Abstract：
:Toluene diisocyanate (TDI), a highly reactive industrial chemical is a leading cause of occupational asthma in westernized countries. It has also been reported to be a skin sensitizer in mice and guinea pigs although instances of skin sensitivity in humans are rare. It is uncertain if skin-contact is necessary to initiate the dermal sensitization. This study sought to determine if exclusive airway exposure to TDI could result in skin sensitivity. A group of guinea pigs was administered 50 microl of 0.6% TDI intratracheally (it.), another group received intranasal (in.) application of 0.6, 1.2, or 1.8% TDI. Eighty percent (4/5) of the it.-dosed animals, and 92% (11/12) of in.-dosed animals exhibited skin sensitivity. None of 14 control animals gave a positive reaction to patch challenge with TDI. These findings indicate that exclusive exposure of the airways to TDI can result in skin sensitivity and suggest that such events may be possible in TDI workers and should be considered in all workers exposed via the airways to chemical sensitizers.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Ebino K,Ueda H,Kawakatsu H,Shutoh Y,Kosaka T,Nagayoshi E,Lemus R,Karol MHdoi
10.1016/s0378-4274(01)00325-3keywords:
subject
Has Abstractpub_date
2001-04-08 00:00:00pages
79-85issue
1eissn
0378-4274issn
1879-3169pii
S0378427401003253journal_volume
121pub_type
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