Abstract：
:Zinc chloride (0.01 mM kept for 3h) is not toxic to cultured cerebellar granule neurons (CGNs) while kainate (0.1mM kept for 3h) demonstrates some but very low toxicity towards these cells. Measurements of the relative intraneuronal zinc ion concentration showed that increase in [Zn(2+)](i) under the simultaneous action of ZnCl(2) and kainate was significantly stronger compared to their separate action. Simultaneous treatment of CGNs with kainate and zinc chloride caused the swelling of neuronal mitochondria and consequent intensive neuronal death, which was totally prevented by NBQX (an AMPA/kainate-receptors blocker) or ruthenium red (a mitochondrial Ca(2+) uniporter blocker). These data imply that Zn(2+) synergistically to kainate increase their separate toxic effects on mitochondria leading to rapid neuronal death.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Lozier ER,Stelmashook EV,Uzbekov RE,Novikova SV,Zorov SD,Alieva IB,Arbeille B,Zorov DB,Isaev NKdoi
10.1016/j.toxlet.2011.10.003subject
Has Abstractpub_date
2012-01-05 00:00:00pages
36-40issue
1eissn
0378-4274issn
1879-3169pii
S0378-4274(11)01570-0journal_volume
208pub_type
杂志文章abstract：:The effect of two herbicides (paraquat and 2,4-dichlorophenoxybutyric acid) and two fungicides (mancozeb and captafol) was studied on the growth of Flagellospora penicillioides, Lunulospora curvula and Phalangispora constricta using the poisoned-food technique. The pesticides did not produce any inhibition of growth a...
journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,多中心研究
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journal_title：Toxicology letters
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pub_type： 杂志文章,评审
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journal_title：Toxicology letters
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更新日期：1990-01-01 00:00:00
