Morphological and transcriptomic effects of endocrine modulators on the gonadal differentiation of chicken embryos: The case of tributyltin (TBT).

abstract：BACKGROUND:Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. METHODS:Two groups of 14 female volunteer...

journal_title：Toxicology letters

authors： Nohynek GJ,Meuling WJ,Vaes WH,Lawrence RS,Shapiro S,Schulte S,Steiling W,Bausch J,Gerber E,Sasa H,Nau H

更新日期：2006-05-05 00:00:00

abstract：:The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...

journal_title：Toxicology letters

authors： Chen T,Yang J,Zhang H,Ren G,Yang Z,Zhang T

更新日期：2014-09-17 00:00:00

abstract：:Reports on adverse health effects related to occupational exposure to toner powder are still inconclusive. Therefore, we have previously conducted an in vitro-study to characterize the genotoxic potential of three commercially available black printer toner powders in A549 lung cells. In these cell-based assays it was ...

journal_title：Toxicology letters

authors： Könczöl M,Weiß A,Gminski R,Merfort I,Mersch-Sundermann V

更新日期：2013-02-04 00:00:00

abstract：:Strong epidemiological evidence supports the association between increased air pollution and the risk of developing atherosclerotic cardiovascular diseases (CVDs). However, the mechanism remains unclear. As an environmental air pollutant and benzo-a-pyrene (BP) metabolite, BP-1,6-quinone (BP-1,6-Q) is present in the p...

journal_title：Toxicology letters

authors： Shukla H,Chitrakar R,Bibi HA,Gaje G,Koucheki A,Trush MA,Zhu H,Li YR,Jia Z

更新日期：2020-04-01 00:00:00

abstract：:Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...

journal_title：Toxicology letters

authors： Imai T,Onose J,Hasumura M,Takizawa T,Hirose M

更新日期：2006-06-20 00:00:00

abstract：:The phototoxic potentials of quinolone derivatives and the possibility of free radical contribution to their phototoxicity were investigated by measuring increments in ear thickness. Balb/c mice, fasted overnight, were orally administered ofloxacin (OFLX), lomefloxacin (LMFX), enoxacin (ENX), ciprofloxacin (CPFX) and ...

journal_title：Toxicology letters

authors： Wagai N,Tawara K

更新日期：1991-10-01 00:00:00

abstract：:A number of zero tolerance provisions are contained in both food and animal feed law, e.g. for chemical substances whose occurrence is not permitted or is directly prohibited in food or animal feed. In the European Union, bans of this kind were introduced to give consumers and animals the greatest possible protection ...

journal_title：Toxicology letters

authors： Heberer T,Lahrssen-Wiederholt M,Schafft H,Abraham K,Pzyrembel H,Henning KJ,Schauzu M,Braeunig J,Goetz M,Niemann L,Gundert-Remy U,Luch A,Appel B,Banasiak U,Böl GF,Lampen A,Wittkowski R,Hensel A

更新日期：2007-12-10 00:00:00

abstract：:When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...

journal_title：Toxicology letters

authors： Gearhart JM,Mahle DA,Greene RJ,Seckel CS,Flemming CD,Fisher JW,Clewell HJ 3rd

更新日期：1993-05-01 00:00:00

abstract：:The effect of paraquat on lung subcellular calcium transport was studied in male Sprague-Dawley rats. With a high dose of 30 mg/kg given i.p., a significant decrease in the lung mitochondrial and microsomal calcium uptake at 24, 48, and 72 h after paraquat was observed. Trend of recovery was evident at 96 h in the sur...

journal_title：Toxicology letters

authors： Agarwal AK,Coleman JW

更新日期：1988-09-01 00:00:00

abstract：:Paraquat poisoning results in damages of multiple organs including liver, kidney and lung, and antioxidants have been proven to have protective effects. As a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), was introduced to clinical use recently, its protective effect was studied on acute ...

journal_title：Toxicology letters

authors： Saibara T,Toda K,Wakatsuki A,Ogawa Y,Ono M,Onishi S

更新日期：2003-06-05 00:00:00

abstract：:The tissue redistribution of accumulated 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in adult male A/J mice using a common human virus coxsackievirus B3. Before infection (day 1), all mice were injected intraperitoneally (i.p.) with 1 microCi 3H-TCDD, corresponding to 0.5 microg TCDD kg(-1...

journal_title：Toxicology letters

authors： Funseth E,Wicklund-Glynn A,Friman G,Ilbäck N

更新日期：2000-07-27 00:00:00

abstract：:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...

journal_title：Toxicology letters

authors： Subramoniam A,Husain R,Seth PK

更新日期：1991-08-01 00:00:00

abstract：:Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. In China, it has also been employed in herbal remedies for hepatitis and abdominal edema. Since E. milii latex--lyophilized or in natura--proved to be a potent plant molluscicide, its toxicity to non-target organisms has been comp...

journal_title：Toxicology letters

authors： Delgado IF,De-Carvalho RR,De-Oliveira AC,Kuriyama SN,Oliveira-Filho EC,Souza CA,Paumgartten FJ

更新日期：2003-11-30 00:00:00

abstract：:Grain should be harvested at lowest possible humidity, or immediately dried to safe storage humidity to prevent the growth of fungi. Critical steps of grain harvest like conditions of used combine harvester, temperatures and aeration are discussed on their impact on mycotoxin formation. ...

journal_title：Toxicology letters

authors： Schrödter R

更新日期：2004-10-10 00:00:00

abstract：:A matched case-control study was conducted to examine the relationship between chromium (Cr) exposure and variation in mitochondrial (mt) DNA methylation. We enrolled 29 pairs of subjects in this study; Cr exposure was confirmed in the cases by detecting blood Cr and other metal ion concentrations. DNA damage caused b...

journal_title：Toxicology letters

authors： Yang L,Xia B,Yang X,Ding H,Wu D,Zhang H,Jiang G,Liu J,Zhuang Z

更新日期：2016-01-22 00:00:00

abstract：:Rats injected i.p. with 100 mg ethylhexyl nitrate/kg body wt excreted 0.3% of the dose in the urine within 24 h. No urinary nitrite was found within 5 postinjection hours while an output of 26.9 +/- 15.8 micrograms nitrite/h X kg body wt. was detected between 5-24 h. Cerebral glutathione concentration was below the co...

journal_title：Toxicology letters

authors： Someroja S,Savolainen H

更新日期：1983-10-01 00:00:00

abstract：:Increasing evidences suggest that microcystins, a kind of toxic metabolites, produced by cyanobacteria in contaminated water may contribute to the aggravation of the human colorectal carcinoma. Our previous study showed that microcystin-LR (MC-LR) exposure caused significant invasion and migration of colorectal cancer...

journal_title：Toxicology letters

authors： Ren Y,Yang M,Chen M,Zhu Q,Zhou L,Qin W,Wang T

更新日期：2017-01-04 00:00:00

abstract：:Toxicokinetics is the assessment of systemic exposure in toxicity studies, in which pharmacokinetic data are generated, either as an integral component in the conduct of the nonclinical toxicity studies or in specially designed supportive studies, in order to assess systemic exposure. The data may be used in the inter...

journal_title：Toxicology letters

authors： Aarons L,Graham G

更新日期：2001-03-31 00:00:00

abstract：:The molecular basis of the interindividual differences of normal individuals to ionizing radiation is poorly understood. Several studies in telomerase KO mice with short telomeres have uncovered an inverse relationship between telomere length and radiation sensitivity. The present work aims to determine if chromosome ...

journal_title：Toxicology letters

authors： Castella M,Puerto S,Creus A,Marcos R,Surralles J

更新日期：2007-07-30 00:00:00

abstract：:An occupational health study was conducted on 45 acetone-exposed male workers in combination with 343 non-exposed men to examine the quantitative relationship between the intensity of acetone vapor exposure and the concentration of acetone in urine. The time-weighted average acetone concentrations were measured by mea...

journal_title：Toxicology letters

authors： Kawai T,Yasugi T,Mizunuma K,Horiguchi S,Iguchi H,Ikeda M

更新日期：1992-08-01 00:00:00

abstract：:Several studies have demonstrated that bisphenol A (BPA) exhibited weak estrogenic activity in the 3-day uterotrophic assay using ovariectomized (OVX) and immature rats (Toxicol. Lett. 115 (2000) 231; Regul. Toxicol. Pharmacol. 32 (2000) 118; J. Toxicol. Sci. 26 (2001) 111) and BPA also possessed anti-androgenic activ...

journal_title：Toxicology letters

authors： Kim HS,Han SY,Kim TS,Kwack SJ,Lee RD,Kim IY,Seok JH,Lee BM,Yoo SD,Park KL

更新日期：2002-09-05 00:00:00

abstract：:1,3-Dinitrobenzene (DNB) causes testicular injury, particularly to Sertoli cells, and induces apoptosis in the surrounding germinal cells in rodents; however, the mechanisms causing this toxicity are poorly understood. Our studies, using standard and molecular tools, were conducted to better understand the pathogenesi...

journal_title：Toxicology letters

authors： Ludwig S,Tinwell H,Rouquié D,Schorsch F,Pallardy M,Bars R

更新日期：2012-09-03 00:00:00

abstract：:The aim of this study was to determine the toxicokinetics and some effects of 1,1,1-trifluoroethane (HFC-143a) in humans. Nine male volunteers were experimentally exposed to 500ppm HFC-143a for 2h during light physical exercise (50W) in an exposure chamber. Blood, urine and exhaled air were sampled before, during and ...

journal_title：Toxicology letters

authors： Gunnare S,Ernstgård L,Sjögren B,Johanson G

更新日期：2007-08-01 00:00:00

abstract：:The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs. Developmental abnormalities were observed in surviving embryos of each of the 3 sp...

journal_title：Toxicology letters

authors： Fulton MH,Chambers JE

更新日期：1985-08-01 00:00:00

abstract：:Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant cont...

journal_title：Toxicology letters

authors： Gardner RM,Nyland JF,Silbergeld EK

更新日期：2010-10-05 00:00:00

abstract：:Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

journal_title：Toxicology letters

authors： Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

更新日期：2021-03-01 00:00:00

abstract：:Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Because inhibition of N-methyl-d-aspartate (NMDA) receptors is one of the possible mechanisms underlying developmental neurotoxicity of toluene, the purpose of the present study was to examine the effects of toluene exposure during two ma...

journal_title：Toxicology letters

authors： Chen HH,Lin YR,Chan MH

更新日期：2011-09-10 00:00:00

abstract：:The main objective of this work was to assess the potentiality of in vitro models to study and understand the uranium-induced cytotoxicity on renal cells. Cytotoxicity and morphological studies were performed in a tubular proximal original established cell line (LLC-PK1 cell line). Dose-dependent cytotoxicity response...

journal_title：Toxicology letters

authors： Mirto H,Hengé-Napoli MH,Gibert R,Ansoborlo E,Fournier M,Cambar J

更新日期：1999-02-22 00:00:00

abstract：:The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this...

journal_title：Toxicology letters

authors： González Cid M,Mudry M,Larripa I

更新日期：1995-03-01 00:00:00

abstract：:In recent years physiologically based pharmacokinetic (PBPK) modeling has found frequent application in risk assessments where PBPK models serve as important adjuncts to studies on modes of action of xenobiotics. In this regard, studies on mode of action provide insight into both the sites/mechanisms of action and the...

journal_title：Toxicology letters

authors： Andersen ME

更新日期：2003-02-18 00:00:00