Urinary mutagenicity after controlled exposure to environmental tobacco smoke (ETS).

abstract：:Neuron specific enolase (ENO2, γ-enolase) is a biomarker used to help identify neuroendocrine differentiation in tumors. This laboratory has shown that ENO2 might be a biomarker for exposure to cadmium and arsenite. In this study these observations are extended to the urothelial cell, where environmental exposures are...

journal_title：Toxicology letters

authors： Soh M,Dunlevy JR,Garrett SH,Allen C,Sens DA,Zhou XD,Sens MA,Somji S

更新日期：2012-07-07 00:00:00

abstract：:Mouse inbred strains with inherited predisposition and resistance to lung cancer provide an essential tool for the dissection of the genetics of this complex disease. We have previously mapped a major locus (Pulmonary adenoma susceptibility 1, Pas1) affecting inherited predisposition to lung cancer in mice on chromoso...

journal_title：Toxicology letters

authors： Manenti G,Nomoto T,De Gregorio L,Gariboldi M,Stefania Falvella F,Nagao M,Dragani TA

更新日期：2000-03-15 00:00:00

abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

journal_title：Toxicology letters

authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

更新日期：2012-10-17 00:00:00

abstract：:A short-term initiation/promotion bioassay has been developed in rat liver using putative preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two protocols of the bioassay used in this study were varied according to the time 2/3 partial hepatectomy was performed in relation to when the in...

journal_title：Toxicology letters

authors： Herren SL,Pereira MA,Britt AL,Khoury MK

更新日期：1982-07-01 00:00:00

abstract：:A toxicogenomics approach was applied to assess the usefulness of the mouse cytotoxic T cell line CTLL-2 for in vitro immunotoxicity testing. CTLL-2 cells were exposed for 6 h to two model immunotoxic compounds: (1) the mycotoxin deoxynivalenol (DON, 1 and 2 μM), a ribotoxic stress inducer, and (2) the organotin compo...

journal_title：Toxicology letters

authors： Schmeits PC,Volger OL,Zandvliet ET,van Loveren H,Peijnenburg AA,Hendriksen PJ

更新日期：2013-02-13 00:00:00

abstract：:The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fe...

journal_title：Toxicology letters

authors： Huan J,Cheeke PR,Lowry RR,Nakaue HS,Snyder SP,Whanger PD

更新日期：1992-09-01 00:00:00

abstract：:Cigarette smoke (CS) is known to cause mitochondrial dysfunction leading to cellular senescence in lung cells. We determined the mechanism of mitochondrial dysfunction by CS in lung epithelial cells. CS extract (CSE) treatment differentially affected mitochondrial function, such as membrane potential, mitochondrial re...

journal_title：Toxicology letters

authors： Sundar IK,Maremanda KP,Rahman I

更新日期：2019-12-15 00:00:00

abstract：:Biochemical and histopathologic parameters of nephrotoxicity were measured in groups of male Fischer-344 rats after a 2-week, 5-days-a-week schedule of oral administration (0.5 ml/kg) of the following substances: aviation gasoline (grade 100) (AVG), automobile regular unleaded gasoline (ULG) and 2,2,4-trimethylpentane...

journal_title：Toxicology letters

authors： Gérin M,Viau C,Talbot D,Greselin E

更新日期：1988-11-01 00:00:00

abstract：:Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, expe...

journal_title：Toxicology letters

authors： Lauková M,Pervez S,Rosman R,Velíšková J,Velíšek L,Shakarjian MP

更新日期：2019-06-15 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:Crotonaldehyde is an environment pollutant and lipid peroxidation product. Crotonaldehyde produces adverse effects to humans and serves as a risk factor for human pulmonary diseases. Like acrolein and 4-hydroxynonenal, crotonaldehyde seems likely to alter many cell signaling cascades, including inflammatory responses....

journal_title：Toxicology letters

authors： Liu XY,Yang ZH,Pan XJ,Zhu MX,Xie JP

更新日期：2010-08-16 00:00:00

abstract：:Two groups, each of 4 rabbits, 17 and 4 months old, respectively, were given s.c. administrations of cadmium (Cd) at a dose level of 0.5 mg/kg/day 6 times per week for up to 32 weeks. In 17-month-old rabbits, low-molecular-weight proteinuria appeared in the 3rd week, proteinuria, glycosuria and anemia in the 6th week;...

journal_title：Toxicology letters

authors： Nomiyama K,Nomiyama H,Yotoriyama M

更新日期：1980-09-01 00:00:00

abstract：:Hsp90, p23 and other chaperosome proteins are critical for the function of several enzymes and steroid hormone receptors. The dioxin receptor (DR) is an Hsp90-regulated transcription factor that binds numerous toxic ligands, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo(p)dioxin. We used a yeast m...

journal_title：Toxicology letters

authors： Cox MB,Miller CA 3rd

更新日期：2002-03-24 00:00:00

abstract：:The distribution of mercury to the brain following an injection of methylmercury (MeHg) or ethylmercury (EtHg) was examined in immature mice. Postnatal day (PND) 16 CD1 mice received MeHg chloride either by IM injection or by gavage. At 24 h and 7 days post-injection, total mercury concentrations were determined in bl...

journal_title：Toxicology letters

authors： Harry GJ,Harris MW,Burka LT

更新日期：2004-12-30 00:00:00

abstract：:Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

journal_title：Toxicology letters

authors： Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

更新日期：2020-10-01 00:00:00

abstract：:Plant protection products have to be evaluated and authorized in the EC-Member States since 1993 in accordance with Directive 91/414/EEC. The programme for evaluating existing active substances (which were on the market before July 1993) involves several steps and stages, stretching over a period of up to formerly 10,...

journal_title：Toxicology letters

authors： Flynn DJ,Lundehn JR

更新日期：2004-04-01 00:00:00

abstract：:A growing body of evidence suggests HIV patients are at a greater risk for developing atherosclerosis. However, clinical investigations have generated conflicting results with regard to whether antiretrovirals are independently involved in the development of HIV-associated atherosclerosis. By administering antiretrovi...

journal_title：Toxicology letters

authors： Jiang B,Hebert VY,Khandelwal AR,Stokes KY,Dugas TR

更新日期：2009-06-22 00:00:00

abstract：:Although the interest is growing towards glyoxalases and methylglyoxal, their role in metabolism is still an enigma. In this paper, the effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules (nucleic acids, proteins). The theories on...

journal_title：Toxicology letters

authors： Kalapos MP

更新日期：1994-07-01 00:00:00

abstract：:Exposure to chemicals released during urban waste disposal and treatment is increasingly regarded as a potential occupational health issue. Indeed, several toxic metals emitted by an incinerator, including As, Be, Cd, Cr, Pb, Mn, Hg, Ni and V, have potentially toxic properties and their exposure, therefore, may be of ...

journal_title：Toxicology letters

authors： Mauriello MC,Sbordone C,Montuori P,Alfano R,Triassi M,Iavicoli I,Manno M

更新日期：2017-04-15 00:00:00

abstract：:The oral LD50 of hymenoxon in Swiss white mice was found to be 241 +/- 37 mg/kg. No significant sex differences were observed. Pretreatment of male mice for 3 days using doses of 50 and 100 mg/kg hymenoxon failed to alter significantly pentobarbital sleeping time. Hymenoxon was found to be a direct-acting mutagen in t...

journal_title：Toxicology letters

authors： Jones DH,Kim HL

更新日期：1981-12-01 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model describing the disposition of 2-butoxyethanol (2-BE) was developed in order to predict the urinary concentration of its major metabolite, butoxyacetic acid (BAA) under a range of exposure scenarios. Based on Corley et al. [Corley, R.A., Bormett, G.A., Ghanayem, B.I....

journal_title：Toxicology letters

authors： Franks SJ,Spendiff MK,Cocker J,Loizou GD

更新日期：2006-04-10 00:00:00

abstract：:Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet. Chronic Cd exposure is a public health concern because Cd is a known carcinogen; it accumulates in the body and causes kidney damage. The National Health and Nutritional Examination Survey (NHANE...

journal_title：Toxicology letters

authors： Ruiz P,Mumtaz M,Osterloh J,Fisher J,Fowler BA

更新日期：2010-09-15 00:00:00

abstract：:Activity of telomerase, the enzyme that synthesizes the telomere ends of linear eukaryotic chromosomes, is repressed in most normal human somatic cells but induced in most human cancers. Normal human cells that lack telomerase activity progressively lose telomere sequences. In contrast, most immortalized cell lines an...

journal_title：Toxicology letters

authors： Meyerson M

更新日期：1998-12-28 00:00:00

abstract：:The 2,4-dinitrophenylhydrazine (2,4-DNPH) derivatization method mainly used for the determination of airborne formaldehyde was extended for acetaldehyde, acetone, 2-butanone, and cyclohexanone, the next four carbonyl compounds of industrial importance. Sampling devices and sampling conditions were adjusted for the res...

journal_title：Toxicology letters

authors： Binding N,Schilder K,Czeschinski PA,Witting U

更新日期：1998-08-01 00:00:00

abstract：:The skin is an immunologically active tissue. Epidermal cells, both keratinocytes and Langerhans cells (LC), produce constitutively or can be stimulated to produce a variety of cytokines, many of which play important roles in the induction and regulation of allergic responses to sensitizing chemicals. Tumor necrosis f...

journal_title：Toxicology letters

authors： Kimber I,Holliday MR,Dearman RJ

更新日期：1995-12-01 00:00:00

abstract：:The degradation of cyanogenic glycosides was studied in spontaneously fermenting cassava root pulp and in fresh pulp samples pretreated to prevent either endogenous beta-glycosidase activity, fermentation, or both. The rate of disappearance of the glycosides, as measured by hydrocyanic acid (HCN) production in situ, i...

journal_title：Toxicology letters

authors： Maduagwu EN

更新日期：1983-03-01 00:00:00

abstract：:The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...

journal_title：Toxicology letters

authors： Nair BS,Erickson JR,Pillai R,Estrada A,Watson RR

更新日期：1991-08-01 00:00:00

abstract：:The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. This spectral map is affected by th...

journal_title：Toxicology letters

authors： Ryan SE,Nguyen HP,Baenziger JE

更新日期：1998-11-23 00:00:00

abstract：:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...

journal_title：Toxicology letters

authors： Tanaka T

更新日期：1992-05-01 00:00:00

abstract：:Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...

journal_title：Toxicology letters

authors： Kulshrestha SK,Arora N

更新日期：1984-01-01 00:00:00