Peroxisome proliferator-activated receptor α mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice.

abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

journal_title：Toxicology letters

authors： Sastry KV,Sunita K

更新日期：1983-04-01 00:00:00

abstract：:Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and youn...

journal_title：Toxicology letters

authors： Patel E,Reynolds M

更新日期：2013-10-09 00:00:00

abstract：:Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...

journal_title：Toxicology letters

authors： Trombetta D,Mondello MR,Cimino F,Cristani M,Pergolizzi S,Saija A

更新日期：2005-12-15 00:00:00

abstract：:Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

journal_title：Toxicology letters

authors： de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

更新日期：2020-05-15 00:00:00

abstract：:Lindane administration to rats (60 mg/kg b.w.) led to an enhancement in the oxidative stress status of the liver at 4 h after treatment, characterized by increases in hepatic thiobarbituric acid reactants (TBARS) formation and chemiluminescence, reduced glutathione (GSH) depletion, and diminution in the biliary conten...

journal_title：Toxicology letters

authors： Videla LA,Arisi AC,Fuzaro AP,Koch OR,Junqueira VB

更新日期：2000-04-10 00:00:00

abstract：:Crotonaldehyde is an environment pollutant and lipid peroxidation product. Crotonaldehyde produces adverse effects to humans and serves as a risk factor for human pulmonary diseases. Like acrolein and 4-hydroxynonenal, crotonaldehyde seems likely to alter many cell signaling cascades, including inflammatory responses....

journal_title：Toxicology letters

authors： Liu XY,Yang ZH,Pan XJ,Zhu MX,Xie JP

更新日期：2010-08-16 00:00:00

abstract：:The necessity to protect humans from the adverse effects of chemicals on structure and function of the developing and/or mature nervous system is increasingly recognized among regulatory bodies throughout the world. Whereas structural changes dominated much of neurotoxicological research in the past, functional marker...

journal_title：Toxicology letters

authors： Winneke G,Lilienthal H

更新日期：1992-12-01 00:00:00

abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...

journal_title：Toxicology letters

authors： Soni M,Nomiyama H,Nomiyama K

更新日期：1990-12-01 00:00:00

abstract：:Combined effects of mycotoxin mixtures are of major concern due to the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon the fu...

journal_title：Toxicology letters

authors： Tammer B,Lehmann I,Nieber K,Altenburger R

更新日期：2007-04-25 00:00:00

abstract：:EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

journal_title：Toxicology letters

authors： Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

更新日期：1984-07-01 00:00:00

abstract：:Cadmium specifically modify amine metabolism at the central nervous system and pituitary hormone secretions. Thus, the physiological functions controlled by these hormones can be modulated by cadmium. This xenobiotic is associated with deleterious effects on the gonadal function and with changes in the secretory patte...

journal_title：Toxicology letters

authors： Lafuente A,Esquifino AI

更新日期：1999-11-22 00:00:00

abstract：:Dopaminergic system dysfunction is proved to be a possible mechanism in acrylamide (ACR) -induced neurotoxicity. The neurotransmitter dopamine (DA) has an increasingly important role in the dopaminergic system. Thus, the goal of this study is to evaluate effects of ACR on dopamine and its metabolite levels, dopamine t...

journal_title：Toxicology letters

authors： Pan X,Guo X,Xiong F,Cheng G,Lu Q,Yan H

更新日期：2015-07-02 00:00:00

abstract：:An unusual case of fatal poisoning by delta-9-tetrahydrocannabinol (delta-9-THC)--a physiologically active constituent of cannabis--is reported. Methods of isolation and detection of delta-9-THC was estimated quantitatively by thin-layer chromatography (TLC) and photoelectric densitometry. ...

journal_title：Toxicology letters

authors： Tewari SN,Sharma JD

更新日期：1980-03-01 00:00:00

abstract：:The effect of lead exposure on dopaminergic mechanisms regulating prolactin (PRL) secretion was studied in rats by measuring dopamine (DA) and dihydroxyphenylacetic acid hypothalamic concentrations and DA receptor density in the hypothalamus and pituitary of lead-exposed animals. [3H]Sulpiride was used as dopamine rec...

journal_title：Toxicology letters

authors： Govoni S,Lucchi L,Battaini F,Spano PF,Trabucchi M

更新日期：1984-03-01 00:00:00

abstract：:The test based on measuring the RNA synthesis rate, already described on Hela S3 in culture (Fauris et al., Les colloques de l'INSERM 106 (1981) 455-463), has been adapted to a human hepatoma cell line Hep 3B which retains a certain capacity towards metabolising. These modifications make it easier to point to the pres...

journal_title：Toxicology letters

authors： Descampiaux B,Herno V,Brice A,Erb F

更新日期：1994-11-01 00:00:00

abstract：:A major issue of inhalation toxicity is that of dose. An inhaled dose is more difficult to determine than the dose from other routes of administration. Via oral or parenteral routes, a discrete amount of test substance is given in a bolus. In inhalation toxicology, the delivered dose depends on the exposure concentrat...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2003-04-11 00:00:00

abstract：:Triptolide (TP) is the main ingredient of Chinese herb Tripterygium wilfordii Hook f. (TWHF). Despite of its multifunction in pharmaceutics, accumulating evidences showed that TP caused obvious hepatotoxicity in clinic. The current study investigated the role of Notch1 signaling in TP-induced hepatotoxicity. Our data ...

journal_title：Toxicology letters

authors： Shen F,Xiong Z,Kong J,Wang L,Cheng Y,Jin J,Huang Z

更新日期：2019-01-01 00:00:00

abstract：:Acute effects of CHBrCl2 on microsomal lipid metabolism were studied in the liver of male Wistar rats administered a single oral dose (215 mg/kg). 3 h after administration, the modulation of phospholipid metabolism and the accumulation of triacylglycerol (TG) were noted in the microsomal membranes. A marked decrease i...

journal_title：Toxicology letters

authors： Koyama Y,Nakazawa Y

更新日期：1985-12-01 00:00:00

abstract：:Colistin is a polypeptide antibiotic that effectively treats infections caused by multidrug-resistant Gram-negative bacteria, but its clinical use is limited due to nephrotoxicity. The purpose of the present study was to identify biomarkers of colistin-induced nephrotoxicity and to further characterize the mechanisms ...

journal_title：Toxicology letters

authors： Jeong ES,Kim G,Moon KS,Kim YB,Oh JH,Kim HS,Jeong J,Shin JG,Kim DH

更新日期：2016-04-25 00:00:00

abstract：:Cultured human proximal tubule cell monolayers maintained on permeable supports were treated simultaneously with the aminoglycoside antibiotic, gentamicin, and poly-L-aspartic acid (PAA), an inhibitor of aminoglycoside nephrotoxicity. Following 4 days of exposure, cell monolayers were placed into Ussing chambers to al...

journal_title：Toxicology letters

authors： Todd JH,Hottendorf GH

更新日期：1997-02-07 00:00:00

abstract：:Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

journal_title：Toxicology letters

authors： Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

更新日期：2016-02-03 00:00:00

abstract：:The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

journal_title：Toxicology letters

authors： Morton DM

更新日期：1998-12-28 00:00:00

abstract：:Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...

journal_title：Toxicology letters

authors： Kulshrestha SK,Arora N

更新日期：1984-01-01 00:00:00

abstract：:The effect of zinc (Zn) administration on the uptake and retention of cadmium (Cd), copper (Cu) and Zn in liver, kidneys and testes of cadmium exposed rats was investigated. Exposure to Cd caused a significant increase in the uptake of these metals in the 3 organs. The administration of Zn after the Cd exposure had li...

journal_title：Toxicology letters

authors： Behari JR,Tandon SK

更新日期：1980-02-01 00:00:00

abstract：:The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods ...

journal_title：Toxicology letters

authors： Hasegawa K,Miwa S,Tsutsumiuchi K,Taniguchi H,Miwa J

更新日期：2004-09-10 00:00:00

abstract：:Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

journal_title：Toxicology letters

authors： Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

更新日期：2012-02-05 00:00:00

abstract：:Lithocholic acid (LCA) is both a secondary bile acid and a vitamin D receptor (VDR) ligand. The VDR is activated by 1,25-dihydroxy vitamin D3 and plays an important role in maintaining integrity of the intestinal mucosal barrier. LCA can also substitute for vitamin D to carry out the in vivo functions of vitamin D. Ho...

journal_title：Toxicology letters

authors： Yao B,He J,Yin X,Shi Y,Wan J,Tian Z

更新日期：2019-11-01 00:00:00

abstract：:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from eithe...

journal_title：Toxicology letters

authors： Vandewaa EA,Barney CC,Gentile JM

更新日期：1982-12-01 00:00:00

abstract：:A wholesomeness feeding study was carried out in mice fed equal amounts of cod or redfish, comprising 45% of the diet. Three groups of animals received either irradiated [1.75 kGy (175 krad)] fish, non-irradiated fish or stock ration. A 90-day subchronic study, a multigeneration reproduction, a dominant lethality and ...

journal_title：Toxicology letters

authors： van Petten LE,Calkins JE,McConnell RF,Gottschalk HM,Elias PS

更新日期：1980-12-01 00:00:00

abstract：:Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...

journal_title：Toxicology letters

authors： Scheri RC,Lee J,Barofsky DF,Curtis LR

更新日期：2009-12-01 00:00:00