Acute effect of bromodichloromethane on lipid metabolism in rat liver microsomes.

abstract：:20 non-smokers on a defined diet low in polycyclic aromatic hydrocarbons (PAH) were exposed to environmental tobacco smoke (ETS) in an unventilated room for 8 h. The urinary mutagenicity in the 24-h urine samples as tested with the Salmonella (TA98) microsome assay did not significantly increase after exposure to eith...

journal_title：Toxicology letters

authors： Scherer G,Westphal K,Biber A,Hoepfner I,Adlkofer F

更新日期：1987-01-01 00:00:00

abstract：:The skin is an immunologically active tissue. Epidermal cells, both keratinocytes and Langerhans cells (LC), produce constitutively or can be stimulated to produce a variety of cytokines, many of which play important roles in the induction and regulation of allergic responses to sensitizing chemicals. Tumor necrosis f...

journal_title：Toxicology letters

authors： Kimber I,Holliday MR,Dearman RJ

更新日期：1995-12-01 00:00:00

abstract：:Occupational high-grade lead exposure has been reduced in recent decades as a result of increased regulation. However, environmental lead exposure remains widespread, and is associated with severe toxicity implicated in human diseases. We performed oral intragastric administration of various dose lead acetate to adult...

journal_title：Toxicology letters

authors： Liu J,Jia DY,Cai SZ,Li CP,Zhang MS,Zhang YY,Yan CH,Wang YP

更新日期：2015-05-19 00:00:00

abstract：:Cigarette smoke (CS) induced chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in China. However, lack of appropriate animal model slows down the progress in understanding pathogenesis of the disease. The aim of current study is to establish and evaluate a more adequate rat model...

journal_title：Toxicology letters

authors： Zheng H,Liu Y,Huang T,Fang Z,Li G,He S

更新日期：2009-09-28 00:00:00

abstract：:Reports on adverse health effects related to occupational exposure to toner powder are still inconclusive. Therefore, we have previously conducted an in vitro-study to characterize the genotoxic potential of three commercially available black printer toner powders in A549 lung cells. In these cell-based assays it was ...

journal_title：Toxicology letters

authors： Könczöl M,Weiß A,Gminski R,Merfort I,Mersch-Sundermann V

更新日期：2013-02-04 00:00:00

abstract：:It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1993-01-01 00:00:00

abstract：:Data on occurrence of dioxins (polychlorinated dibenzo-p-dioxins [PCDDs] and dibenzofurans [PCDFs]), dioxin-like PCBs (polychlorinated non-ortho and mono-ortho biphenyls) and non-dioxin-like PCBs (as represented by the so-called indicator-PCBs: congeners 28, 52, 101, 118, 138, 153 and 180) in food products consumed in...

journal_title：Toxicology letters

authors： Baars AJ,Bakker MI,Baumann RA,Boon PE,Freijer JI,Hoogenboom LA,Hoogerbrugge R,van Klaveren JD,Liem AK,Traag WA,de Vries J

更新日期：2004-06-15 00:00:00

abstract：:The in vitro interactions of carbaryl and carcinogenic N-nitrosocarbaryl with rat liver microsomal monooxygenase activities are compared. The inhibitory effect of the nitroso-compound is demonstrated to be non-competitive on aminopyrine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase. The nature of...

journal_title：Toxicology letters

authors： Beraud M,Forgue MF,Pipy B,Derache P

更新日期：1989-02-01 00:00:00

abstract：:Enzymatic activities of Na+/K+-ATPase and Mg2+ -ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to prevent and recover the CuSO4-induced inhibition. The influence of experimentally added CuSO4 and E...

journal_title：Toxicology letters

authors： Vasić V,Jovanović D,Krstić D,Nikezić G,Horvat A,Vujisić L,Nedeljković N

更新日期：1999-10-29 00:00:00

abstract：:Methamphetamine (METH) is a widely abused psychostimulant. Lactulose is a non-absorbable sugar, which effectively decreases METH-induced neurotoxicity in rat. However, the exact mechanisms need further investigation. In this study, 5-week-old male Sprague Dawley rats received METH (15 mg/kg, 8 intraperitoneal injectio...

journal_title：Toxicology letters

authors： Xie XL,He JT,Wang ZT,Xiao HQ,Zhou WT,Du SH,Xue Y,Wang Q

更新日期：2018-06-01 00:00:00

abstract：:Amiodarone is an effective antidysrhythmic agent, restricted in use by the development of pulmonary toxicity. Several in vivo animal models have been used to study amiodarone-induced pulmonary toxicity. Intratracheal administration of amiodarone to the hamster has been used as a model for the critical amiodarone-induc...

journal_title：Toxicology letters

authors： Leeder RG,Evans CD,Brien JF,Massey TE

更新日期：1994-10-01 00:00:00

abstract：:Pulmonary fibrosis is a serious adverse effect of radiotherapy for thoracic tumor, which is believed to be a process that is tightly regulated by the phenotype of the developing Th response after radiation. Here, we will investigate whether CpG-oligodeoxynucleotides (ODN) prevent radiation-induced pulmonary fibrosis b...

journal_title：Toxicology letters

authors： Zhang C,Zhao H,Li BL,Fu-Gao,Liu H,Cai JM,Zheng M

更新日期：2018-08-01 00:00:00

abstract：:Cadmium (Cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. Previously, we have shown that Cd activated mitogen-activated protein kinases and that sulfur amino acid deficiency potentiated Cd-induced cytotoxicity vi...

journal_title：Toxicology letters

authors： Kim SC,Cho MK,Kim SG

更新日期：2003-10-15 00:00:00

abstract：:We examined the ability of the multidrug resistance-associated protein 1 (MRP1/ABCC1) to transport pesticides, as this transporter mediates the cellular efflux of a variety of xenobiotics, typically as glucuronide, sulfate, or glutathione conjugates. NIH3T3 cells stably expressing MRP1 were 3.37-fold more resistant to...

journal_title：Toxicology letters

authors： Tribull TE,Bruner RH,Bain LJ

更新日期：2003-04-30 00:00:00

abstract：:The toxicity of benz (e) acephenanthrylene (BeA) has been studied earlier with regard to the carcinogenicity of its metabolites, but its phototogenotoxicity is not well understood. Present study aimed to analyze the photodynamic response of BeA in human skin cell line (A375) under ambient environmental intensity of UV...

journal_title：Toxicology letters

authors： Ali D,Ray RS,Hans RK

更新日期：2010-11-30 00:00:00

abstract：:The development of novel alternative testing methods is required to identify the sensitizing capacity of chemicals as a replacement for animal experimentation. We aimed to evaluate in vitro assays as screening tools for detecting skin sensitizers. The murine epidermal keratinocyte cell line HEL-30 was exposed to 16 re...

journal_title：Toxicology letters

authors： Son D,Na Y,Cho WS,Lee BH,Heo Y,Park JH,Seok SH

更新日期：2013-01-10 00:00:00

abstract：:Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was ...

journal_title：Toxicology letters

authors： Foster PM,Thomas LV,Cook MW,Walters DG

更新日期：1983-02-01 00:00:00

abstract：:Aim of this pilot study was to correlate the human exposure to formaldehyde (F) with N-methylenvaline, a molecular adduct formed by addiction of F to the N-terminal valine in hemoglobin. A group of 21 subjects employed in a plywood factory and a laminate factory, and occupationally exposed to F, together with a group ...

journal_title：Toxicology letters

authors： Bono R,Vincenti M,Schiliro' T,Scursatone E,Pignata C,Gilli G

更新日期：2006-02-08 00:00:00

abstract：:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...

journal_title：Toxicology letters

authors： Matsukura M,Koike K,Zon G

更新日期：1995-12-01 00:00:00

abstract：:The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on th...

journal_title：Toxicology letters

authors： Takehana K,Hirota K,Roth SH,Masuda A,Ito Y

更新日期：2000-05-19 00:00:00

abstract：RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

journal_title：Toxicology letters

authors： Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

更新日期：2021-02-01 00:00:00

abstract：:Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it can interfere with steroid biosynthesis and metabolism. However, the mechanism is unclear. The objective of the present study is to investigate the effects of BPA on two isoforms of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2)...

journal_title：Toxicology letters

authors： Guo J,Yuan X,Qiu L,Zhu W,Wang C,Hu G,Chu Y,Ye L,Xu Y,Ge RS

更新日期：2012-11-30 00:00:00

abstract：:The 2,4-dinitrophenylhydrazine (2,4-DNPH) derivatization method mainly used for the determination of airborne formaldehyde was extended for acetaldehyde, acetone, 2-butanone, and cyclohexanone, the next four carbonyl compounds of industrial importance. Sampling devices and sampling conditions were adjusted for the res...

journal_title：Toxicology letters

authors： Binding N,Schilder K,Czeschinski PA,Witting U

更新日期：1998-08-01 00:00:00

abstract：:Cyanotoxins are now recognised by international and national health and environment agencies as significant health hazards. These toxins, and the cells which produce them, are also vulnerable to exploitation for illegitimate purposes. Cyanotoxins are increasingly being subjected to national and international guideline...

journal_title：Toxicology letters

authors： Metcalf JS,Meriluoto JA,Codd GA

更新日期：2006-05-25 00:00:00

abstract：:Fourteen amino acids protected at the N-terminal and at their side chains were screened for resolving the enantiomers of V-agents by NMR. While none of the shift reagents tested showed really effective separation in proton NMR, two of them (BOC-Gln(Xan)-OH, 16, and Z-Arg(Z)2-OH), 21, with 16 superior to 21) were found...

journal_title：Toxicology letters

authors： Koller M,Thiermann H,Worek F

更新日期：2020-03-01 00:00:00

abstract：:Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...

journal_title：Toxicology letters

authors： Kulshrestha SK,Arora N

更新日期：1984-01-01 00:00:00

abstract：:The classical way to demonstrate the efficiency of remediation is measuring the reduction of toxic compounds in the environment. Nevertheless, more important is the risk reduction in human health. To determine changing health effects, exposure and bio-effects have to be monitored at time of and during remediation. Kin...

journal_title：Toxicology letters

authors： Rolle-Kampczyk UE,Rehwagen M,Franck U,Weiss H,Krumbiegel P,Herbarth O

更新日期：2006-04-10 00:00:00

abstract：:Aminoglycosides have detrimental effects on the hair cells of the inner ear, yet these agents indisputably are one of the cornerstones in antibiotic therapy. Hence, there is a demand for strategies to prevent aminoglycoside-induced ototoxicity, which are not available today. In vitro data suggests that the pleiotropic...

journal_title：Toxicology letters

authors： Bächinger D,Horvath L,Eckhard A,Goosmann MM,Honegger T,Gassmann M,Vogel J,Naldi AM

更新日期：2018-07-01 00:00:00

abstract：:Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibit...

journal_title：Toxicology letters

authors： Ge DT,Law PY,Kong SK,Ho YY

更新日期：2009-01-30 00:00:00

abstract：:The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respective...

journal_title：Toxicology letters

authors： Bhunya SP,Pati PC

更新日期：1988-06-01 00:00:00