Abstract：
:The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fed a diet with 5% TR, while serum and liver zinc and vitamin A decreased. When PA were removed from the diet, partial restoration of normal serum vitamin A level occurred, indicating that the ability to mobilize liver vitamin A is not irreversibly inhibited by PA. The decline in serum vitamin A occurred by 8 days of TR feeding with a concurrent decline in growth rate. When chicks were fed a diet high in vitamin A (25,000 IU/kg), followed by a basal diet containing TR, serum vitamin A levels were significantly (P < 0.01) decreased, while liver vitamin A level increased. This indicates that mobilization of previously stored vitamin A from the liver is impaired by PA. Prior feeding of a high vitamin A level resulted in protective effects against PA toxicity, as assessed by histopathology. This study shows that a dietary source of PA modifies metabolism and tissue distribution of minerals and vitamin A.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Huan J,Cheeke PR,Lowry RR,Nakaue HS,Snyder SP,Whanger PDdoi
10.1016/0378-4274(92)90017-ekeywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
139-53issue
2-3eissn
0378-4274issn
1879-3169pii
0378-4274(92)90017-Ejournal_volume
62pub_type
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pub_type： 杂志文章,多中心研究
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更新日期：1981-05-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2004-06-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2001-03-31 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.10.016
更新日期：2007-01-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2014-02-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2001-04-08 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2014-04-21 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(92)90233-a
更新日期：1992-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.12.020
更新日期：2014-03-03 00:00:00
