Chlordecone potentiates auto-immune hepatitis and promotes brain entry of MHV3 during viral hepatitis in mouse models.


:Chlordecone is an organochlorine used in the 1970's as a pesticide in banana plantations. It has a long half-life in the soil and can potentially contaminate humans and animals through food. Chlordecone targets, and mainly accumulates in, the liver, leading to hepatomegaly and neurological signs in mammals. Chlordecone does not cause liver injuries or any inflammation by itself at low doses, but it can potentiate the hepatotoxic effects of other chemicals and drugs. We studied the impact of chlordecone on the progression of acute hepatitis in mouse models of co-exposure to chlordecone with Concanavalin A or murine hepatitis virus type 3. We examined the progression of these two types of hepatitis by measuring hepatic transaminase levels in the serum and inflammatory cells in the liver, liver histological studies. Amplified tremors presented in the MHV3- chlordecone mouse model had led us to study the expression of specific genes in the brain. We show that chlordecone amplifies the auto-immune hepatitis induced by Concanavalin A by increasing the number of liver NKT cells, which are involved in liver damage. Chlordecone also accelerated the death of mice infected by murine hepatitis virus and enhanced the entry of the virus into the cervical spinal cord in infected mice, leading to considerable neurological damage. In conclusion, chlordecone potentiates both the Concanavalin A-induced hepatitis and brain damage caused by an hepatotropic/neurotropic virus.


Toxicol Lett


Toxicology letters


Tabet E,Gelu-Simeon M,Genet V,Lamontagne L,Piquet-Pellorce C,Samson M




Has Abstract


2018-12-15 00:00:00












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    abstract::The phototoxic potentials of quinolone derivatives and the possibility of free radical contribution to their phototoxicity were investigated by measuring increments in ear thickness. Balb/c mice, fasted overnight, were orally administered ofloxacin (OFLX), lomefloxacin (LMFX), enoxacin (ENX), ciprofloxacin (CPFX) and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wagai N,Tawara K

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  • The mutagenicity of butadiene towards Salmonella typhimurium.

    abstract::Gaseous butadiene (BUT) was mutagenic towards S. typhimurium strain TA 1530 when the incubation mixture was supplemented with a NADPH-fortified rat liver microsomal preparation; mutagenicity increased with the dose. A significant mutagenic effect was similarly observed when the petri dishes, containing the bacteria bu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: de Meester C,Poncelet F,Roberfroid M,Mercier M

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  • Multiple signal transduction pathways alterations during nerve agent toxicity.

    abstract::Nerve agent toxicity is primarily due to the synaptic build up of toxic levels of acetylcholine. The acute lethal effects of the nerve agents are generally attributed to respiratory failure caused by a combination of effects at both central and peripheral levels and are further complicated by copious secretions, muscl...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: RamaRao G,Bhattacharya BK

    更新日期:2012-01-05 00:00:00

  • Phosphine-mediated Heinz body formation and hemoglobin oxidation in human erythrocytes.

    abstract::In this work the in vitro reactions of phosphine with intact red blood cells and membrane-free hemoglobin extracts are reported. We demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreve...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Potter WT,Rong S,Griffith J,White J,Garry VF

    更新日期:1991-06-01 00:00:00

  • A few considerations in the design and analysis of experiments in neurotoxicology.

    abstract::To help minimize errors and confusion in the scientific literature, a few principles can be followed. The original intent and hypothesis of each study should be made clear, and deviations from the initial purpose should be stated. The hypothesis-testing portions of the research need to be clearly differentiated from t...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Maurissen JP

    更新日期:1995-12-01 00:00:00

  • Generally recognized as safe (GRAS): history and description.

    abstract::Generally recognized as safe (GRAS), a system for review and approval of ingredients for addition to food, was conceived at a time when the need for a less doctrinaire review of food ingredients was critical. The GRAS approval process for a food ingredient relies on the judgment of "...experts qualified by scientific ...

    journal_title:Toxicology letters

    pub_type: 历史文章,杂志文章,评审


    authors: Burdock GA,Carabin IG

    更新日期:2004-04-15 00:00:00

  • Differential mechanisms of action are involved in chlorpyrifos effects in estrogen-dependent or -independent breast cancer cells exposed to low or high concentrations of the pesticide.

    abstract::It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

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  • Chromosome damage induced by carboplatin (CBDCA).

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: González Cid M,Mudry M,Larripa I

    更新日期:1995-03-01 00:00:00

  • Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

    更新日期:2004-05-02 00:00:00

  • Induction of pro-inflammatory signals by 1-nitropyrene in cultured BEAS-2B cells.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Park EJ,Park K

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  • Effects of sorbic acid and sorbic acid-nitrite in vivo on bone marrow chromosomes of mice.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


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  • Extremely low dose of acrylamide decreases lifespan in Caenorhabditis elegans.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hasegawa K,Miwa S,Tsutsumiuchi K,Taniguchi H,Miwa J

    更新日期:2004-09-10 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Stucki D,Brenneisen P,Reichert AS,Stahl W

    更新日期:2018-10-01 00:00:00

  • MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

    更新日期:2017-08-05 00:00:00

  • Measuring problems in estimating the exposure to passive smoking using the excretion of cotinine.

    abstract::Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

    更新日期:1987-01-01 00:00:00

  • Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nagl V,Woechtl B,Schwartz-Zimmermann HE,Hennig-Pauka I,Moll WD,Adam G,Berthiller F

    更新日期:2014-08-17 00:00:00

  • Interpreting NHANES biomonitoring data, cadmium.

    abstract::Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet. Chronic Cd exposure is a public health concern because Cd is a known carcinogen; it accumulates in the body and causes kidney damage. The National Health and Nutritional Examination Survey (NHANE...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ruiz P,Mumtaz M,Osterloh J,Fisher J,Fowler BA

    更新日期:2010-09-15 00:00:00

  • Styrene: from characterisation of DNA adducts to application in styrene-exposed lamination workers.

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Hemminki K,Vodicka P

    更新日期:1995-05-01 00:00:00

  • Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice.

    abstract::The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ohhira S,Matsui H,Watanabe K

    更新日期:2000-11-20 00:00:00

  • Dithiocarbamate propineb induces acetylcholine release through cytoskeletal actin depolymerization in PC12 cells.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Viviani B,Bartesaghi S,Binaglia M,Corsini E,Boraso M,Grazi E,Galli CL,Marinovich M

    更新日期:2008-11-10 00:00:00

  • Lead-induced apoptosis in PC 12 cells: involvement of p53, Bcl-2 family and caspase-3.

    abstract::It has been reported that lead could induce apoptosis in a variety of cell types. Although mitochondrion is regarded as the most pertinent pathway in mediating apoptosis, the exact mechanisms of lead-induced apoptosis are still largely unknown. Furthermore, there is little information about expressions and regulations...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Xu J,Ji LD,Xu LH

    更新日期:2006-10-10 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Allen JW,Johnson RS,Bhatia SN

    更新日期:2005-01-15 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Patel R,Rosengren RJ

    更新日期:2001-05-31 00:00:00

  • EGR1 is essential for deoxynivalenol-induced G2/M cell cycle arrest in HepG2 cells via the ATF3ΔZip2a/2b-EGR1-p21 pathway.

    abstract::Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fu F,Liu H,Gao R,Zhao P,Lu X,Zhang R,Wang L,Wang H,Pei C

    更新日期:2020-03-15 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Batista-Duharte A,Lindblad EB,Oviedo-Orta E

    更新日期:2011-06-10 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


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    更新日期:2014-12-01 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Chapkin RS,Fan Y,Lupton JR

    更新日期:2000-03-15 00:00:00

  • Strain differences in susceptibility to di-2-ethylhexyl phthalate-induced testicular atrophy in mice.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Oishi S

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  • Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine.

    abstract::Manganese (Mn) is an essential trace element required for normal function and development. However, exposure to this metal at elevated levels may cause manganism, a progressive neurodegenerative disorder with neurological symptoms similar to idiopathic Parkinson's disease (IPD). Elevated body burdens of Mn from exposu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Stephenson AP,Schneider JA,Nelson BC,Atha DH,Jain A,Soliman KF,Aschner M,Mazzio E,Renee Reams R

    更新日期:2013-04-26 00:00:00