Programmed cell death and its protective role with particular reference to apoptosis.

Abstract:

:Apoptosis is a type of programmed cell death involved in growth control of tissues. It is considered as a cellular suicide functionally opposite to mitosis. It may serve to remove "unwanted" damaged or dangerous, e.g. precancerous, cells. Chemical compounds can interfere with the regulatory network which controls apoptosis and can thereby stimulate or prevent cell death. Both induction or inhibition of apoptosis may result in various diseases such as of the immune system, malformation or tumor development. The protective role of apoptosis against carcinogenesis is described in some detail. Tumor formation seems to occur through several stages, namely initiation, promotion, progression, and involves formation and growth of premalignant cell populations. At least in some model systems initiated cells and premalignant cell populations have been found to exhibit enhanced cell replication, but also enhanced apoptotic activity as compared to the normal tissue. Therefore, initiated cells may be eliminated by apoptosis. Tumor promoters can inhibit apoptosis in putative preneoplastic cells and thereby accelerate tumor development. Furthermore, in hormone-dependent cancers malignant cells may undergo massive apoptosis in response to hormone withdrawal or antihormone treatment. Finally, the regulation of apoptosis will be addressed. Our results suggest that transforming growth factor beta 1, a negative regulator of epithelial tissue growth, is a signal inducing apoptosis of liver cells.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Schulte-Hermann R,Bursch W,Kraupp-Grasl B,Oberhammer F,Wagner A

doi

10.1016/0378-4274(92)90233-a

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

569-74

eissn

0378-4274

issn

1879-3169

pii

0378-4274(92)90233-A

journal_volume

64-65 Spec No

pub_type

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