 days. Exposure diaries recorded use of ...

journal_title：Toxicology letters

authors： Koch HM,Aylward LL,Hays SM,Smolders R,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R

更新日期：2014-12-01 00:00:00

abstract：:Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...

journal_title：Toxicology letters

authors： Chapkin RS,Fan Y,Lupton JR

更新日期：2000-03-15 00:00:00

abstract：:It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1993-01-01 00:00:00

abstract：:Manganese (Mn) is an essential trace element required for normal function and development. However, exposure to this metal at elevated levels may cause manganism, a progressive neurodegenerative disorder with neurological symptoms similar to idiopathic Parkinson's disease (IPD). Elevated body burdens of Mn from exposu...

journal_title：Toxicology letters

authors： Stephenson AP,Schneider JA,Nelson BC,Atha DH,Jain A,Soliman KF,Aschner M,Mazzio E,Renee Reams R

更新日期：2013-04-26 00:00:00