Abstract：
:Pregnant rats were given di-n-butyltin dichloride (DBT) by gastric intubation at a dose of 0, 2.5, 5.0, 7.5 or 10.0 mg/kg on days 7-15 of pregnancy. Maternal toxicity occurred in the 7.5 and 10.0 mg/kg groups as evidenced by a significant increase in maternal death and decrease in food consumption and body weight gain. The incidence of fetuses with malformations was roughly proportional to the dose of DBT, and was significantly increased in the 5.0, 7.5 and 10.0 mg/kg groups. Cleft jaw, ankyloglossia, defects of the mandible, fusion of the ribs and deformity of the vertebral column were predominantly found. It is concluded that DBT produced teratogenic effects in the absence of maternal toxicity.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Ema M,Itami T,Kawasaki Hdoi
10.1016/0378-4274(91)90047-asubject
Has Abstractpub_date
1991-11-01 00:00:00pages
347-56issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(91)90047-Ajournal_volume
58pub_type
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2008-08-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2013-11-25 00:00:00
