Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat.

Abstract:

:Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was demonstrated by this compound on hepatic cytochrome P-450 content. Treatment of animals with a phthalate ester not causing testicular atrophy (diethyl phthalate; DEP) produced no significant changes in any of the parameters measured. This effect on the enzymes responsible for androgen production may be important as a mechanism of action involved in the development of phthalate-induced testicular damage.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Foster PM,Thomas LV,Cook MW,Walters DG

doi

10.1016/0378-4274(83)90226-6

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

265-71

issue

2-3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(83)90226-6

journal_volume

15

pub_type

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